A positive modulator of K Ca2 and K Ca3 channels, 4,5-dichloro- 1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 1, 2009, Pages 28-39

  Hougaard, C ^a   Fraser, M O ^b,c   Chien, C ^b,c   Bookout, A ^b   Katofiasc, M ^b,c   Jensen, B S ^a   Rode, F ^a   Bitsch Norhave J ^a   Teuber, L ^a   Thor, K B ^a,c   Strobaek D ^a   Burgard, E C ^b,c   Ronn L C B ^a  

^a NEUROSEARCH A S   (Denmark)

^b Dynogen Pharmaceuticals Inc   (United States)

^c Urogenix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 2 BENZIMIDAZOLINONE; 4,5 DICHLORO 1,3 DIETHYL 1,3 DIHYDROBENZOIMIDAZOL 2 ONE; 5,6 DICHLORO 1 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; ACETIC ACID; APAMIN; BENZIMIDAZOLE DERIVATIVE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CAPSAICIN; CARBACHOL; NS 4591; OXYHEMOGLOBIN; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG; 4,5-DICHLORO-1,3-DIETHYL-1,3-DIHYDROBENZOIMIDAZOL-2-ONE; CALCIUM CHLORIDE; CHLORIDE CHANNEL; MAGNESIUM CHLORIDE; POTASSIUM; POTASSIUM CHANNEL; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER PRESSURE; CAT; CELL STRAIN HEK293; CONTROLLED STUDY; CYSTOMETRY; DETRUSOR MUSCLE; DRUG BIOAVAILABILITY; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICTURITION; MYOGRAPHY; NERVE CELL CULTURE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; OVERACTIVE BLADDER; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL GANGLION; URODYNAMICS; ACTION POTENTIAL; ANIMAL; BLADDER; CELL LINE; CELL MEMBRANE; INNERVATION; KIDNEY; NERVE CELL; PHYSIOLOGY; SENSORY NERVE; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMALS; BENZIMIDAZOLES; CALCIUM CHLORIDE; CELL LINE; CELL MEMBRANE; CHLORIDE CHANNELS; FEMALE; GANGLIA, SPINAL; HUMANS; KIDNEY; MAGNESIUM CHLORIDE; NEURONS; POTASSIUM; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; URINARY BLADDER; URINATION;

EID: 59149087581     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.143123     Document Type: Article

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