Perinatal Endocrinology: Common Endocrine Disorders in the Sick and Premature Newborn

Pediatric Clinics of North America

Volumn 58, Issue 5, 2011, Pages 1083-1098

  Hyman, Sharon J ^a   Novoa, Yeray ^a   Holzman, Ian ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Endocrine; Ill; Low birth weight; Newborn; Premature; Small for gestational age

Indexed keywords

CALCITRIOL; CALCIUM CARBONATE; CALCIUM GLUBIONATE; GLUCONATE CALCIUM; HYDROCORTISONE; INSULIN; MAGNESIUM SULFATE; PLACEBO; THYROXINE;

ADRENAL INSUFFICIENCY; CRITICALLY ILL PATIENT; ENDOCRINE DISEASE; EUTHYROID SICK SYNDROME; HUMAN; HYPERGLYCEMIA; HYPOCALCEMIA; HYPOGLYCEMIA; HYPOMAGNESEMIA; HYPOPARATHYROIDISM; HYPOTHYROIDISM; LOW BIRTH WEIGHT; LOW DRUG DOSE; NEWBORN; NEWBORN INTENSIVE CARE; PREMATURITY; REVIEW; SMALL FOR DATE INFANT; STRESS; THYROID DISEASE; TRANSIENT HYPOTHYROXINEMIA OF PREMATURITY; VERY LOW BIRTH WEIGHT; GENETICS; METABOLIC DISORDER;

ADRENAL INSUFFICIENCY; ENDOCRINE SYSTEM DISEASES; HUMANS; HYPOCALCEMIA; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; METABOLIC DISEASES; THYROID DISEASES;

EID: 80053597311     PISSN: 00313955     EISSN: 15578240     Source Type: Journal    
DOI: 10.1016/j.pcl.2011.07.003     Document Type: Review

References (84)

1. van Tijn D.A., de Vijlder J.J.M., Verbeeten B., et al. Neonatal detection of congenital hypothyroidism of central origin. J Clin Endocrinol Metab 2005, 90(6):3350-3359.
2. Ogilvy-Stuart A.L. Neonatal thyroid disorders. Arch Dis Child Fetal Neonatal Ed 2002, 87(3):F165-F171.
3. Kratzsch J. Thyroid gland development and defects. Best Pract Res Clin Endocrinol Metab 2008, 22(1):57-75.
4. Rapaport R., Rose S.R., Freemark M. Hypothyroxinemia in the preterm infants: the benefits and risks of thyroxine treatment. J Pediatr 2001, 139:182-188.
5. Cuestas R.A. Thyroid function in healthy premature infants. J Pediatr 1978, 92(6):963-967.
6. van Wassenaer A.G., Kok J.H. Hypothyroxinaemia and thyroid function after preterm birth. Semin Neonatol 2004, 9:3-11.
7. Mercado M., Yu V.Y.H., Francis I., et al. Thyroid function in very preterm infants. Early Hum Dev 1988, 16:131-141.
8. Williams F.L.R., Visser T.J., Hume R. Transient hypothyroxinaemia in preterm infants. Early Hum Dev 2006, 82(12):797-802.
9. Uhrmann S., Marks K.H., Maisels M.J., et al. Frequency of transient hypothyroxinaemia in low birthweight infants. Arch Dis Child 1981, 56:214-217.
10. Osborn D.A. Thyroid hormone for preventing of neurodevelopmental impairment in preterm infants. Cochrane Database Syst Rev 2000, (2). CD001070.
11. Chowdhry P., Scanlon J.W., Auerbach R., et al. Results of controlled double-blind study of thyroid replacement in very low birth weight premature infants with hypothyroxinaemia. Pediatrics 1984, 73:301-305.
12. Vanhole C., Aerssens P., Naulaers G., et al. L-thyroxine treatment of preterm newborns: clinical and endocrine effects. Pediatr Res 1997, 42:87-92.
13. Amato M., Pasquier S., Carasso A., et al. Postnatal thyroxine administration for idiopathic respiratory distress syndrome in preterm infants. Horm Res 1988, 29:301-305.
14. van Wassenaer A.G., Kok J.H., de Vijlder J.J., et al. Effects of thyroxine supplementation on neurologic development in infants born at less than 30 weeks' gestation. N Engl J Med 1997, 42:87-92.
15. Osborn D.A. Thyroid hormones for preventing neurodevelopmental impairment in preterm infants. Cochrane Database Syst Rev 2001, (4). CD001070.
16. Osborn D.A., Hunt R.W. Postnatal thyroid hormones for preterm infants with transient hypothyroxinaemia. Cochrane Database Syst Rev 2007, (1). CD005945.
17. Weber G., Vigone M.C., Rapa A., et al. Neonatal transient hypothyroidism: aetiological study. Italian collaborative study on transient hypothyroidism. Arch Dis Child Fetal Neonatal Ed 1998, 79(1):F70-F72.
18. I'Allemand D., Gruters A., Beyer P., et al. Iodine in contrast agents and skin disinfectants is the major cause for hypothyroidism in premature infants during intensive care. Horm Res 1987, 28(1):42-49.
19. Smerdely P., Boyages S.C., Wu D., et al. Topical iodine-containing antiseptics and neonatal hypothyroidism in very low birth weight infants. Lancet 1989, 2(8664):661-664.
20. Gordon C.M., Rowitch D.H., Mitchell M.L., et al. Topical iodine and neonatal hypothyroidism. Arch Pediatr Adolesc Med 1995, 149:1336-1339.
21. Hyman S.J., Greig F., Holzman I., et al. Late rise of thyroid stimulating hormone in ill newborns. J Pediatr Endocrinol Metab 2007, 20(4):501-510.
22. Mandel S.J., Hermos R.J., Larson C.A., et al. Atypical hypothyroidism and the very low birth weight infant. Thyroid 2000, 10:693-695.
23. Larson C., Hermos R., Delaney A., et al. Risk factors associated with delayed thyrotropin elevations in congenital hypothyroidism. J Pediatr 2003, 143:587-591.
24. Root A.W., Diamond F.B. Disorders of mineral homeostasis in the neonate and infant. Pediatric endocrinology 2008, 691-706. Saunders Elsevier, Philadelphia. 3rd edition. M.A. Sperling (Ed.).
25. Hsu S.C., Levine M.A. Perinatal calcium metabolism: physiology and pathophysiology. Semin Neonatol 2004, 9:23-36.
26. Tsang R.C., Oh W. Neonatal hypocalcemia in low birth weight infants. Pediatrics 1970, 45:773-781.
27. Roberton N.R., Smith M.A. Early neonatal hypocalcemia. Arch Dis Child 1975, 50:604-609.
28. Driscoll D.A., Budarf M.L., Emanuel B.S. A genetic etiology for DiGeorge syndrome: consistent deletions and microdeletions of 22q11. Am J Hum Genet 1992, 50:924-933.
29. De la Chapelle A., Herva R., Koivisto M., et al. A deletion in chromosome 22 can cause DiGeorge syndrome. Hum Genet 1981, 57:253-256.
30. Greig F., Paul E., DiMartino-Nardi J., et al. Transient congenital hypoparathyroidism: resolution and recurrence in chromosome 22q11 deletion. J Pediatr 1996, 128:563-567.
31. Watterberg K.L. Adrenocortical function and dysfunction in the fetos and neonate. Semin Neonatol 2004, 9:13-21.
32. Pepe G.J., Albrecht E.D. Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr Rev 1995, 16:608-648.
33. Mediano S., Jaffe R.B. Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev 1997, 18:378-403.
34. Parker C.R., Faye-Peterson O., Stankovic A.K., et al. Immunohistochemical evaluation of the cellular localization and ontogeny of 3B-hydroxysteroid dehydrogenase/delta 5-4 isomerase in the human fetal adrenal gland. Endocr Res 1995, 21:69-80.
35. Ng P.C., Lam W.K., Lee C.H., et al. Reference ranges and factors affecting the human corticotropin-releasing hormone test in preterm, very low birth weight infants. J Clin Endocrinol Metab 2002, 87(10):4621-4628.
36. Wittekind C.A., Arnold J.D., Leslie G.I., et al. Longitudinal study of plasma ACTH and cortisol in very low birth weight infants in the first 8 weeks of life. Early Hum Dev 1993, 33:191-200.
37. Al Saedi S., Dean H., Dent W., et al. Reference ranges for serum cortisol and 17-OH-progesterone levels in preterm infants. J Pediatr 1995, 126:985-987.
38. Heckmann M., Wudy S.A., Haack D., et al. Reference range for serum cortisol in well preterm infants. Arch Dis Child Fetal Neonatal Ed 1999, 81:F171-F174.
39. Aucott S.W., Watterberg K.L., Shaffer M.L., et al. Do cortisol concentrations predict short-term outcomes in extremely low birth weight infants?. Pediatrics 2008, 122:775-781. PROPHET study group.
40. Hingre R.V., Gross S.J., Hingre K.S., et al. Adrenal steroidogenesis in very low birth weight preterm infants. J Clin Endocrinol Metab 1994, 78(2):266-270.
41. Ng P.C. Is there a normal range of serum cortisol concentration for preterm infants?. Pediatrics 2008, 122:873-875.
42. Arnold J., Leslie G., Bowen J., et al. Longitudinal study of plasma cortisol and 17-hydroxyprogesterone in very low birth weight infants during the first 16 weeks of life. Biol Neonate 1997, 72(3):148-155.
43. Ng P.C., Lee H.C., Lam C.W.K., et al. Transient adrenocortical insufficiency of prematurity and systemic hypotension in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 2004, 89:F119-F126.
44. Karlsson R., Kallio J., Toppari J., et al. Timing of peak serum cortisol values in preterm infants in low-dose and the standard ACTH tests. Pediatr Res 1999, 45(3):367-369.
45. Bolt R.J., Van Weissenbruch M.M., Popp-Snijders C., et al. Maturity of the adrenal cortex in very preterm infants is related to gestational age. Pediatr Res 2002, 52(3):405-410.
46. Bolt R.J., Van Weissenbruch M.M., Popp-Snijders, et al. Fetal growth and the function of the adrenal cortex in preterm infants. J Clin Endocrinol Metab 2002, 87(3):1194-1199.
47. Ng P.C., Lee C.H., Bnur F.L., et al. A double-blind, randomized, controlled study of a stress dose of hydrocortisone for rescue treatment of refractory hypotension in infants. Pediatrics 2006, 117:367-375.
48. Watterberg K.L., Scott S.M. Evidence of early adrenal insufficiency in babies who develop bronchopulmonary dysplasia. Pediatrics 1995, 85:120-125.
49. Banks B.A., Stouffer N., Cnaan A., et al. Association of plasma cortisol and chronic lung disease in preterm infants. Pediatrics 2001, 107:494-498.
50. Nykanen P., Antila E., Heinonen K., et al. Early hypoadrenalism in premature infants at risk for bronchopulmonary dysplasia or death. Acta Paediatr 2007, 96:1600-1605.
51. Merz U., Pfaffle R., Peschgens T., et al. The hypothalamic-pituitary-adrenal axis in preterm infants weighting ≤1250 g: association with perinatal data and chronic lung disease. Acta Paediatr 1998, 87:313-317.
52. Watterberg K.L., Demmers L.M., Scott S.M., et al. Chorioamnionitis and early lung inflammation in babies who develop bronchopulmonary dysplasia. Pediatrics 1996, 97:210-215.
53. Watterberg K.L., Verdes J.S., Gifford K.L., et al. Prophylaxis against early adrenal insufficiency to prevent chronic lung disease in premature infants. Pediatrics 1999, 104:1258-1263.
54. Watterberg K.L., Gerdes J.S., Cole C.H., et al. Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial. Pediatrics 2004, 114:1649-1657.
55. Langdon D.R., Stanley C.A., Sperling M.A. Hypoglycemia in the infant and child. Pediatric endocrinology 2008, 422-443. Saunders Elsevier, Philadelphia. 3rd edition. M.A. Sperling (Ed.).
56. Rozance P.J., Hay W.W. Hypoglycemia in newborn infants: features associated with adverse outcomes. Biol Neonate 2006, 90:74-86.
57. Sunehag A.L., Haymond M.W. Glucose extremes in newborn infants. Clin Perinatol 2002, 29:245-260.
58. Koh T.H., Vong S.K. Definition of neonatal hypoglycemia: is there a change?. J Paediatr Child Health 1996, 32(4):302-305.
59. Koh T.H., Eyre J.A., Aynsley-Green A. Neonatal hypoglycaemia: the controversy regarding definition. Arch Dis Child 1988, 63:1386-1388.
60. Mitanchez D. Glucose regulation in preterm newborn infants. Horm Res 2007, 68:265-271.
61. Hume R., Burchell A., Williams F.L.R., et al. Glucose homeostasis in the newborn. Early Hum Dev 2005, 81:95-101.
62. Hawdon J.M. Hypoglycaemia and the neonatal brain. Eur J Pediatr 1999, 158(Suppl 1):S9-S12.
63. Stanley C.A. Hyperinsulinism in infants and children. Pediatr Clin North Am 1997, 44(2):363-374.
64. Hussain K. Diagnosis and management of hyperinsulinaemic hypoglycaemia of infancy. Horm Res 2008, 69:2-13.
65. Valayannopoulos V., Romano S., Mention K., et al. What's new in metabolic and genetic hypoglycaemias: diagnosis and management. Eur J Pediatr 2008, 167:257-265.
66. Hays S.P., Smith E.O., Sunehag A.L. Hyperglycemia is a risk factor for early death and morbidity in extremely low birth-weight infants. Pediatrics 2006, 118:1811-1818.
67. Palladino A., Bennett M.J., Stanley C.A. Hyperinsulinism in infancy and childhood: when an insulin level is not always enough. Clin Chem 2008, 54(2):256-263.
68. Beardsall K., Vanhaesebrouck S., Ogilvy-Stuart A.L., et al. A randomized controlled trial of early insulin therapy in very low birth weight infants, NIRTURE (neonatal insulin replacement therapy in Europe). BMC Pediatr 2007, 7:29-39.
69. Kairamknonda V.R., Khashu M. Controversies in the management of hyperglycemia in the ELBW infant. Indian Pediatr 2008, 45:29-38.
70. Garg R., Agthe A.G., Donohue P.K., et al. Hyperglycemia and retinopathy of prematurity in very low birth weight infants. J Perinatol 2003, 23:186-194.
71. Bochicchio G.V., Sung J., Joshi M., et al. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005, 58:921-924.
72. Thureen P.J. Early aggressive nutrition in the neonate. Pediatr Rev 1999, 44:e45-e55.
73. van Kempen A.A.M.W., van der Crabben S.N., Ackermans M.T., et al. Stimulation of gluconeogenesis by intravenous lipids in preterm infants: response depends on fatty acid profile. Am J Physiol Endocrinol Metab 2006, 290:e723-e730.
74. Berseth C.L. Effect of early feeding on maturation of the preterm infant's small intestine. J Pediatr 1992, 120:947-953.
75. Mena P., Llanos A., Uauy R. Insulin homeostasis n the extremely low birth weight infant. Semin Perinatol 2001, 25:436-446.
76. Shield J.P., Gardner R.J., Wadsworth E.J., et al. Aetiopathology and genetic basis of neonatal diabetes. Arch Dis Child Fetal Neonatal Ed 1997, 76:F39-F42.
77. Shield J.P., Baum J.D. Is transient neonatal diabetes a risk factor for diabetes later in life?. Lancet 1993, 341:693.
78. Shield J.P. Neonatal diabetes: new insights into etiology and implications. Hormone Res 2000, 53(Suppl S1):7-11.
79. Vaxillaire M., Dechaume A., Busiah K., et al. New ABCC8 mutations in relapsing neonatal diabetes and clinical features. Diabetes 2007, 56:1737-1741.
80. Stoffers D.A., Zinken N.T., Stanojevic V., et al. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF-1 gene coding sequence. Nat Genet 1997, 15:106-110.
81. Njolstad P.R., Sagen J.V., Bjorkhaug L., et al. Permanent neonatal diabetes caused by glucokinase deficiency. Diabetes 2003, 52:2854-2860.
82. Stoy J., Edghill E.L., Flanagan S.E., et al. Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A 2007, 104:15040-15044.
83. Sellick G.S., Garrett C., Houlston R.S. A novel gene for neonatal diabetes maps to chromosome 10p12.1-p13. Diabetes 2003, 52:2636-2638.
84. Gloyn A.L., Diatloff-Zito C., Edghill E.L., et al. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Eur J Hum Genet 2006, 14:824-830.