In Vitro potency and In Vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 4, 2012, Pages 2201-2204

  Mansouri, Mohammad D ^a,b   Opperman, Timothy J ^c   Williams, John D ^c   Stager, Charles ^a,b   Darouiche, Rabih O ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MICROBIOTIX INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; MBX 1631; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; CATHETER INFECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; EXPERIMENTAL RABBIT; FEMALE; IN VITRO STUDY; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS EPIDERMIDIS; SUSTAINED RELEASE PREPARATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; CATHETER-RELATED INFECTIONS; CATHETERS; COLONY COUNT, MICROBIAL; CULTURE MEDIA; INDOLES; RABBITS; STAPHYLOCOCCAL INFECTIONS;

EID: 84863360092     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05521-11     Document Type: Article

References (27)

1. Bassetti S, Hu J, D'Agostino RB, Sherertz RJ. 2001. Prolonged antimicrobial activity of a catheter containing chlorhexidine-silver sulfadiazine extends protection against catheter infections in vivo. Antimicrob. Agents Chemother. 45:1535-1538. (Pubitemid 32374130)
2. Butler MM, et al. 2010. Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. Antimicrob. Agents Chemother. 54:3974-3977.
3. Butler MM, et al. 2008. Novel bis-(imidazolinylindole) antibacterials active against a broad spectrum of bacteria, abstr F1-3933. Abstr. 48th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
4. Crnich CJ, Maki DG. 2001. The role of intravascular devices in sepsis. Curr. Infect. Dis. Rep. 3:496-506.
5. Darouiche RO, et al. 1999. A comparison of two antimicrobialimpregnated central venous catheters. Catheter Study Group. N. Engl. J. Med. 340:1-8. (Pubitemid 29024677)
6. Darouiche R, Raad I, Morek D, Texas Medical Center Catheter Study Group. 1995. Scanning electron microscopy (SEM) studies and antimicrobial durability of indwelling central venous catheters (CVC) coated with minocycline and rifampin (M/R), abstr J8. Abstr. 35th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
7. Dimick JB, et al. 2001. Increased resource use associated with catheterrelated bloodstream infection in the surgical intensive care unit. Arch. Surg. 136:229-234. (Pubitemid 32143849)
8. Kaplan M, et al. 2011. Use of antibiotic-impregnated DuraGen® to reduce the risk of infection in dura repair: an in vitro study. Cen. Eur. Neurosurg. 72:75-77.
9. Kluger DM, Maki DG. 1999. The relative risk of intravascular device related bloodstream infection in adults, p 514. Abstr. 39th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
10. Maki D, Mermel M. 1998. Infections due to infusion therapy, p 689-724. In Bennett JV, Brachman PS (ed), Hospital infections, 4th ed. Lippincott- Raven, Philadelphia, PA.
11. Mansouri MD, Darouiche RO. January 2006. Method for treating medical devices using glycerol and an antimicrobial agent. U.S. patent 6,589,591.
12. Mansouri MD, Boone TB, Darouiche RO. 2009. Comparative assessment of antimicrobial activities of antibiotic-treated penile prostheses. Eur. Urol. 56:1039-1045.
13. Mermel LA. 2000. Prevention of intravascular catheter-related infections. Ann. Intern. Med. 132:391-402. (Pubitemid 30127778)
14. O'Grady NP, et al. 2002. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. MMWR Recomm. Rep. 51:1-29.
15. Opperman TJ, et al. 2010. The mechanism of antibacterial action of novel bis-indole antibiotics, abstr F1-1631. Abstr. 50th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
16. Opperman TJ, et al. 2009. DNA binding activity of novel bis-indole antibiotics, abstr F1-1976. Abstr. 49th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
17. Panchal RG, et al. 2009. Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains. Antimicrob. Agents Chemother. 53:4283-4291.
18. Raad II, Hanna H, Maki D. 2007. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect. Dis. 7:645-657. (Pubitemid 47444563)
19. Raad I, Darouiche R, Hachem R, Mansouri M, Bodey GP. 1996. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J. Infect. Dis. 173:418-424. (Pubitemid 26042443)
20. Raad I, Darouiche R, Texas Medical Center Catheter Study Group. 1995. Central venous catheters (CVC) coated with minocycline and rifampin (M/R) for the prevention of catheter-related bacteremia (CRB), abstr J7. Abstr. 35th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
21. Rello J, et al. 2000. Evaluation of outcome of intravenous catheter-related infections in critically ill patients. Am. J. Respir. Crit. Care Med. 162:1027-1030.
22. Rosenthal VD, et al. 2006. International Nosocomial Infection Control Consortium. Device-associated nosocomial infections in 55 intensive care units of 8 developing countries. Ann. Intern. Med. 145:582-591. (Pubitemid 46780937)
23. Safdar N, Fine JP, Maki DG. 2005. Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann. Intern. Med. 142:451-466. (Pubitemid 40365432)
24. Sherertz RJ, Forman DM, Solomon DD. 1989. Efficacy of dicloxacillincoated polyurethane catheters in preventing subcutaneous Staphylococcus aureus infection in mice. Antimicrob. Agents Chemother. 33:1174-1178. (Pubitemid 19191951)
25. Sherertz RJ, Carruth WA, Hampton AA, Byron MP, Solomon DD. 1993. Efficacy of antibiotic-coated catheters in preventing subcutaneous Staphylococcus aureus infection in rabbits. J. Infect. Dis. 167:98-106. (Pubitemid 23002843)
26. Stevens EA, Palavecino E, Sherertz RJ, Shihabi Z, Couture DE. 2010. Effects of antibiotic-impregnated external ventricular drains on bacterial culture results: an in vitro analysis. J. Neurosurg. 113:86-92.
27. Tunney MM, Gorman SP, Patrick S. 1996. Infection associated with medical devices. Rev. Med. Microbiol. 7:195-205. (Pubitemid 26372073)