NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels

British Journal of Pharmacology

Volumn 168, Issue 7, 2013, Pages 1611-1625

  Parajuli, Shankar P ^a   Hristov, Kiril L ^a   Soder, Rupal P ^a   Kellett, Whitney F ^a   Petkov, Georgi V ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

apamin; contractility; Patch clamp; single cell RT PCR

Indexed keywords

APAMIN; MESSENGER RNA; NS 309; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL 3; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE CONTROL; FEMALE; HYPERPOLARIZATION; IMMUNOCYTOCHEMISTRY; MALE; MUSCLE EXCITATION; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; OVERACTIVE BLADDER; PATCH CLAMP; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE CELL ANALYSIS; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL; SPASMOLYSIS;

ANIMALS; APAMIN; CELL SIZE; ELECTRIC STIMULATION; FEMALE; INDOLES; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION CHANNEL GATING; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; OXIMES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; URINARY BLADDER;

EID: 84875130871     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12049     Document Type: Article

References (43)

1. Afeli SA, Hristov KL, Petkov GV, (2012a). Do beta3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility? Am J Physiol Renal Physiol 302: F251-F263.
2. Afeli SA, Rovner ES, Petkov GV, (2012b). SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions. Am J Physiol Renal Physiol 303: F559-F568.
3. Alexander SP, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164 (Suppl. 1): S1-S324.
4. Andersson KE, Arner A, (2004). Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 84: 935-986.
5. Andersson KE, Wein AJ, (2004). Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 56: 581-631.
6. Brading AF, (2006). Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J Physiol 570 (Pt 1): 13-22.
7. Buckner SA, Milicic I, Daza AV, Coghlan MJ, Gopalakrishnan M, (2002). Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators. Br J Pharmacol 135: 639-648.
8. Chen M, Petkov GV, (2009). Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle. J Urol 182: 374-381.
9. Darblade B, Behr-Roussel D, Oger S, Hieble JP, Lebret T, Gorny D, et al,. (2006). Effects of potassium channel modulators on human detrusor smooth muscle myogenic phasic contractile activity: potential therapeutic targets for overactive bladder. Urology 68: 442-448.
10. Epstein BJ, Gums JG, Molina E, (2006). Newer agents for the management of overactive bladder. Am Fam Physician 74: 2061-2068.
11. Gardos G, (1958). The function of calcium in the potassium permeability of human erythrocytes. Biochim Biophys Acta 30: 653-654.
12. + channels in normal and impaired EDHF-dilator responses-relevance to cardiovascular pathologies and drug discovery. Br J Pharmacol 157: 509-526.
13. Hashitani H, Brading AF, (2003a). Electrical properties of detrusor smooth muscles from the pig and human urinary bladder. Br J Pharmacol 140: 146-158.
14. Hashitani H, Brading AF, (2003b). Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder. Br J Pharmacol 140: 159-169.
15. Hashitani H, Brading AF, Suzuki H, (2004). Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 141: 183-193.
16. + channels regulate action potential repolarization in urinary bladder smooth muscle. Am J Physiol 273 (1 Pt 1): C110-C117.
17. 2+ channels and ryanodine receptors in guinea-pig urinary bladder myocytes. J Physiol 541 (Pt 2): 483-492.
18. Herrera GM, Heppner TJ, Nelson MT, (2000). Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. Am J Physiol Regul Integr Comp Physiol 279: R60-R68.
19. Herrera GM, Pozo MJ, Zvara P, Petkov GV, Bond CT, Adelman JP, et al,. (2003). Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. J Physiol 551 (Pt 3): 893-903.
20. Ca channels in mouse urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol 289: R402-R409.
21. + channels. Br J Pharmacol 151: 655-665.
22. Ca3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo. J Pharmacol Exp Ther 328: 28-39.
23. + channels. Am J Physiol Cell Physiol 295: C1344-C1353.
24. + channels regulate human detrusor smooth muscle function. Am J Physiol Cell Physiol 301: C903-C912.
25. + channels. Am J Physiol Cell Physiol 302: C1632-C1641.
26. + channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta Physiol Scand 173: 323-333.
27. + channels in rat bladder. Am J Physiol Regul Integr Comp Physiol 298: R1310-R1319.
28. Kohler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J, et al,. (1996). Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273: 1709-1714.
29. + channels in urinary bladder smooth muscle cells. J Pharmacol Sci 100: 237-241.
30. Nielsen JS, Rode F, Rahbek M, Andersson KE, Ronn LC, Bouchelouche K, et al,. (2011). Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3- dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. BJU Int 108: 771-777.
31. + channels in mouse urinary bladder smooth muscle cells. Jpn J Pharmacol 84: 97-100.
32. Pandita RK, Ronn LC, Jensen BS, Andersson KE, (2006). Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats. J Urol 176: 1220-1224.
33. Parajuli SP, Soder RP, Hristov KL, Petkov GV, (2012). Pharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility. J Pharmacol Exp Ther 340: 114-123.
34. Petkov GV, (2012). Role of potassium ion channels in detrusor smooth muscle function and dysfunction. Nat Rev Urol 9: 30-40.
35. + channel regulates contractile activity of mouse urinary bladder smooth muscle. J Physiol 537 (Pt 2): 443-452.
36. Petkov GV, Heppner TJ, Bonev AD, Herrera GM, Nelson MT, (2001b). Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder. Am J Physiol Regul Integr Comp Physiol 280: R1427-R1433.
37. Ca3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol 75: 281-295.
38. + channels and afterhyperpolarizations. Toxicon 43: 933-949.
39. + channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta 1665: 1-5.
40. + channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Mol Pharmacol 70: 1771-1782.
41. + channel 2 is the key functional component of SK channels in mouse urinary bladder. Am J Physiol Regul Integr Comp Physiol 294: R1737-R1743.
42. Wein AJ, Rackley RR, (2006). Overactive bladder: a better understanding of pathophysiology, diagnosis and management. J Urol 175 (3 Pt 2): S5-S10.
43. + channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev 108: 1744-1773.