Silicon reduces aluminum accumulation in rats: Relevance to the aluminum hypothesis of Alzheimer disease

Alzheimer Disease and Associated Disorders

Volumn 12, Issue 2, 1998, Pages 83-87

  Belles M ^a   Sanchez D J ^a   Gomez M ^a   Corbella, J ^b   Domingo, J L ^a,c  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c Lab of Toxicol and Environ Health School of Medicine   (Spain)

Author keywords

Aluminum; Oral exposure; Rats; Silicon; Tissue retention; Urinary excretion

Indexed keywords

ALUMINUM; ALUMINUM NITRATE; DRINKING WATER; SILICON;

ABSORPTION; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BONE; BRAIN; CONTROLLED STUDY; FEEDING; GASTROINTESTINAL ABSORPTION; HUMAN; KIDNEY; LIVER; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN; URINALYSIS;

EID: 0345059889     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-199806000-00005     Document Type: Article

References (33)

1. Abdel-Ghany M, El-Sebae AK, Shalloway D. Aluminum-induced nonenzymatic phospho-incorporation into human tau and other proteins. J Biol Chem 1993;268:11976-81.
2. Bellia JP, Birchall JD, Roberts NB. The role of silicic acid in the renal excretion of aluminum. Ann Clin Lab Sci 1996;26:227-33.
3. Birchall JD. The interrelationship between silicon and aluminum in the biological effects of aluminum. In: Chadwick DJ, Whelan J, eds. Aluminum in biology and medicine (Ciba Foundation Symposium). Chichester: John Wiley & Sons, 1992:50-68.
4. Birchall JD, Chappell JS. The chemistry of aluminum and silicon in relation to Alzheimer's disease. Clin Chem 1988;34:265-7.
5. Birchall JD, Chappell JS. Aluminum, water chemistry and Alzheimer's disease. Lancet 1989;1:953.
6. Birchall JD, Exley C, Chapell JS, Phillips MJ. Acute toxicity of aluminum to fish eliminated in silicon-rich acid waters. Nature 1989;338:146-8.
7. Candy JM, Oakley AE, Klinowski J, et al. Aluminosilicates and senile plaque formation in Alzheimer's disease. Lancet 1986;1:354-7.
8. Carlisle EM, Curran MJ. Effect of dietary silicon and aluminum on silicon and aluminum levels in rat brain. Alzheimer Dis Assoc Disord 1987;1:83-9.
9. Clauberg M, Joshi JG. Regulation of serine protease activity by aluminum: implications for Alzheimer disease. Proc Natl Acad Sci USA 1993;90: 1009-12.
10. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601.
11. Domingo JL, Gomez M, Llobet JM, Del Castillo D, Corbella J. Influence of citric, ascorbic and lactic acids on the gastrointestinal absorption of aluminum in uremic rats. Nephron 1994;66:108-9.
12. Domingo JL, Llorens J, Sanchez DJ, Gomez M, Llobet JM, Corbella J. Age-related effects of aluminum ingestion on brain aluminum accumulation and behavior in rats. Life Sci 1996;58:1387-95.
13. Edwardson JA, Moore PB, Ferrier IN, et al. Effect of silicon on gastrointestinal absorption of aluminum. Lancet 1993;342:211-2.
14. Esiri MM, Wilcock GK. The olfactory bulbs in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1984;47:56-60.
15. Exley C, Birchall JD. A mechanism of hydroxyaluminosilicate formation. Polyhedron 1993;12:1007-17.
16. Fasman GD, Moore CD. The solubilization of model Alzheimer tangles: reversing the β-sheet conformation induced by aluminum with silicates. Proc Natl Acad Sci USA 1994;91:11232-5.
17. Fasman GD, Perczel A, Moore CD. Solubilization of β-amyloid-(1-42)-peptide: reversing the β-sheet conformation induced by aluminum with silicates. Proc Natl Acad Sci USA 1995;92:369-71.
18. Forbes WF, Agwani N. A suggested mechanism for aluminum biotoxicity. J Theor Biol 1994;171:207-14.
19. Forbes WF, Gentleman JF, Maxwell CJ. Concerning the role of aluminum in causing dementia. Exp Gerontol 1995;30:23-32.
20. Good PF, Perl DP. Aluminum in Alzheimer's disease. Nature 1993;362:418.
21. Harrington CR, Wischik CM, McArthur FK, Taylor GA, Edwardson JA, Candy JM. Alzheimer's-disease-like changes in tau processing: association with aluminum accumulation in brains of renal dialysis patients. Lancet 1994;343:993-7.
22. Jacqmin-Gadda H, Commenges D, Letenneur L, Dartigues JF. Silica and aluminum in drinking water and cognitive impairment in the elderly. Epidemiology 1996;7:281-5.
23. Kawahara M, Muramoto K, Kobayashi K, Mon H, Kuroda Y. Aluminum promotes the aggregation of Alzheimer's amyloid β-protein in vitro. Biochem Biophys Res Commun 1994;198:531-5.
24. Llobet JM, Domingo JL, Gomez M, Tomas JM, Corbella I. Acute toxicity studies of aluminum compounds: antidotal efficacy of several chelating agents. Pharmacol Toxicol 1987;60:280-3.
25. Martyn CN, Barker DJP, Osmond C, Harris EC, Edwardson JA, Lacey RF. Geographical relation between Alzheimer's disease and aluminum in drinking water. Lancet 1989;1:59-62.
26. McLachlan DRC. Aluminum and the risk for Alzheimer's disease. Environmetrics 1995;6:233-75.
27. McLachlan DRC, Bergeron C, Smith JE, Boomer D, Rifat SL. Risk for neuropathologically confirmed Alzheimer's disease and residual aluminum in municipal drinking water employing weighted residential histories. Neurology 1996;46:401-5.
28. Perl DP, Good PF. Aluminum, Alzheimer's disease, and the olfactory system. Ann NY Acad Sci 1991;640:8-13.
29. Petersen OH, Wakui M, Petersen CCH. Intracellular effects of aluminum on receptor-activated cytoplasmic Ca2+ signals in pancreatic acinar cells. In: Chadwick DJ, Whelan J, eds. Aluminum in biology and medicine (Ciba Foundation Symposium). Chichester: John Wiley & Sons, 1992:237-53.
30. Roberts E. Alzheimer's disease may begin in the nose and may be caused by aluminosilicates. Neurobiol Aging 1986;7:561-7.
31. Savory J, Exley C, Forbes WF, et al. Can the controversy of the role of aluminum in Alzheimer's disease be resolved? What are the suggested approaches to this controversy and methodological issues to be considered? J Toxicol Environ Health 1996;48:615-35.
32. Storey E, Masters CL. Amyloid, aluminum and the etiology of Alzheimer's disease. Med J Aust 1995;163:256-9.
33. 27Al NMR investigation. J Protein Chem 1995;14:633-44.