Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 9875-9890

  Castellano, Sabrina ^a   Spannhoff, Astrid ^b   Milite, Ciro ^a   Dal Piaz, Fabrizio ^a   Cheng, Donghang ^b   Tosco, Alessandra ^a   Viviano, Monica ^a   Yamani, Abdellah ^a,f   Cianciulli, Agostino ^a   Sala, Marina ^a   Cura, Vincent ^e   Cavarelli, Jean ^e   Novellino, Ettore ^c   Mai, Antonello ^d   Bedford, Mark T ^b   Sbardella, Gianluca ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^f Celon Pharma Sp Zoo   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 (3 (4 NITROPHENYL)UREIDO)ACETAMIDO) 1H INDOLE 2 CARBOXYLIC ACID; ARGININE; DNA METHYLTRANSFERASE 1; ETHYL 5 (2 (3 (4 NITROPHENYL)UREIDO)ACETAMIDO) 1H INDOLE 2 CARBOXYLATE; HISTONE H3; POLYADENYLIC ACID BINDING PROTEIN; SMALL MOLECULE TRANSPORT AGENT; TERT BUTYL 5 (2 (3 PHENYLUREIDO)ACETAMIDO) 1H INDOLE3 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HISTONE METHYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN METHYLATION; SIGNAL TRANSDUCTION;

ARGININE; BLOTTING, WESTERN; CATALYSIS; ENZYME ACTIVATORS; HISTONES; HUMANS; INDOLES; METHYLATION; MOLECULAR STRUCTURE; POLY(A)-BINDING PROTEIN I; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-ARGININE N-METHYLTRANSFERASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TRANS-ACTIVATORS;

EID: 84869995779     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301097p     Document Type: Article

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