Discovery of 3,3′-diindolylmethanes as potent antileishmanial agents

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 435-443

  Bharate, Sandip B ^a   Bharate, Jaideep B ^a   Khan, Shabana I ^b   Tekwani, Babu L ^b   Jacob, Melissa R ^b   Mudududdla, Ramesh ^a   Yadav, Rammohan R ^a   Singh, Baljinder ^a   Sharma, P R ^a   Maity, Sudip ^c   Singh, Baldev ^a   Khan, Ikhlas A ^b   Vishwakarma, Ram A ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c CSIR CENTRAL INSTITUTE OF MINING AND FUEL RESEARCH   (India)

Author keywords

3,3 Diindolylmethanes; Antifungal; Antileishmanial; Antimalarial; Fe pillared interlayered clay; Leishmania donovani

Indexed keywords

3,3' (3 BROMOPHENYL METHANEDIYL)BISINDOLE; 3,3' (4 FLUORO 3 BROMO PHENYLMETHANEDIYL)BISINDOLE; 3,3' (4 METHOXY 3 BROMOPHENYL METHANEDIYL)BISINDOLE; 3,3' DIINDOLYLMETHANE; 5,5' DIIODO 3,3' (2,6 DICHLOROPHENYL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (4 BROMOPHENYL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (4 FLUORO 3 BROMOPHENYL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (4 HYDROXY 3 METHOXYPHENYL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (4 HYDROXYPHENYL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (4 NITROPHENYL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (5 NITROFURAN 2 YL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (ANTHRACEN 10 YL METHANEDIYL)BISINDOLE; 5,5' DIIODO 3,3' (NAPHTH 1 YL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (2,6 DICHLOROPHENYL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (4 FLUORO 3 BROMOPHENYL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (4 HYDROXY 3 METHOXYPHENYL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (4 HYDROXYPHENYL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (5 NITROFURAN 2 YL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (ANTHRACEN 10 YL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (NAPHTH 1 YL METHANEDIYL)BISINDOLE; 5,5' DIMETHOXY 3,3' (THIOPHEN 2 YL METHANEDIYL)BISINDOLE; ANTILEISHMANIAL AGENT; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTILEISHMANIAL ACTIVITY; ANTIMALARIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CATALYST; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; LEISHMANIA DONOVANI; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; PROMASTIGOTE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTIPROTOZOAL AGENTS; DRUG DISCOVERY; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875027917     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.02.024     Document Type: Article

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