Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease

Journal of Neural Transmission

Volumn 105, Issue 2-3, 1998, Pages 269-277

  Jimenez Jimenez F J ^a,c   Molina, J A ^b   Gomez P ^b   Vargas, C ^b   De Bustos, F ^b   Benito Leon J ^b   Tallon Barranco A ^a   Orti Pareja M ^a   Gasalla, T ^a   Arenas, J ^b  

^a HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c NONE   (Spain)

Author keywords

Alzheimer's disease; Aspartate; Cerebrospinal fluid; GABA; Glutamate; Glycine; Neurotransmitter amino acids; Plasma

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID; ASPARAGINE; ASPARTIC ACID; GLUTAMIC ACID; GLUTAMINE; GLYCINE; NEUROTRANSMITTER;

ADULT; AGED; ALZHEIMER DISEASE; AMINO ACID BLOOD LEVEL; ARTICLE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; HUMAN; ION EXCHANGE CHROMATOGRAPHY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL;

AGED; ALZHEIMER DISEASE; FEMALE; HUMANS; MALE; NEUROTRANSMITTER AGENTS; PSYCHIATRIC STATUS RATING SCALES;

EID: 7144257853     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050056     Document Type: Article

References (46)

1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (DSM-IV). American Psychiatric Press, Washington DC
2. Arai H, Kobayashi K, Ichimiya Y, Kosaka K, lizuka R (1984) A preliminary study of free amino acids in the postmortem temporal cortex from Alzheimer-type dementia patients. Neurobiol Aging 5: 319-321
3. Bareggi SR, Franceschi M, Bonini L, Zecca L, Smirne S (1982) Decreased CSF concentrations of homovanillic acid and gamma-amino-butyric acid in Alzheimer's disease. Arch Neurol 39: 709-712
4. Basun H, Forsell LG, Almkvist O, Cowburn RF, Eklöf R, Winblad B, Wetteberg L (1990) Amino acid concentrations in cerebrospinal fluid and plasma in Alzheimer's disease and healthy control subjects. J Neural Transm [PD Sect] 2: 295-304
5. Christiansen P, Schlosser A, Henriksen O (1995) Reduced N-acetylaspartate content in the frontal part of the brain in patients with probable Alzheimer's disease. Magn Reson Imaging 13: 457-462
6. Cooper JR, Bloom FE, Roth RH (1991) Amino acid transmitters. In: Cooper JR, Bloom FE, Roth RH (eds) The biochemical basis of the neuropharmacology, 6th ed. Oxford University Press, New York Oxford, pp 133-189
7. Csernansky JG, Bardgett ME, Sheline YI, Morris JC, Olney JW (1996) CSF excitatory amino acids and severity of illness in Alzheimer's disease. Neurology 46: 1715-1720
8. Degrell I, Hellsing K, Nagy E, Niklasson F (1989) Amino acid concentrations in cerebrospinal fluid in presenile and senile dementia of Alzheimer type and multi-infarct dementia. Arch Gerontol Geriatr 9: 123-135
9. DeLorey TM, Olsen RW (1994) GABA and glycine. In: Siegel GJ, Agranoff BW, Albers RW, Molinoff PB (eds) Basic neurochemistry: molecular, cellular, and medical aspects, Vth ed. Raven Press, New York, pp 389-399
10. Dewar D, Chalmers DT, Graham DI, McCulloch J (1991) Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus. Brain Res 553: 58-64
11. Dingledine R, McBain CJ (1994) Excitatory amino acid transmitters. In: Siegel GJ, Agranoff BW, Albers RW, Molinoff PB (eds) Basic neurochemistry: molecular, cellular, and medical aspects, Vth ed. Raven Press, New York, pp 367-387
12. Ferrarese C, Pecora N, Frigo M, Appollonio I, Frattola L (1993) Assessment of reliability and biological significance of glutamate levels in cerebrospinal fluid. Ann Neurol 33: 316-319
13. Ferraro TN, Hare TA (1985) Free and conjugated amino acids in human CSF: influence of age and sex. Brain Res 338: 53-60
14. Fisher GH, D'Aniello A, Vetere A, Cusano GP, Chávez M, Petrucelli L (1992) Quantification of D-aspartate in normal and Alzheimer brains. Neurosci Lett 143: 215-218
15. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-Mental State". A practical method for grading the cognitive state of patients for the clinician. J Psychiatry Res 12: 189-198
16. Gelot MA, Jeandel C, Belleville F, Nabet P, Penin F, Cuny G (1990) Acides amines du liquide cephalo-rachidien dans la maladie d'Alzheimer. Ann Biol Clin Paris 48: 182-184
17. Gjessing LR, Gjesdahl P, Dietrichson P, Presthus J (1974) Free amino acids in the cerebrospinal fluid in old age and in Parkinson's disease. Eur Neurol 12: 33-37
18. Hachinski VC, Ihift LD, Zilhka E, du Boulay GG, McAllister VL, Marshall J, Russell RW, Symov L (1975) Cerebral blood flow in dementia. Arch Neurol 32: 632-637
19. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62
20. Jaarsma D, Veenma-van-der-Duin L, Korf J (1994) N-acetylaspartyl-glutamate levels in Alzheimer's disease post-mortem brain tissue. J Neurol Sci 127: 230-233
21. Jiménez-Jiménez FJ, Molina JA, Vargas C, Gómez P, Navarro JA, Benito-León J, Ortí-Pareja M, Gasalla T, Cisneros E, Arenas J (1996) Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease. J Neurol Sci 141: 39-44
22. Klunk WE, Panchalingam K, Moossy J, McClure RJ, Pettegrew JW (1992) N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease: a preliminary proton nuclear magnetic resonance study. Neurology 42: 1578-1585
23. Kwo-on-Yuen PF, Newmark RD, Budinger TF, Kaye JA, Ball MJ, Jagust WJ (1994) Brain N-acetyl-L-aspartic acid in Alzheimer's disease: a proton magnetic resonance spectroscopy study. Brain Res 667: 167-174
24. Lowe SL, Bowden DM, Francis PT, Neary D (1990) Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease. Neuroscience 38: 571-577
25. Martínez M, Frank A, Díez-Tejedor E, Hernánz A (1993) Amino acid concentrations in cerebrospinal fluid and serum in Alzheimer's disease and vascular dementia. J Neural Transm [PD Sect] 6: 1-9
26. McKahnn G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34: 939-944
27. Miulli DE, Norwell BY, Schwartz FN (1993) Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease. J Am Osteopath Assoc 93: 670-676
28. Mochizuki Y, Oishi M, Hara M, Takasu T (1996) Amino acid concentration in dementia of the Alzheimer type and multi-infarct dementia. Ann Clin Lab Sci 26: 275-278
29. 1H nuclear magnetic resonance study of the temporoprietal cortex of Alzheimer brains. Exp Brain Res 102: 503-510
30. Moreu E, Molinero LM, Fernández E (1990) R-Sigma: Base de datos bioestadística para un ordenador personal. Horus Hardware. Madrid
31. Mountjoy CQ, Rossor MN, Iversen LL, Roth M (1984) Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. Brain 107: 507-518
32. Perry EK, Atack JR, Perry RH, Hardy JA, Dodd PR, Edwardson JA, Blessed G, Tomlimson BE, Fairbairn AF (1984) Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal. J Neurochem 42: 1402-1410
33. Perry TL, Yong VW, Bergeron C, Hansen S, Jones K (1987) Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease. Ann Neurol 21: 331-336
34. Perry TL, Krieger C, Hansen S, Eisen A (1990) Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid. Ann Neurol 28: 12-17
35. Pomara N, Deptula D, Galloway MP, LeWitt PA, Stanley M (1989) CSF GABA in caregiver spouses of Alzheimer patients. Am J Psychiatry 146: 787-788
36. Pomara N, Singh R, Deptula D, Chou JC, Schwartz MB, LeWitt PA (1992) Glutamate and other CSF amino acids in Alzheimer's disease. Am J Psychiatry 149: 251-254
37. Procter AW, Palmer AM, Francis PT, Lowe SL, Neary D, Murphy E, Doshi R, Bowen DM (1988) Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease. J Neurochem 50: 790-802
38. Rossor MN, Garrett NJ, Johnson AL, Mountjoy CQ, Roth M, Iversen LL (1982) A postmortem study of the cholinergic and GABA systems in senile dementia. Brain 105: 313-330
39. Sasaki H, Muramoto O, Kanazawa I, Arai H, Kosaka K, Iisurka R (1986) Regional distribution of amino acid neurotransmitters in postmortem brains of presenile and senile dementia of the Alzheimer type. Ann Neurol 19: 263-269
40. Schmitt L, Escande M, Gayral LF, Charlet JP, Thouvenot JP (1984) Anomalies des acides aminés du liquide céphalo-rachidien des démences séniles. J Psychiatr Biol Ther 16: 13-16
41. Shonk TK, Moats RA, Gifford P, Michaelis T, Mandigo JC, Izumi J, Ross BD (1995) Probable Alzheimer disease: diagnosis with proton MR spectroscopy. Radiology 195: 65-72
42. Smith CCT, Bowen DM, Francis PT, Snowden JS, Neary D (1985) Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's disease. J Neurol Neurosurg Psychiatry 47: 469-471
43. Sukava R, Haltia M, Paetau A, Wikstrom J, Palo J (1983) Accuracy of clinical diagnosis in primary degenerative dementia: correlation with neuropathological findings. J Neurol Neurosurg Psychiatry 46: 9-13
44. Tarbit I, Perry EK, Perry RH (1980) Hippocampal free amino acids in Alzheimer's disease. J Neurochem 35: 1246-1249
45. Tohgi H, Abe T, Takahashi S, Kimura M (1992) A selective reduction of excitatory amino acids in cerebrospinal fluid of patients with Alzheimer type dementia compared with vascular dementia of the Binswanger type. Neurosci Lett 141: 5-8
46. Walker V, Mills GA (1995) Quantitative methods for amino acid analysis in biological fluids. Ann Clin Biochem 32: 28-57