Genetic diversity of Toll-like receptor 5 among pig populations

Genetics and Molecular Biology

Volumn 36, Issue 1, 2013, Pages 37-42

  Yang, Xiuqin ^a   Li, Haitao ^a   Guan, Qingzhi ^a   Liu, Di ^b  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b HEILONGJIANG ACADEMY OF AGRICULTURAL SCIENCES   (China)

Author keywords

Haplotype; Porcine; SNPs; TLR5

Indexed keywords

AMINO ACID; FLAGELLIN; TOLL LIKE RECEPTOR 5;

ARTICLE; BREEDING LINE; CONTROLLED STUDY; GENE CLUSTER; GENE FREQUENCY; GENE SEQUENCE; GENETIC MARKER; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POPULATION GENETICS; PROTEIN DOMAIN; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE; TLR5 GENE;

EID: 84874896379     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572013005000004     Document Type: Article

References (37)

1. Akira S, Takeda K and Kaisho T (2001) Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol 2:675-680.
2. Andersen-Nissen E, Smith KD, Bonneau R, Strong RK and Aderem A (2007) A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. J Exp Med 204:393-403.
3. Barreiro LB, Ben-Ali M, Quach H, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, et al. (2009) Evolutionary dynamics of human toll-like receptors and their different contributions to host defense. PLoS Genetics 5:e1000562.
4. Bell JK, Mullen GE, Leifer CA, Mazzoni A, Davies DR and Segal DM (2003) Leucine-rich repeats and pathogen recognition in Toll-like receptors. Trends Immunol 24:528-533.
5. Chung W, Nam DH, Jo DJ and Lee JH (2011) Association of toll-like receptor 5 gene polymorphism with susceptibility to ossification of the posterior longitudinal ligament of the spine in korean population. J Korean Neurosurg Soc 49:8-12.
6. Cortazzo P, Cerveñansky C, Marín M, Reiss C, Ehrlich R and Deana A (2002) Silent mutations affect in vivo protein folding in Escherichia coli. Biochem Biophys Res Commun 293:537-541.
7. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J and Gejman PV (2003) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12:205-216.
8. Dunn PP, Hammond L, Coates E, Street J, Griner L and Darke C (2011) A "silent" nucleotide substitution in exon 4 is responsible for the "alternative expression" of HLA-A*01:01:38L through aberrant splicing. Hum Immunol 72:717-722.
9. Fay JC and Wu CI (2000) Hitchhiking under positive Darwinian selection. Genetics 155:1405-1413.
10. Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL and Cho JH (2006) Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Am J Physiol Gastrointest Liver Physiol 290:G1157-G1163.
11. Gupta SK, Majumdar S, Bhattacharya TK and Ghosh TC (2000) Studies on the relationships between the synonymous codon usage and protein secondary structural units. Biochem Biophys Res Commun 269:692-696.
12. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM and Aderem A (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-1103.
13. Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS and Laws RJ (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 198:1563-1572.
14. Hawn TR, Wu H, Grossman JM, Hahn BH, Tsao BP and Aderem A (2005) A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci USA 102:10593-10597.
15. Hawn TR, Scholes D, Li SS, Wang H, Yang Y, Roberts PL, Stapleton AE, Janer M, Aderem A, Stamm WE, et al. (2009) Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS One 4:e5990.
16. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmöller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, et al. (2000) Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 97:3473-3478.
17. Janeway Jr CA and Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197-216.
18. Johnson AD, Wang D and Sadee W (2005) Polymorphisms affecting gene regulation and mRNA processing: Broad implications for pharmacogenetics. Pharmacol Ther 106:19-38.
19. Kathrani A, House A, Catchpole B, Murphy A, German A and Werling D (2010) Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs. PLoS One 12:15740-15747.
20. Kimchi-Sarfaty C, Oh JM, Kim IW, Sauna ZE and Calcagno AM (2007) A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 315:525-528.
21. Komar AA (2007) Silent SNPs: Impact on gene function and phenotype. Pharmacogenomics 8:1075-1080.
22. Kryazhimskiy S and Plotkin JB (2008) The population genetics of dN/dS. PLoS Genetics 4:e1000304.
23. Matsushima N, Enkhbayar P, Kamiya M, Osaki M and Kretsinger RH (2005) Leucine-rich repeats (LRRs): Structure, function, evolution and interaction with ligands. Drug Des Rev 2:305-322.
24. Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K and Kuroki Y (2007) Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics 8:e124.
25. Medzhitov R and Janeway Jr C (2000) Innate immunity. N Engl J Med 343:338-344.
26. Medzhitov R, Preston-Hurlburt P and Janeway Jr CA (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-397.
27. Merx S, Zimmer W, Neumaier M and Ahmad-Nejad P (2006) Characterization and functional investigation of single nucleotide polymorphisms (SNPs) in the human TLR5 gene. Hum Mutat 27:293-299.
28. Muzio M, Polentarutti N, Bosisio D, Prahladan MK and Mantovani A (2000) Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J Leukoc Biol 67:450-456.
29. Nei M (1987) Molecular Evolutionary Genetics. Columbia University Press, New York, 512 pp.
30. Poltorak A, He X, Smirnoval I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282:2085-2088.
31. Sharp PM, Tuohy TM and Mosurski KR (1986) Codon usage in yeast: Cluster analysis clearly differentiates highly and lowly expressed genes. Nucleic Acids Res 14:5125-5143.
32. Tajima F (1989) Statistical-method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123:585-595.
33. Takeda K, Kaisho T and Akira S (2002) Toll-like receptors. Annu Rev Immunol 21:335-376.
34. Wang D, Johnson AD, Papp AC, Kroetz DL and Sadée W (2005) Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C > T affects mRNA stability. Pharmacogenet Genomics 15:693-704.
35. Wei T, Gong J, Rössle SC, Jamitzky F, Heckl WM and Stark RW (2011) A leucine-rich repeat assembly approach for homology modeling of the human TLR5-10 and mouse TLR11-13 ectodomains. J Mol Model 17:27-36.
36. Wlasiuk G, Khan S, Switzer WM and Nachman MW (2009) A history of recurrent positive selection at the toll-like receptor 5 in primates. Mol Biol Evol 26:937-949.
37. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA and Ghosh S (2004) A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303:1522-1526.