CDKN2A germ-line mutations in individuals with multiple cutaneous melanomas

Cancer Research

Volumn 60, Issue 24, 2000, Pages 6864-6867

  Hashemi, Jamileh ^a   Platz, Anton ^a   Ueno, Takayuki ^a   Stierner, Ulrika ^b   Ringborg, Ulrik ^a   Hansson, Johan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PROTEIN P16; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CODON; FAMILY HISTORY; FEMALE; FOUNDER EFFECT; GENE DELETION; GENE INSERTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MELANOMA; MUTATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SWEDEN;

ADOLESCENT; ADULT; AGE OF ONSET; BASE SEQUENCE; CODON; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; DNA, COMPLEMENTARY; EXONS; FAMILY HEALTH; FEMALE; FOUNDER EFFECT; GENE DELETION; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; MALE; MELANOMA; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SEQUENCE ANALYSIS, DNA; SKIN NEOPLASMS;

EID: 0034671754     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. High risk of malignant melanoma in melanoma-prone families with dysplastic nevi
2. Genetic epidemiology of familial melanoma
3. Hereditary cancer in adults
4. Molecular genetics of familial cutaneous melanoma
5. Hereditary cutaneous melanoma
6. INK4A: Determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4
7. Novel germ-line p16 mutation in familial malignant melanoma in southern Sweden
8. Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma
9. Multiple primary melanomas: An analysis of cancer registry data from Victoria and New South Wales
10. Multiple primary melanomas: Implications for screening and follow-up programs for melanoma
11. Multiple primary melanoma: Incidence and risk factors in 283 patients
12. CDKN2A mutations in multiple primary melanomas
13. Screening of multiple DNA samples for detection of sequence changes
14. INK4B is a potential effector of TGF-β-induced cell cycle arrest
15. INK4 in human cancer
16. INK4a/CDKN2A: Correlation with protein structure information
17. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
18. Melanoma development in relation to non-functional p16/INK4A protein and dysplastic nevus syndrome in Swedish melanoma kindreds
19. Multiple primary cutaneous melanomas
20. INK4 CDK inhibitory activity
21. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
22. p53 and p16/CDKN2 gene mutations in esophageal tumors from a high-incidence area in South Africa
23. Mutation of the CDKN2A 5′ UTR creates an aberrant initiation codon and predisposes to melanoma
24. Mutation screening of the CDKN2A promoter in melanoma families