Hepatitis B virus (HBV) antigen-pulsed monocyte-derived dendritic cells from HBV-associated hepatocellular carcinoma patients significantly enhance specific T cell responses in vitro

Clinical and Experimental Immunology

Volumn 147, Issue 2, 2007, Pages 277-286

  Shi, M ^a   Qian, S ^a   Chen, W W ^a   Zhang, H ^a   Zhang, B ^a   Tang, Z R ^a   Zhang, Z ^a   Wang, F S ^a  

^a BEIJING 302 HOSPITAL   (China)

Author keywords

Antigens epitopes; Dendritic cell; Hepatitis B virus; Liver cancer; Therapy immunotherapy

Indexed keywords

ALANINE AMINOTRANSFERASE; B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HEPATITIS B ANTIGEN; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; TETRAMER;

ADULT; ARTICLE; CANCER PATIENT; CD8+ T LYMPHOCYTE; CELL THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; LYMPHOCYTE PROLIFERATION; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; ALANINE TRANSAMINASE; CARCINOMA, HEPATOCELLULAR; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; HEPATITIS B ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; LIVER NEOPLASMS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MONOCYTES; T-LYMPHOCYTES; VIRAL LOAD;

EID: 33846241276     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03281.x     Document Type: Article

References (44)

1. Ganem D, Prince AM. Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med 2004; 350:1118-29.
2. Kakimi K, Isogawa M, Chung J, Sette A, Chisari FV. Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections. J Virol 2002; 76:8609-20.
3. Reignat S, Webster GJ, Brown D et al. Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. J Exp Med 2002; 195:1089-101.
4. Auffermann-Gretzinger S, Keeffe EB, Levy S. Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 2001; 97:3171-6.
5. Knight SC, Macatonia SE, Patterson S. Infection of dendritic cells with HIV1: virus load regulates stimulation and suppression of T-cell activity. Res Virol 1993; 144:75-80.
6. Bertoletti A, Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology 2003; 38:4-13.
7. Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001; 19:65-91.
8. Chisari FV. Viruses, immunity, and cancer: lessons from hepatitis B. Rous-Whipple Award Lecture. Am J Pathol 2000; 156:1117-32.
9. Duan XZ, Wang M, Li HW et al. Decreased frequency and function of firculating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans. J Clin Immunol 2004; 24:637-46.
10. Duan XZ, Zhuang H, Wang M, Li HW, Liu JC, Wang FS. Decreased numbers and impaired function of circulating dendritic cell subsets in patients with chronic hepatitis B infection. J Gastroenterol Hepatol 2005; 20:234-42.
11. Akbar SM, Abe M, Masumoto T, Horiike N, Onji M. Mechanism of action of vaccine therapy in murine hepatitis B virus carriers: vaccine-induced activation of antigen presenting dendritic cells. J Hepatol 1999; 30:755-64.
12. Beckebaum S, Cicinnati VR, Zhang X et al. Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape. Immunology 2003; 109:487-95.
13. Wang FS, Xing LH, Liu MX et al. Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection. World J Gastroenterol 2001; 7:537-41.
14. Ninomiya T, Akbar SM, Masumoto T, Horiike N, Onji M. Dendritic cells with immature phenotype and defective function in the peripheral blood from patients with hepatocellular carcinoma. J Hepatol 1999; 31:323-31.
15. Arima S, Akbar SM, Michitaka K et al. Impaired function of antigen-presenting dendritic cells in patients with chronic hepatitis B: localization of HBV DNA and HBV RNA in blood DC by in situ hybridization. Int J Mol Med 2003; 11:169-74.
16. Qian S, Shi M, Zhang H, Zhang B, Xu DP, Wang FS. Phenotype and function of myeloid dendritic cells pulsed with hepatitis B virus antigens in patients with HBV-associated hepatocellular carcinoma. Zhonghua Yi Xue Za Zhi 2005; 85:248-52.
17. Kakumu S, Ito S, Ishikawa T et al. Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection. J Gastroenterol Hepatol 2000; 15:431-6.
18. Oka Y, Akbar SMF, Horiike N, Joko K, Onji M. Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice. Immunology 2001; 103:90-7.
19. Shimizu Y, Guidotti LG, Fowler P, Chisari FV. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice. J Immunol 1998; 161:4520-9.
20. Fazle Akbar SM, Furukawa S, Onji M et al. Safety and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers. Hepatol Res 2004; 9:136-41.
21. Akbar SM, Furukawa S, Hasebe A, Horiike N, Michitaka K, Onji M. Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrier. Int J Mol Med 2004; 14:295-9.
22. Chen M, Li YG, Zhang DZ et al. Therapeutic effect of autologous dendritic cell vaccine on patients with chronic hepatitis B: a clinical study. World J Gastroenterol 2005; 11:1806-8.
23. Akbar SM, Furukawa S, Horiike N, Onji M. Vaccine therapy for hepatitis B virus carrier. Curr Drug Targets Infect Disord 2004; 4:93-101.
24. Rosenberg SA. Shedding light on immunotherapy for cancer. N Engl J Med 2004; 350:1461-3.
25. Nestle FO, Alijagic S, Gilliet M et al. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med 1998; 4:328-32.
26. Kugler A, Stuhler G, Walden P et al. Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nat Med 2000; 6:332-6.
27. Qiu SJ, Lu L, Qiao C et al. Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transduced by adenoviral vectors encoding HBsAg: comparison to protein immunization. J Cancer Res Clin Oncol 2005; 131:429-38.
28. Ilan Y, Gabay E, Amit G et al. Suppression of human hepatoma in mice through adoptive transfer of immunity to hepatitis B surface antigen. J Hepatol 1997; 27:170-5.
29. Gotsman I, Alper R, Klein A, Rabbani E, Engelhardt D, Ilan Y. Induction oral immune regulation of hepatitis B virus envelope proteins suppresses the growth of hepatocellular carcinoma in mice. Cancer 2002; 94:406-14.
30. Craig JR. Tumors of the liver. In: Zakim D, Boyer TD, eds. Hepatology, a textbook of liver disease, chapter 45, 4th edn. Philadelphia: Saunders, 2003:1355-70.
31. Shi M, Zhang B, Tang ZR et al. Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma. World J Gastroenterol 2004; 10:1146-51.
32. Jonuleit H, Kuhn U, Muller G et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 1997; 27:3135-42.
33. Zhang Z, Fu JL, Zhao QX et al. Differential restoration of myeloid and plasmacytoid dendritic cells in HIV-1-infected children after treatment with highly active antiretroviral therapy. J Immunol 2006; 176:5644-51.
34. Tavakoli S, Schwerin W, Rohwer A et al. Phenotype and function of monocyte derived dendritic cells in chronic hepatitis B virus infection. J Gen Virol 2004; 85:2829-36.
35. + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006; 177:739-47.
36. Banchereau J, Palucka AK, Dhodapkar M et al. Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res 2001; 61:6451-8.
37. Ragde H, Cavanagh WA, Tjoa BA. Dendritic cell based vaccines: progress in immunotherapy studies for prostate cancer. J Urol 2004; 172:2532-8.
38. Marten A, Flieger D, Renoth S et al. Therapeutic vaccination against metastatic renal cell carcinoma by autologous dendritic cells: preclinical results and outcome of a first clinical phase I/II trial. Cancer Immunol Immunother 2002; 51:637-44.
39. Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nat Immunol 2000; 1:199-205.
40. Hyodo N, Nakamura I, Imawari M. Hepatitis B core antigen stimulates interleukin-10 secretion by both T cells and monocytes from peripheral blood of patients with chronic hepatitis B virus infection. Clin Exp Immunol 2004; 135:462-6.
41. Franco A, Guidotti LG, Hobbs MV, Pasquetto V, Chisari FV. Pathogenetic effector function of CD4-positive T helper-1 cells in hepatitis B virus transgenic mice. J Immunol 1997; 159:2001-8.
42. Rossol S, Marinos G, Carucci P, Singer MV, Williams R, Naoumov NV. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J Clin Invest 1997; 99:3025-33.
43. Hyodo N, Tajimi M, Ugajin T, Nakamura I, Imawari M. Frequencies of interferon-gamma and interleukin-10 secreting cells in peripheral blood mononuclear cells and liver infiltrating lymphocytes in chronic hepatitis B virus infection. Hepatol Res 2003; 27:109-16.
44. Jung M, Hartmann B, Gerlach JT et al. Virus-specific lymphokine production differs quantitatively but not qualitatively in acute and chronic hepatitis B infection. Virology 1999; 261:165-72.