-
1
-
-
0003964361
-
-
American Cancer Society American Cancer Society Atlanta
-
American Cancer Society (2007) Cancer facts and figures 2007. American Cancer Society, Atlanta
-
(2007)
Cancer Facts and Figures 2007
-
-
-
2
-
-
69349104224
-
WHO histological classification of tumours of the lung
-
World Health Organization (eds) IARC Lyon
-
World Health Organization (2004) WHO histological classification of tumours of the lung. In: Travis WB, Brambilla A, Muller-Hermelinck HK, Harris CC (eds) World Health Organization classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart. IARC, Lyon, p 10
-
(2004)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart
, pp. 10
-
-
Travis, W.B.1
Brambilla, A.2
Muller-Hermelinck, H.K.3
Harris, C.C.4
-
3
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
18506025 10.1200/JCO.2007.15.0375 1:CAS:528:DC%2BD1cXpvVWmtLg%3D
-
Scagliotti GV, Parikh P, von Pawel J et al (2008) Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26:3543-3551
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
Von Pawel, J.3
-
4
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
17167137 10.1056/NEJMoa061884 1:CAS:528:DC%2BD28XhtlWqsbzI
-
Sandler A, Gray R, Perry MC et al (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542-2550
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
5
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
-
10.1016/S1470-2045(10)70112-1
-
Cappuzzo F, Ciuleanu T, Stelmakh L et al (2006) Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11:521-529
-
(2006)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
-
6
-
-
33748435058
-
DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
-
16957145 10.1056/NEJMoa060570 1:CAS:528:DC%2BD28XpsFKmtLw%3D
-
Olaussen KA, Dunant A, Fouret P et al (2006) DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med 355:983-991
-
(2006)
N Engl J Med
, vol.355
, pp. 983-991
-
-
Olaussen, K.A.1
Dunant, A.2
Fouret, P.3
-
7
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
17982442 10.1038/nature06358 1:CAS:528:DC%2BD2sXhtl2gsbvM
-
Weir BA, Woo MS, Getz G et al (2007) Characterizing the cancer genome in lung adenocarcinoma. Nature 450:893-898
-
(2007)
Nature
, vol.450
, pp. 893-898
-
-
Weir, B.A.1
Woo, M.S.2
Getz, G.3
-
8
-
-
46249096082
-
Lung adenocarcinoma: Modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis
-
18391747 10.1097/PAS.0b013e31815cb162
-
Motoi N, Szoke J, Riely GJ et al (2008) Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surg Pathol 32:810-827
-
(2008)
Am J Surg Pathol
, vol.32
, pp. 810-827
-
-
Motoi, N.1
Szoke, J.2
Riely, G.J.3
-
9
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
18948947 10.1038/nature07423 1:CAS:528:DC%2BD1cXht1yju73J
-
Ding L, Getz G, Wheeler DA et al (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455:1069-1075
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
-
10
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
The Cancer Genome Atlas Research Network 10.1038/nature11404
-
The Cancer Genome Atlas Research Network (2012) Comprehensive genomic characterization of squamous cell lung cancers. Nature 489:519-525
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
-
11
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
18083107 10.1016/j.cell.2007.11.025 1:CAS:528:DC%2BD1cXksFGnsQ%3D%3D
-
Rikova K, Guo A, Zeng Q et al (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190-1203
-
(2007)
Cell
, vol.131
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
12
-
-
79251490374
-
New driver mutations in non-small-cell lung cancer
-
21277552 10.1016/S1470-2045(10)70087-5 1:CAS:528:DC%2BC3MXht12ns74%3D
-
Pao W, Girard N (2011) New driver mutations in non-small-cell lung cancer. Lancet Oncol 12:175-180
-
(2011)
Lancet Oncol
, vol.12
, pp. 175-180
-
-
Pao, W.1
Girard, N.2
-
13
-
-
4644274700
-
Mutations and addiction to EGFR: The Achilles "heal" of lung cancers?
-
15464447 10.1016/j.molmed.2004.08.008 1:CAS:528:DC%2BD2cXotF2is78%3D
-
Gazdar AF, Shigematsu H, Herz J et al (2004) Mutations and addiction to EGFR: the Achilles "heal" of lung cancers? Trends Mol Med 10:481-486
-
(2004)
Trends Mol Med
, vol.10
, pp. 481-486
-
-
Gazdar, A.F.1
Shigematsu, H.2
Herz, J.3
-
14
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
-
22954507 10.1016/S1470-2045(12)70344-3 1:CAS:528:DC%2BC38XhsVCjsb3E
-
Camidge DR, Bang YJ, Kwak EL et al (2012) Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 13:1011-1019
-
(2012)
Lancet Oncol
, vol.13
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
-
15
-
-
84872569905
-
Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive non-small cell lung cancer (NSCLC) (PROFILE 1007)
-
Abstract: LBA-1
-
Shaw AT, Kim DW, Nakagawa K, et al (2012) Phase III study of crizotinib versus pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive non-small cell lung cancer (NSCLC) (PROFILE 1007). European Society for Medical Oncology. Abstract: LBA-1
-
(2012)
European Society for Medical Oncology
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
16
-
-
84864450130
-
Tumour molecular profiling for deciding therapy - The French initiative
-
22777058 10.1038/nrclinonc.2012.42 1:CAS:528:DC%2BC38XhtFansrnJ
-
Nowak F, Soria JC, Calvo F (2012) Tumour molecular profiling for deciding therapy - the French initiative. Nat Rev Clin Oncol 9:479-486
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 479-486
-
-
Nowak, F.1
Soria, J.C.2
Calvo, F.3
-
17
-
-
74949133978
-
American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer
-
19917871 10.1200/JCO.2009.23.5622 1:CAS:528:DC%2BC3cXht1agsbs%3D
-
Azzoli CG, Baker S Jr, Temin S et al (2009) American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol 27:6251-6626
-
(2009)
J Clin Oncol
, vol.27
, pp. 6251-6626
-
-
Azzoli, C.G.1
Baker, Jr.S.2
Temin, S.3
-
18
-
-
78650451788
-
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
-
21160078 10.1126/scitranslmed.3001451 1:CAS:528:DC%2BC3MXhsFWisLc%3D
-
Weiss J, Sos ML, Seidel D et al (2010) Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med 2:62ra93
-
(2010)
Sci Transl Med
, vol.2
-
-
Weiss, J.1
Sos, M.L.2
Seidel, D.3
-
19
-
-
84871527692
-
Abstract LB-122: A phase i dose escalation study of NVP-BGJ398, a selective pan FGFR inhibitor in genetically preselected advanced solid tumors
-
doi: 10.1158/1538-7445.AM2012-LB-122
-
Wolf J, LoRusso PM, Camidge RD, et al (2012) Abstract LB-122: A phase I dose escalation study of NVP-BGJ398, a selective pan FGFR inhibitor in genetically preselected advanced solid tumors. Cancer Research 72. doi: 10.1158/1538-7445.AM2012-LB-122
-
(2012)
Cancer Research
, vol.72
-
-
Wolf, J.1
Lorusso, P.M.2
Camidge, R.D.3
-
20
-
-
84866709500
-
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
-
22328973 10.1158/2159-8274.CD-11-0005 1:CAS:528:DC%2BC3MXpsVylsbg%3D
-
Hammerman PS, Sos ML, Ramos AH et al (2011) Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov 1:78-89
-
(2011)
Cancer Discov
, vol.1
, pp. 78-89
-
-
Hammerman, P.S.1
Sos, M.L.2
Ramos, A.H.3
-
21
-
-
61549138135
-
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
-
19096300 10.1097/JTO.0b013e3181913e0e
-
Onozato R, Kosaka T, Kuwano H et al (2009) Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol 4:5-11
-
(2009)
J Thorac Oncol
, vol.4
, pp. 5-11
-
-
Onozato, R.1
Kosaka, T.2
Kuwano, H.3
-
22
-
-
41749097250
-
MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort
-
18379349 10.1097/JTO.0b013e318168d9d4
-
Beau-Faller M, Ruppert AM, Voegeli AC et al (2008) MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort. J Thorac Oncol 3:331-339
-
(2008)
J Thorac Oncol
, vol.3
, pp. 331-339
-
-
Beau-Faller, M.1
Ruppert, A.M.2
Voegeli, A.C.3
-
23
-
-
63849163410
-
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
-
19255323 10.1200/JCO.2008.19.1635
-
Cappuzzo F, Marchetti A, Skokan M et al (2009) Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 27:1667-1674
-
(2009)
J Clin Oncol
, vol.27
, pp. 1667-1674
-
-
Cappuzzo, F.1
Marchetti, A.2
Skokan, M.3
-
24
-
-
0032533495
-
C-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype
-
9823327 1:CAS:528:DyaK1cXnsFSmtLs%3D
-
Otsuka T, Takayama H, Sharp R et al (1998) c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res 58:5157-5167
-
(1998)
Cancer Res
, vol.58
, pp. 5157-5167
-
-
Otsuka, T.1
Takayama, H.2
Sharp, R.3
-
25
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of MET in lung cancer
-
16397241 10.1158/0008-5472.CAN-05-2749 1:CAS:528:DC%2BD28XhsFWgtQ%3D%3D
-
Kong-Beltran M, Seshagiri S, Zha J et al (2006) Somatic mutations lead to an oncogenic deletion of MET in lung cancer. Cancer Res 66:283-289
-
(2006)
Cancer Res
, vol.66
, pp. 283-289
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
-
26
-
-
65249122512
-
Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
-
19318488 10.1158/1078-0432.CCR-08-1306 1:CAS:528:DC%2BD1MXjvVWltrY%3D
-
Eder JP, Vande Woude GF, Boerner SA, LoRusso PM (2009) Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 15:2207-2214
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2207-2214
-
-
Eder, J.P.1
Vande Woude, G.F.2
Boerner, S.A.3
Lorusso, P.M.4
-
27
-
-
84874938826
-
Final efficacy results from a randomized phase II study (OAM4558g) evaluating Met Mab or placebo in combination with erlotinib in advanced NSCLC
-
Spigel D, Ervin T, Ramlau R et al (2011) Final efficacy results from a randomized phase II study (OAM4558g) evaluating Met Mab or placebo in combination with erlotinib in advanced NSCLC. J Thorac Oncol 6:S359
-
(2011)
J Thorac Oncol
, vol.6
, pp. 359
-
-
Spigel, D.1
Ervin, T.2
Ramlau, R.3
-
28
-
-
84865506979
-
Rationale and design of MARQUEE: A phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer
-
10.1016/j.cllc.2012.01.003 1:CAS:528:DC%2BC38Xht1GktrrF
-
Scagliotti GV, Novello S, Schiller JH et al (2012) Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer. Clin Lung Canc 13:391-395
-
(2012)
Clin Lung Canc
, vol.13
, pp. 391-395
-
-
Scagliotti, G.V.1
Novello, S.2
Schiller, J.H.3
-
29
-
-
0022399581
-
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
-
2999974 10.1126/science.2999974 1:CAS:528:DyaL28XmslKhuw%3D%3D
-
Coussens L, Yang-Feng TL, Liao YC et al (1985) Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230:1132-1139
-
(1985)
Science
, vol.230
, pp. 1132-1139
-
-
Coussens, L.1
Yang-Feng, T.L.2
Liao, Y.C.3
-
30
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
15457249 10.1038/431525b 1:CAS:528:DC%2BD2cXnvFCntLg%3D
-
Stephens P, Hunter C, Bignell G et al (2004) Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 431:525-526
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
-
31
-
-
1242341493
-
The role of HER2/neu expression and trastuzumab in non-small cell lung cancer
-
14981584 10.1053/j.seminoncol.2003.12.018 1:CAS:528:DC%2BD2cXisFelsbY%3D
-
Hirsch FR, Langer CJ (2004) The role of HER2/neu expression and trastuzumab in non-small cell lung cancer. Semin Oncol 31:75-82
-
(2004)
Semin Oncol
, vol.31
, pp. 75-82
-
-
Hirsch, F.R.1
Langer, C.J.2
-
32
-
-
84866360342
-
Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
-
22761469 10.1158/1078-0432.CCR-12-0912 1:CAS:528:DC%2BC38Xhtl2lt7%2FM
-
Arcila ME, Chaft JE, Nafa K et al (2012) Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res 18:4910-4918
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4910-4918
-
-
Arcila, M.E.1
Chaft, J.E.2
Nafa, K.3
-
33
-
-
58849132314
-
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy
-
19122144 10.1073/pnas.0808930106 1:CAS:528:DC%2BD1MXhtVGktrw%3D
-
Perera SA, Li D, Shimamura T, Raso MG et al (2009) HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci U S A 106:474-479
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 474-479
-
-
Perera, S.A.1
Li, D.2
Shimamura, T.3
Raso, M.G.4
-
34
-
-
84858002759
-
Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
-
22325357 10.1016/j.lungcan.2012.01.008
-
De Grève J, Teugels E, Geers C et al (2012) Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer 76:123-127
-
(2012)
Lung Cancer
, vol.76
, pp. 123-127
-
-
De Grève, J.1
Teugels, E.2
Geers, C.3
-
35
-
-
84877600056
-
Lung cancer harboring HER2 mutation: Epidemiological characteristics and therapeutic perspectives
-
Abstract: 1232PD
-
Mazieres J, Peters S, Cortot A, et al (2011) Lung cancer harboring HER2 mutation: epidemiological characteristics and therapeutic perspectives. European Society for Medical Oncology. Abstract: 1232PD
-
(2011)
European Society for Medical Oncology
-
-
Mazieres, J.1
Peters, S.2
Cortot, A.3
-
36
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
2547513 1:CAS:528:DyaL1MXltlWksL4%3D
-
Bos JL (1989) Ras oncogenes in human cancer: a review. Cancer Res 49:4682-4689
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
37
-
-
53249145767
-
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
-
18794081 10.1158/1078-0432.CCR-08-0646 1:CAS:528:DC%2BD1cXhtFaitrrK
-
Riely GJ, Kris MG, Rosenbaum D et al (2008) Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 14:5731-5734
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5731-5734
-
-
Riely, G.J.1
Kris, M.G.2
Rosenbaum, D.3
-
38
-
-
64249109679
-
EGFR and KRAS mutations in patients with adenocarcinoma of the lung
-
10.3904/kjim.2009.24.1.48
-
Jang TW, Oak CH, Chang HK et al (2009) EGFR and KRAS mutations in patients with adenocarcinoma of the lung. Kor J Intern Med 24:48-54
-
(2009)
Kor J Intern Med
, vol.24
, pp. 48-54
-
-
Jang, T.W.1
Oak, C.H.2
Chang, H.K.3
-
39
-
-
0035893318
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
-
11751631 10.1101/gad.947701 1:CAS:528:DC%2BD38XivFyktA%3D%3D
-
Fisher GH, Wellen SL, Klimstra D et al (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 15:3249-3262
-
(2001)
Genes Dev
, vol.15
, pp. 3249-3262
-
-
Fisher, G.H.1
Wellen, S.L.2
Klimstra, D.3
-
40
-
-
0038362742
-
Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer
-
12721252 10.1200/JCO.2003.09.075 1:CAS:528:DC%2BD2cXpsVWqtr0%3D
-
Adjei AA, Mauer A, Bruzek L et al (2003) Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer. J Clin Oncol 21:1760-1766
-
(2003)
J Clin Oncol
, vol.21
, pp. 1760-1766
-
-
Adjei, A.A.1
Mauer, A.2
Bruzek, L.3
-
41
-
-
84874000882
-
A phase II study of sorafenib in patients with locally advanced and/or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) with a K-Ras mutation
-
Abstract: LBA-27
-
Dingemans AM, Mellema WW, Groen HJM, et al (2011) A phase II study of sorafenib in patients with locally advanced and/or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) with a K-Ras mutation. European Society for Medical Oncology. Abstract: LBA-27
-
(2011)
European Society for Medical Oncology
-
-
Dingemans, A.M.1
Mellema, W.W.2
Hjm, G.3
-
42
-
-
84874932973
-
Association between tumor EGFR and KRAS mutation status and clinical outcomes in NSCLC patients randomized to sorafenib plus best supportive care (BSC) or BSC alone: Subanalysis of the phase III MISSION trial
-
Abstract: LBA9-PR
-
Mok TSK, Paz-Ares L, Wu YL, et al (2012) Association between tumor EGFR and KRAS mutation status and clinical outcomes in NSCLC patients randomized to sorafenib plus best supportive care (BSC) or BSC alone: subanalysis of the phase III MISSION trial. European Society for Medical Oncology. Abstract: LBA9-PR
-
(2012)
European Society for Medical Oncology
-
-
Tsk, M.1
Paz-Ares, L.2
Wu, Y.L.3
-
43
-
-
84874935059
-
Efficacy and patient (pt)-reported outcomes with selumetinib (AZD6244, ARRY-142866; Sel) + docetaxel (doc) in KRAS-mutant advanced non-small cell lung cancer (NSCLC): A randomized, phase II trial
-
Abstract: 1233PD
-
Janne PA, Shaw AT, Rodrigues Pereira J, et al. (2012) Efficacy and patient (pt)-reported outcomes with selumetinib (AZD6244, ARRY-142866; sel) + docetaxel (doc) in KRAS-mutant advanced non-small cell lung cancer (NSCLC): a randomized, phase II trial. European Society for Medical Oncology. Abstract: 1233PD
-
(2012)
European Society for Medical Oncology
-
-
Janne, P.A.1
Shaw, A.T.2
Rodrigues Pereira, J.3
-
44
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
19029981 10.1038/nm.1890 1:CAS:528:DC%2BD1cXhsVWhu7rI
-
Engelman JA, Chen L, Tan X et al (2008) Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 14:1351-1356
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
-
45
-
-
0032472913
-
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
-
9450999 10.1093/emboj/17.3.743 1:CAS:528:DyaK1cXht1Wgsrs%3D
-
Jimenez C, Jones DR, Rodríguez-Viciana P et al (1998) Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. EMBO J 17:743-753
-
(1998)
EMBO J
, vol.17
, pp. 743-753
-
-
Jimenez, C.1
Jones, D.R.2
Rodríguez-Viciana, P.3
-
46
-
-
11144358645
-
High frequency of mutations of the PIK3CAgene in human cancers
-
15016963 10.1126/science.1096502 1:CAS:528:DC%2BD2cXjsVGmsbk%3D
-
Samuels Y, Wang Z, Bardelli A et al (2004) High frequency of mutations of the PIK3CAgene in human cancers. Science 304:554
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
47
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
16930767 10.1016/j.lungcan.2006.07.006
-
Kawano O, Sasaki H, Endo K et al (2006) PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 54:209-215
-
(2006)
Lung Cancer
, vol.54
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
-
48
-
-
21144457217
-
Functional analysis of PIK3CA gene mutations in human colorectal cancer
-
15930273 10.1158/0008-5472.CAN-04-4114 1:CAS:528:DC%2BD2MXks1Oht7c%3D
-
Ikenoue T, Kanai F, Hikiba Y et al (2005) Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 65:4562-4567
-
(2005)
Cancer Res
, vol.65
, pp. 4562-4567
-
-
Ikenoue, T.1
Kanai, F.2
Hikiba, Y.3
-
49
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
11572954 10.1073/pnas.211430998 1:CAS:528:DC%2BD3MXnt1yqsrY%3D
-
Testa JR, Bellacosa A (2001) AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98:10983-10985
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
50
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
17611497 10.1038/nature05933 1:CAS:528:DC%2BD2sXotFajtbk%3D
-
Carpten JD, Faber AL, Horn C et al (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448:439-444
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
-
51
-
-
34547469939
-
Raf kinases: Function, regulation and role in human cancer
-
17555829 10.1016/j.bbamcr.2007.05.001 1:CAS:528:DC%2BD2sXosFyksb8%3D
-
Leicht DT, Balan V, Kaplun A et al (2007) Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta 1773:1196-1212
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1196-1212
-
-
Leicht, D.T.1
Balan, V.2
Kaplun, A.3
-
52
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
12068308 10.1038/nature00766 1:CAS:528:DC%2BD38XkvVagsLo%3D
-
Davies H, Bignell GR, Cox C et al (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
53
-
-
33646791858
-
Uncommon V599E BRAF mutations in Japanese patients with lung cancer
-
16376942 10.1016/j.jss.2005.10.022 1:CAS:528:DC%2BD28XkvVGjurY%3D
-
Sasaki H, Kawano O, Endo K et al (2006) Uncommon V599E BRAF mutations in Japanese patients with lung cancer. J Surg Res 133:203-206
-
(2006)
J Surg Res
, vol.133
, pp. 203-206
-
-
Sasaki, H.1
Kawano, O.2
Endo, K.3
-
54
-
-
79956316170
-
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
-
21483012 10.1200/JCO.2010.33.1280
-
Paik PK, Arcila ME, Fara M et al (2011) Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 29:2046-2051
-
(2011)
J Clin Oncol
, vol.29
, pp. 2046-2051
-
-
Paik, P.K.1
Arcila, M.E.2
Fara, M.3
-
55
-
-
80053014471
-
Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
-
21825258 10.1200/JCO.2011.35.9638 1:CAS:528:DC%2BC3MXhtlWqsLrJ
-
Marchetti A, Felicioni L, Malatesta S et al (2011) Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J Clin Oncol 29:3574-3579
-
(2011)
J Clin Oncol
, vol.29
, pp. 3574-3579
-
-
Marchetti, A.1
Felicioni, L.2
Malatesta, S.3
-
56
-
-
84861740806
-
Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib
-
22649091 10.1126/scitranslmed.3003513 1:CAS:528:DC%2BC38Xhs12rtbbF
-
Sen B, Peng S, Tang X et al (2012) Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. Sci Transl Med 4:136ra70
-
(2012)
Sci Transl Med
, vol.4
-
-
Sen, B.1
Peng, S.2
Tang, X.3
-
57
-
-
63549123584
-
Carboplatin/paclitaxel with/without sorafenib in chemonaive patients with stage IIIb-IV non-small cell lung cancer: Interim analysis (IA) results from a randomized phase III trial (ESCAPE)
-
(Abstract 214)
-
Hanna NH, Pawel JV, Reck M, Scagliotti G (2008) Carboplatin/paclitaxel with/without sorafenib in chemonaive patients with stage IIIb-IV non-small cell lung cancer: interim analysis (IA) results from a randomized phase III trial (ESCAPE). J Thorac Oncol 3:S268 (Abstract 214)
-
(2008)
J Thorac Oncol
, vol.3
-
-
Hanna, N.H.1
Pawel, J.V.2
Reck, M.3
Scagliotti, G.4
-
58
-
-
84873680338
-
Monotherapy administration of sorafenib in patients with non-small cell lung cancer: Phase III, randomized, double-blind, placebo-controlled MISSION trial
-
Abstract: LBA33-PR
-
Paz-Ares L, Hirsh V, Zhang L, et al (2012) Monotherapy administration of sorafenib in patients with non-small cell lung cancer: phase III, randomized, double-blind, placebo-controlled MISSION trial. European Society for Medical Oncology. Abstract: LBA33-PR
-
(2012)
European Society for Medical Oncology
-
-
Paz-Ares, L.1
Hirsh, V.2
Zhang, L.3
-
59
-
-
0026754369
-
Activation of the MAP kinase pathway by the protein kinase RAF
-
1330321 10.1016/0092-8674(92)90361-F 1:CAS:528:DyaK3sXht1Wlsbs%3D
-
Howe LR, Leevers SJ, Gómez N et al (1992) Activation of the MAP kinase pathway by the protein kinase RAF. Cell 71:335-342
-
(1992)
Cell
, vol.71
, pp. 335-342
-
-
Howe, L.R.1
Leevers, S.J.2
Gómez, N.3
-
60
-
-
48649107410
-
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
-
18632602 10.1158/0008-5472.CAN-08-0099 1:CAS:528:DC%2BD1cXovVCgurs%3D
-
Marks JL, Gong Y, Chitale D et al (2008) Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Cancer Res 68:5524-5528
-
(2008)
Cancer Res
, vol.68
, pp. 5524-5528
-
-
Marks, J.L.1
Gong, Y.2
Chitale, D.3
-
61
-
-
84863338079
-
ROS1 rearrangements define a unique molecular class of lung cancers
-
22215748 10.1200/JCO.2011.35.6345 1:CAS:528:DC%2BC38XntV2lsbg%3D
-
Bergethon K, Shaw AT, Ou SH et al (2012) ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 30:863-870
-
(2012)
J Clin Oncol
, vol.30
, pp. 863-870
-
-
Bergethon, K.1
Shaw, A.T.2
Ou, S.H.3
-
62
-
-
84865091460
-
Zeroing in on ROS1 rearrangements in non-small cell lung cancer
-
22859716 10.1158/1078-0432.CCR-12-1812 1:CAS:528:DC%2BC38Xht1ajs7bN
-
Stumpfova M, Jänne PA (2012) Zeroing in on ROS1 rearrangements in non-small cell lung cancer. Clin Cancer Res 18:4222-4224
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4222-4224
-
-
Stumpfova, M.1
Jänne, P.A.2
-
63
-
-
84865089246
-
Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion
-
22661537 10.1158/1078-0432.CCR-11-3351 1:CAS:528:DC%2BC38Xht1ajsL7P
-
Rimkunas VM, Crosby KE, Li D et al (2012) Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res 18:4449-4457
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4449-4457
-
-
Rimkunas, V.M.1
Crosby, K.E.2
Li, D.3
-
64
-
-
84865092224
-
Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement
-
(Abstract: 7508)
-
Shaw AT, Camidge DR, Engelman JA, et al (2012) Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement. J Clin Oncol 30 (Abstract: 7508)
-
(2012)
J Clin Oncol
, vol.30
-
-
Shaw, A.T.1
Camidge, D.R.2
Engelman, J.A.3
-
65
-
-
0028009192
-
Ret protooncogene and human-diseases - Review
-
21566893 1:CAS:528:DyaK2cXivFGhtbo%3D
-
Takahashi M (1994) Ret protooncogene and human-diseases - review. Int J Oncol 4:81-84
-
(1994)
Int J Oncol
, vol.4
, pp. 81-84
-
-
Takahashi, M.1
-
66
-
-
84857929267
-
KIF5B-RET fusions in lung adenocarcinoma
-
22327624 10.1038/nm.2644 1:CAS:528:DC%2BC38XitFaltb8%3D
-
Kohno T, Ichikawa H, Totoki Y et al (2012) KIF5B-RET fusions in lung adenocarcinoma. Nat Med 18:375-377
-
(2012)
Nat Med
, vol.18
, pp. 375-377
-
-
Kohno, T.1
Ichikawa, H.2
Totoki, Y.3
-
67
-
-
84862776857
-
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
-
22327622 10.1038/nm.2673 1:CAS:528:DC%2BC38XitFalsbk%3D
-
Lipson D, Capelletti M, Yelensky R et al (2012) Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med 18:382-384
-
(2012)
Nat Med
, vol.18
, pp. 382-384
-
-
Lipson, D.1
Capelletti, M.2
Yelensky, R.3
-
68
-
-
84868309107
-
The transcriptional landscape and mutational profile of lung adenocarcinoma
-
doi: 10.1101/gr.145144.112
-
Seo JS, Ju YS, Lee WC et al (2012) The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res. doi: 10.1101/gr.145144. 112
-
(2012)
Genome Res.
-
-
Seo, J.S.1
Ju, Y.S.2
Lee, W.C.3
-
69
-
-
84863230117
-
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing
-
22194472 10.1101/gr.133645.111 1:CAS:528:DC%2BC38XjsV2lsLk%3D
-
Ju YS, Lee WC, Shin JY et al (2012) A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res 22:436-445
-
(2012)
Genome Res
, vol.22
, pp. 436-445
-
-
Ju, Y.S.1
Lee, W.C.2
Shin, J.Y.3
-
70
-
-
0037838562
-
Value of immunohistochemical markers in preinvasive bronchial lesions in risk assessment of lung cancer
-
12796386 1:CAS:528:DC%2BD3sXksVWqu7g%3D
-
Jeanmart M, Lantuejoul S, Fievet F et al (2003) Value of immunohistochemical markers in preinvasive bronchial lesions in risk assessment of lung cancer. Clin Cancer Res 9:2195-2203
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2195-2203
-
-
Jeanmart, M.1
Lantuejoul, S.2
Fievet, F.3
-
71
-
-
74949110711
-
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
-
19949011 10.1200/JCO.2009.24.7049 1:CAS:528:DC%2BC3cXjtVSqtb8%3D
-
Jackman D, Pao W, Riely GJ et al (2010) Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol 28:357-360
-
(2010)
J Clin Oncol
, vol.28
, pp. 357-360
-
-
Jackman, D.1
Pao, W.2
Riely, G.J.3
-
72
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
21430269 10.1126/scitranslmed.3002003
-
Sequist LV, Waltman BA, Dias-Santagata D et al (2011) Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 3:75ra26
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
73
-
-
79952711946
-
Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: Distinct natural history of patients with tumors harboring the T790M mutation
-
21135146 10.1158/1078-0432.CCR-10-2692 1:CAS:528:DC%2BC3MXjtFCht7s%3D
-
Oxnard GR, Arcila ME, Sima CS et al (2011) Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clin Cancer Res 17:1616-1622
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1616-1622
-
-
Oxnard, G.R.1
Arcila, M.E.2
Sima, C.S.3
-
74
-
-
34547625913
-
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
-
17671201 10.1158/0008-5472.CAN-06-4625 1:CAS:528:DC%2BD2sXosVemt7o%3D
-
Godin-Heymann N, Bryant I, Rivera MN et al (2007) Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation. Cancer Res 67:7319-7326
-
(2007)
Cancer Res
, vol.67
, pp. 7319-7326
-
-
Godin-Heymann, N.1
Bryant, I.2
Rivera, M.N.3
-
75
-
-
75349110926
-
Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
-
20026433 10.1016/j.bbapap.2009.12.010 1:CAS:528:DC%2BC3cXhs1ymsrs%3D
-
Eck MJ, Yun CH (2010) Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer. Biochim Biophys Acta 1804:559-566
-
(2010)
Biochim Biophys Acta
, vol.1804
, pp. 559-566
-
-
Eck, M.J.1
Yun, C.H.2
-
76
-
-
47949114668
-
Detection of mutations in EGFR in circulating lung-cancer cells
-
18596266 10.1056/NEJMoa0800668 1:CAS:528:DC%2BD1cXovFSqtbc%3D
-
Maheswaran S, Sequist LV, Nagrath S et al (2008) Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 359:366-377
-
(2008)
N Engl J Med
, vol.359
, pp. 366-377
-
-
Maheswaran, S.1
Sequist, L.V.2
Nagrath, S.3
-
77
-
-
84874944290
-
Resistance to EGFR T790M kinase inhibitors through a multistep process involving the IGF1R pathway
-
Abstract: O27.01
-
Cortot AB, Repellin CE, Shimamura T, et al (2011) Resistance to EGFR T790M kinase inhibitors through a multistep process involving the IGF1R pathway. World Conference on Lung Cancer. Abstract: O27.01
-
(2011)
World Conference on Lung Cancer
-
-
Cortot, A.B.1
Repellin, C.E.2
Shimamura, T.3
-
78
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
18093943 10.1073/pnas.0710370104 1:CAS:528:DC%2BD1cXktlyhsg%3D%3D
-
Bean J, Brennan C, Shih JY et al (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104:20932-20937
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
79
-
-
80052441453
-
Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
-
Abstract: 7525
-
Janjigian YY, Groen HJ, Horn L, et al (2011) Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol 29. Abstract: 7525
-
(2011)
J Clin Oncol
, vol.29
-
-
Janjigian, Y.Y.1
Groen, H.J.2
Horn, L.3
-
80
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
22235099 10.1158/1078-0432.CCR-11-2906 1:CAS:528:DC%2BC38Xjt1Wksro%3D
-
Doebele RC, Pilling AB, Aisner DL et al (2012) Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res 18:1472-1482
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
81
-
-
84878358097
-
Phase II activity of the HSP90 inhibitor AUY922 in patients with ALK-rearranged (ALK+) or EGFR-mutated advanced non-small cell lung cancer (NSCLC)
-
Abstract: 438O
-
Felip E, Carcereny E, Barlesi F, et al (2012) Phase II activity of the HSP90 inhibitor AUY922 in patients with ALK-rearranged (ALK+) or EGFR-mutated advanced non-small cell lung cancer (NSCLC). European Society for Medical Oncology. Abstract: 438O
-
(2012)
European Society for Medical Oncology
-
-
Felip, E.1
Carcereny, E.2
Barlesi, F.3
-
82
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
21376230 10.1016/j.cell.2011.02.013 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
-
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
83
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
22980976 10.1016/j.cell.2012.08.024 1:CAS:528:DC%2BC38XhtlKrtr7I
-
Govindan R, Ding L, Griffith M et al (2012) Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150:1121-1134
-
(2012)
Cell
, vol.150
, pp. 1121-1134
-
-
Govindan, R.1
Ding, L.2
Griffith, M.3
-
84
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
12091876 1:CAS:528:DC%2BD38Xls12msLo%3D
-
Dong H, Strome SE, Salomao DR et al (2002) Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8:793-800
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
85
-
-
0032736029
-
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
-
10581077 10.1038/70932 1:CAS:528:DyaK1MXnvFCqt74%3D
-
Dong H, Zhu G, Tamada K, Chen L (1999) B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5:1365-1369
-
(1999)
Nat Med
, vol.5
, pp. 1365-1369
-
-
Dong, H.1
Zhu, G.2
Tamada, K.3
Chen, L.4
-
86
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
11015443 10.1084/jem.192.7.1027 1:CAS:528:DC%2BD3cXntFSlt7o%3D
-
Freeman GJ, Long AJ, Iwai Y et al (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192:1027-1034
-
(2000)
J Exp Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
87
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
22658128 10.1056/NEJMoa1200694 1:CAS:528:DC%2BC38XhtV2rsbnJ
-
Brahmer JR, Tykodi SS, Chow LQ et al (2012) Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366:2455-2465
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
88
-
-
77954899030
-
Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
20516446 10.1200/JCO.2009.26.7609 1:CAS:528:DC%2BC3cXpslajtLw%3D
-
Brahmer JR, Drake CG, Wollner I et al (2010) Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28:3167-3175
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
89
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
-
22547592 10.1200/JCO.2011.38.4032 1:CAS:528:DC%2BC38XhtVynsbvP
-
Lynch TJ, Bondarenko I, Luft A et al (2012) Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 30:2046-2054
-
(2012)
J Clin Oncol
, vol.30
, pp. 2046-2054
-
-
Lynch, T.J.1
Bondarenko, I.2
Luft, A.3
-
90
-
-
84866410479
-
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
-
22980975 10.1016/j.cell.2012.08.029 1:CAS:528:DC%2BC38XhtlKrsL7M
-
Imielinski M, Berger AH, Hammerman PS et al (2012) Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150:1107-20
-
(2012)
Cell
, vol.150
, pp. 1107-1120
-
-
Imielinski, M.1
Berger, A.H.2
Hammerman, P.S.3
|