Perinatal and early postnatal factors underlying developmental delay and disabilities

Developmental Disabilities Research Reviews

Volumn 17, Issue 2, 2011, Pages 59-70

  Ergaz, Zivanit ^a   Ornoy, Asher ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Developmental disabilities; Developmental milestone delay; Neonatal encephalopathy; Neuroprotection; Perinatal risk factors

Indexed keywords

ACETYLSALICYLIC ACID; ALLOPURINOL; BILIRUBIN; ERYTHROPOIETIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; MAGNESIUM; PHENOBARBITAL; PHOSPHOLIPID ANTIBODY;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; ATTENTION DEFICIT DISORDER; AUTOIMMUNE DISEASE; BILIRUBIN BLOOD LEVEL; BLEEDING; BODY HEIGHT; BODY MASS; BRAIN HEMORRHAGE; BRAIN INFARCTION; CHORIOAMNIONITIS; CLINICAL EXAMINATION; DEVELOPMENTAL DISORDER; DIABETES MELLITUS; DISEASE SEVERITY; DRUG MEGADOSE; EATING DISORDER; ELECTROENCEPHALOGRAPHY; EPIDURAL DRUG ADMINISTRATION; GESTATIONAL AGE; HEMIPARESIS; HUMAN; HYPERACTIVITY; HYPERBILIRUBINEMIA; HYPOCALCEMIA; HYPOGLYCEMIA; HYPOTHYROIDISM; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; INTELLIGENCE QUOTIENT; INTRAUTERINE GROWTH RETARDATION; LEUKOMALACIA; MATERNAL OBESITY; MATERNAL SMOKING; NEONATAL ENCEPHALOPATHY; NEONATAL ISCHEMIC STROKE; NEUROIMAGING; NEUROPROTECTION; NEWBORN DISEASE; NEWBORN HYPOXIA; NEWBORN MORBIDITY; NEWBORN MORTALITY; OCCLUSIVE CEREBROVASCULAR DISEASE; PERINATAL MORBIDITY; PERINATAL PERIOD; PREECLAMPSIA; PREMATURITY; PRIORITY JOURNAL; PROGNOSIS; PSYCHOMOTOR DISORDER; QUADRIPLEGIA; RESUSCITATION; SCHIZOPHRENIA; SEIZURE; SEPSIS; SOLUTIO PLACENTAE; SUBARACHNOID HEMORRHAGE; SYSTEMATIC REVIEW (TOPIC); TREATMENT DURATION; UNDERWEIGHT; FEMALE; NEWBORN; PREGNANCY; REVIEW; RISK FACTOR;

DEVELOPMENTAL DISABILITIES; FEMALE; HUMANS; INFANT, NEWBORN; PERIPARTUM PERIOD; PREGNANCY; RISK FACTORS;

EID: 84875267756     PISSN: 19405510     EISSN: 19405529     Source Type: Journal    
DOI: 10.1002/ddrr.1101     Document Type: Article

References (126)

1. Abou-Nassara K, Carriera M, Ramsayb T, et al. 2011. The association between antiphospholipid antibodies and placenta mediated complications: a systematic review and metaanalysis. Thromb Res 128:77-85.
2. Adamkin DH. 2011. Postnatal glucose homeostasis in late-preterm and term infants. Pediatrics 127:575-579.
3. Adams-Chapman I, Hansen NI, Stoll BJ, et al. 2008. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics 121:e1167-e1177.
4. Alfven G, Bergqvist G, Bolme P, et al. 1978. Long-term follow-up of neonatal septicemia. Acta Paediatr Scand 67:769-773.
5. Allen KL, Byrne SM, Forbes D, et al. 2009. Risk factors for full- and partial-syndrome early adolescent eating disorders: a populationbased pregnancy cohort study. J Am Acad Child Adolesc Psychiatry 48:800-809.
6. Arad I, Ergaz Z. 2004. The fetal inflammatory response syndrome and associated infant morbidity. Isr Med Assoc J 6:766-769.
7. Arcangeli T, Thilaganathan B, Hooper R, et al. 2012. Neurodevelopmental delay in small babies at term. A systematic review. Ultrasound Obstet Gynecol 40:267-275.
8. Argyropoulou MI. 2010. Brain lesions in preterm infants: initial diagnosis and follow-up. Pediatr Radiol 40:811-818.
9. Asakura H, Schifrin BS, Myers SA. 1994. Intrapartum, atraumatic, non-asphyxial intracranial hemorrhage in a full-term infant. Obstet Gynecol 84 (Part 2):680-683.
10. Bassan H, Feldman HA, Limperopoulos C, et al. 2006. Periventricular hemorrhagic infarction: risk factors and neonatal outcome. Pediatr Neurol 35:85-92.
11. Bersani I, Thomas W, Speer CP. 2012. Chorioamnionitis- the good or the evil for neonatal outcome? J Matern Fetal Neona 25 Suppl 1:12-16.
12. Blair E, de Groot J, Nelson KB. 2011. Placental infarction identified by macroscopic examination and risk of cerebral palsy in infants at 35 weeks of gestational age and over. Am J Obstet Gynecol 205:124.e121-124.e127.
13. Brooks JC, Fisher-Owens SA, Wu YW, et al. 2011. Evidence suggests there was not a "resurgence" of kernicterus in the 1990s. Pediatrics 127:672-679.
14. Brouwer AJ, van Stam C, Uniken Venema M, et al. 2011. Cognitive and neurological outcome at the age of 5-8 years of preterm infants with post-hemorrhagic ventricular dilatation requiring neurosurgical intervention. Neonatology 101:210-216.
15. Burns CM, Rutherford MA, Boardman JP, et al. 2008. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia. Pediatrics 122:65-74.
16. Carroll TY, Mulla MJ, Han CS, et al. 2011. Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin. Am J Reprod Immunol 66:286-296.
17. Cetinkaya M, Alkan T, Ozyener F, et al. 2011. Possible neuroprotective effects of magnesium sulfate and melatonin as both pre- and post-treatment in a neonatal hypoxic-ischemic rat model. Neonatology 99:302-310.
18. Chakkarapani E, Dingley J, Liu X, et al. 2010. Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs. Ann Neurol 68:330-341.
19. Chalmers E, Williams M, Brennand J, et al. 2011. Guideline on the management of haemophilia in the fetus and neonate. Br J Haematol 154:208-215.
20. Chamnanvanakij S, Perlman JM. 1999. Extensive late-onset primary subarachnoid hemorrhage in a preterm infant. Pediatr Neurol 21:735- 738.
21. Chaudhari T, McGuire W. 2008. Allopurinol for preventing mortality and morbidity in newborn infants with suspected hypoxic-ischaemic encephalopathy. Cochrane Database Syst Rev (2):CD006817.
22. deVeber GA, MacGregor D, Curtis R, et al. 2000. Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 15:316-324.
23. Dodd JM, McLeod A, Windrim RC, et al. 2010. Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction. Cochrane Database Syst Rev (6):CD006780.
24. Drougia A, Giapros V, Krallis N, et al. 2007. Incidence and risk factors for cerebral palsy in infants with perinatal problems: a 15-year review. Early Hum Dev 83:541-547.
25. Dyet LE, Kennea N, Counsell SJ, et al. 2006. Natural history of brain lesions in extremely preterm infants studied with serial magnetic resonance imaging from birth and neurodevelopmental assessment. Pediatrics 118:536-548.
26. Edwards AD, Brocklehurst P, Gunn AJ, et al. 2010. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 340:c363.
27. Elmahdy H, El-Mashad AR, El-Bahrawy H, et al. 2010. Human recombinant erythropoietin in asphyxia neonatorum: pilot trial. Pediatrics 125:e1135-e1142.
28. Ergaz Z, Avgil M, Ornoy A. 2005. Intrauterine growth restriction-etiology and consequences: what do we know about the human situation and experimental animal models? Reprod Toxicol 20:301-322.
29. Fan X, Kavelaars A, Heijnen CJ, et al. 2010. Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. Curr Neuropharmacol 8:324-334.
30. Ferriero DM. 2004. Neonatal brain injury. N Engl J Med 351:1985-1995.
31. Franco SM, Cornelius VE, Andrews BF. 1992. Long-term outcome of neonatal meningitis. Am J Dis Child 146:567-571.
32. Garfinkle J, Shevell MI. 2011. Cerebral palsy, developmental delay, and epilepsy after neonatal seizures. Pediatr Neurol 44:88-96.
33. Gathwala G, Khera A, Singh J, et al. 2010. Magnesium for neuroprotection in birth asphyxia. J Pediatr Neurosci 5:102-104.
34. Gkoltsiou K, Tzoufi M, Counsell S, et al. 2008. Serial brain MRI and ultrasound findings: relation to gestational age, bilirubin level, neonatal neurologic status and neurodevelopmental outcome in infants at risk of kernicterus. Early Hum Dev 84: 829-838.
35. Golomb MR, Garg BP, Carvalho KS, et al. 2007. Perinatal stroke and the risk of developing childhood epilepsy. J Pediatr 151:409-413, 413.e401-413.e402.
36. Gordon AL, English M, Tumaini Dzombo J, et al. 2005. Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. Trop Med Int Health 10: 1114-1120.
37. Gray PH, O'Callaghan MJ, Harvey JM, et al. 1999. Placental pathology and neurodevelopment of the infant with intrauterine growth restriction. Dev Med Child Neurol 41:16-20.
38. Greenwood C, Yudkin P, Sellers S, et al. 2005. Why is there a modifying effect of gestational age on risk factors for cerebral palsy? Arch Dis Child Fetal Neonatal Ed 90: F141-F146.
39. Haddow JE, Palomaki GE, Allan WC, et al. 1999. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549-555.
40. Han Z, Mulla S, Beyene J, et al. 2011. Maternal underweight and the risk of preterm birth and low birth weight: a systematic review and meta-analyses. Int J Epidemiol 40: 65-101.
41. Helderman JB, O'Shea TM, Kuban KC, et al. 2012. Antenatal antecedents of cognitive impairment at 24 months in extremely low gestational age newborns. Pediatrics 129:494-502.
42. Higgins M, Felle P, Mooney EE, et al. 2011. Stereology of the placenta in type 1 and type 2 diabetes. Placenta 32:564-569.
43. Hsu SC, Levine MA. 2004. Perinatal calcium metabolism: physiology and pathophysiology. Semin Neonatol 9:23-36.
44. Hyman SJ, Novoa Y, Holzman I. 2011. Perinatal endocrinology: common endocrine disorders in the sick and premature newborn. Pediatr Clin North Am 58:1083-1098, ix.
45. Ichiba H, Yokoi T, Tamai H, et al. 2006. Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate. Pediatr Int 48:70-75.
46. Jacobs S, Hunt R, Tarnow-Mordi W, et al. 2007. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev (4):CD003311.
47. Johnson L, Bhutani VK. 2011. The clinical syndrome of bilirubin-induced neurologic dysfunction. Semin Perinatol 35:101-113.
48. Kaandorp JJ, van Bel F, Veen S, et al. 2012. Long-term neuroprotective effects of allopurinol after moderate perinatal asphyxia: follow-up of two randomised controlled trials. Arch Dis Child Fetal Neonatal Ed 97:F162-166.
49. Kaplan M, Bromiker R, Hammerman C. 2011. Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? Neonatology 100:354-362.
50. Khandaker GM, Dibben CR, Jones PB. 2012. Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring? Obes Rev 13:518-527.
51. Khwaja O, Volpe JJ. 2008. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed 93:F153- F161.
52. Kirton A, Armstrong-Wells J, Chang T, et al. 2011. Symptomatic neonatal arterial ischemic stroke: the International Pediatric Stroke Study. Pediatrics 128:e1402-e1410.
53. Kitamura G, Kido D, Wycliffe N, et al. 2011. Hypoxic-ischemic injury: utility of susceptibility- weighted imaging. Pediatr Neurol 45:220-224.
54. Ko A, Filardi T, Giussani C, et al. 2010. An intracranial aneurysm and dural arteriovenous fistula in a newborn. Pediatr Neurosurg 46:450-456.
55. Koksal V, Oktem S. 2010. Ventriculosubgaleal shunt procedure and its long-term outcomes in premature infants with post-hemorrhagic hydrocephalus. Childs Nerv Syst 26:1505-1515.
56. Kossoff EH, Silvia MT, Maret A, et al. 2002. Neonatal hypocalcemic seizures: case report and literature review. J Child Neurol 17:236-239.
57. Lam PK, Torfs CP, Brand RJ. 1999. A low pregnancy body mass index is a risk factor for an offspring with gastroschisis. Epidemiology 10:717-721.
58. Levent F, Baker CJ, Rench MA, et al. 2010. Early outcomes of group B streptococcal meningitis in the 21st century. Pediatr Infect Dis J 29:1009-1012.
59. Limperopoulos C, Bassan H, Gauvreau K, et al. 2007. Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics 120:584-593.
60. Lynch JK. 2009. Epidemiology and classification of perinatal stroke. Semin Fetal Neonatal Med 14:245-249.
61. Lynch JK, Nelson KB. 2001. Epidemiology of perinatal stroke. Curr Opin Pediatr 13:499-505.
62. Maartens IA, Wassenberg T, Buijs J, et al. 2012. Neurodevelopmental outcome in full-term newborns with refractory neonatal seizures. Acta Paediatr 101:e178-178.
63. Maisels MJ, McDonagh AF. 2008. Phototherapy for neonatal jaundice. N Engl J Med 358:920-928.
64. Martinez-Biarge M, Madero R, Gonzalez A, et al. 2012. Perinatal morbidity and risk of hypoxic-ischemic encephalopathy associated with intrapartum sentinel events. Am J Obstet Gynecol 206:e141-147.
65. McCarthy LK, Donoghue V, Murphy JF. 2011. Ultrasonically detectable cerebellar haemorrhage in preterm infants. Arch Dis Child Fetal Neonatal Ed 96:F281-F285.
66. McQuillen PS, Barkovich AJ, Hamrick SE, et al. 2007. Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects. Stroke 38 (Suppl):736-741.
67. Merrill JD, Piecuch RE, Fell SC, et al. 1998. A new pattern of cerebellar hemorrhages in preterm infants. Pediatrics 102:E62.
68. Moharir MD, Shroff M, Pontigon AM, et al. 2011. A prospective outcome study of neonatal cerebral sinovenous thrombosis. J Child Neurol 26:1137-1144.
69. Moharir MD, Shroff M, Stephens D, et al. 2010. Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study. Ann Neurol 67:590-599.
70. Molesky MG. 2011. Chromosome 22q11.2 microdeletion syndrome. Neonatal Netw 30:304-311.
71. Momotani N, Iwama S, Momotani K. 2012. Neurodevelopment in children born to hypothyroid mothers restored to normal thyroxine (T4) concentration by late pregnancy in Japan: no apparent influence of maternal T4 deficiency. J Clin Endocrinol Metab 97:1104-1108.
72. Montassir H, Maegaki Y, Ogura K, et al. 2009. Associated factors in neonatal hypoglycemic brain injury. Brain Dev 31:649-656.
73. Nadeem M, Murray DM, Boylan GB, et al. 2011. Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy. BMC Pediatr 11:10.
74. Neggers YH, Goldenberg RL, Ramey SL, et al. 2003. Maternal prepregnancy body mass index and psychomotor development in children. Acta Obstet Gynecol Scand 82:235-240. Nielsen LF, Schendel D, Grove J, et al. 2008. Asphyxia- related risk factors and their timing in spastic cerebral palsy. BJOG 115:1518- 1528.
75. Nowak L, Bregestovski P, Ascher P, et al. 1984. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307:462-465.
76. Ozaltin E, Hill K, Subramanian SV. 2010. Association of maternal stature with offspring mortality, underweight, and stunting in low- to middle-income countries. JAMA 303:1507- 1516.
77. Peretta P, Ragazzi P, Carlino CF, et al. 2007. The role of Ommaya reservoir and endoscopic third ventriculostomy in the management of post-hemorrhagic hydrocephalus of prematurity. Childs Nerv Syst 23:765-771.
78. Perlman JM. 2004. Brain injury in the term infant. Semin Perinatol 28:415-424.
79. Perlman JM, Wyllie J, Kattwinkel J, et al. 2010. Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Circulation 122 (Suppl 2): S516-S538.
80. Perrone S, Toti P, Toti MS, et al. 2012. Perinatal outcome and placental histological characteristics: a single-center study. J Matern Fetal Neonatal Med 1:110-113.
81. Petersen MC, Kube DA, Palmer FB. 1998. Classification of developmental delays. Semin Pediatr Neurol 5:2-14.
82. Pisani F, Sisti L, Seri S. 2009. A scoring system for early prognostic assessment after neonatal seizures. Pediatrics 124:e580-e587.
83. Pop VJ, Kuijpens JL, van Baar AL, et al. 1999. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf) 50:149-155.
84. Prass K, Scharff A, Ruscher K, et al. 2003. Hypoxia- induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 34:1981-1986.
85. Przekop A, Sanger TD. 2011. Birth-related syndromes of athetosis and kernicterus. Handb Clin Neurol 100:387-395.
86. Radetti G, Gentili L, Paganini C, et al. 2000. Psychomotor and audiological assessment of infants born to mothers with subclinical thyroid dysfunction in early pregnancy. Minerva Pediatr 52:691-698.
87. Resch B, Neubauer K, Hofer N, et al. 2012. Episodes of hypocarbia and early-onset sepsis are risk factors for cystic periventricular leukomalacia in the preterm infant. Early Hum Dev 88:27-31.
88. Roland EH, Flodmark O, Hill A. 1990. Thalamic hemorrhage with intraventricular hemorrhage in the full-term newborn. Pediatrics 85:737-742.
89. Ronen GM, Buckley D, Penney S, et al. 2007. Long-term prognosis in children with neonatal seizures: a population-based study. Neurology 69:1816-1822.
90. Rosier-van Dunne FM, van Wezel-Meijler G, Kaschula RO, et al. 2011. Placental histology related to fetal brain sonography. Arch Dis Child Fetal Neonatal Ed 96:F53-F58.
91. Rozance PJ, Hay WW Jr. 2010. Describing hypoglycemia-definition or operational threshold? Early Hum Dev 86:275-280.
92. Sarnat HB, Sarnat MS. 1976. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 33:696-705.
93. Sgro M, Campbell D, Barozzino T, et al. 2011. Acute neurological findings in a national cohort of neonates with severe neonatal hyperbilirubinemia. J Perinatol 31:392-396.
94. Shah PS, Beyene J, To T, et al. 2006. Postasphyxial hypoxic-ischemic encephalopathy in neonates: outcome prediction rule within 4 hours of birth. Arch Pediatr Adolesc Med 160:729-736.
95. Shah SK, Jain S, Richardson J. 2008. Case 12-2008: apnea and seizures in a newborn infant. N Engl J Med 359:315; author reply 316.
96. Shankaran S, Pappas A, McDonald SA, et al. 2012. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 366:2085-2092.
97. Shatrov JG, Birch SC, Lam LT, et al. 2010. Chorioamnionitis and cerebral palsy: a metaanalysis. Obstet Gynecol 116 (Part 1):387- 392.
98. Shi X, Yasumoto S, Kurahashi H, et al. 2012. Clinical spectrum of SCN2A mutations. Brain Dev 34:541-545.
99. Sie LT, van der Knaap MS, Oosting J, et al. 2000. MR patterns of hypoxic-ischemic brain damage after prenatal, perinatal or postnatal asphyxia. Neuropediatrics 31:128-136.
100. Singh D, Kumar P, Majumdar S, et al. 2004. Effect of phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy- a randomized controlled trial. J Perinat Med 32:278-281.
101. Singh D, Kumar P, Narang A. 2005. A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy. J Matern Fetal Neonatal Med 18: 391-395.
102. Souvenir R, Fathali N, Ostrowski RP, et al. 2011. Tissue inhibitor of matrix metalloproteinase- 1 mediates erythropoietin-induced neuroprotection in hypoxia ischemia. Neurobiol Dis 44:28-37.
103. Stoll BJ, Hansen NI, Adams-Chapman I, et al. 2004. Neurodevelopmental and growth impairment among extremely low-birthweight infants with neonatal infection. JAMA 292:2357-2365.
104. Stoll BJ, Hansen NI, Sanchez PJ, et al. 2011. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics 127:817-826.
105. Stothard KJ, Tennant PW, Bell R, et al. 2009. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 301:636-650.
106. Suarez L, Felkner M, Brender JD, et al. Dieting to lose weight and occurrence of neural tube defects in offspring of Mexican-American women. Matern Child Health J 16:844-849.
107. Tekgul H, Gauvreau K, Soul J, et al. 2006. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics 117:1270-1280.
108. Thayyil S, Chandrasekaran M, Taylor A, et al. 2010. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a metaanalysis. Pediatrics 125:e382-e395.
109. Ul'ianinskii LS, Zviaginstseva MA. 1991. Sympathetic regulation of heart rhythm under the effect of delta sleep peptide and its deficiency. Biull Eksp Biol Med 112:7-9.
110. van Doormaal PJ, Meiners LC, Ter Horst HJ, et al. 2012. The prognostic value of multivoxel magnetic resonance spectroscopy determined metabolite levels in white and grey matter brain tissue for adverse outcome in term newborns following perinatal asphyxia. Eur Radiol 22:772-778.
111. Van Lieshout RJ, Taylor VH, Boyle MH. 2011. Pre-pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review. Obes Rev 12:e548- e559.
112. Vannucci RC, Vannucci SJ. 2001. Hypoglycemic brain injury. Semin Neonatol 6:147-155.
113. Vinchon M, Pierrat V, Tchofo PJ, et al. 2005. Traumatic intracranial hemorrhage in newborns. Childs Nerv Syst 21:1042-1048.
114. Vulsma T, Gons MH, de Vijlder JJ. 1989. Maternal- fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med 321:13-16.
115. Wachtel EV, Hendricks-Munoz KD. 2011. Current management of the infant who presents with neonatal encephalopathy. Curr Probl Pediatr Adolesc Health Care 41:132-153.
116. Wahlbeck K, Forsen T, Osmond C, et al. 2001. Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood. Arch Gen Psychiatry 58:48-52.
117. Wald ER, Bergman I, Taylor HG, et al. 1986. Long-term outcome of group B streptococcal meningitis. Pediatrics 77:217-221.
118. Waller DK, Tita AT, Werler MM, et al. 2003. Association between prepregnancy maternal body mass index and the risk of having an infant with a congenital diaphragmatic hernia. Birth Defects Res A Clin Mol Teratol 67:73-76.
119. Weckhuysen S, Mandelstam S, Suls A, et al. 2012. KCNQ2 encephalopathy: emerging phenotype of a neonatal epileptic encephalopathy. Ann Neurol 71:15-25.
120. Werner EF, Janevic TM, Illuzzi J, et al. 2011. Mode of delivery in nulliparous women and neonatal intracranial injury. Obstet Gynecol 118:1239-1246.
121. Williams AF. 2005. Neonatal hypoglycaemia: clinical and legal aspects. Semin Fetal Neonatal Med 10:363-368.
122. Witthuhn BA, Quelle FW, Silvennoinen O, et al. 1993. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227-236.
123. Xiong T, Qu Y, Mu D, et al. 2011. Erythropoietin for neonatal brain injury: opportunity and challenge. Int J Dev Neurosci 29:583-591.
124. Yamamoto H, Okumura A, Fukuda M. 2011. Epilepsies and epileptic syndromes starting in the neonatal period. Brain Dev 33:213-220.
125. Ylijoki M, Ekholm E, Haataja L, et al. 2012. Is chorioamnionitis harmful for the brain of preterm infants? A clinical overview. Acta Obstet Gynecol Scand 91:403-419.
126. Zhu C, Kang W, Xu F, et al. 2009. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics 124:e218-e226.