Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer

Human Gene Therapy

Volumn 9, Issue 5, 1998, Pages 707-718

  Putzer B M ^a   Bramson, J L ^a   Addison, C L ^a   Hitt, M ^a   Siegel, P M ^a   Muller, W J ^a   Graham, F L ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 2; PROTEIN P53; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST CANCER; CANCER THERAPY; CELL LINE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA SYNTHESIS; GENE OVEREXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; IMMUNE RESPONSE; IMMUNOMODULATION; INTRATUMORAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TUMOR CELL; TUMOR GROWTH; TUMOR REGRESSION;

ADENOVIRIDAE; ANIMALIA; HUMAN ADENOVIRUS TYPE 5; HUMAN HERPESVIRUS 5; MURINAE; MUS MUSCULUS;

EID: 0032549487     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.5-707     Document Type: Article

References (6)

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2. ADDISON, C.L., HITT, M., KUNSKEN, D., and GRAHAM, F.L. (1997). Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J. Gen. Virol. 78, 1653-1661.
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4. BACCHETTI, S., and GRAHAM, F.L. (1993). Inhibition of cell proliferation by an adenovirus vector expressing the human wild type p53 protein. Int. J. Oncol. 3, 781-788.
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