Beneficial therapeutic effect of Chinese herbal Bushen formula on CHB patients with mildly elevated alanine aminotransferase by down-regulating CD4+CD25+T cells

Journal of Ethnopharmacology

Volumn 146, Issue 2, 2013, Pages 614-622

  Li, Man ^a   Sun, Xue Hua ^a   Zhou, Zhen Hua ^a   Yu, Zhuo ^a   Jin, Shu Gen ^a   Zhu, Xiao Jun ^a   Gao, Yue Qiu ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

ALT (1 2 times ULN); Bushen formula; CD4+CD25+T cells; Chronic hepatitis B; Foxp3; IFN

Indexed keywords

ALANINE AMINOTRANSFERASE; BUSHEN FORMULA; CHINESE DRUG; GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL SEPARATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME BLOOD LEVEL; FEMALE; FLOW CYTOMETRY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INFECTION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; VIRUS LOAD;

ALANINE TRANSAMINASE; CD4-POSITIVE T-LYMPHOCYTES; DNA, VIRAL; DOWN-REGULATION; DRUGS, CHINESE HERBAL; FORKHEAD TRANSCRIPTION FACTORS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-4; VIRAL LOAD;

HEPATITIS B VIRUS;

EID: 84875216168     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.01.038     Document Type: Article

References (51)

1. R.M. Andrade, P.G. Lima, R.G. Filho, J. Hygino, S.F. Milczanowski, A.F. Andrade, C. Lauria, R. Brindeiro, A. Tanuri, and C.A. Bento Interleukin-10- secreting CD4 cells from aged patients with AIDS decrease in-vitro HIV replication and tumour necrosis factor alpha production AIDS 21 2007 1763 1770 (Pubitemid 47237564)
2. M. Asano, M. Toda, N. Sakaguchi, and S. Sakaguchi Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation Journal of Experimental Medicine 184 1996 387 396 (Pubitemid 26324092)
3. Y. Belkaid, C.A. Piccirillo, S. Mendez, E.M. Shevach, and D.L. Sacks CD4+CD25+regulatory T cells control Leishmania major persistence and immunity Nature 420 2002 502 507 (Pubitemid 35477041)
4. C.L. Bennett, J. Christie, F. Ramsdell, M.E. Brunkow, P.J. Ferguson, L. Whitesell, T.E. Kelly, F.T. Saulsbury, P.F. Chance, and H.D. Ochs The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome(IPEX) is caused by mutations of FOXP3 Nature Genetics 27 2001 20 21 (Pubitemid 32044513)
5. M.E. Brunknow, E.W. Jeffery, K.A. Hjerrild, B. Paeper, L.B. Clark, S.A. Yasayko, J.E. Wilkinson, D. Galas, S.F. Ziegler, and F. Ramsdell Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse Nature Genetics 27 2001 68 73 (Pubitemid 32044521)
6. T. Cao, P. Meuleman, I. Desombere, M. Sallberg, and G. Leroux-Roels In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T cell clone in a hu-PBL-NOD/SCID mouse model Journal of Virology 75 2001 11449 11456 (Pubitemid 33063236)
7. F.V. Chisari, M. Isogawa, and S.F. Wieland Pathogensis of hepatitis B virus infection Pathologie Biologie (Paris) 58 2010 258 266
8. M. Dure, and F. Macian IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes Molecular Immunology 46 2009 999 1006
9. N. Eastaff-Leung, N. Mabarrack, A. Barbour, A. Cummins, and S. Barry Foxp3+regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease Journal of Clinical Immunology 30 2010 80 89
10. O. El-Badawy, D. Sayed, M.S. Badary, M.E. Abd-Alrahman, M.A. El-Feky, and A.G. Thabit Relations of regulatory T cells with hepatitis markers in chronic hepatitis B virus infection Human Immunology 73 2012 335 341
11. J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+regulatory T cells Nature Immunology 4 2003 330 336 (Pubitemid 36432314)
12. O. Franzese, P.T. Kennedy, A.J. Gehring, J. Gotto, R. Williams, M.K. Maini, and A. Bertoletti Modulation of the CD8+-T-cell response by CD4+CD25+regulatory T cells in patients with hepatitis B virus infection Journal of Virology 79 2005 3322 3328 (Pubitemid 40327921)
13. Y.Q. Gao, Y. Yao, and M. Li Effect of bushen recipe on the immune effector molecules of natural killer cells in patients with chronic hepatitis B Zhongguo Zhong Xi Yi Jie He Za Zhi 30 2010 710 713
14. M. Ghoreishi, and J.P. Dutz Tolerance induction by transcutaneous immunization through ultraviolet-irradiated skin is transferable through CD4+CD25+ T regulatory cells and is dependent on host-derived IL-10 Journal of Immunology 176 2006 2635 2644 (Pubitemid 43201716)
15. L.G. Guidotti, and F.V. Chisari Noncytolytic control of viral infections by the innate and adaptive immune response Annual Review of Immunology 19 2001 65 91 (Pubitemid 32368030)
16. S. Hori, T.L. Carvalho, and J. Demengeot CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice European Journal of Immunology 32 2002 1282 1291 (Pubitemid 34546255)
17. W.Y. Jiang Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science Trends in Pharmacological Sciences 26 2005 558 563
18. H. Jonuleit, E. Schmitt, H. Kakirman, M. Stassen, J. Knop, and A.H. Enk Infectious tolerance: human CD25(+) regulatory T cells convery suppressor activity to conventional CD4(+) T helper cells Journal of Experimental Medicine 196 2002 255 260 (Pubitemid 34787515)
19. E.B. Keeffe, D.T. Dieterich, S.H. Han, I.M. Jacobson, P. Martin, E.R. Schiff, and H. Tobias A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update Clinical Gastroenterology and Hepatology 6 2008 1315 1341 (quiz 1286)
20. R. Khattri, T. Cox, S.A. Yasayko, and F. Ramsdell An essential role for scurfin in CD4+CD25+ T regulatory cells Nature Immunology 5 2003 337 342 (Pubitemid 36432315)
21. H.C. Kim, C.M. Nam, S.H. Jee, K.H. Han, D.K. Oh, and I. Suh Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study British Medical Journal 328 2004 983
22. T. Kimura, A. Rokuhara, A. Matsumoto, S. Yagi, E. Tanaka, K. Kiyosawa, and N. Maki New enzyme immunoassay for detection of hepatitis B virus core antigen (HBcAg) and relation between levels of HBcAg and HBV DNA Journal of Clinical Microbiology 41 2003 1901 1906 (Pubitemid 36576510)
23. M. Li, X.H. Sun, X.J. Zhu, S.G. Jin, Z.J. Zeng, Z.H. Zhou, Z. Yu, and Y.Q. Gao HBcAg induces PD-1 upregulation on CD4+T cells through activation of JNK, ERK and PI3K/AKT pathways in chronic hepatitis-B-infected patients Laboratory Investigation 92 2012 295 304
24. Y.F. Liaw, N. Leung, J.H. Kao, T. Piratvisuth, E. Gane, K.H. Han, R. Guan, G.K. Lau, and S. Locarnini Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update Hepatology International 2 2008 263 283
25. Y. Liu, P. Liu, R. Dai, J. Wang, Y. Zheng, J. Shen, F. Guo, L. Wang, H. Li, and M. Wei Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B Journal of Pharmaceutical and Biomedical Analysis 59 2010 173 178
26. A.S. Lok, and B.J. McMahon Chronic hepatitis B Hepatology 45 2007 507 539 (Pubitemid 46374607)
27. S.G. Park, H.M. Ryu, S.O. Lim, Y.I. Kim, S.B. Hwang, and G. Jung Interferon-gamma inhibits hepatitis B virus-induced NF-kappaB activation through nuclear localization of NF-kappaB-inducing kinase Gastroenterology 128 2005 2042 2053 (Pubitemid 40824712)
28. M.K. Parvez, D. Sehgal, S.K. Sarin, S.F. Basir, and S. Jameel Inhibition of hepatitis B virus DNA replicative intermediate forms by recombinant interferon-gamma World Journal of Gastroenterology 12 2006 3006 3014 (Pubitemid 43811076)
29. C.M. Petersen, E.I. Christensen, B.S. Andresen, and B.K. Moller Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells Experimental Cell Research 201 1992 160 173
30. X.K. Qin, P. Li, M. Han, and J.P. Liu Xiaochaihu Tang for treatment of chronic hepatitis B: a systematic review of randomized trials Zhong Xi Yi Jie He Xue Bao 8 2010 312 320
31. S. Read, V. Malmstrom, and F. Powrie Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation Journal of Experimental Medicine 192 2000 295 302 (Pubitemid 30470312)
32. B. Rehermann, and M. Nascimbeni Immunology of hepatitis B virus and hepatitis C virus infection Nature Reviews Immunology 5 2005 215 229 (Pubitemid 40364823)
33. M.D. Robek, S.F. Wieland, and F.V. Chisari Inhibition of hepatitis B virus replication by interferon requires proteasome activity Journal of Virology 76 2002 3570 3574 (Pubitemid 34224559)
34. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases Journal of Immunology 155 1995 1151 1164
35. K. Schroder, P.J. Hertzog, T. Ravasi, and D.A. Hume Interferon-gamma: an overview of signals, mechanisms and functions Journal of Leukocyte Biology 75 2004 163 189 (Pubitemid 38174573)
36. M. Shi, S. Qian, W.W. Chen, H. Zhang, B. Zhang, Z.R. Tang, Z. Zhang, and F.S. Wang Hepatitis B virus (HBV) antigen-pulsed monocyte-derived dendritic cells from HBV-associated hepatocellular carcinoma patients significantly enhance specific T cell responses in vitro Clinical and Experimental Immunology 147 2007 277 286 (Pubitemid 46096006)
37. B. Singh, S. Read, C. Asseman, V. Malmstrom, C. Mottet, L.A. Stephens, R. Stepankova, H. Tlaskalova, and F. Powrie Control of intestinal inflammation by regulatory T cells Immunological Reviews 182 2001 190 200 (Pubitemid 33070218)
38. J.N. Stoop, R.G. van der Molen, C.C. Baan, L.J. van der Laan, E.J. Kuipers, J.G. Kusters, and H.L. Janssen Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection Hepatology 41 2005 771 778 (Pubitemid 40462939)
39. E. Suri-Payer, A.Z. Amar, A.M. Thornton, and E.M. Shevach CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells Journal of Immunology 160 1998 1212 1218 (Pubitemid 28093417)
40. B.Z. Tang, M. Li, and Y.Q. Gao Curative effect of Yidu recipe in treating chronic hepatitis B patients of gan-shen yin-deficiency and damp-heat syndrome type and its influence of T-cell subsets Zhongguo Zhong Xi Yi Jie He Za Zhi 30 2010 823 827
41. A.M. Thornton, and E.M. Shevach CD4+CD25+immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production Journal of Experimental Medicine 188 1998 287 296 (Pubitemid 28357757)
42. S.F. Wieland, A. Eustaquio, C. Whitten-Bauer, B. Boyd, and F.V. Chisari Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids Proceedings of the National Academy of Sciences USA 102 2005 9913 9917 (Pubitemid 40993667)
43. R.S. Wildin, F. Ramsdell, J. Peake, F. Faravelli, J.L. Casanova, N. Buist, E. Levy-Lahad, M. Mazzella, O. Goulet, L. Perroni, F.D. Bricarelli, G. Byrne, M. McEuen, S. Proll, M. Appleby, and M.E. Brunkow X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy Nature Genetics 27 2001 18 20 (Pubitemid 32044512)
44. D. Xu, H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, J. Alexander, and F.Y. Liew CD4+CD25+regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice Journal of Immunology 170 2003 394 399 (Pubitemid 36026164)
45. H. Yagi, T. Nomura, K. Nakamura, S. Yamazaki, T. Kitawaki, S. Hori, M. Maeda, M. Onodera, T. Uchiyama, S. Fujii, and S. Sakaguchi Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells International Immunology 16 2004 1643 1656
46. M.F. Yuen, H.J. Yuan, D.K. Wong, J.C. Yuen, W.M. Wong, A.O. Chan, B.C. Wong, K.C. Lai, and C.L. Lai Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications Gut 54 2005 1610 1614 (Pubitemid 41531781)
47. H.H. Zhang, F. Guo, R. Fei, H. Ma, X. Cong, L. Wei, and H.S. Chen Inhibition of CD4+CD25+ regulatory T cells in chronic hepatitis B patients Zhonghua Yi Xue Za Zhi 88 2008 511 515 (Pubitemid 351682024)
48. L. Zhang, G. Wang, W. Hou, P. Li, A. Dulin, and H.L. Bonkovsky Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review Hepatology 51 2010 690 698
49. T. Zhang, Y. Wang, and K.W. Sun Effects of entecavir and Shenxian Yiganling combination therapy on patients with HBeAg-positive chronic hepatitis B for 48 weeks Zhongguo Zhong Xi Yi Jie He Za Zhi 32 2012 180 182
50. L.P. Zhou, H. Shang, Z.N. Zhang, Y.N. Wang, G.F. Li, W.Y. Shi, and H.B. Ding Correlation between the function of monocytes/macrophages and disease progression in people living with HIV/AIDS in several provinces in China Zhonghua Yi Xue Za Zhi 87 2007 2394 2397 (Pubitemid 350258950)
51. S.F. Ziegler FOXP3: of mice and men Annual Review of Immunology 24 2006 209 226