Tetanus neurotoxin

Toxicon

Volumn 66, Issue , 2013, Pages 59-63

  Rossetto, O ^a   Scorzeto, M ^a   Megighian, A ^a   Montecucco, C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Metalloprotease; Neurotoxin; Synaptobrevin; Tetanus; VAMP

Indexed keywords

CARBOXY TERMINAL TETANUS NEUROTOXIN; GANGLIOSIDE GT 1B; NERVE GROWTH FACTOR; NEUROTOXIN; NEUROTROPHIN RECEPTOR P75; TETANUS NEUROTOXIN; TETANUS TOXIN; TETANUS TOXOID; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GENOME; CLOSTRIDIUM TETANI; ENDOCYTOSIS; INTERNEURON; ISOLATION PROCEDURE; LD 50; LIPID RAFT; MOTONEURON; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RETROGRADE NERVE FIBER TRANSPORT; REVIEW; STRUCTURE ACTIVITY RELATION; TETANUS; TOXIN STRUCTURE;

ANIMALS; CLOSTRIDIUM TETANI; GENOME, BACTERIAL; METALLOENDOPEPTIDASES; NEUROTRANSMITTER AGENTS; PERIPHERAL NERVES; PRESYNAPTIC TERMINALS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TETANUS TOXIN;

EID: 84875255750     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.12.027     Document Type: Review

References (57)

1. Bagetta G., Nisticò G. Tetanus toxin as a neurobiological tool to study mechanisms of neuronal cell death in the mammalian brain. Pharmacol. Ther. 1994, 62:29-39.
2. Bilsland L.G., Sahai E., Kelly G., Golding M., Greensmith L., Schiavo G. Deficits in axonal transport precede ALS symptoms in vivo. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:20523-20528.
3. Binz T., Rummel A. Cell entry strategy of clostridial neurotoxins. J. Neurochem. 2009, 109:1584-1595.
4. Blum F.C., Chen C., Kroken A.R., Barbieri J.T. Tetanus toxin and botulinum toxin A utilize unique mechanisms to enter neurons of the central nervous system. Infect. Immun. 2012, 80:1662-1669.
5. Brooks V.B., Curtis D.R., Eccles J.C. The action of tetanus toxin on the inhibition of motoneurons. J. Physiol. 1955, 135:655-672.
6. Brooks V.B., Curtis D.R., Eccles J.C. Mode of action of tetanus toxin. Nature 1955, 175:120-121.
7. Bruggemann H., Baumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. The genome sequence of Clostridium tetani, the causative agent of tetanus disease. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:1316-1321.
8. Bruschettini A. Sulla diffusione del veleno del tetano nell'organismo. Rif. Med. 1892, 8:270-273.
9. Carle A., Rattone G. Studio esperimentale sull'eziologia del tetano. Giorn. Accad. Med. Torino 1884, 32:174-179.
10. Chen C., Fu Z., Fu J.J., Kim P., Barbieri J.T., Baldwin M.R. Gangliosides as high affinity receptors for tetanus neurotoxin. J. Biol. Chem. 2009, 284:26569-26577.
11. Cornille F., Martin L., Lenoir C., Cussac D., Roques B.P., Fournie-Zaluski M.C. Cooperative exosite-dependent cleavage of synaptobrevin by tetanus toxin light chain. J. Biol. Chem. 1997, 272:3459-3464.
12. Deinhardt K., Berninghausen O., Willison H.J., Hopkins C.R., Schiavo G. Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J. Cell. Biol. 2006, 174:459-471.
13. Deinhardt K., Schiavo G. Endocytosis and retrograde axonal traffic in motor neurons. Biochem. Soc. Symp. 2005, 72:139-150.
14. Eisel U., Jarausch W., Goretzki K., Henschen A., Engels J., Weller U., Hudel M., Habermann E., Niemann H. Tetanus toxin: primary structure, expression in E. coli and homology with botulinum toxins. EMBO J. 1986, 5:2495-2502.
15. Faber K. Die Pathogenie des Tetanus. Berl. klin. Wochenschr. 1890, 27:717-720.
16. Fairweather N.F., Lyness V.A. The complete nucleotide sequence of tetanus toxin. Nucleic Acids Res. 1986, 14:7809-7812.
17. Fischer A., Nakai Y., Eubanks L.M., Clancy C.M., Tepp W.H., Pellett S., Dickerson T.J., Johnson E.A., Janda K.D., Montal M. Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:1330-1335.
18. Fotinou C., Emsley P., Black I., Ando H., Ishida H., Kiso M., Sinha K.A., Fairweather N.F., Isaacs N.W. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. J. Biol. Chem. 2001, 276:32274-32281.
19. Francis J.W., Figueiredo D., vanderSpek J.C., Ayala L.M., Kim Y.S., Remington M.P., Young P.J., Lorson C.L., Ikebe S., Fishman P.S., Brown R.H. A survival motor neuron: tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons. Brain Res. 2004, 995:84-96.
20. Galazka A., Gasse F. The present status of tetanus and tetanus vaccination. Curr. Top. Microbiol. Immunol. 1995, 195:31-53.
21. Galli T., Zahraoui A., Vaidyanathan V.V., Raposo G., Tian J.M., Karin M., Niemann H., Louvard D. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol. Biol. Cell. 1998, 9:1437-1448.
22. Gill D.M. Bacterial toxins: a table of lethal amounts. Microbiol. Rev. 1982, 46:86-94.
23. Habermann E., Dreyer F. Clostridial neurotoxins: handling and action at the cellular and molecular level. Curr. Top. Microbiol. Immunol. 1986, 129:93-179.
24. Jayaraman S., Eswaramoorthy S., Kumaran D., Swaminathan S. Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin. Proteins 2005, 61:288-295.
25. Kitasato S. Ueber den Tetanus bacillus. Z. Hyg. Infekt. Kr. 1889, 7:225-233.
26. Lacy D.B., Stevens R.C. Sequence homology and structural analysis of the clostridial neurotoxins. J. Mol. Biol. 1999, 291:1091-1104.
27. Lalli G., Bohnert S., Deinhardt K., Verastegui C., Schiavo G. The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol. 2003, 11:431-437.
28. Lalli G., Schiavo G. Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR. J. Cell. Biol. 2002, 156:233-239.
29. Matteoli M., Verderio C., Rossetto O., Iezzi N., Coco S., Schiavo G., Montecucco C. Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:13310-13315.
30. Middlebrook J.L., Brown J.E. Immunodiagnosis and immunotherapy of tetanus and botulinum neurotoxins. Curr. Top. Microbiol. Immunol. 1995, 195:89-122.
31. Montal M. Botulinum neurotoxin: a marvel of protein design. Annu. Rev. Biochem. 2010, 79:591-617.
32. Montecucco C. How do tetanus and botulinum toxins bind to neuronal membranes?. Trends Biochem. Sci. 1986, 11:315-317.
33. Montecucco C., Schiavo G., Brunner J., Duflot E., Boquet P., Roa M. Tetanus toxin is labeled with photoactivatable phospholipids at low pH. Biochemistry 1986, 25:919-924.
34. Moreno-Igoa M., Calvo A.C., Penas C., Manzano R., Olivan S., Munoz M.J., Mancuso R., Zaragoza P., Aguilera J., Navarro X., Osta Pinzolas R. Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapy. J. Mol. Med. (Berl) 2010, 88:297-308.
35. Patarnello T., Bargelloni L., Rossetto O., Schiavo G., Montecucco C. Neurotransmission and secretion. Nature 1993, 364:581-582.
36. Pellizzari R., Rossetto O., Lozzi L., Giovedì S., Johnson E., Shone C.C., Montecucco C. Structural determinants of the specificity for VAMP/synaptobrevin of tetanus and botulinum B and G neurotoxins. J. Biol. Chem. 1996, 271:20353-20358.
37. Pirazzini M., Bordin F., Rossetto O., Shone C.C., Binz T., Montecucco C. The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals. FEBS Lett. 2012, 21. pii: S0014-5793(12) 00853-8.
38. Pirazzini M., Rossetto O., Bertasio C., Bordin F., Shone C.C., Binz T., Montecucco C. Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons. Biochem. Biophys. Res. Commun. 2012, pii: S0006-291X(12)02223-1. 10.1016/j.bbrc.
39. Pirazzini M., Rossetto O., Bolognese P., Shone C.C., Montecucco C. Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons. Cell. Microbiol. 2011, 13:1731-1743.
40. Popoff M.R. Ecology of neurotoxigenic strains of Clostridia. Curr. Top. Microbiol. Immunol. 1995, 195:1-29.
41. Rossetto O., Caccin P., Rigoni M., Tonello F., Bortoletto N., Stevens R.C., Montecucco C. Active-site mutagenesis of tetanus neurotoxin implicates tyr-375 and glu-271 in metalloprotease activity. Toxicon 2001, 39:1151-1159.
42. Rossetto O., Schiavo G., Montecucco C., Poulain B., Deloye F., Lozzi L., Shone C.C. SNARE motif and neurotoxin recognition. Nature 1994, 372:415-416.
43. Rummel A., Bade S., Alves J., Bigalke H., Binz T. Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity. J. Mol. Biol. 2003, 326:835-847.
44. Schiavo G., Montecucco C. Tetanus and botulinum neurotoxins: isolation and assay. Methods Enzymol. 1995, 248:643-652.
45. Schiavo G., Benfenati F., Poulain B., Rossetto O., Polverino de Laureto P., DasGupta B.R., Montecucco C. Tetanus and botulinum-B neurotoxins block neurotransmitter release by a proteolytic cleavage of synaptobrevin. Nature 1992, 359:832-835.
46. Schiavo G., Matteoli M., Montecucco C. Neurotoxins affecting neuroexocytosis. Physiol. Rev. 2000, 80:1-50.
47. Schiavo G., Papini E., Genna G., Montecucco C. An intact interchain disulfide bond is required for the neurotoxicity of tetanus toxin. Infect. Immun. 1990, 58:4136-4141.
48. Schiavo G., Poulain B., Rossetto O., Benfenati F., Tauc L., Montecucco C. Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc. EMBO J. 1992, 11:3577-3583.
49. Schiavo G., Rossetto O., Benfenati F., Poulain B., Montecucco C. Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus. Ann. N. Y. Acad. Sci. 1994, 710:65-75.
50. Schwab M.E., Suda K., Thoenen H. Selective retrograde transsynaptic transfer of a protein, tetanus toxin, subsequent to its retrograde axonal transport. J. Cell. Biol. 1979, 82:798-810.
51. Takamori S., Holt M., Stenius K., Lemke E.A., Grønborg M., Riedel D., Urlaub H., Schenck S., Brügger B., Ringler P., Müller S.A., Rammner B., Gräter F., Hub J.S., De Groot B.L., Mieskes G., Moriyama Y., Klingauf J., Grubmüller H., Heuser J., Wieland F., Jahn R. Molecular anatomy of a trafficking organelle. Cell 2006, 127:831-846.
52. Tizzoni G., Cattani G. Uber das Tetanusgift. Zentralbl. Bakt. 1890, 8:69-73.
53. Tonello F., Montecucco C. The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity. Mol. Aspects Med. 2009, 30:431-438.
54. Umland T.C., Wingert L.M., Swaminathan S., Furey W.F., Schmidt J.J., Sax M. Structure of the receptor binding fragment HC of tetanus neurotoxin. Nat. Struct. Biol. 1997, 4:788-792.
55. van Heyningen W.E. Tetanus. Sci. Am. 1968, 218:69-77.
56. Williamson L.C., Neale E.A. Bafilomycin A1 inhibits the action of tetanus toxin in spinal cord neurons in cell culture. J. Neurochem. 1994, 63:2342-2345.
57. Yeh F.L., Dong M., Yao J., Tepp W.H., Lin G., Johnson E.A., Chapman E.R. SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathog. 2010, 6:e1001207. 10.1371/journal.ppat.1001207.