Okadaic acid induces epileptic seizures and hyperphosphorylation of the NR2B subunit of the NMDA receptor in rat hippocampus in vivo

Experimental Neurology

Volumn 177, Issue 1, 2002, Pages 284-291

  Arias, Clorinda ^a   Montiel, Teresa ^a   Pea, Fernando ^a   Ferrera, Patricia ^a   Tapia, Ricardo ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Epilepsy; Hippocampus; Neurodegeneration; NMDA receptor phosphorylation; Okadaic acid; Protein phosphatases

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; DIZOCILPINE MALEATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE INHIBITOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EPILEPSY; HIPPOCAMPUS; IMMUNOBLOTTING; IN VIVO STUDY; LIMBIC SYSTEM; MALE; NERVE EXCITABILITY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SEIZURE;

EID: 0036434293     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.7988     Document Type: Article

References (38)

1. Arendt, T., M. Holzer, R. Fruth, M. K. Brückner, and U. Gärtner. 1995. Paired helical filament-like phosphorylation of tau, deposition of β/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A. Neuroscience 69: 691-698.
2. Arias, C., N. Sharma, P. Davies, and B. Shafit-Zagardo. 1993. Okadaic acid induces early changes in microtubule-associated protein 2 and tau phosphorylation prior to neurodegeneration in cultured cortical neurons. J. Neurochem. 61: 673-682.
3. Arias, C., F. Becerra-García, I. Arrieta, and R. Tapia. 1998. The protein phosphatase inhibitor okadaic acid induces heat-shock protein expression and neurodegeneration in rat hippocampus in vivo. Exp. Neurol. 153: 242-254.
4. Armstrong, J. N., J.-C. L. Plumier, H. A. Robertson, and R. W. Currie. 1996. The inducible 70,000 molecular/weight heat shock protein is expressed in degenerating dentate hilus and piriform cortex after systemic administration of kainic acid. Neuroscience 74: 685-693.
5. Ben-Ari, Y., L. Aniksztejn, and P. Bregestovski. 1992. Protein kinase C modulation of NMDA currents: An important link for LTP induction. Trends Neurosci. 15: 333-339.
6. Bialojan, C., and A. Takai. 1988. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases: Specificity and kinetics. Biochem. J. 256: 283-290.
7. Cerne, R., K. I. Rusin, and M. Randic. 1993. Enhancement of the N-methyl-D-aspartate response in spinal dorsal horn neurons by cAMP-dependent protein kinase. Neurosci. Lett. 161: 124-128.
8. Choi, D. W. 1988. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634.
9. Cohen, P., C. B. F. Holmes, and Y. Tsukitani. 1990. Okadaic acid: A new probe for the study of cellular regulation. Trends Biochem. Sci. 15: 98-102.
10. Fernández, M. T., V. Zitko, S. Gascón, A. Torreblanca, and A. Novelli. 1993. Neurotoxic effect of okadaic acid, a seafood-related toxin, on cultured cerebellar neurons. Ann. N. Y. Acad. Sci. 679: 260-269.
11. Greengard, P., J. Jen, A. C. Nairn, and C. F. Stevens. 1991. Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science 253: 1135-1138.
12. Holmes, C. F. B., H. A. Luu, F. Carrier, and F. J. Schmitz. 1990. Inhibition of protein phosphatases-1 and -2A with acanthifolicin. Comparison with diarrhetic shellfish toxins and identification of a region on okadaic acid important for phosphatase inhibition. FEBS Lett. 270: 216-218.
13. Kojima, N., H. Ishibashi, K. Obata, and E. R. Kandel. 1998. Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice. Learn. Memory 5: 429-445.
14. Leonard, A. S., and J. W. Hell. 1997. Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites. J. Biol. Chem. 272: 12107-12115.
15. 2+-dependent phosphatase. Nature 369: 235-239.
16. Meldrum, B. 1991. Excitotoxicity and epileptic brain damage. Epilepsy Res. 10: 55-61.
17. Meldrum, B. S. 1992. Excitatory amino acids in epilepsy and potential novel therapies. Epilepsy Res. 12: 189-196.
18. Monyer, H., R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N. Burnashev, B. Sakmann, and P. Seeburg. 1992. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science 256: 1217-1221.
19. Monyer, H., N. Burnashev, D. J. Laurie, B. Sakmann, and P. H. Seeburg. 1994. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540.
20. Mori, H., and M. Mishina. 1995. Structure and function of the NMDA receptor channel. Neuropharmacology 34: 1219-1237.
21. Paxinos, G., and C. Watson. 1982. The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
22. Peña, F., and R. Tapia. 2000. Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: Role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience 101: 547-561.
23. Raman, I. M., G. Tong, and C. E. Jahr. 1996. β-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase. Neuron 16: 415-421.
24. Raymond, L. A., C. D. Blackstone, and R. L. Huganir. 1993. Phosphorylation of amino acid neurotransmitter receptors in synaptic plasticity. Trends Neurosci. 16: 147-153.
25. Sacher, M., E. S. Athlan, and W. E. Mushynski. 1992. Okadaic acid induces the rapid and reversible disruption of the neurofilament network in rat dorsal root ganglion neurons. Biochem. Biophys. Res. Commun. 186: 524-530.
26. Shea, T. B., P. A. Paskevich, and M. L. Beermann. 1993. The protein phosphatase inhibitor okadaic acid increases axonal neurofilaments and neurite caliber, and decreases axonal microtubules in NB2a/d1 cells. J. Neurosci. Res. 35: 507-521.
27. Sloviter, R. S., and D. H. Lowenstein. 1992. Heat shock protein expression in vulnerable cells of the rat hippocampus as an indicator of excitation-induced neuronal stress. J. Neurosci. 12: 3004-3009.
28. r 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor. J. Neurosci. 18: 10297-10303.
29. Tachibana, K., P. J. Scheuer, Y. Tsukitani, H. Kikuchi, D. Van Engen, J. Clardy, Y. Gopichand, and J. Schmitz. 1981. Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Hallichondria. J. Am. Chem. Soc. 103: 2469-2471.
30. Tang, Y.-P., E. Shimizu, G. R. Dube, C. Rampon, G. A. Kerchner, M. Zhuo, G. Liu, and J. Z. Tsien. 1999. Genetic enhancement of learning and memory in mice. Nature 401: 63-69.
31. Tapia, R., L. Medina-Ceja, and F. Peña. 1999. On the relationship between extracellular glutamate, hyperexcitation and neurodegeneration, in vivo. Neurochem. Int. 34: 23-31.
32. Tapia, R., F. Peña, and C. Arias. 1999. Neurotoxic and synaptic effects of okadaic acid, an inhibitor of protein phosphatases. Neurochem. Res. 24: 1423-1430.
33. Wang, L.-Y., M. W. Salter, and J. F. MacDonald. 1991. Regulation of kainate receptors by CAMP-dependent protein kinase and phosphatases. Science 253: 1132-1135.
34. Wang, L.-Y., B. A. Orser, D. L. Brautigan, and J. F. MacDonald. 1994. Regulation of the NMDA receptors in cultured hippocampal neurons by protein phosphatase 1 and 2A. Nature 369: 230-232.
35. Westphal, R. S., S. J. Tavalin, J. W. Lin, N. M. Alto, I. D. C. Fraser, L. K. Langeberg, M. Sheng, and J. D. Scott. 1999. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285: 93-96.
36. 2+-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses. Neuron 13: 635-643.
37. Yoshida, M., N. Ohkoshi, and N. Tsuru. 1997. Effects of acute treatment and long-term treatment with MK-801 against amygdaloid kindled seizures in rats. Epilepsy Res. 26: 407-413.
38. Zhang, X., A. A. Boulton, and P. H. Yu. 1996. Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain. Eur. J. Neurosci. 8: 1432-1440.