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Volumn 133, Issue 4, 2013, Pages 1043-1051

Familial melanoma - Associated mutations in p16 uncouple its tumor-suppressor functions

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; PROTEIN P16; REACTIVE OXYGEN METABOLITE; TUMOR SUPPRESSOR PROTEIN;

EID: 84875217967     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.401     Document Type: Article
Times cited : (24)

References (48)
  • 1
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclindependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta DA, Xiong Y, Phelps D et al. (1996) Involvement of the cyclindependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 93:13742-7
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3
  • 2
    • 7444271583 scopus 로고    scopus 로고
    • BRCA1 induces antioxidant gene expression and resistance to oxidative stress
    • Bae I, Fan S, Meng Q et al. (2004) BRCA1 induces antioxidant gene expression and resistance to oxidative stress. Cancer Res 64:7893-909
    • (2004) Cancer Res , vol.64 , pp. 7893-7909
    • Bae, I.1    Fan, S.2    Meng, Q.3
  • 3
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova J, Lukas J, Guldberg P et al. (1996) The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 56:5475-83
    • (1996) Cancer Res , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3
  • 4
    • 27144495926 scopus 로고    scopus 로고
    • The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired
    • Becker TM, Ayub AL, Kefford RF et al. (2005) The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired. Int J Cancer 117:569-73
    • (2005) Int J Cancer , vol.117 , pp. 569-573
    • Becker, T.M.1    Ayub, A.L.2    Kefford, R.F.3
  • 5
    • 0034797707 scopus 로고    scopus 로고
    • Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding
    • Becker TM, Rizos H, Kefford RF et al. (2001) Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding. Clin Cancer Res 7:3282-8
    • (2001) Clin Cancer Res , vol.7 , pp. 3282-3288
    • Becker, T.M.1    Rizos, H.2    Kefford, R.F.3
  • 6
    • 0037134702 scopus 로고    scopus 로고
    • Geographical variation in the penetrance of CDKN2A mutations for melanoma
    • Bishop DT, Demenais F, Goldstein AM et al. (2002) Geographical variation in the penetrance of CDKN2A mutations for melanoma. J Natl Cancer Inst 94:894-903
    • (2002) J Natl Cancer Inst , vol.94 , pp. 894-903
    • Bishop, D.T.1    Demenais, F.2    Goldstein, A.M.3
  • 7
    • 34547098814 scopus 로고    scopus 로고
    • Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation
    • Bragado P, Armesilla A, Silva A et al. (2007) Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis 12:1733-42
    • (2007) Apoptosis , vol.12 , pp. 1733-1742
    • Bragado, P.1    Armesilla, A.2    Silva, A.3
  • 8
    • 0031991891 scopus 로고    scopus 로고
    • Tumor suppressor p16INK4A: Determination of solution structure and analyses of its interaction with cyclindependent kinase 4
    • Byeon IJ, Li J, Ericson K et al. (1998) Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclindependent kinase 4. Mol Cell 1:421-31
    • (1998) Mol Cell , vol.1 , pp. 421-431
    • Byeon, I.J.1    Li, J.2    Ericson, K.3
  • 9
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    • Chen W, Sun Z, Wang XJ et al. (2009) Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell 34:663-73
    • (2009) Mol Cell , vol.34 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.J.3
  • 10
    • 34848838265 scopus 로고    scopus 로고
    • Absence of senescenceassociated beta-galactosidase activity in human melanocytic nevi in vivo
    • Cotter MA, Florell SR, Leachman SA et al. (2007) Absence of senescenceassociated beta-galactosidase activity in human melanocytic nevi in vivo. J Invest Dermatol 127:2469-71
    • (2007) J Invest Dermatol , vol.127 , pp. 2469-2471
    • Cotter, M.A.1    Florell, S.R.2    Leachman, S.A.3
  • 11
    • 3242888906 scopus 로고    scopus 로고
    • Electron microscopy evidence that cytoplasmic localization of the p16(INK4A) ''nuclear'' cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas
    • Evangelou K, Bramis J, Peros I et al. (2004) Electron microscopy evidence that cytoplasmic localization of the p16(INK4A) ''nuclear'' cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas. Biotech Histochem 79:5-10
    • (2004) Biotech Histochem , vol.79 , pp. 5-10
    • Evangelou, K.1    Bramis, J.2    Peros, I.3
  • 12
    • 0029177397 scopus 로고    scopus 로고
    • Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
    • Fahraeus R, Paramio JM, Ball KL et al. (1996) Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A. Curr Biol 6:84-91
    • (1996) Curr Biol , vol.6 , pp. 84-91
    • Fahraeus, R.1    Paramio, J.M.2    Ball, K.L.3
  • 13
    • 33847282821 scopus 로고    scopus 로고
    • Features associated with germline CDKN2A mutations: A GenoMEL study of melanoma-prone families from three continents
    • Goldstein AM, Chan M, Harland M et al. (2007) Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet 44:99-106
    • (2007) J Med Genet , vol.44 , pp. 99-106
    • Goldstein, A.M.1    Chan, M.2    Harland, M.3
  • 14
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
    • Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18:2714-3
    • (1997) Electrophoresis , vol.18 , pp. 2714-2723
    • Guex, N.1    Peitsch, M.C.2
  • 15
    • 0034671754 scopus 로고    scopus 로고
    • CDKN2A germ-line mutations in individuals with multiple cutaneous melanomas
    • Hashemi J, Platz A, Ueno T et al. (2000) CDKN2A germ-line mutations in individuals with multiple cutaneous melanomas. Cancer Res 60:6864-7
    • (2000) Cancer Res , vol.60 , pp. 6864-6867
    • Hashemi, J.1    Platz, A.2    Ueno, T.3
  • 16
    • 33644893598 scopus 로고    scopus 로고
    • Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin
    • Herrling T, Jung K, Fuchs J (2006) Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin. Spectrochim Acta A Mol Biomol Spectrosc 63:840-5
    • (2006) Spectrochim Acta A Mol Biomol Spectrosc , vol.63 , pp. 840-845
    • Herrling, T.1    Jung, K.2    Fuchs, J.3
  • 17
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai H, Roussel MF, Kato JY et al. (1995) Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15:2672-81
    • (1995) Mol Cell Biol , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.Y.3
  • 18
    • 78751647836 scopus 로고    scopus 로고
    • The p16(INK4A) tumor suppressor regulates cellular oxidative stress
    • Jenkins NC, Liu T, Cassidy P et al. (2011) The p16(INK4A) tumor suppressor regulates cellular oxidative stress. Oncogene 30:265-74
    • (2011) Oncogene , vol.30 , pp. 265-274
    • Jenkins, N.C.1    Liu, T.2    Cassidy, P.3
  • 19
    • 35148825975 scopus 로고    scopus 로고
    • A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
    • Jones R, Ruas M, Gregory F et al. (2007) A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6. Cancer Res 67:9134-41
    • (2007) Cancer Res , vol.67 , pp. 9134-9141
    • Jones, R.1    Ruas, M.2    Gregory, F.3
  • 20
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • Kamijo T, Zindy F, Roussel MF et al. (1997) Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91:649-59
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3
  • 21
    • 63749090185 scopus 로고    scopus 로고
    • Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients
    • Kannengiesser C, Brookes S, del Arroyo AG et al. (2009) Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients. Hum Mutat 30:564-74
    • (2009) Hum Mutat , vol.30 , pp. 564-574
    • Kannengiesser, C.1    Brookes, S.2    Del Arroyo, A.G.3
  • 22
    • 0029052951 scopus 로고
    • Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
    • Koh J, Enders GH, Dynlacht BD et al. (1995) Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375:506-10
    • (1995) Nature , vol.375 , pp. 506-510
    • Koh, J.1    Enders, G.H.2    Dynlacht, B.D.3
  • 23
    • 0034307185 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells
    • Le Page F, Randrianarison V, Marot D et al. (2000) BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. Cancer Res 60:5548-2
    • (2000) Cancer Res , vol.60 , pp. 5548-5552
    • Le Page, F.1    Randrianarison, V.2    Marot, D.3
  • 24
    • 0033537672 scopus 로고    scopus 로고
    • Tumor suppressor INK4: Determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A
    • Li J, Byeon IJ, Ericson K et al. (1999) Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. Biochemistry 38:2930-40
    • (1999) Biochemistry , vol.38 , pp. 2930-2940
    • Li, J.1    Byeon, I.J.2    Ericson, K.3
  • 25
    • 33845934490 scopus 로고    scopus 로고
    • Ankyrin repeat: A unique motif mediating protein-protein interactions
    • Li J, Mahajan A, Tsai MD (2006) Ankyrin repeat: a unique motif mediating protein-protein interactions. Biochemistry 45:15168-78
    • (2006) Biochemistry , vol.45 , pp. 15168-15178
    • Li, J.1    Mahajan, A.2    Tsai, M.D.3
  • 26
    • 0029054399 scopus 로고
    • Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
    • Lukas J, Parry D, Aagaard L et al. (1995) Retinoblastoma-protein- dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375:503-6
    • (1995) Nature , vol.375 , pp. 503-506
    • Lukas, J.1    Parry, D.2    Aagaard, L.3
  • 27
    • 0242552555 scopus 로고    scopus 로고
    • Influence of induced reactive oxygen species in p53-mediated cell fate decisions
    • Macip S, Igarashi M, Berggren P et al. (2003) Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 23:8576-85
    • (2003) Mol Cell Biol , vol.23 , pp. 8576-8585
    • Macip, S.1    Igarashi, M.2    Berggren, P.3
  • 28
    • 0036566326 scopus 로고    scopus 로고
    • Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
    • Macip S, Igarashi M, Fang L et al. (2002) Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J 21:2180-8
    • (2002) EMBO J , vol.21 , pp. 2180-2188
    • Macip, S.1    Igarashi, M.2    Fang, L.3
  • 29
    • 34848827883 scopus 로고    scopus 로고
    • Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16
    • Mahajan A, Guo Y, Yuan C et al. (2007) Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16. J Mol Biol 373:990-1005
    • (2007) J Mol Biol , vol.373 , pp. 990-1005
    • Mahajan, A.1    Guo, Y.2    Yuan, C.3
  • 30
    • 77952681688 scopus 로고    scopus 로고
    • Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A
    • McKenzie HA, Fung C, Becker TM et al. (2010) Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A. Hum Mutat 31:692-701
    • (2010) Hum Mutat , vol.31 , pp. 692-701
    • McKenzie, H.A.1    Fung, C.2    Becker, T.M.3
  • 31
    • 79960749722 scopus 로고    scopus 로고
    • Classifying variants of CDKN2A using computational and laboratory studies
    • Miller PJ, Duraisamy S, Newell JA et al. (2011) Classifying variants of CDKN2A using computational and laboratory studies. Hum Mutat 32:900-11
    • (2011) Hum Mutat , vol.32 , pp. 900-911
    • Miller, P.J.1    Duraisamy, S.2    Newell, J.A.3
  • 32
    • 0033796319 scopus 로고    scopus 로고
    • Regulation of CDK7-carboxylterminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation
    • Nishiwaki E, Turner SL, Harju S et al. (2000) Regulation of CDK7-carboxylterminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation. Mol Cell Biol 20:7726-34
    • (2000) Mol Cell Biol , vol.20 , pp. 7726-7734
    • Nishiwaki, E.1    Turner, S.L.2    Harju, S.3
  • 33
    • 0029980941 scopus 로고    scopus 로고
    • Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma
    • Parry D, Peters G (1996) Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma. Mol Cell Biol 16:3844-52
    • (1996) Mol Cell Biol , vol.16 , pp. 3844-3852
    • Parry, D.1    Peters, G.2
  • 34
    • 0030930366 scopus 로고    scopus 로고
    • A model for p53-induced apoptosis
    • Polyak K, Xia Y, Zweier JL et al. (1997) A model for p53-induced apoptosis. Nature 389:300-5
    • (1997) Nature , vol.389 , pp. 300-305
    • Polyak, K.1    Xia, Y.2    Zweier, J.L.3
  • 35
    • 38849209818 scopus 로고    scopus 로고
    • Survivin repression by p53, Rb and E2F2 in normal human melanocytes
    • Raj D, Liu T, Samadashwily G et al. (2008) Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Carcinogenesis 29:194-201
    • (2008) Carcinogenesis , vol.29 , pp. 194-201
    • Raj, D.1    Liu, T.2    Samadashwily, G.3
  • 36
    • 0028998866 scopus 로고
    • Mutations associated with familial melanoma impair p16INK4 function
    • Ranade K, Hussussian CJ, Sikorski RS et al. (1995) Mutations associated with familial melanoma impair p16INK4 function. Nat Genet 10:114-6
    • (1995) Nat Genet , vol.10 , pp. 114-116
    • Ranade, K.1    Hussussian, C.J.2    Sikorski, R.S.3
  • 37
    • 0028971677 scopus 로고
    • P16 proteins from melanoma-prone families are deficient in binding to Cdk4
    • Reymond A, Brent R (1995) p16 proteins from melanoma-prone families are deficient in binding to Cdk4. Oncogene 11:1173-8
    • (1995) Oncogene , vol.11 , pp. 1173-1178
    • Reymond, A.1    Brent, R.2
  • 38
    • 0032541623 scopus 로고    scopus 로고
    • Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
    • Russo AA, Tong L, Lee JO et al. (1998) Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395:237-43
    • (1998) Nature , vol.395 , pp. 237-243
    • Russo, A.A.1    Tong, L.2    Lee, J.O.3
  • 39
    • 0032489377 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH
    • Serizawa H (1998) Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH. J Biol Chem 273:5427-30
    • (1998) J Biol Chem , vol.273 , pp. 5427-5430
    • Serizawa, H.1
  • 40
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704-7
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 41
    • 0031594707 scopus 로고    scopus 로고
    • P16INK4A participates in a G1 arrest checkpoint in response to DNA damage
    • Shapiro GI, Edwards CD, Ewen ME et al. (1998) p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol 18:378-87
    • (1998) Mol Cell Biol , vol.18 , pp. 378-387
    • Shapiro, G.I.1    Edwards, C.D.2    Ewen, M.E.3
  • 42
    • 0033037541 scopus 로고    scopus 로고
    • The INK4A/ARF locus and its two gene products
    • Sharpless NE, DePinho RA (1999) The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev 9:22-30
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 22-30
    • Sharpless, N.E.1    Depinho, R.A.2
  • 43
    • 33750510904 scopus 로고    scopus 로고
    • Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
    • Takahashi A, Ohtani N, Yamakoshi K et al. (2006) Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 8:1291-7
    • (2006) Nat Cell Biol , vol.8 , pp. 1291-1297
    • Takahashi, A.1    Ohtani, N.2    Yamakoshi, K.3
  • 44
    • 0029665942 scopus 로고    scopus 로고
    • Tumor suppressor p16INK4A: Structural characterization of wild-type and mutant proteins by NMR and circular dichroism
    • Tevelev A, Byeon IJ, Selby T et al. (1996) Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism. Biochemistry 35:9475-87
    • (1996) Biochemistry , vol.35 , pp. 9475-9487
    • Tevelev, A.1    Byeon, I.J.2    Selby, T.3
  • 45
    • 84655169936 scopus 로고    scopus 로고
    • Tumor suppressor genes and ROS: Complex networks of interactions
    • Vurusaner B, Poli G, Basaga H (2012) Tumor suppressor genes and ROS: complex networks of interactions. Free Radic Biol Med 52:7-18
    • (2012) Free Radic Biol Med , vol.52 , pp. 7-18
    • Vurusaner, B.1    Poli, G.2    Basaga, H.3
  • 46
    • 0028971713 scopus 로고
    • Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds
    • Walker GJ, Hussussian CJ, Flores JF et al. (1995) Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds. Hum Mol Genet 4:1845-52
    • (1995) Hum Mol Genet , vol.4 , pp. 1845-1852
    • Walker, G.J.1    Hussussian, C.J.2    Flores, J.F.3
  • 47
    • 37549038168 scopus 로고    scopus 로고
    • Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer
    • Welm BE, Dijkgraaf GJ, Bledau AS et al. (2008) Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell 2:90-102
    • (2008) Cell Stem Cell , vol.2 , pp. 90-102
    • Welm, B.E.1    Dijkgraaf, G.J.2    Bledau, A.S.3
  • 48
    • 0028979432 scopus 로고
    • Mutational effects on the p16INK4a tumor suppressor protein
    • Yang R, Gombart AF, Serrano M et al. (1995) Mutational effects on the p16INK4a tumor suppressor protein. Cancer Res 55:2503-6
    • (1995) Cancer Res , vol.55 , pp. 2503-2506
    • Yang, R.1    Gombart, A.F.2    Serrano, M.3


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