Lasting reduction of cocaine action in neostriatum - A hydrolase gene therapy approach

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 2, 2009, Pages 449-457

  Gao, Yang ^a   Brimijoin, Stephen ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; CHOLINESTERASE; COCAINE; TRANSCRIPTION FACTOR FOSB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; COCAINE DEPENDENCE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG METABOLISM; GENE THERAPY; IMMUNOHISTOCHEMISTRY; MALE; NEOSTRIATUM; NEUROMODULATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSGENE;

ANIMALS; BUTYRYLCHOLINESTERASE; COCAINE; GENE THERAPY; GENETIC VECTORS; HUMANS; MALE; NEOSTRIATUM; PILOT PROJECTS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 67651055389     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.152231     Document Type: Article

References (45)

1. Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R, Zhao Q, Singh M, and Carroll ME (2008) A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology 33:2715-2725.
2. Brimijoin S, Mintz KP, and Alley M (1983) Production and characterization of separate monoclonal antibodies to human acetylcholinesterase and butyrylcholinesterase. Mol Pharmacol 24: 513-520. (Pubitemid 14249849)
3. Brimijoin S, Shen ML, and Sun H (2002) Radiometric solvent-partitioning assay for screening cocaine hydrolases and measuring cocaine levels in milligram tissue samples. Anal Biochem 309:200-205. (Pubitemid 35387310)
4. Carrera MR, Ashley JA, Zhou B, Wirsching P, Koob GF, and Janda KD (2000) Cocaine vaccines: antibody protection against relapse in a rat model. Proc Natl Acad Sci U S A 97:6202-6206. (Pubitemid 30367547)
5. Chen HH, Mack LM, Kelly R, Ontell M, Kochanek S, and Clemens PR (1997) Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc Natl Acad Sci U S A 94:1645-1650. (Pubitemid 27113889)
6. Chilukuri N, Duysen EG, Parikh K, Sun W, Doctor BP, Lockridge O, and Saxena A (2008) Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo. Chem Biol Interact 175:327-331.
7. Clark MG, Sun W, Myers TM, Bansal R, Doctor BP, and Saxena A (2005) Effects of physostigmine and human butyrylcholinesterase on acoustic startle reflex and prepulse inhibition in C57BL/6J mice. Pharmacol Biochem Behav 81:497-505. (Pubitemid 40966795)
8. Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, and Woods JH (2006) Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol 70:1885-1891. (Pubitemid 44771904)
9. Duysen EG, Bartels CF, and Lockridge O (2002) Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity. J Pharmacol Exp Ther 302:751-758.
10. Ehrhardt A, Xu H, and Kay MA (2003) Episomal persistence of recombinant adenoviral vector genomes during the cell cycle in vivo. J Virol 77:7689-7695. (Pubitemid 36734541)
11. Ettinger RH, Ettinger WF, and Harless WE (1997) Active immunization with cocaine- protein conjugate attenuates cocaine effects. Pharmacol Biochem Behav 58:215-220.
12. Gao Y and Brimijoin S (2004) An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats. J Pharmacol Exp Ther 310:1046-1052. (Pubitemid 39108926)
13. Gao Y and Brimijoin S (2005) Visualizing viral transduction of a cocaine-hydrolyzing, human butyrylcholinesterase in rats. Chem Biol Interact 157-158:97-103. (Pubitemid 41757639)
14. Gao Y and Brimijoin S (2006) Viral transduction of cocaine hydrolase in brain reward centers. Cell Mol Neurobiol 26:355-361.
15. Gao Y, Atanasova E, Sui N, Pancook JD, Watkins JD, and Brimijoin S (2005) Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats. Mol Pharmacol 67:204-211. (Pubitemid 40069980)
16. Hoel PG (1962) Introduction to Mathematical Statistics, pp 4-40, John Wiley & Sons, New York.
17. Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS, and Nestler EJ (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13:1235-1244. (Pubitemid 24372141)
18. Johnson CD and Russell RL (1975) A rapid simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal Biochem 64:229-238.
19. Kim IH, Józkowicz A, Piedra PA, Oka K, and Chan L (2001) Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci U S A 98:13282-13287. (Pubitemid 33051354)
20. Ko MC, Bowen LD, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Cooper ZD, and Woods JH (2007) Cocaine esterase: interactions with cocaine and immune responses in mice. J Pharmacol Exp Ther 320:926-933. (Pubitemid 46147977)
21. Kosten T and Owens SM (2005) Immunotherapy for the treatment of drug abuse. Pharmacol Ther 108:76-85.
22. Kumar-Singh R and Farber DB (1998) Encapsidated adenovirus mini-chromosomemediated delivery of genes to the retina: application to the rescue of photoreceptor degeneration. Hum Mol Genet 7:1893-1900. (Pubitemid 28499420)
23. Mastrangeli A, Harvey BG, Yao J, Wolff G, Kovesdi I, Crystal RG, and Falck- Pedersen E (1996) "Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Hum Gene Ther 7:79-87. (Pubitemid 126664642)
24. McClung CA and Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci 6:1208-1215.
25. Mordenti J, Chen SA, Moore JA, Ferraiolo BL, and Green JD (1991) Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins. Pharm Res 8:1351-1359.
26. Morral N, O'Neal W, Rice K, Leland M, Kaplan J, Piedra PA, Zhou H, Parks RJ, Velji R, Aguilar-Córdova E, et al. (1999) Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liverdirected gene transfer in baboons. Proc Natl Acad Sci U S A 96:12816-12821. (Pubitemid 29513585)
27. Morral N, Parks RJ, Zhou H, Langston C, Schiedner G, Quinones J, Graham FL, Kochanek S, and Beaudet AL (1998) High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity. Hum Gene Ther 9:2709-2716. (Pubitemid 29027014)
28. Muruve DA, Pétrilli V, Zaiss AK, White LR, Clark SA, Ross PJ, Parks RJ, and Tschopp J (2008) The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452:103-107. (Pubitemid 351355095)
29. Ndikum-Moffor FM, Schoeb TR, and Roberts SM (1998) Liver toxicity from norcocaine nitroxide, an N-oxidative metabolite of cocaine. J Pharmacol Exp Ther 284:413-419.
30. Nestler EJ (2005) The neurobiology of cocaine addiction. Sci Pract Perspect 3:4-10.
31. Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, and Kosten TR (2008) Substance abuse vaccines. Ann N Y Acad Sci 1141:257-269.
32. Pancook JD, Pecht G, Ader M, Mosko M, Lockridge O, and Watkins JD (2003) Application of directed evolution technology to optimize the cocaine hydrolase activity of human butyrylcholinesterase. FASEB J 17:A565.
33. Pan Y, Gao D, Yang W, Cho H, Yang G, Tai HH, and Zhan CG (2005) Computational redesign of human butyrylcholinesterase for anticocaine medication. Proc Natl Acad Sci U S A 102:16656-16661. (Pubitemid 41688832)
34. Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, and Graham FL (1996) A helper-dependent adenovirus vector system: removal of helper virus by Cremediated excision of the viral packaging signal. Proc Natl Acad Sci U S A 93: 13565-13570. (Pubitemid 26424159)
35. Saxena A, Ashani Y, Raveh L, Stevenson D, Patel T, and Doctor BP (1998) Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases. Mol Pharmacol 53:112-122. (Pubitemid 28068378)
36. Saxena A, Sun W, Luo C, Myers TM, Koplovitz I, Lenz DE, and Doctor BP (2006) Bioscavenger for protection from toxicity of organophosphorus compounds. J Mol Neurosci 30:145-148. (Pubitemid 46035354)
37. Shuster L, Garhart CA, Powers J, Grunfeld Y, and Kanel G (1988) Hepatotoxicity of cocaine. NIDA Res Monogr 88:250-275.
38. Simonet WS, Bucay N, Lauer SJ, and Taylor JM (1993) A far-downstream hepatocyte- specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice. J Biol Chem 268:8221-8229. (Pubitemid 23120410)
39. Smith TA, White BD, Gardner JM, Kaleko M, and McClelland A (1996) Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector. Gene Ther 3:496-502. (Pubitemid 26197539)
40. Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, and Pang YP (2001) Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase: engineering effective butyrylcholinesterase mutants for cocaine detoxification. J Biol Chem 276:9330-9336. (Pubitemid 37385519)
41. Sun H, Pang YP, Lockridge O, and Brimijoin S (2002a) Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol Pharmacol 62:220-224.
42. Sun H, Shen ML, Pang YP, Lockridge O, and Brimijoin S (2002b) Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. J Pharmacol Exp Ther 302:710-716. (Pubitemid 34787239)
43. Toietta G, Mane VP, Norona WS, Finegold MJ, Ng P, McDonagh AF, Beaudet AL, and Lee B (2005) Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci U S A 102:3930-3935. (Pubitemid 40388534)
44. Zheng F, Yang W, Ko MC, Liu J, Cho H, Gao D, Tong M, Tai HH, Woods JH, and Zhan CG (2008) Most efficient cocaine hydrolase designed by virtual screening of transition states. J Am Chem Soc 130:12148-12155.
45. Zheng YW, Ohkohchi N, and Taniguchi H (2005) Quantitative evaluation of longterm liver repopulation and the reconstitution of bile ductules after hepatocellular transplantation. World J Gastroenterol 11:6176-6181. (Pubitemid 43085061)