Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus

Natural Product Communications

Volumn 7, Issue 9, 2012, Pages 1123-1126

  Machumi, Francis ^a   Yenesew, Abiy ^a   Midiwo, Jacob O ^a   Heydenreich, Matthias ^b   Kleinpeter, Erich ^b   Tekwani, Babu L ^c,d   Khan, Shabana I ^c,d   Walker, Larry A ^c,d   Muhammad, Ilias ^c  

^a UNIVERSITY OF NAIROBI   (Kenya)

^b UNIVERSITY OF POTSDAM   (Germany)

^c UNIVERSITY OF MISSISSIPPI   (United States)

^d UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Anticancer; Antileishmanial; Antiplasmodial; Asteraceae; Carvotacetones; Sphaeranthus bullatus

Indexed keywords

3 ACETOXY 5,7 DIHYDROXYCARVOTACETONE; 3 ACETOXY 7 HYDROXY 5 TIGLOYLOXYCARVOTACETONE; 3,5,7 TRIHYDROXYCARVOTACETONE; 3,7 DIHYDROXY 5 TIGLOYLOXYCARVOTACETONE; 5 O BETA GLUCOPYRANOSYLCARVOTACETONE; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; ARTEMISININ; CARVOTACETONE DERIVATIVE; CHLOROQUINE; DOXORUBICIN; PENTAMIDINE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; SPHAERANTHUS BULLATUS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASTERACEAE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG RESISTANCE; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; EPITHELIUM CELL; FIBROBLAST; HAPLORHINI; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KIDNEY EPITHELIUM; LEISHMANIA DONOVANI; NONHUMAN; PLASMODIUM FALCIPARUM; PROMASTIGOTE; SPHAERANTHUS BULLATUS; SWINE;

ASTERACEAE; PLASMODIUM FALCIPARUM; SPHAERANTHUS; SUIDAE;

EID: 84866770626     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1200700902     Document Type: Article

References (29)

1. Nkuo-Akenji TK, Menang, ON. (2005) Prevalence of falciparum malaria together with acute diarrhoea in children residing in a malaria endemic zone. Africa Journal of Traditional, Complementary and Alternative Medicine, 12, 26-30.
2. Rugemalila, JB, Wanga, CL, Kilama WL. (2006) Sixth Africa malaria day in 2006: how far have we come after Abuja declaration. Malaria Journal, 12, 102-106.
3. Tonui WK. (2006) Situational analysis of Leishmaniases research in Kenya. African Journal of Health Sciences, 13, 7-21.
4. Kigondu EVM, Rukunga GM, Keriko JM, Tonui WK, Gathirwa JW, Kirira PG, Irungu B, Ingonga JM, Ndiege IO. (2009) Anti-parasitic activity and cytotoxicity of selected medicinal plants from Kenya. Journal of Ethnopharmacology, 123, 504-509.
5. American Cancer Society. (2008) Global cancer: facts and figures 2008.
6. Beentje HK. (1994) Kenyan trees, shrubs and lianas. National Museums of Kenya. Nairobi, Kenya
7. Glover PE, Stewart J, Gwynne MD. (1966) Masai and Kipsigis notes on East African plants, Part III - Medicinal uses of plants. East African Agricultural and Forestry Journal, 32, 200-207.
8. Jakupovic J, Grenz M, Bohlmann F, Mungai GM. (1990) Carvotacetone derivatives and eudesman-12,6β-olides from Sphaeranthus species. Phytochemistry, 29, 1213-1217.
9. Ragasa CY, Tsai P-W, Galvez CT, Shen C-C. (2010) New carvotanacetone derivatives from Sphaeranthus africanus. Planta Medica, 76, 146-151.
10. Zdero C, Bohlmann F, Mungai GM. (1991) Carvotacetone derivatives and other constituents from representatives of the Sphaeranthus group. Phytochemistry, 30, 3297-3303.
11. Pouni I, Vispe S, Marcourt L, Long C, Vandenberghe I, Aussagues Y, Raux R, Mutiso PBC, Massiot G, Sautel F. (2011) Four new carvotanacetone derivatives from Sphaeranthus ukambaensis, inhibitors of the ubiquitin-proteasome pathway. Planta Medica, 77, 1605-1609.
12. Ahmed AA, Mahmoud AA. (1997) Carvotacetone derivatives from the Egyptian plant Sphaeranthus suaveolens. Phytochemistry, 45, 533-535. (Pubitemid 27227465)
13. Rezanka T, Dembitsky VM, Hanus LO. (2003) Two cyclohexenone glycosides from the North American fern Woodwardia virginica (L.) Smith. Phytochemistry, 63, 931-937. (Pubitemid 36987619)
14. Yang GZ, Li YF, Yu X, Mei ZN. (2007) Terpenoids and flavonoids from Laggera pterodonta. Acta Pharmaceutica Sinica, 42, 511-515.
15. Ali MS, Saleem M, Akhtar F, Jahangir M, Parvez M, Ahmad VU. (1999) Three p-cymene derivatives from Zataria multiflora. Phytochemistry, 52, 685-688. (Pubitemid 29518682)
16. Ameho CK, Chen CYO, Smith D, Sánchez-Moreno C, Milbury PE, Blumberg JB. (2008) Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats. Journal of Nutritional Biochemistry, 19, 467-474. (Pubitemid 351783407)
17. Ayanoglu E, Ulubelen A, Clark WD, Brown GK, Kerr RR, Mabry TJ. (1981) Myricetin and quercetin methyl ethers from Haplopappus integerrimus var. punctatus. Phytochemistry, 20, 1715-1717.
18. Horie T, Ohtsumu Y, Shibata K, Yamashita K, Tsukayama M, Kawamura Y. (1998) 13C-NMR spectral assignment of the A-ring of polyoxygenated flavones. Phytochemistry, 47, 865-874. (Pubitemid 28139457)
19. Jay M, Voirin B. (1976) Les flavonoides de deux especes du genre Chrysosplenium. Phytochemistry, 15, 517-519.
20. Luyengi L, Lee IS, Mar W, Fong HHS, Pezzuto JM, Kinghorn AD. (1994) Rotenoids and chalcones from Mundelea sericea that inhibit phorbol ester-induced ornithine decarboxylase activity. Phytochemistry, 36, 1523-1526. (Pubitemid 2134002)
21. Andueza S, Manzocco L, Paz de Pena M, Cid C, Nicoli C. (2009) Caffeic acid decomposition products: Anti-oxidants or pro-oxidants? Food Research International, 42, 51-55.
22. Sy L, Brown GD. (1999) Coniferaldehyde derivatives from tissue culture of Artemisia annua and Tanacetum parthenium. Phytochemistry, 50, 781-785 (Pubitemid 29135040)
23. Ferrari B, Tomi F, Casanova J. (2005) Terpenes and acetylene derivatives from the roots of Santolina corsica (Asteraceae). Biochemical Systematics and Ecology, 33, 445-449. (Pubitemid 40281374)
24. Chawla AS, Kaith BS, Handa SS, Kulshreshtha DK, Srimal RC. (1990) Chemical investigation and anti-inflammatory activity of Pluchea lanceolata roots. Indian Journal of Chemistry, 29B, 918-922. (Pubitemid 20348133)
25. Makler MT, Ries JM, Williams JA, Bancroft JE, Piper RC, Gibbins BL, Hinriches DJ. (1993) Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. American Journal of Tropical Medicine Hygiene, 48, 739-741. (Pubitemid 23238452)
26. Samoylenko V, Jacob MR, Khan SI, Zhao J, Tekwani BL, Midiwo JO, Walker LA, Muhammad I. (2009) Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana. Natural Product Communications, 4, 791-796.
27. Mikus J, Steverding D. (2000) A simple colorimetric method to screen drug cytotoxicity against Leishmania by using the dye Alamar Blue. Parasitology International, 48, 265-269.
28. Borenfreund E, Babich H, Martin-Alguacil N. (1990) Rapid chemosensitivity assay with human normal and tumor cells in vitro. In vitro cellular and developmental biology: Journal of the Tissue Culture Association, 26, 1030-1034.
29. Rahman AA, Samoylenko V, Jacob MR, Sahu R, Jain SK, Khan SI, Tekwani BL, Muhammad I. (2011) Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa. Planta Medica, advance online publication 7 March 2011; doi: 10.1055/s-0030-1270906.