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Volumn 52, Issue , 2013, Pages 163-170

Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment

Author keywords

Aluminum; Cholinesterases; Memory; Monoamine oxidase; Oxidative stress; Saffron

Indexed keywords

ACETYLCHOLINESTERASE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CHOLINESTERASE; CROCETIN; CROCUS SATIVUS EXTRACT; GLUTATHIONE; ISOENZYME; LIPID;

EID: 84875121716     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.11.016     Document Type: Article
Times cited : (97)

References (65)
  • 3
    • 77956410642 scopus 로고    scopus 로고
    • New applications and mechanisms of action of saffron and its important ingredients
    • Bathaie S.Z., Mousavi S.Z. New applications and mechanisms of action of saffron and its important ingredients. Crit. Rev. Food Sci. Nutr. 2010, 50:761-786.
    • (2010) Crit. Rev. Food Sci. Nutr. , vol.50 , pp. 761-786
    • Bathaie, S.Z.1    Mousavi, S.Z.2
  • 4
    • 0345059889 scopus 로고    scopus 로고
    • Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease
    • Bellés M., Sánchez D.J., Gómez M., Corbella J., Domingo J.L. Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease. Alzheimer Dis. Assoc. Disord. 1998, 12:83-87.
    • (1998) Alzheimer Dis. Assoc. Disord. , vol.12 , pp. 83-87
    • Bellés, M.1    Sánchez, D.J.2    Gómez, M.3    Corbella, J.4    Domingo, J.L.5
  • 5
    • 67449149962 scopus 로고    scopus 로고
    • Protective role of lithium in ameliorating the aluminium-induced oxidative stress and histological changes in rat brain
    • Bhalla P., Dhawan D.K. Protective role of lithium in ameliorating the aluminium-induced oxidative stress and histological changes in rat brain. Cell. Mol. Neurobiol. 2009, 29:513-521.
    • (2009) Cell. Mol. Neurobiol. , vol.29 , pp. 513-521
    • Bhalla, P.1    Dhawan, D.K.2
  • 6
    • 77149169100 scopus 로고    scopus 로고
    • Protective role of lithium during aluminium-induced neurotoxicity
    • Bhalla P., Garg M.L., Dhawan D.K. Protective role of lithium during aluminium-induced neurotoxicity. Neurochem. Int. 2010, 56:256-262.
    • (2010) Neurochem. Int. , vol.56 , pp. 256-262
    • Bhalla, P.1    Garg, M.L.2    Dhawan, D.K.3
  • 7
    • 84871642984 scopus 로고    scopus 로고
    • Aluminum induced immunoexcitotoxicity in neurodevelopmental and neurodegenerative disorders
    • Blaylock R.L. Aluminum induced immunoexcitotoxicity in neurodevelopmental and neurodegenerative disorders. Curr. Inorg. Chem. 2012, 2:46-53.
    • (2012) Curr. Inorg. Chem. , vol.2 , pp. 46-53
    • Blaylock, R.L.1
  • 8
    • 51249118269 scopus 로고    scopus 로고
    • Monoamine oxidase inactivation: from pathophysiology to therapeutics
    • Bortolato M., Chen K., Shih J.C. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv. Drug Deliv. Rev. 2008, 60:1527-1533.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1527-1533
    • Bortolato, M.1    Chen, K.2    Shih, J.C.3
  • 9
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 10
    • 79953220423 scopus 로고    scopus 로고
    • A new validated SPE-HPLC method for monitoring crocetin in human plasma-application after saffron tea consumption
    • Chryssanthi D.G., Lamari F.N., Georgakopoulos C.D., Cordopatis P. A new validated SPE-HPLC method for monitoring crocetin in human plasma-application after saffron tea consumption. J. Pharm. Biomed. Anal. 2011, 55:563-568.
    • (2011) J. Pharm. Biomed. Anal. , vol.55 , pp. 563-568
    • Chryssanthi, D.G.1    Lamari, F.N.2    Georgakopoulos, C.D.3    Cordopatis, P.4
  • 11
    • 19344373684 scopus 로고    scopus 로고
    • Role of molecular isoforms of acetylcholinesterase in learning and memory functions
    • Das A., Dikshit M., Nath C. Role of molecular isoforms of acetylcholinesterase in learning and memory functions. Pharmacol. Biochem. Behav. 2005, 81:89-99.
    • (2005) Pharmacol. Biochem. Behav. , vol.81 , pp. 89-99
    • Das, A.1    Dikshit, M.2    Nath, C.3
  • 12
    • 0036019850 scopus 로고    scopus 로고
    • Effect of long-term aluminum feeding on kinetics attributes of tissue cholinesterases
    • Dave K.R., Syal A.R., Katyare S.S. Effect of long-term aluminum feeding on kinetics attributes of tissue cholinesterases. Brain Res. Bull. 2002, 58:225-233.
    • (2002) Brain Res. Bull. , vol.58 , pp. 225-233
    • Dave, K.R.1    Syal, A.R.2    Katyare, S.S.3
  • 14
    • 0034906934 scopus 로고    scopus 로고
    • Effect of cadmium and aluminum intake on the antioxidant status and lipid peroxidation in rat tissues
    • El-Maraghy S.A., Gad M.Z., Fahim A.T., Hamdy M.A. Effect of cadmium and aluminum intake on the antioxidant status and lipid peroxidation in rat tissues. J. Biochem. Mol. Toxicol. 2001, 15:207-214.
    • (2001) J. Biochem. Mol. Toxicol. , vol.15 , pp. 207-214
    • El-Maraghy, S.A.1    Gad, M.Z.2    Fahim, A.T.3    Hamdy, M.A.4
  • 16
    • 23744457490 scopus 로고    scopus 로고
    • Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats
    • Esparza J.L., Gómez M., Rosa Nogués M., Paternain J.L., Mallol J., Domingo J.L. Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum-exposed rats. J. Pineal Res. 2005, 39:129-136.
    • (2005) J. Pineal Res. , vol.39 , pp. 129-136
    • Esparza, J.L.1    Gómez, M.2    Rosa Nogués, M.3    Paternain, J.L.4    Mallol, J.5    Domingo, J.L.6
  • 17
    • 50649096994 scopus 로고    scopus 로고
    • The level of butyrylcholinesterase activity increases and the content of the mRNA remains unaffected in brain of senescence-accelerated mouse SAMP8
    • Fernández-Gómez F.J., Muñoz-Delgado E., Montenegro M.F., Campoy F.J., Vidal C.J., Jordán J. The level of butyrylcholinesterase activity increases and the content of the mRNA remains unaffected in brain of senescence-accelerated mouse SAMP8. Chem. Biol. Interact. 2008, 175:332-335.
    • (2008) Chem. Biol. Interact. , vol.175 , pp. 332-335
    • Fernández-Gómez, F.J.1    Muñoz-Delgado, E.2    Montenegro, M.F.3    Campoy, F.J.4    Vidal, C.J.5    Jordán, J.6
  • 19
    • 0028987924 scopus 로고
    • [D-Pen2, D-Pen5]enkephalin, a delta opioid agonist reduces endogenous aluminum content in the rat central nervous system
    • Gulya K., Szikra J., Kása P. [D-Pen2, D-Pen5]enkephalin, a delta opioid agonist reduces endogenous aluminum content in the rat central nervous system. Neuroscience 1995, 66:499-506.
    • (1995) Neuroscience , vol.66 , pp. 499-506
    • Gulya, K.1    Szikra, J.2    Kása, P.3
  • 20
    • 84860390096 scopus 로고    scopus 로고
    • Neurotransmitter metabolic enzymes and antioxidant status on Alzheimer's disease induced mice treated with Alpinia galanga (L.) Willd
    • Hanish Singh J.C., Alagarsamy V., Sathesh Kumar S., Narsimha Reddy Y. Neurotransmitter metabolic enzymes and antioxidant status on Alzheimer's disease induced mice treated with Alpinia galanga (L.) Willd. Phytother. Res. 2011, 25:1061-1067.
    • (2011) Phytother. Res. , vol.25 , pp. 1061-1067
    • Hanish Singh, J.C.1    Alagarsamy, V.2    Sathesh Kumar, S.3    Narsimha Reddy, Y.4
  • 21
    • 27444442382 scopus 로고    scopus 로고
    • Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus
    • Hosseinzadeh H., Sadeghnia H.R. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J. Pharm. Pharm. Sci. 2005, 8:394-399.
    • (2005) J. Pharm. Pharm. Sci. , vol.8 , pp. 394-399
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2
  • 23
    • 0026782650 scopus 로고
    • Determination of aluminum in biological fluids by furnace atomic absorption spectrophotometry
    • Johnson K.E., Treble R.G. Determination of aluminum in biological fluids by furnace atomic absorption spectrophotometry. J. Clin. Lab. Anal. 1992, 6:264-268.
    • (1992) J. Clin. Lab. Anal. , vol.6 , pp. 264-268
    • Johnson, K.E.1    Treble, R.G.2
  • 24
    • 0028783992 scopus 로고
    • Altered cholinergic metabolism in rat CNS following aluminum exposure: implications on learning performance
    • Julka D., Sandhir R., Gill K.D. Altered cholinergic metabolism in rat CNS following aluminum exposure: implications on learning performance. J. Neurochem. 1995, 65:2157-2164.
    • (1995) J. Neurochem. , vol.65 , pp. 2157-2164
    • Julka, D.1    Sandhir, R.2    Gill, K.D.3
  • 25
    • 33744972325 scopus 로고    scopus 로고
    • Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain
    • Jyoti A., Sharma D. Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain. Neurotoxicology 2006, 27:451-457.
    • (2006) Neurotoxicology , vol.27 , pp. 451-457
    • Jyoti, A.1    Sharma, D.2
  • 26
    • 52549116539 scopus 로고    scopus 로고
    • Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes
    • Kaizer R.R., Corrêa M.C., Gris L.R., da Rosa C.S., Bohrer D., Morsch V.M., Schetinger M.R. Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochem. Res. 2008, 33:2294-2301.
    • (2008) Neurochem. Res. , vol.33 , pp. 2294-2301
    • Kaizer, R.R.1    Corrêa, M.C.2    Gris, L.R.3    da Rosa, C.S.4    Bohrer, D.5    Morsch, V.M.6    Schetinger, M.R.7
  • 27
    • 8444241250 scopus 로고    scopus 로고
    • Orally administrated aluminum-maltolate complex enhances oxidative stress in the organs of mice
    • Kaneko N., Yasui H., Takada J., Suzuki K., Sakurai H. Orally administrated aluminum-maltolate complex enhances oxidative stress in the organs of mice. J. Inorg. Biochem. 2004, 98:2022-2031.
    • (2004) J. Inorg. Biochem. , vol.98 , pp. 2022-2031
    • Kaneko, N.1    Yasui, H.2    Takada, J.3    Suzuki, K.4    Sakurai, H.5
  • 28
    • 0031080876 scopus 로고    scopus 로고
    • Learning/memory processes under stress conditions
    • Kaneto H. Learning/memory processes under stress conditions. Behav. Brain Res. 1997, 83:71-74.
    • (1997) Behav. Brain Res. , vol.83 , pp. 71-74
    • Kaneto, H.1
  • 29
    • 79955394531 scopus 로고    scopus 로고
    • Link between aluminum and the pathogenesis of Alzheimer's disease: the integration of the aluminum and amyloid cascade hypotheses
    • Kawahara M., Kato-Negishi M. Link between aluminum and the pathogenesis of Alzheimer's disease: the integration of the aluminum and amyloid cascade hypotheses. Int. J. Alzheimers Dis. 2011, 2011:276393.
    • (2011) Int. J. Alzheimers Dis. , vol.2011 , pp. 276393
    • Kawahara, M.1    Kato-Negishi, M.2
  • 30
    • 0036888265 scopus 로고    scopus 로고
    • Aluminium-induced changes in the rat brain serotonin system
    • Kumar S. Aluminium-induced changes in the rat brain serotonin system. Food Chem. Toxicol. 2002, 40:1875-1880.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 1875-1880
    • Kumar, S.1
  • 31
    • 70349907456 scopus 로고    scopus 로고
    • Aluminium neurotoxicity: neurobehavioural and oxidative aspects
    • Kumar V., Gill K.D. Aluminium neurotoxicity: neurobehavioural and oxidative aspects. Arch. Toxicol. 2009, 83:965-978.
    • (2009) Arch. Toxicol. , vol.83 , pp. 965-978
    • Kumar, V.1    Gill, K.D.2
  • 32
    • 30344485665 scopus 로고    scopus 로고
    • Targeting acetylcholinesterase and butyrylcholinesterase in dementia
    • Lane R.M., Potkin S.G., Enz A. Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int. J. Neuropsychopharmacol. 2006, 9:101-124.
    • (2006) Int. J. Neuropsychopharmacol. , vol.9 , pp. 101-124
    • Lane, R.M.1    Potkin, S.G.2    Enz, A.3
  • 33
    • 0032515372 scopus 로고    scopus 로고
    • Ontogenetic differences in the regional and cellular acetylcholinesterase and butyrylcholinesterase activity in the rat brain
    • Lassiter T.L., Barone S., Padilla S. Ontogenetic differences in the regional and cellular acetylcholinesterase and butyrylcholinesterase activity in the rat brain. Dev. Brain Res. 1998, 105:109-123.
    • (1998) Dev. Brain Res. , vol.105 , pp. 109-123
    • Lassiter, T.L.1    Barone, S.2    Padilla, S.3
  • 35
    • 0028018502 scopus 로고
    • An enzymatic assay for the MAO-B inhibitor selegiline in plasma
    • Mahmood I., Neau S.H., Mason W.D. An enzymatic assay for the MAO-B inhibitor selegiline in plasma. J. Pharm. Biomed. Anal. 1994, 12:895-899.
    • (1994) J. Pharm. Biomed. Anal. , vol.12 , pp. 895-899
    • Mahmood, I.1    Neau, S.H.2    Mason, W.D.3
  • 39
    • 0021228062 scopus 로고
    • Glutathione content of cultured cells and rodent brain regions: a specific fluorometric assay
    • Mokrasch L.C., Teschke E.J. Glutathione content of cultured cells and rodent brain regions: a specific fluorometric assay. Anal. Biochem. 1984, 140:506-509.
    • (1984) Anal. Biochem. , vol.140 , pp. 506-509
    • Mokrasch, L.C.1    Teschke, E.J.2
  • 40
    • 33749165597 scopus 로고    scopus 로고
    • Reversal of an aluminium induced alteration in redox status in different regions of rat brain by administration of centrophenoxine
    • Nehru B., Bhalla P. Reversal of an aluminium induced alteration in redox status in different regions of rat brain by administration of centrophenoxine. Mol. Cell. Biochem. 2006, 290:185-191.
    • (2006) Mol. Cell. Biochem. , vol.290 , pp. 185-191
    • Nehru, B.1    Bhalla, P.2
  • 41
    • 13544274008 scopus 로고    scopus 로고
    • Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial
    • Noorbala A.A., Akhondzadeh S., Tahmacebi-Pour N., Jamshidi A.H. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J. Ethnopharmacol. 2005, 97:281-284.
    • (2005) J. Ethnopharmacol. , vol.97 , pp. 281-284
    • Noorbala, A.A.1    Akhondzadeh, S.2    Tahmacebi-Pour, N.3    Jamshidi, A.H.4
  • 43
    • 0343851617 scopus 로고    scopus 로고
    • Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors
    • Otano A., García-Osta A., Ballaz S., Frechilla D., Del Río J. Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors. Br. J. Pharmacol. 1999, 128:1691-1698.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 1691-1698
    • Otano, A.1    García-Osta, A.2    Ballaz, S.3    Frechilla, D.4    Del Río, J.5
  • 44
    • 0028302137 scopus 로고
    • A mechanism for the stimulatory effect of aluminum on iron-induced lipid peroxidation
    • Oteiza P.I. A mechanism for the stimulatory effect of aluminum on iron-induced lipid peroxidation. Arch. Biochem. Biophys. 1994, 308:374-379.
    • (1994) Arch. Biochem. Biophys. , vol.308 , pp. 374-379
    • Oteiza, P.I.1
  • 46
    • 59649099426 scopus 로고    scopus 로고
    • Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity
    • Papandreou M.A., Dimakopoulou A., Linardaki Z.I., Cordopatis P., Klimis-Zacas D., Margarity M., Lamari F.N. Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav. Brain Res. 2009, 198:352-358.
    • (2009) Behav. Brain Res. , vol.198 , pp. 352-358
    • Papandreou, M.A.1    Dimakopoulou, A.2    Linardaki, Z.I.3    Cordopatis, P.4    Klimis-Zacas, D.5    Margarity, M.6    Lamari, F.N.7
  • 48
    • 33750024445 scopus 로고    scopus 로고
    • Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat
    • Pitsikas N., Sakellaridis N. Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat. Behav. Brain Res. 2006, 173:112-115.
    • (2006) Behav. Brain Res. , vol.173 , pp. 112-115
    • Pitsikas, N.1    Sakellaridis, N.2
  • 49
    • 0029123436 scopus 로고
    • Aluminum impairs hippocampal long-term potentiation in rats in vitro and in vivo
    • Platt B., Carpenter D.O., Büsselberg D., Reymann K.G., Riedel G. Aluminum impairs hippocampal long-term potentiation in rats in vitro and in vivo. Exp. Neurol. 1995, 134:73-86.
    • (1995) Exp. Neurol. , vol.134 , pp. 73-86
    • Platt, B.1    Carpenter, D.O.2    Büsselberg, D.3    Reymann, K.G.4    Riedel, G.5
  • 51
    • 34548445132 scopus 로고    scopus 로고
    • Saffron in phytotherapy: pharmacology and clinical uses
    • Schmidt M., Betti G., Hensel A. Saffron in phytotherapy: pharmacology and clinical uses. Wien. Med. Wochenschr. 2007, 157:315-319.
    • (2007) Wien. Med. Wochenschr. , vol.157 , pp. 315-319
    • Schmidt, M.1    Betti, G.2    Hensel, A.3
  • 52
    • 56249145473 scopus 로고    scopus 로고
    • Aluminium-induced electrophysiological, biochemical and cognitive modifications in the hippocampus of aging rats
    • Sethi P., Jyoti A., Singh R., Hussain E., Sharma D. Aluminium-induced electrophysiological, biochemical and cognitive modifications in the hippocampus of aging rats. Neurotoxicology 2008, 29:1069-1079.
    • (2008) Neurotoxicology , vol.29 , pp. 1069-1079
    • Sethi, P.1    Jyoti, A.2    Singh, R.3    Hussain, E.4    Sharma, D.5
  • 54
    • 78951485995 scopus 로고    scopus 로고
    • Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup
    • Shati A.A., Elsaid F.G., Hafez E.E. Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup. Neuroscience 2011, 175:66-74.
    • (2011) Neuroscience , vol.175 , pp. 66-74
    • Shati, A.A.1    Elsaid, F.G.2    Hafez, E.E.3
  • 55
    • 0029066081 scopus 로고
    • Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV-visible photodiode-array detection-mass spectrometry
    • Tarantilis P.A., Tsoupras G., Polissiou M. Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV-visible photodiode-array detection-mass spectrometry. J. Chromatogr. A 1995, 699:107-118.
    • (1995) J. Chromatogr. A , vol.699 , pp. 107-118
    • Tarantilis, P.A.1    Tsoupras, G.2    Polissiou, M.3
  • 56
    • 79953280497 scopus 로고    scopus 로고
    • Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?
    • Tomljenovic L. Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?. J. Alzheimers Dis. 2011, 23:567-598.
    • (2011) J. Alzheimers Dis. , vol.23 , pp. 567-598
    • Tomljenovic, L.1
  • 57
    • 58249127254 scopus 로고    scopus 로고
    • Influence of age on aluminum induced lipid peroxidation and neurolipofuscin in frontal cortex of rat brain: a behavioral, biochemical and ultrastructural study
    • Tripathi S., Mahdi A.A., Nawab A., Chander R., Hasan M., Siddiqui M.S., Mahdi F., Mitra K., Bajpai V.K. Influence of age on aluminum induced lipid peroxidation and neurolipofuscin in frontal cortex of rat brain: a behavioral, biochemical and ultrastructural study. Brain Res. 2009, 1253:107-116.
    • (2009) Brain Res. , vol.1253 , pp. 107-116
    • Tripathi, S.1    Mahdi, A.A.2    Nawab, A.3    Chander, R.4    Hasan, M.5    Siddiqui, M.S.6    Mahdi, F.7    Mitra, K.8    Bajpai, V.K.9
  • 58
    • 57249103549 scopus 로고    scopus 로고
    • Aluminium and lead: molecular mechanisms of brain toxicity
    • Verstraeten S.V., Aimo L., Oteiza P.I. Aluminium and lead: molecular mechanisms of brain toxicity. Arch. Toxicol. 2008, 82:789-802.
    • (2008) Arch. Toxicol. , vol.82 , pp. 789-802
    • Verstraeten, S.V.1    Aimo, L.2    Oteiza, P.I.3
  • 59
    • 70350033993 scopus 로고    scopus 로고
    • APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease
    • Walton J.R., Wang M.X. APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease. J. Inorg. Biochem. 2009, 103:1548-1554.
    • (2009) J. Inorg. Biochem. , vol.103 , pp. 1548-1554
    • Walton, J.R.1    Wang, M.X.2
  • 60
    • 0030471998 scopus 로고    scopus 로고
    • Intraneuronal aluminum potentiates iron-induced oxidative stress in cultured rat hippocampal neurons
    • Xie C.X., Mattson M.P., Lovell M.A., Yokel R.A. Intraneuronal aluminum potentiates iron-induced oxidative stress in cultured rat hippocampal neurons. Brain Res. 1996, 743:271-277.
    • (1996) Brain Res. , vol.743 , pp. 271-277
    • Xie, C.X.1    Mattson, M.P.2    Lovell, M.A.3    Yokel, R.A.4
  • 62
    • 0032754346 scopus 로고    scopus 로고
    • The distribution of aluminum into and out of the brain
    • Yokel R.A., Allen D.D., Ackley D.C. The distribution of aluminum into and out of the brain. J. Inorg. Biochem. 1999, 76:127-132.
    • (1999) J. Inorg. Biochem. , vol.76 , pp. 127-132
    • Yokel, R.A.1    Allen, D.D.2    Ackley, D.C.3
  • 63
    • 33748749719 scopus 로고    scopus 로고
    • Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration
    • Yokel R.A. Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. J. Alzheimers Dis. 2006, 10:223-253.
    • (2006) J. Alzheimers Dis. , vol.10 , pp. 223-253
    • Yokel, R.A.1
  • 64
    • 81455138108 scopus 로고    scopus 로고
    • Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain
    • Yoshino F., Yoshida A., Umigai N., Kubo K., Lee M.C. Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain. J. Clin. Biochem. Nutr. 2011, 49:182-187.
    • (2011) J. Clin. Biochem. Nutr. , vol.49 , pp. 182-187
    • Yoshino, F.1    Yoshida, A.2    Umigai, N.3    Kubo, K.4    Lee, M.C.5
  • 65
    • 0041828392 scopus 로고    scopus 로고
    • The herbal medicine Dipsacus asper wall extract reduces the cognitive deficits and overexpression of beta-amyloid protein induced by aluminum exposure
    • Zhang Z.J., Qian Y.H., Hu H.T., Yang J., Yang G.D. The herbal medicine Dipsacus asper wall extract reduces the cognitive deficits and overexpression of beta-amyloid protein induced by aluminum exposure. Life Sci. 2003, 73:2443-2454.
    • (2003) Life Sci. , vol.73 , pp. 2443-2454
    • Zhang, Z.J.1    Qian, Y.H.2    Hu, H.T.3    Yang, J.4    Yang, G.D.5


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