Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity

Toxicon

Volumn 39, Issue 8, 2001, Pages 1151-1159

  Rossetto, O ^a   Caccin, P ^a   Rigoni, M ^a   Tonello, F ^a   Bortoletto, N ^a   Stevens, R C ^b   Montecucco, C ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Botulinum neurotoxins; Clostridial neurotoxins; Metalloproteases; Tetanus neurotoxin; Zinc coordination

Indexed keywords

ALANINE; ASPARTIC ACID; BOTULINUM TOXIN A; BOTULINUM TOXIN B; GLUTAMINE; NEUROTOXIN; PHENYLALANINE; SYNAPTOBREVIN; TETANUS NEUROTOXIN; TETANUS TOXIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENZYME ACTIVE SITE; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SITE DIRECTED MUTAGENESIS; SYNAPSE VESICLE; TETANUS; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; BOTULINUM TOXIN TYPE A; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; R-SNARE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETANUS TOXIN; ZINC;

EID: 0035072510     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(00)00252-X     Document Type: Article

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