Oxytocin modulates mTORC1 pathway in the gut

Biochemical and Biophysical Research Communications

Volumn 432, Issue 3, 2013, Pages 466-471

  Klein, Benjamin Y ^a   Tamir, Hadassah ^a,b   Hirschberg, David L ^a   Glickstein, Sara B ^c   Welch, Martha G ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c EB Sciences   (United States)

Author keywords

4E BP1; Autism; Caco2BB; Enterocyte; PI3K Akt

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; OXYTOCIN; PROTEIN KINASE B;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERNALIZATION; INTESTINE; INTESTINE CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CACO-2 CELLS; EUKARYOTIC INITIATION FACTOR-4E; GASTROINTESTINAL TRACT; HUMANS; MULTIPROTEIN COMPLEXES; OXYTOCIN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

MAMMALIA; RATTUS;

EID: 84874989393     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.01.121     Document Type: Article

References (36)

1. Takeda S., Kuwabara Y., Mizuno M. Concentrations and origin of oxytocin in breast milk. Endocrinol. Jpn. 1986, 33:821-826.
2. Welch M.G., Tamir H., Gross K.J., Chen J., Anwar M., Gershon M.D. Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. J. Comp. Neurol. 2009, 512:256-270.
3. Welch M.G., Anwar M., Chang C.Y., Gross K.J., Ruggiero D.A., Tamir H., Gershon M.D. Combined administration of secretin and oxytocin inhibits chronic colitis and associated activation of forebrain neurons. Neurogastroenterol. Motil. 2010, 22:654-e202.
4. Biyikli N.K., Tugtepe H., Sener G., Velioglu-Ogunc A., Cetinel S., Midillioglu S., Gedik N., Yegen B.C. Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism. Peptides 2006, 27:2249-2257.
5. Szeto A., Nation D.A., Mendez A.J., Dominguez-Bendala J., Brooks L.G., Schneiderman N., McCabe P.M. Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E1495-E1501.
6. 2BB gut cells. J. Cell. Biochem. 2011, 112:3216-3226.
7. Inoki K., Ouyang H., Li Y., Guan K.L. Signaling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 2005, 69:79-100.
8. Dunlop E.A., Tee A.R. Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cell. Signal. 2009, 21:827-835.
9. Ma X.M., Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 2009, 10:307-318.
10. Corradetti M.N., Guan K.L. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?. Oncogene 2006, 25:6347-6360.
11. Potter C.J., Pedraza L.G., Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 2002, 4:658-665.
12. Inoki K., Li Y., Zhu T., Wu J., Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 2002, 4:648-657.
13. Lamming D.W., Ye L., Katajisto P., Goncalves M.D., Saitoh M., Stevens D.M., Davis J.G., Salmon A.B., Richardson A., Ahima R.S., Guertin D.A., Sabatini D.M., Baur J.A. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012, 335:1638-1643.
14. Selman C., Tullet J.M., Wieser D., Irvine E., Lingard S.J., Choudhury A.I., Claret M., Al-Qassab H., Carmignac D., Ramadani F., Woods A., Robinson I.C., Schuster E., Batterham R.L., Kozma S.C., Thomas G., Carling D., Okkenhaug K., Thornton J.M., Partridge L., Gems D., Withers D.J. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009, 326:140-144.
15. Fingar D.C., Salama S., Tsou C., Harlow E., Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4E-BP1/eIF4E. Genes Dev. 2002, 16:1472-1487.
16. Gingras A.C., Gygi S.P., Raught B., Polakiewicz R.D., Abraham R.T., Hoekstra M.F., Aebersold R., Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999, 13:1422-1437.
17. Rong L., Livingstone M., Sukarieh R., Petroulakis E., Gingras A.C., Crosby K., Smith B., Polakiewicz R.D., Pelletier J., Ferraiuolo M.A., Sonenberg N. Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA 2008, 14:1318-1327.
18. Niedzwiecka A., Marcotrigiano J., Stepinski J., Jankowska-Anyszka M., Wyslouch-Cieszynska A., Dadlez M., Gingras A.C., Mak P., Darzynkiewicz E., Sonenberg N., Burley S.K., Stolarski R. Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J. Mol. Biol. 2002, 319:615-635.
19. Manning M., Miteva K., Pancheva S., Stoev S., Wo N.C., Chan W.Y. Design and synthesis of highly selective in vitro and in vivo uterine receptor antagonists of oxytocin: comparisons with atosiban. Int. J. Pept. Protein Res. 1995, 46:244-252.
20. Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 2008, 30:214-226.
21. Shair H.N., Smith J.A., Welch M.G. Cutting the vagus nerve below the diaphragm prevents maternal potentiation of infant rat vocalization. Dev. Psychobiol. 2012, 54:70-76.
22. Gimpl G., Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 2001, 81:629-683.
23. Angelidou A., Asadi S., Alysandratos K.D., Karagkouni A., Kourembanas S., Theoharides T.C. Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012, 12:89.
24. Talos D.M., Sun H., Zhou X., Fitzgerald E.C., Jackson M.C., Klein P.M., Lan V.J., Joseph A., Jensen F.E. The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway. PloS One 2012, 7:e35885.
25. Bartz J.A., Hollander E. Oxytocin and experimental therapeutics in autism spectrum disorders. Prog. Brain Res. 2008, 170:451-462.
26. Horvath K., Papadimitriou J.C., Rabsztyn A., Drachenberg C., Tildon J.T. Gastrointestinal abnormalities in children with autistic disorder. J. Pediatr. 1999, 135:559-563.
27. Lang C.H., Frost R.A. Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J. Cell. Physiol. 2005, 203:144-155.
28. Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
29. Richter J.D., Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 2005, 433:477-480.
30. Niedzwiecka A., Stepinski J., Darzynkiewicz E., Sonenberg N., Stolarski R. Positive heat capacity change upon specific binding of translation initiation factor eIF4E to mRNA 5' cap. Biochemistry 2002, 41:12140-12148.
31. Gingras A.C., Gygi S.P., Raught B., Polakiewicz R.D., Abraham R.T., Hoekstra M.F., Aebersold R., Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999, 13:1422-1437.
32. Devost D., Carrier M.E., Zingg H.H. Oxytocin-induced activation of eukaryotic elongation factor 2 in myometrial cells is mediated by protein kinase C. Endocrinology 2008, 149:131-138.
33. Dunlop E.A., Hunt D.K., Acosta-Jaquez H.A., Fingar D.C., Tee A.R. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 2011, 7:737-747.
34. Lee J.W., Park S., Takahashi Y., Wang H.G. The association of AMPK with ULK1 regulates autophagy. PLoS One 2011, 5(11).
35. Bentzinger C.F., Romanino K., Cloetta D., Lin S., Mascarenhas J.B., Oliveri F., Xia J., Casanova E., Costa C.F., Brink M., Zorzato F., Hall M.N., Ruegg M.A. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 2008, 8:411-424.
36. Tremblay F., Brule S., Hee Um S., Li Y., Masuda K., Roden M., Sun X.J., Krebs M., Polakiewicz R.D., Thomas G., Marette A. Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc. Natl. Acad. Sci. USA 2007, 104:14056-14061.