SHAFTS: A hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3564-3574

  Lu, Weiqiang ^a   Liu, Xiaofeng ^a   Cao, Xianwen ^a   Xue, Mengzhu ^a   Liu, Kangdong ^b   Zhao, Zhenjiang ^a   Shen, Xu ^a   Jiang, Hualiang ^a   Xu, Yufang ^a   Huang, Jin ^a   Li, Honglin ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE 2 INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN P90; PROTEIN P90 RIBOSOMAL S6 PROTEIN KINASE 2; S6 KINASE; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CANCER CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; THREE DIMENSIONAL IMAGING; VIRTUAL REALITY; WOUND HEALING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; COMPUTATIONAL BIOLOGY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROSPECTIVE STUDIES; PROTEIN STRUCTURE, TERTIARY; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

EID: 79957771857     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200139j     Document Type: Article

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