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Volumn 16, Issue 6, 2012, Pages 302-309

Polymeric micelles for cancer therapy: 3 C's to enhance efficacy

Author keywords

Cancer; Combination therapy; Covalent drug entrapment; Crosslinking; Drug targeting; Nanomedicine; PEG; pHPMA; Polymeric micelles

Indexed keywords

CROSSLINKING; DISEASES; MEDICAL NANOTECHNOLOGY; MICELLES; ONCOLOGY; POLYETHYLENE GLYCOLS; POLYMERS;

EID: 84875260268     PISSN: 13590286     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cossms.2012.10.003     Document Type: Review
Times cited : (45)

References (79)
  • 1
    • 81855170441 scopus 로고    scopus 로고
    • Nanomedicine(s) under the microscope
    • R. Duncan, and R. Gaspar Nanomedicine(s) under the microscope Mol Pharm 8 2011 2101 2141
    • (2011) Mol Pharm , vol.8 , pp. 2101-2141
    • Duncan, R.1    Gaspar, R.2
  • 2
    • 48349107149 scopus 로고    scopus 로고
    • Tumor-targeted nanomedicines: Principles and practice
    • T. Lammers, W.E. Hennink, and G. Storm Tumor-targeted nanomedicines: principles and practice Br J Cancer 99 2008 392 397
    • (2008) Br J Cancer , vol.99 , pp. 392-397
    • Lammers, T.1    Hennink, W.E.2    Storm, G.3
  • 3
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • R.K. Jain, and T. Stylianopoulos Delivering nanomedicine to solid tumors Nat Rev Clin Oncol 7 2010 653 664
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2
  • 4
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: An emerging treatment modality for cancer
    • M.E. Davis, Z. Chen, and D.M. Shin Nanoparticle therapeutics: an emerging treatment modality for cancer Nat Rev Drug Discovery 7 2008 771 782
    • (2008) Nat Rev Drug Discovery , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.2    Shin, D.M.3
  • 5
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J Control Release 65 2000 271 284
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 6
    • 84869496799 scopus 로고    scopus 로고
    • Macromolecular therapeutics in cancer treatment: The EPR effect and beyond
    • in press
    • Maeda H. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. J Control Release, in press. http://dx.doi.org/10.1016/j.jconrel. 2012.04.038.
    • J Control Release
    • Maeda, H.1
  • 9
    • 33746307391 scopus 로고    scopus 로고
    • Nanostructured devices based on block copolymer assemblies for drug delivery: Designing structures for enhanced drug function
    • N. Nishiyama, and K. Kataoka Nanostructured devices based on block copolymer assemblies for drug delivery: designing structures for enhanced drug function Adv Polym Sci 193 2006 67 101
    • (2006) Adv Polym Sci , vol.193 , pp. 67-101
    • Nishiyama, N.1    Kataoka, K.2
  • 10
    • 78651279520 scopus 로고    scopus 로고
    • Polymeric micelles in anticancer therapy: Targeting, imaging and triggered release
    • C. Oerlemans, W. Bult, M. Bos, G. Storm, J.F.W. Nijsen, and W.E. Hennink Polymeric micelles in anticancer therapy: targeting, imaging and triggered release Pharm Res 2010 1 21
    • (2010) Pharm Res , pp. 1-21
    • Oerlemans, C.1    Bult, W.2    Bos, M.3    Storm, G.4    Nijsen, J.F.W.5    Hennink, W.E.6
  • 11
    • 0036495566 scopus 로고    scopus 로고
    • From self-organizing polymers to nanohybrid and biomaterials
    • S. Forster, and T. Plantenberg From self-organizing polymers to nanohybrid and biomaterials Angew Chem Int Ed 41 2002 689 714
    • (2002) Angew Chem Int Ed , vol.41 , pp. 689-714
    • Forster, S.1    Plantenberg, T.2
  • 12
    • 33845388144 scopus 로고    scopus 로고
    • Micellar nanocarriers: Pharmaceutical perspectives
    • V.P. Torchilin Micellar nanocarriers: pharmaceutical perspectives Pharm Res 24 2007 1 16
    • (2007) Pharm Res , vol.24 , pp. 1-16
    • Torchilin, V.P.1
  • 14
    • 77952575335 scopus 로고    scopus 로고
    • Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
    • H. Maeda Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects Bioconjugate Chem 21 2010 797 802
    • (2010) Bioconjugate Chem , vol.21 , pp. 797-802
    • Maeda, H.1
  • 15
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • D.E. Owens Iii, and N.A. Peppas Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int J Pharm 307 2006 93 102
    • (2006) Int J Pharm , vol.307 , pp. 93-102
    • Owens Iii, D.E.1    Peppas, N.A.2
  • 16
    • 84862804633 scopus 로고    scopus 로고
    • Polymeric micelles drug delivery system in oncology
    • J. Gong, M. Chen, Y. Zheng, S. Wang, and Y. Wang Polymeric micelles drug delivery system in oncology J Control Release 159 2012 312 323
    • (2012) J Control Release , vol.159 , pp. 312-323
    • Gong, J.1    Chen, M.2    Zheng, Y.3    Wang, S.4    Wang, Y.5
  • 17
    • 84862698355 scopus 로고    scopus 로고
    • Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress
    • T. Lammers, F. Kiessling, W.E. Hennink, and G. Storm Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress J Control Release 161 2012 175 187
    • (2012) J Control Release , vol.161 , pp. 175-187
    • Lammers, T.1    Kiessling, F.2    Hennink, W.E.3    Storm, G.4
  • 18
    • 67449084321 scopus 로고    scopus 로고
    • Preclinical and clinical studies of anticancer agent-incorporating polymer micelles
    • Y. Matsumura, and K. Kataoka Preclinical and clinical studies of anticancer agent-incorporating polymer micelles Cancer Sci 100 2009 572 579
    • (2009) Cancer Sci , vol.100 , pp. 572-579
    • Matsumura, Y.1    Kataoka, K.2
  • 19
    • 39749178252 scopus 로고    scopus 로고
    • Multicenter phase II trial of Genexol-PM, a cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer
    • K.S. Lee, H.C. Chung, S.A. Im, Y.H. Park, C.S. Kim, and S.B. Kim Multicenter phase II trial of Genexol-PM, a cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer Breast Cancer Res Tr 108 2008 241 250
    • (2008) Breast Cancer Res Tr , vol.108 , pp. 241-250
    • Lee, K.S.1    Chung, H.C.2    Im, S.A.3    Park, Y.H.4    Kim, C.S.5    Kim, S.B.6
  • 20
    • 37349080672 scopus 로고    scopus 로고
    • Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer
    • D.W. Kim, S.Y. Kim, H.K. Kim, S.W. Kim, S.W. Shin, and J.S. Kim Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer Ann Oncol 18 2007 2009 2014
    • (2007) Ann Oncol , vol.18 , pp. 2009-2014
    • Kim, D.W.1    Kim, S.Y.2    Kim, H.K.3    Kim, S.W.4    Shin, S.W.5    Kim, J.S.6
  • 21
    • 20944450473 scopus 로고    scopus 로고
    • NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumor activity and reduce the neurotoxicity of paclitaxel
    • T. Hamaguchi, Y. Matsumura, M. Suzuki, K. Shimizu, R. Goda, and I. Nakamura NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumor activity and reduce the neurotoxicity of paclitaxel Br J Cancer 92 2005 1240 1246
    • (2005) Br J Cancer , vol.92 , pp. 1240-1246
    • Hamaguchi, T.1    Matsumura, Y.2    Suzuki, M.3    Shimizu, K.4    Goda, R.5    Nakamura, I.6
  • 22
    • 34447331464 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation
    • T. Hamaguchi, K. Kato, H. Yasui, C. Morizane, M. Ikeda, and H. Ueno A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation Br J Cancer 97 2007 170 176
    • (2007) Br J Cancer , vol.97 , pp. 170-176
    • Hamaguchi, T.1    Kato, K.2    Yasui, H.3    Morizane, C.4    Ikeda, M.5    Ueno, H.6
  • 23
    • 10844293438 scopus 로고    scopus 로고
    • Phase i clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
    • Y. Matsumura, T. Hamaguchi, T. Ura, K. Muro, Y. Yamada, and Y. Shimada Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin Br J Cancer 91 2004 1775 1781
    • (2004) Br J Cancer , vol.91 , pp. 1775-1781
    • Matsumura, Y.1    Hamaguchi, T.2    Ura, T.3    Muro, K.4    Yamada, Y.5    Shimada, Y.6
  • 25
    • 79951682119 scopus 로고    scopus 로고
    • A Phase i clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumors
    • R. Plummer, R.H. Wilson, H. Calvert, A.V. Boddy, M. Griffin, and J. Sludden A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumors Br J Cancer 104 2011 593 598
    • (2011) Br J Cancer , vol.104 , pp. 593-598
    • Plummer, R.1    Wilson, R.H.2    Calvert, H.3    Boddy, A.V.4    Griffin, M.5    Sludden, J.6
  • 26
    • 77958073029 scopus 로고    scopus 로고
    • Phase i study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors
    • T. Hamaguchi, T. Doi, T. Eguchi-Nakajima, K. Kato, Y. Yamada, and Y. Shimada Phase I study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors Clin Cancer Res 16 2010 5058 5066
    • (2010) Clin Cancer Res , vol.16 , pp. 5058-5066
    • Hamaguchi, T.1    Doi, T.2    Eguchi-Nakajima, T.3    Kato, K.4    Yamada, Y.5    Shimada, Y.6
  • 27
    • 84855921796 scopus 로고    scopus 로고
    • A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction
    • J.W. Valle, A. Armstrong, C. Newman, V. Alakhov, G. Pietrzynski, and J. Brewer A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction Invest New Drug 29 2011 1029 1037
    • (2011) Invest New Drug , vol.29 , pp. 1029-1037
    • Valle, J.W.1    Armstrong, A.2    Newman, C.3    Alakhov, V.4    Pietrzynski, G.5    Brewer, J.6
  • 28
    • 84861233382 scopus 로고    scopus 로고
    • Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications
    • E. Fleige, M.A. Quadir, and R. Haag Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications Adv Drug Delivery Rev 64 2012 866 884
    • (2012) Adv Drug Delivery Rev , vol.64 , pp. 866-884
    • Fleige, E.1    Quadir, M.A.2    Haag, R.3
  • 29
  • 30
    • 84862661182 scopus 로고    scopus 로고
    • Designing switchable nanosystems for medical application
    • R. Lehner, X. Wang, M. Wolf, and P. Hunziker Designing switchable nanosystems for medical application J Controlled Release 161 2012 307 316
    • (2012) J Controlled Release , vol.161 , pp. 307-316
    • Lehner, R.1    Wang, X.2    Wolf, M.3    Hunziker, P.4
  • 32
    • 49749101644 scopus 로고    scopus 로고
    • Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers
    • E.V. Batrakova, and A.V. Kabanov Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers J Control Release 130 2008 98 106
    • (2008) J Control Release , vol.130 , pp. 98-106
    • Batrakova, E.V.1    Kabanov, A.V.2
  • 33
    • 33751040846 scopus 로고    scopus 로고
    • Temperature-controlled assembly and release from polymer vesicles of poly(ethylene oxide)-block-poly(N-isopropylacrylamide)
    • S. Qin, Y. Geng, D.E. Discher, and S. Yang Temperature-controlled assembly and release from polymer vesicles of poly(ethylene oxide)-block-poly(N- isopropylacrylamide) Adv Mater 18 2006 2905 2909
    • (2006) Adv Mater , vol.18 , pp. 2905-2909
    • Qin, S.1    Geng, Y.2    Discher, D.E.3    Yang, S.4
  • 34
    • 22744433806 scopus 로고    scopus 로고
    • Thermoresponsive micellization of poly(ethylene glycol)-b-poly(N- isopropylacrylamide) in water
    • W. Zhang, L. Shi, K. Wu, and Y. An Thermoresponsive micellization of poly(ethylene glycol)-b-poly(N-isopropylacrylamide) in water Macromolecules 38 2005 5743 5747
    • (2005) Macromolecules , vol.38 , pp. 5743-5747
    • Zhang, W.1    Shi, L.2    Wu, K.3    An, Y.4
  • 35
    • 0031383195 scopus 로고    scopus 로고
    • Thermosensitive micelle-forming block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide)
    • M.D.C. Topp, P.J. Dijkstra, H. Talsma, and J. Feijen Thermosensitive micelle-forming block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide) Macromolecules 30 1997 8518 8520
    • (1997) Macromolecules , vol.30 , pp. 8518-8520
    • Topp, M.D.C.1    Dijkstra, P.J.2    Talsma, H.3    Feijen, J.4
  • 36
    • 0037151313 scopus 로고    scopus 로고
    • Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
    • A.V. Kabanov, E.V. Batrakova, and V.Y. Alakhov Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery J Control Release 82 2002 189 212
    • (2002) J Control Release , vol.82 , pp. 189-212
    • Kabanov, A.V.1    Batrakova, E.V.2    Alakhov, V.Y.3
  • 37
    • 1642564456 scopus 로고    scopus 로고
    • Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic PluronicB® block copolymers
    • K.T. Oh, T.K. Bronich, and A.V. Kabanov Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic PluronicB® block copolymers J Control Release 94 2004 411 422
    • (2004) J Control Release , vol.94 , pp. 411-422
    • Oh, K.T.1    Bronich, T.K.2    Kabanov, A.V.3
  • 38
    • 2542635670 scopus 로고    scopus 로고
    • Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): A new class of biodegradable polymers with tuneable thermosensitivity
    • O. Soga, C.F. van Nostrum, and W.E. Hennink Poly(N-(2-hydroxypropyl) methacrylamide mono/di lactate): a new class of biodegradable polymers with tuneable thermosensitivity Biomacromolecules 5 2004 818 821
    • (2004) Biomacromolecules , vol.5 , pp. 818-821
    • Soga, O.1    Van Nostrum, C.F.2    Hennink, W.E.3
  • 39
    • 6444232811 scopus 로고    scopus 로고
    • Physicochemical characterization of degradable thermosensitive polymeric micelles
    • O. Soga, C.F. van Nostrum, A. Ramzi, T. Visser, F. Soulimani, and P.M. Frederik Physicochemical characterization of degradable thermosensitive polymeric micelles Langmuir 20 2004 9388 9395
    • (2004) Langmuir , vol.20 , pp. 9388-9395
    • Soga, O.1    Van Nostrum, C.F.2    Ramzi, A.3    Visser, T.4    Soulimani, F.5    Frederik, P.M.6
  • 41
    • 36048953122 scopus 로고    scopus 로고
    • Photosensitiser-loaded biodegradable polymeric micelles: Preparation, characterisation and in vitro PDT efficacy
    • C.J.F. Rijcken, J.W. Hofman, F. van Zeeland, W.E. Hennink, and C.F. van Nostrum Photosensitiser-loaded biodegradable polymeric micelles: preparation, characterisation and in vitro PDT efficacy J Control Release 124 2007 144 153
    • (2007) J Control Release , vol.124 , pp. 144-153
    • Rijcken, C.J.F.1    Hofman, J.W.2    Van Zeeland, F.3    Hennink, W.E.4    Van Nostrum, C.F.5
  • 43
    • 63249128638 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: Toward a targeted nanomedicine suitable for image-guided drug delivery
    • M. Talelli, C.J.F. Rijcken, T. Lammers, P.R. Seevinck, G. Storm, and C.F. van Nostrum Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery Langmuir 25 2009 2060 2067
    • (2009) Langmuir , vol.25 , pp. 2060-2067
    • Talelli, M.1    Rijcken, C.J.F.2    Lammers, T.3    Seevinck, P.R.4    Storm, G.5    Van Nostrum, C.F.6
  • 44
    • 79955806381 scopus 로고    scopus 로고
    • Covalently cross-linked amphiphilic block copolymer micelles
    • C.F. Van Nostrum Covalently cross-linked amphiphilic block copolymer micelles Soft Matter 7 2011 3246 3259
    • (2011) Soft Matter , vol.7 , pp. 3246-3259
    • Van Nostrum, C.F.1
  • 45
    • 33750281612 scopus 로고    scopus 로고
    • Cross-linked block copolymer micelles: Functional nanostructures of great potential and versatility
    • R.K. O'Reilly, C.J. Hawker, and K.L. Wooley Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility Chem Soc Rev 35 2006 1068 1083
    • (2006) Chem Soc Rev , vol.35 , pp. 1068-1083
    • O'Reilly, R.K.1    Hawker, C.J.2    Wooley, K.L.3
  • 46
    • 34447622159 scopus 로고    scopus 로고
    • Recent advances in shell cross-linked micelles
    • E.S. Read, and S.P. Armes Recent advances in shell cross-linked micelles Chem Commun 2007 3021 3035
    • (2007) Chem Commun , pp. 3021-3035
    • Read, E.S.1    Armes, S.P.2
  • 47
    • 80051510862 scopus 로고    scopus 로고
    • Galactose-decorated cross-linked biodegradable poly(ethylene glycol)-b-poly(*-caprolactone) block copolymer micelles for enhanced hepatoma-targeting delivery of paclitaxel
    • R. Yang, F. Meng, S. Ma, F. Huang, H. Liu, and Z. Zhong Galactose-decorated cross-linked biodegradable poly(ethylene glycol)-b-poly(*-caprolactone) block copolymer micelles for enhanced hepatoma-targeting delivery of paclitaxel Biomacromolecules 12 2011 3047 3055
    • (2011) Biomacromolecules , vol.12 , pp. 3047-3055
    • Yang, R.1    Meng, F.2    Ma, S.3    Huang, F.4    Liu, H.5    Zhong, Z.6
  • 48
    • 37549054058 scopus 로고    scopus 로고
    • Facile fabrication of reversible core cross-linked micelles possessing thermosensitive swellability
    • J. Zhang, X. Jiang, Y. Zhang, Y. Li, and S. Liu Facile fabrication of reversible core cross-linked micelles possessing thermosensitive swellability Macromolecules 40 2007 9125 9132
    • (2007) Macromolecules , vol.40 , pp. 9125-9132
    • Zhang, J.1    Jiang, X.2    Zhang, Y.3    Li, Y.4    Liu, S.5
  • 49
    • 72449160680 scopus 로고    scopus 로고
    • Macromolecular cobalt carbonyl complexes encapsulated in a click-cross-linked micelle structure as a nanoparticle to deliver cobalt pharmaceuticals
    • A.B.J. Withey, G. Chen, T.L.U. Nguyen, and M.H. Stenzel Macromolecular cobalt carbonyl complexes encapsulated in a click-cross-linked micelle structure as a nanoparticle to deliver cobalt pharmaceuticals Biomacromolecules 10 2009 3215 3226
    • (2009) Biomacromolecules , vol.10 , pp. 3215-3226
    • Withey, A.B.J.1    Chen, G.2    Nguyen, T.L.U.3    Stenzel, M.H.4
  • 50
    • 0033076145 scopus 로고    scopus 로고
    • Core-polymerized reactive micelles from heterotelechelic amphiphilic block copolymers
    • M. Iijima, Y. Nagasaki, T. Okada, M. Kato, and K. Kataoka Core-polymerized reactive micelles from heterotelechelic amphiphilic block copolymers Macromolecules 32 1999 1140 1146
    • (1999) Macromolecules , vol.32 , pp. 1140-1146
    • Iijima, M.1    Nagasaki, Y.2    Okada, T.3    Kato, M.4    Kataoka, K.5
  • 52
    • 70350324658 scopus 로고    scopus 로고
    • Photo-cross-linking induces size change and stealth properties of water-dispersible cinnamic acid derivative nanoparticles
    • D. Shi, M. Matsusaki, and M. Akashi Photo-cross-linking induces size change and stealth properties of water-dispersible cinnamic acid derivative nanoparticles Bioconjugate Chem 20 2009 1917 1923
    • (2009) Bioconjugate Chem , vol.20 , pp. 1917-1923
    • Shi, D.1    Matsusaki, M.2    Akashi, M.3
  • 53
    • 34250218235 scopus 로고    scopus 로고
    • Core-bound polymeric micellar system based on photocrosslinking of thymine
    • K. Saito, L.R. Ingalls, J. Lee, and J.C. Warner Core-bound polymeric micellar system based on photocrosslinking of thymine Chem Commun 2007 2503 2505
    • (2007) Chem Commun , pp. 2503-2505
    • Saito, K.1    Ingalls, L.R.2    Lee, J.3    Warner, J.C.4
  • 54
    • 60849122214 scopus 로고    scopus 로고
    • Reduction-sensitive polymers and bioconjugates for biomedical applications
    • F. Meng, W.E. Hennink, and Z. Zhong Reduction-sensitive polymers and bioconjugates for biomedical applications Biomaterials 30 2009 2180 2198
    • (2009) Biomaterials , vol.30 , pp. 2180-2198
    • Meng, F.1    Hennink, W.E.2    Zhong, Z.3
  • 55
    • 25844495323 scopus 로고    scopus 로고
    • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution
    • X. Sun, R. Rossin, J.L. Turner, M.L. Becker, M.J. Joralemon, and M.J. Welch An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution Biomacromolecules 6 2005 2541 2554
    • (2005) Biomacromolecules , vol.6 , pp. 2541-2554
    • Sun, X.1    Rossin, R.2    Turner, J.L.3    Becker, M.L.4    Joralemon, M.J.5    Welch, M.J.6
  • 56
    • 36649028267 scopus 로고    scopus 로고
    • Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging
    • Z. Yang, S. Zheng, W.J. Harrison, J. Harder, X. Wen, and J.G. Gelovani Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging Biomacromolecules 8 2007 3422 3428
    • (2007) Biomacromolecules , vol.8 , pp. 3422-3428
    • Yang, Z.1    Zheng, S.2    Harrison, W.J.3    Harder, J.4    Wen, X.5    Gelovani, J.G.6
  • 57
    • 35349022545 scopus 로고    scopus 로고
    • Hydrolysable core-crosslinked thermosensitive polymeric micelles: Synthesis, characterisation and in vivo studies
    • C.J. Rijcken, C.J. Snel, R.M. Schiffelers, C.F. van Nostrum, and W.E. Hennink Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies Biomaterials 28 2007 5581 5593
    • (2007) Biomaterials , vol.28 , pp. 5581-5593
    • Rijcken, C.J.1    Snel, C.J.2    Schiffelers, R.M.3    Van Nostrum, C.F.4    Hennink, W.E.5
  • 60
    • 77955768765 scopus 로고    scopus 로고
    • Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin
    • M. Talelli, M. Iman, A.K. Varkouhi, C.J. Rijcken, R.M. Schiffelers, and T. Etrych Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin Biomaterials 31 2010 7797 7804
    • (2010) Biomaterials , vol.31 , pp. 7797-7804
    • Talelli, M.1    Iman, M.2    Varkouhi, A.K.3    Rijcken, C.J.4    Schiffelers, R.M.5    Etrych, T.6
  • 62
    • 84555220701 scopus 로고    scopus 로고
    • Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry
    • M. Talelli, K. Morita, C.J.F. Rijcken, R.W.M. Aben, T. Lammers, and H.W. Scheeren Synthesis and characterization of biodegradable and thermosensitive polymeric micelles with covalently bound doxorubicin-glucuronide prodrug via click chemistry Bioconjugate Chem 22 2012 2519 2530
    • (2012) Bioconjugate Chem , vol.22 , pp. 2519-2530
    • Talelli, M.1    Morita, K.2    Rijcken, C.J.F.3    Aben, R.W.M.4    Lammers, T.5    Scheeren, H.W.6
  • 63
    • 57049128257 scopus 로고    scopus 로고
    • One-pot conversion of RAFT-generated multifunctional block copolymers of HPMA to doxorubicin conjugated acid- and reductant-sensitive crosslinked micelles
    • Z. Jia, L. Wong, T.P. Davis, and V. Bulmus One-pot conversion of RAFT-generated multifunctional block copolymers of HPMA to doxorubicin conjugated acid- and reductant-sensitive crosslinked micelles Biomacromolecules 9 2008 3106 3113
    • (2008) Biomacromolecules , vol.9 , pp. 3106-3113
    • Jia, Z.1    Wong, L.2    Davis, T.P.3    Bulmus, V.4
  • 64
    • 77951610250 scopus 로고    scopus 로고
    • Preparation of novel ferrocene-based shell cross-linked thermoresponsive hybrid micelles with antitumor efficacy
    • H. Wei, C.Y. Quan, C. Chang, X.Z. Zhang, and R.X. Zhuo Preparation of novel ferrocene-based shell cross-linked thermoresponsive hybrid micelles with antitumor efficacy J Phys Chem B 114 2010 5309 5314
    • (2010) J Phys Chem B , vol.114 , pp. 5309-5314
    • Wei, H.1    Quan, C.Y.2    Chang, C.3    Zhang, X.Z.4    Zhuo, R.X.5
  • 65
    • 70349213715 scopus 로고    scopus 로고
    • Disulfide-crosslinked polyion micelles for delivery of protein therapeutics
    • M.J. Heffernan, and N. Murthy Disulfide-crosslinked polyion micelles for delivery of protein therapeutics Ann Biomed Eng 37 2009 1993 2002
    • (2009) Ann Biomed Eng , vol.37 , pp. 1993-2002
    • Heffernan, M.J.1    Murthy, N.2
  • 66
    • 33746172167 scopus 로고    scopus 로고
    • Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    • D.B. Kirpotin, D.C. Drummond, Y. Shao, M.R. Shalaby, K. Hong, and U.B. Nielsen Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models Cancer Res 66 2006 6732 6740
    • (2006) Cancer Res , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6
  • 68
    • 0141921483 scopus 로고    scopus 로고
    • Polymeric micelle for tumor pH and folate-mediated targeting
    • E.S. Lee, K. Na, and Y.H. Bae Polymeric micelle for tumor pH and folate-mediated targeting J Control Release 91 2003 103 113
    • (2003) J Control Release , vol.91 , pp. 103-113
    • Lee, E.S.1    Na, K.2    Bae, Y.H.3
  • 69
    • 33845791448 scopus 로고    scopus 로고
    • Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs
    • S.Q. Liu, N. Wiradharma, S.J. Gao, Y.W. Tong, and Y.Y. Yang Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs Biomaterials 28 2007 1423 1433
    • (2007) Biomaterials , vol.28 , pp. 1423-1433
    • Liu, S.Q.1    Wiradharma, N.2    Gao, S.J.3    Tong, Y.W.4    Yang, Y.Y.5
  • 70
    • 33749841749 scopus 로고    scopus 로고
    • In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy
    • Y. Bae, N. Nishiyama, S. Fukushima, and K. Kataoka In vivo antitumor activity of folate-conjugated pH-sensitive polymeric micelles for tumor-targeting cancer therapy Polym Prepr Jpn 55 2006 1916
    • (2006) Polym Prepr Jpn , vol.55 , pp. 1916
    • Bae, Y.1    Nishiyama, N.2    Fukushima, S.3    Kataoka, K.4
  • 71
    • 34249023676 scopus 로고    scopus 로고
    • Functionalized micellar systems for cancer targeted drug delivery
    • D. Sutton, N. Nasongkla, E. Blanco, and J. Gao Functionalized micellar systems for cancer targeted drug delivery Pharm Res 24 2007 1029 1046
    • (2007) Pharm Res , vol.24 , pp. 1029-1046
    • Sutton, D.1    Nasongkla, N.2    Blanco, E.3    Gao, J.4
  • 74
    • 80755171254 scopus 로고    scopus 로고
    • Targeting EGFR-overexpressing tumor cells using Cetuximab-immunomicelles loaded with doxorubicin and superparamagnetic iron oxide
    • C. Liao, Q. Sun, B. Liang, J. Shen, and X. Shuai Targeting EGFR-overexpressing tumor cells using Cetuximab-immunomicelles loaded with doxorubicin and superparamagnetic iron oxide Eur J Radiol 80 2011 699 705
    • (2011) Eur J Radiol , vol.80 , pp. 699-705
    • Liao, C.1    Sun, Q.2    Liang, B.3    Shen, J.4    Shuai, X.5
  • 75
    • 56349164381 scopus 로고    scopus 로고
    • Block copolymer micelles conjugated with anti-EGFR antibody for targeted delivery of anticancer drug
    • T. Noh, Y.H. Kook, C. Park, H. Youn, H. Kim, and E.T. Oh Block copolymer micelles conjugated with anti-EGFR antibody for targeted delivery of anticancer drug J Polym Sci Polym Chem 46 2008 7321 7331
    • (2008) J Polym Sci Polym Chem , vol.46 , pp. 7321-7331
    • Noh, T.1    Kook, Y.H.2    Park, C.3    Youn, H.4    Kim, H.5    Oh, E.T.6


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