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Volumn 34, Issue 16, 2013, Pages 4159-4172

A pH-responsive cyclodextrin-based hybrid nanosystem as a nonviral vector for gene delivery

Author keywords

Antisense therapy; Cyclodextrin; Nanomedicine; Nanovector; PH responsive

Indexed keywords

ANTISENSE OLIGONUCLEOTIDES; ANTISENSE THERAPIES; DOSE-DEPENDENT MANNER; HUMAN LUNG ADENOCARCINOMA CELLS; LOW MOLECULAR WEIGHT; NANOVECTOR; PH-RESPONSIVE; POLYETHYLENIMINES;

EID: 84874969295     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.02.035     Document Type: Article
Times cited : (68)

References (59)
  • 1
    • 64549134676 scopus 로고    scopus 로고
    • Nonviral vectors for gene delivery
    • Mintzer M.A., Simanek E.E. Nonviral vectors for gene delivery. Chem Rev 2009, 109:259-302.
    • (2009) Chem Rev , vol.109 , pp. 259-302
    • Mintzer, M.A.1    Simanek, E.E.2
  • 3
    • 84858642577 scopus 로고    scopus 로고
    • Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses
    • Miyata K., Nishiyama N., Kataoka K. Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses. Chem Soc Rev 2012, 41:2562-2574.
    • (2012) Chem Soc Rev , vol.41 , pp. 2562-2574
    • Miyata, K.1    Nishiyama, N.2    Kataoka, K.3
  • 4
    • 46549090126 scopus 로고    scopus 로고
    • Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
    • Morille M., Passirani C., Vonarbourg A., Clavreul A., Benoit J.P. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 2008, 29:3477-3496.
    • (2008) Biomaterials , vol.29 , pp. 3477-3496
    • Morille, M.1    Passirani, C.2    Vonarbourg, A.3    Clavreul, A.4    Benoit, J.P.5
  • 6
    • 67249128859 scopus 로고    scopus 로고
    • The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic
    • Davis M.E. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol Pharmaceut 2009, 6:659-668.
    • (2009) Mol Pharmaceut , vol.6 , pp. 659-668
    • Davis, M.E.1
  • 7
    • 65949106130 scopus 로고    scopus 로고
    • Orally delivered siRNA targeting macrophage map4k4 suppresses systemic inflammation
    • Aouadi M., Tesz G.J., Nicoloro S.M., Wang M.X., Chouinard M., Soto E., et al. Orally delivered siRNA targeting macrophage map4k4 suppresses systemic inflammation. Nature 2009, 458:1180-1184.
    • (2009) Nature , vol.458 , pp. 1180-1184
    • Aouadi, M.1    Tesz, G.J.2    Nicoloro, S.M.3    Wang, M.X.4    Chouinard, M.5    Soto, E.6
  • 9
    • 38849166053 scopus 로고    scopus 로고
    • Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
    • Peer D., Park E.J., Morishita Y., Carman C.V., Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 2008, 319:627-630.
    • (2008) Science , vol.319 , pp. 627-630
    • Peer, D.1    Park, E.J.2    Morishita, Y.3    Carman, C.V.4    Shimaoka, M.5
  • 11
    • 33744805790 scopus 로고    scopus 로고
    • Polymers for gene delivery across length scales
    • Putnam D. Polymers for gene delivery across length scales. Nat Mater 2006, 5:439-451.
    • (2006) Nat Mater , vol.5 , pp. 439-451
    • Putnam, D.1
  • 12
    • 33751320460 scopus 로고    scopus 로고
    • Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency
    • Olton D., Li J.H., Wilson M.E., Mary E., Rogers T., Close J., et al. Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency. Biomaterials 2007, 28:1267-1279.
    • (2007) Biomaterials , vol.28 , pp. 1267-1279
    • Olton, D.1    Li, J.H.2    Wilson, M.E.3    Mary, E.4    Rogers, T.5    Close, J.6
  • 13
    • 33845975678 scopus 로고    scopus 로고
    • Quantum-dot based nanoparticles for targeted silencing of her2/neu gene via RNA interference
    • Tan W.B., Jiang S., Zhang Y. Quantum-dot based nanoparticles for targeted silencing of her2/neu gene via RNA interference. Biomaterials 2007, 28:1565-1571.
    • (2007) Biomaterials , vol.28 , pp. 1565-1571
    • Tan, W.B.1    Jiang, S.2    Zhang, Y.3
  • 14
    • 84858793517 scopus 로고    scopus 로고
    • Self-assembled RNA interference microsponges for efficient siRNA delivery
    • Lee J.B., Hong J., Bonner D.K., Poon Z.Y., Hammond P.T. Self-assembled RNA interference microsponges for efficient siRNA delivery. Nat Mater 2012, 11:316-322.
    • (2012) Nat Mater , vol.11 , pp. 316-322
    • Lee, J.B.1    Hong, J.2    Bonner, D.K.3    Poon, Z.Y.4    Hammond, P.T.5
  • 15
    • 77953645331 scopus 로고    scopus 로고
    • Nanomaterials based on DNA
    • Seeman N.C. Nanomaterials based on DNA. Annu Rev Biochem 2010, 79:65-87.
    • (2010) Annu Rev Biochem , vol.79 , pp. 65-87
    • Seeman, N.C.1
  • 16
    • 84862659504 scopus 로고    scopus 로고
    • Therapeutic plasmid DNA versus siRNA delivery: common and different tasks for synthetic carriers
    • Scholz C., Wagner E. Therapeutic plasmid DNA versus siRNA delivery: common and different tasks for synthetic carriers. J Control Release 2012, 161:554-565.
    • (2012) J Control Release , vol.161 , pp. 554-565
    • Scholz, C.1    Wagner, E.2
  • 17
    • 84862902835 scopus 로고    scopus 로고
    • Polymers for siRNA delivery: inspired by viruses to be targeted, dynamic, and precise
    • Wagner E. Polymers for siRNA delivery: inspired by viruses to be targeted, dynamic, and precise. Acc Chem Res 2012, 45:1005-1013.
    • (2012) Acc Chem Res , vol.45 , pp. 1005-1013
    • Wagner, E.1
  • 18
    • 84863906869 scopus 로고    scopus 로고
    • MicroRNAs as therapeutic targets and their potential applications in cancer therapy
    • Cho W.C.S. MicroRNAs as therapeutic targets and their potential applications in cancer therapy. Expert Opin Ther Targets 2012, 16:747-759.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 747-759
    • Cho, W.C.S.1
  • 19
    • 84863579159 scopus 로고    scopus 로고
    • Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly
    • Hu Q.L., Li W., Hu X.R., Hu Q.D., Shen J., Jin X., et al. Synergistic treatment of ovarian cancer by co-delivery of survivin shRNA and paclitaxel via supramolecular micellar assembly. Biomaterials 2012, 33:6580-6591.
    • (2012) Biomaterials , vol.33 , pp. 6580-6591
    • Hu, Q.L.1    Li, W.2    Hu, X.R.3    Hu, Q.D.4    Shen, J.5    Jin, X.6
  • 20
    • 84860756787 scopus 로고    scopus 로고
    • Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing
    • Kubo T., Yanagihara K., Takei Y., Mihara K., Sato Y., Seyama T. Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing. Mol Pharmaceut 2012, 9:1374-1383.
    • (2012) Mol Pharmaceut , vol.9 , pp. 1374-1383
    • Kubo, T.1    Yanagihara, K.2    Takei, Y.3    Mihara, K.4    Sato, Y.5    Seyama, T.6
  • 21
    • 84856431819 scopus 로고    scopus 로고
    • RNA therapeutics: beyond RNA interference and antisense oligonucleotides
    • Kole R., Krainer A.R., Altman S. RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat Rev Drug Discov 2012, 11:125-140.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 125-140
    • Kole, R.1    Krainer, A.R.2    Altman, S.3
  • 22
    • 1942439012 scopus 로고    scopus 로고
    • Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor
    • Zhao X.B., Lee R.J. Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor. Adv Drug Deliv Rev 2004, 56:1193-1204.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1193-1204
    • Zhao, X.B.1    Lee, R.J.2
  • 23
    • 1942534976 scopus 로고    scopus 로고
    • "Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes
    • Fattal E., Couvreur P., Dubernet C. "Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes. Adv Drug Deliv Rev 2004, 56:931-946.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 931-946
    • Fattal, E.1    Couvreur, P.2    Dubernet, C.3
  • 24
    • 84863951245 scopus 로고    scopus 로고
    • Peptide vectors for the nonviral delivery of nucleic acids
    • Hoyer J., Neundorf I. Peptide vectors for the nonviral delivery of nucleic acids. Acc Chem Res 2012, 45:1048-1056.
    • (2012) Acc Chem Res , vol.45 , pp. 1048-1056
    • Hoyer, J.1    Neundorf, I.2
  • 25
    • 83655211651 scopus 로고    scopus 로고
    • Polymers for gene delivery: charged for success
    • Mastrobattista E., Hennink W.E. Polymers for gene delivery: charged for success. Nat Mater 2012, 11:10-12.
    • (2012) Nat Mater , vol.11 , pp. 10-12
    • Mastrobattista, E.1    Hennink, W.E.2
  • 26
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis
    • Fischer D., Li Y.X., Ahlemeyer B., Krieglstein J., Kissel T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003, 24:1121-1131.
    • (2003) Biomaterials , vol.24 , pp. 1121-1131
    • Fischer, D.1    Li, Y.X.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 27
    • 33746438424 scopus 로고    scopus 로고
    • Toxicity of cationic lipids and cationic polymers in gene delivery
    • Lv H., Zhang S., Wang B., Cui S., Yan J. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 2006, 114:100-109.
    • (2006) J Control Release , vol.114 , pp. 100-109
    • Lv, H.1    Zhang, S.2    Wang, B.3    Cui, S.4    Yan, J.5
  • 28
    • 0036371914 scopus 로고    scopus 로고
    • Side-effects of a systemic injection of linear polyethylenimine-DNA complexes
    • Chollet P., Favrot M.C., Hurbin A., Coll J.L. Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J Gene Med 2002, 4:84-91.
    • (2002) J Gene Med , vol.4 , pp. 84-91
    • Chollet, P.1    Favrot, M.C.2    Hurbin, A.3    Coll, J.L.4
  • 29
    • 34250770499 scopus 로고    scopus 로고
    • Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation
    • Akagi D., Oba M., Koyama H., Nishiyama N., Fukushima S., Miyata T., et al. Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation. Gene Ther 2007, 14:1029-1038.
    • (2007) Gene Ther , vol.14 , pp. 1029-1038
    • Akagi, D.1    Oba, M.2    Koyama, H.3    Nishiyama, N.4    Fukushima, S.5    Miyata, T.6
  • 30
    • 66249083866 scopus 로고    scopus 로고
    • Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
    • Woodrow K.A., Cu Y., Booth C.J., Saucier-Sawyer J.K., Wood M.J., Saltzman W.M. Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater 2009, 8:526-533.
    • (2009) Nat Mater , vol.8 , pp. 526-533
    • Woodrow, K.A.1    Cu, Y.2    Booth, C.J.3    Saucier-Sawyer, J.K.4    Wood, M.J.5    Saltzman, W.M.6
  • 31
    • 77958494386 scopus 로고    scopus 로고
    • Orally delivered thioketal nanoparticles loaded with TNF-siRNA target inflammation and inhibit gene expression in the intestines
    • Wilson D.S., Dalmasso G., Wang L.X., Sitaraman S.V., Merlin D., Murthy N. Orally delivered thioketal nanoparticles loaded with TNF-siRNA target inflammation and inhibit gene expression in the intestines. Nat Mater 2010, 9:923-928.
    • (2010) Nat Mater , vol.9 , pp. 923-928
    • Wilson, D.S.1    Dalmasso, G.2    Wang, L.X.3    Sitaraman, S.V.4    Merlin, D.5    Murthy, N.6
  • 32
    • 78649934086 scopus 로고    scopus 로고
    • PH-responsive nanoparticles for drug delivery
    • Gao W.W., Chan J.M., Farokhzad O.C. pH-responsive nanoparticles for drug delivery. Mol Pharmaceut 2010, 7:1913-1920.
    • (2010) Mol Pharmaceut , vol.7 , pp. 1913-1920
    • Gao, W.W.1    Chan, J.M.2    Farokhzad, O.C.3
  • 33
    • 39649120532 scopus 로고    scopus 로고
    • A review of stimuli-responsive nanocarriers for drug and gene delivery
    • Ganta S., Devalapally H., Shahiwala A., Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Release 2008, 126:187-204.
    • (2008) J Control Release , vol.126 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amiji, M.4
  • 34
    • 67649229657 scopus 로고    scopus 로고
    • Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymer
    • Bae Y., Kataoka K. Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymer. Adv Drug Deliv Rev 2009, 61:768-784.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 768-784
    • Bae, Y.1    Kataoka, K.2
  • 35
    • 84862662236 scopus 로고    scopus 로고
    • Stimuli-triggered structural engineering of synthetic and biological polymeric assemblies
    • Zhang J.X., Li X.D., Li X.H. Stimuli-triggered structural engineering of synthetic and biological polymeric assemblies. Prog Polym Sci 2012, 37:1130-1176.
    • (2012) Prog Polym Sci , vol.37 , pp. 1130-1176
    • Zhang, J.X.1    Li, X.D.2    Li, X.H.3
  • 36
    • 1542333716 scopus 로고    scopus 로고
    • Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines
    • Wang C., Ge Q., Ting D., Nguyen D., Shen H.R., Chen J.Z., et al. Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nat Mater 2004, 3:190-196.
    • (2004) Nat Mater , vol.3 , pp. 190-196
    • Wang, C.1    Ge, Q.2    Ting, D.3    Nguyen, D.4    Shen, H.R.5    Chen, J.Z.6
  • 37
    • 77955766504 scopus 로고    scopus 로고
    • Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells
    • Cohen J.A., Beaudette T.T., Cohen J.L., Broaders K.E., Bachelder E.M., Frechet J.M.J. Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells. Adv Mater 2010, 22:3593-3597.
    • (2010) Adv Mater , vol.22 , pp. 3593-3597
    • Cohen, J.A.1    Beaudette, T.T.2    Cohen, J.L.3    Broaders, K.E.4    Bachelder, E.M.5    Frechet, J.M.J.6
  • 38
    • 48149091967 scopus 로고    scopus 로고
    • Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery
    • Lee Y., Miyata K., Oba M., Ishii T., Fukushima S., Han M., et al. Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery. Angew Chem Int Ed 2008, 47:5163-5166.
    • (2008) Angew Chem Int Ed , vol.47 , pp. 5163-5166
    • Lee, Y.1    Miyata, K.2    Oba, M.3    Ishii, T.4    Fukushima, S.5    Han, M.6
  • 40
    • 79960438571 scopus 로고    scopus 로고
    • Facile engineering of biocompatible materials with pH-modulated degradability
    • Zhang J.X., Jia Y., Li X.D., Hu Y.Q., Li X.H. Facile engineering of biocompatible materials with pH-modulated degradability. Adv Mater 2011, 23:3035-3040.
    • (2011) Adv Mater , vol.23 , pp. 3035-3040
    • Zhang, J.X.1    Jia, Y.2    Li, X.D.3    Hu, Y.Q.4    Li, X.H.5
  • 41
    • 27744469880 scopus 로고    scopus 로고
    • Optimizing double emulsion process to decrease the burst release of protein from biodegradable polymer microspheres
    • Zhang J.X., Chen D., Wang S.J., Zhu K.J. Optimizing double emulsion process to decrease the burst release of protein from biodegradable polymer microspheres. J Microencapsul 2005, 22:413-422.
    • (2005) J Microencapsul , vol.22 , pp. 413-422
    • Zhang, J.X.1    Chen, D.2    Wang, S.J.3    Zhu, K.J.4
  • 42
    • 84861711607 scopus 로고    scopus 로고
    • Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxia
    • Liu T., Li Y., Lin K., Yin H., He B., Zheng M., et al. Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxia. Int J Biochem Cell Biol 2012, 44:1337-1345.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 1337-1345
    • Liu, T.1    Li, Y.2    Lin, K.3    Yin, H.4    He, B.5    Zheng, M.6
  • 43
    • 77957784479 scopus 로고    scopus 로고
    • Activation of the sonic Hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia
    • Wang G., Zhang Z., Xu Z., Yin H., Bai L., Ma Z., et al. Activation of the sonic Hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia. Biochim Biophys Acta 2010, 1803:1359-1367.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 1359-1367
    • Wang, G.1    Zhang, Z.2    Xu, Z.3    Yin, H.4    Bai, L.5    Ma, Z.6
  • 44
    • 0032811354 scopus 로고    scopus 로고
    • Poly(ethylenimine) and its role in gene delivery
    • Godbey W.T., Wu K.K., Mikos A.G. Poly(ethylenimine) and its role in gene delivery. J Control Release 1999, 60:149-160.
    • (1999) J Control Release , vol.60 , pp. 149-160
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 45
    • 0343907187 scopus 로고    scopus 로고
    • One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate
    • Okada H. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate. Adv Drug Deliv Rev 1997, 28:43-70.
    • (1997) Adv Drug Deliv Rev , vol.28 , pp. 43-70
    • Okada, H.1
  • 46
    • 84873738436 scopus 로고    scopus 로고
    • Nanocomplexation-assisted solubilization of pDNA in organic solvents for improved microencapsulation
    • Wang Y., Zhou J.Z., Tang Y., Wei Y.L., Gong H., Li X.H., et al. Nanocomplexation-assisted solubilization of pDNA in organic solvents for improved microencapsulation. J Colloid Interface Sci 2013, 394:573-581.
    • (2013) J Colloid Interface Sci , vol.394 , pp. 573-581
    • Wang, Y.1    Zhou, J.Z.2    Tang, Y.3    Wei, Y.L.4    Gong, H.5    Li, X.H.6
  • 47
    • 0023196815 scopus 로고
    • A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
    • Ritger P.L., Peppas N.A. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release 1987, 5:37-42.
    • (1987) J Control Release , vol.5 , pp. 37-42
    • Ritger, P.L.1    Peppas, N.A.2
  • 48
    • 23944464631 scopus 로고    scopus 로고
    • Recent advances in rational gene transfer vector design based on poly(ethyleneimine) and its derivatives
    • Neu M., Fischer D., Kissel T. Recent advances in rational gene transfer vector design based on poly(ethyleneimine) and its derivatives. J Gene Med 2005, 7:992-1009.
    • (2005) J Gene Med , vol.7 , pp. 992-1009
    • Neu, M.1    Fischer, D.2    Kissel, T.3
  • 50
    • 77953809654 scopus 로고    scopus 로고
    • Cationic carriers of genetic material and cell death: a mitochondrial tale
    • Hunter A.C., Moghimi S.M. Cationic carriers of genetic material and cell death: a mitochondrial tale. Biochim Biophys Acta 2010, 1797:1203-1209.
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 1203-1209
    • Hunter, A.C.1    Moghimi, S.M.2
  • 51
    • 44249116184 scopus 로고    scopus 로고
    • Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells
    • Kongkaneramit L., Sarisuta N., Azad N., Lu Y., Iyer A.K., Wang L., et al. Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells. J Pharmacol Exp Ther 2008, 325:969-977.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 969-977
    • Kongkaneramit, L.1    Sarisuta, N.2    Azad, N.3    Lu, Y.4    Iyer, A.K.5    Wang, L.6
  • 53
    • 83355163230 scopus 로고    scopus 로고
    • In vivo treatment of tumors using host-guest conjugated nanoparticles functionalized with doxorubicin and therapeutic gene pTRAIL
    • Fan H., Hu Q.D., Xu F.J., Liang W.Q., Tang G.P., Yang W.T. In vivo treatment of tumors using host-guest conjugated nanoparticles functionalized with doxorubicin and therapeutic gene pTRAIL. Biomaterials 2012, 33:1428-1436.
    • (2012) Biomaterials , vol.33 , pp. 1428-1436
    • Fan, H.1    Hu, Q.D.2    Xu, F.J.3    Liang, W.Q.4    Tang, G.P.5    Yang, W.T.6
  • 54
    • 77649177146 scopus 로고    scopus 로고
    • Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery
    • Zhang J.X., Sun H.L., Ma P.X. Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery. ACS Nano 2010, 4:1049-1059.
    • (2010) ACS Nano , vol.4 , pp. 1049-1059
    • Zhang, J.X.1    Sun, H.L.2    Ma, P.X.3
  • 55
    • 79151485126 scopus 로고    scopus 로고
    • Host-guest interactions mediated nano-assemblies using cyclodextrin-containing hydrophilic polymers and their biomedical applications
    • Zhang J.X., Ma P.X. Host-guest interactions mediated nano-assemblies using cyclodextrin-containing hydrophilic polymers and their biomedical applications. Nano Today 2010, 5:337-350.
    • (2010) Nano Today , vol.5 , pp. 337-350
    • Zhang, J.X.1    Ma, P.X.2
  • 56
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • Davis M.E., Zuckerman J.E., Choi C.H.J., Seligson D., Tolcher A., Alabi C.A., et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010, 464:1067-1070.
    • (2010) Nature , vol.464 , pp. 1067-1070
    • Davis, M.E.1    Zuckerman, J.E.2    Choi, C.H.J.3    Seligson, D.4    Tolcher, A.5    Alabi, C.A.6
  • 57
    • 57549083059 scopus 로고    scopus 로고
    • Versatile supramolecular pDNA vehicles via "click polymerization" of β-cyclodextrin with oligoethyleneamines
    • Srinivasachari S., Reineke T.M. Versatile supramolecular pDNA vehicles via "click polymerization" of β-cyclodextrin with oligoethyleneamines. Biomaterials 2009, 30:928-938.
    • (2009) Biomaterials , vol.30 , pp. 928-938
    • Srinivasachari, S.1    Reineke, T.M.2
  • 58
    • 34248643411 scopus 로고    scopus 로고
    • Evaluation of polyamidoamine dendrimer/α-cyclodextrin conjugate (Generation 3, G3) as a novel carrier for small interfering RNA (siRNA)
    • Tsutsumi T., Hirayama F., Uekama K., Arima H. Evaluation of polyamidoamine dendrimer/α-cyclodextrin conjugate (Generation 3, G3) as a novel carrier for small interfering RNA (siRNA). J Control Release 2007, 119:349-359.
    • (2007) J Control Release , vol.119 , pp. 349-359
    • Tsutsumi, T.1    Hirayama, F.2    Uekama, K.3    Arima, H.4
  • 59
    • 78650287162 scopus 로고    scopus 로고
    • Oligoamines conjugated chitosan derivatives: synthesis, characterization, in vitro and in vivo biocompatibility evaluations
    • Jia Y., Hu Y.Q., Zhu Y.X., Che L., Shen Q.Y., Zhang J.X., et al. Oligoamines conjugated chitosan derivatives: synthesis, characterization, in vitro and in vivo biocompatibility evaluations. Carbohydr Polym 2011, 83:1153-1161.
    • (2011) Carbohydr Polym , vol.83 , pp. 1153-1161
    • Jia, Y.1    Hu, Y.Q.2    Zhu, Y.X.3    Che, L.4    Shen, Q.Y.5    Zhang, J.X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.