Is immune aging a cause of disease among the elderly, or is it a passive indicator of general decline of physiologic function?

Aging and Disease

Volumn 2, Issue 6, 2011, Pages 444-448

  Vallejo, Abbe N ^a,b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84874781544     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Note

References (48)

1. Girard TD, Ely EW (2007). Bacteremia and sepsis in older adults. Clin Geriatr Med, 23: 633-47.
2. Falsey AR (2007). Community-acquired viral pneumonia. Clin Geriatr Med, 23: 535-52.
3. Zhang HG, Grizzle WE (2003). Aging, immunity, and tumor susceptibility. Immunol Allergy Clin North Am, 23: 83-102.
4. Ramos-Casals M, Garcia-Carrasco M, Brito MP, Lopez-Soto A, Font J (2003). Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly. Lupus, 12: 341-55.
5. DePinho RA, Wong KK (2003). The age of cancer: telomeres, checkpoints, and longevity. J Clin Invest, 111: S9-14.
6. Graw F, Magnus C, Regoes RR (2010). Theoretical analysis of the evolution of immune memory. BMC Evol Biol, 10: 380.
7. Bronikowski AM, Altmann J, Brockman DK, Cords M, Fedigan LM, Pusey A, Stoinski T, Morris WF, Strier KB, Alberts SC (2011). Aging in the natural world: comparative data reveal similar mortality patterns across primates. Science, 331: 1325-8.
8. Casals F, Sikora M, Laayouni H, Montanucci L, Muntasell A, Lazarus R, Calafell F, Awadalla P, Netea MG, Bertranpetit J (2011). Genetic adaptation of the antibacterial human innate immunity network. BMC Evol Biol, 11: 202.
9. Tilstra JS, Clauson CL, Niedernhofer LJ, Robbins PD (2011). NFkB in aging and disease. Aging Dis, 2:449-465
10. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature, 376: 167-70.
11. Klement JF, Rice NR, Car BD, Abbondanzo SJ, Powers GD, Bhatt PH, Chen CH, Rosen CA, Stewart CL (1996). IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. Mol Cell Biol, 16: 2341-9.
12. Dave SH, Tilstra JS, Matsuoka K, Li F, Karrasch T, Uno JK, Sepulveda AR, Jobin C, Baldwin AS, Robbins PD, Plevy SE (2007). Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol, 179: 7852-9.
13. Reay DP, Yang M, Watchko JF, Daood M, O'Day TL, Rehman KK, Guttridge DC, Robbins PD, Clemens PR (2011). Systemic delivery of NEMO binding domain/IKKgamma inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology. Neurobiol Dis, 43: 598-608.
14. Oeckinghaus A, Hayden MS, Ghosh S (2011). Crosstalk in NF-kappaB signaling pathways. Nat Immunol, 12: 695-708.
15. Singh T, Newman AB (2011). Inflammatory markers in population studies of aging. Ageing Res Rev, 10: 319-29.
16. Li H, Manwani N, Leng SX (2011). Frailty, inflammation, and immuniity. Aging Dis, 2:446-473
17. Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, Masaki K, Murray A, Newman AB (2005). Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc, 53: 1321-30.
18. Yao X, Hamilton RG, Weng NP, Xue QL, Bream JH, Li H, Tian J, Yeh SH, Resnick B, Xu X, Walston J, Fried LP, Leng SX (2011). Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults. Vaccine, 29: 5015-21.
19. Oxenkrug G (2011). Interferon gamma-inducible inflammation: Contributions to aging and aging-assocated psychiatric disorders. Aging Dis, 2:474-486.
20. Kincses ZT, Toldi J, Vecsei L (2010). Kynurenines, neurodegeneration and Alzheimer's disease. J Cell Mol Med, 14: 2045-54.
21. Oxenkrug GF (2010). Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later. Isr J Psychiatry Relat Sci, 47: 56-63.
22. O'Connor JC, Andre C, Wang Y, Lawson MA, Szegedi SS, Lestage J, Castanon N, Kelley KW, Dantzer R (2009). Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci, 29: 4200-9.
23. O'Connor JC, Lawson MA, Andre C, Briley EM, Szegedi SS, Lestage J, Castanon N, Herkenham M, Dantzer R, Kelley KW (2009). Induction of IDO by bacille Calmette-Guerin is responsible for development of murine depressive-like behavior. J Immunol, 182: 3202-12.
24. Boyd AR, Orihuela CJ (2011). Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging Dis, 2:487-500
25. Kale S, Yende S (2011). Effects of aging on inflammation and hemostasis through the continuum of critical illness. Aging Dis, 2:501-511
26. Kruithof EK (2008). Regulation of plasminogen activator inhibitor type 1 gene expression by inflammatory mediators and statins. Thromb Haemost, 100: 969-75.
27. Carter AM (2005). Inflammation, thrombosis and acute coronary syndromes. Diab Vasc Dis Res, 2: 113-21.
28. Myers CE, Mirza NN, Lustgarten J (2011). Immunity, cancerm and aging: Lessons from mouse models. Aging Dis, 2:512-523
29. Ziegler SF (2006). FOXP3: of mice and men. Annu Rev Immunol, 24: 209-26.
30. Hohensinner PJ, Goronzy JJ, Weyand CM (2011). Telomere dysfunction, autoimmunity, and aging. Aging Dis, 2:524-537
31. Dagarag M, Evazyan T, Rao N, Effros RB (2004). Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization. J Immunol, 173: 6303-11.
32. Sanders JL, Cauley JA, Boudreau RM, Zmuda JM, Strotmeyer ES, Opresko PL, Hsueh WC, Cawthon RM, Li R, Harris TB, Kritchevsky SB, Newman AB (2009). Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study. J Bone Miner Res, 24: 1531-6.
33. Den Elzen WP, Martin-Ruiz C, von Zglinicki T, Westendorp RG, Kirkwood TB, Gussekloo J (2011). Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study. Age Ageing, 40: 494-500.
34. Fitzpatrick AL, Kronmal RA, Kimura M, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Hardikar S, Aviv A (2011). Leukocyte telomere length and mortality in the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci, 66: 421-9.
35. Harris SE, Martin-Ruiz C, von Zglinicki T, Starr JM, Deary IJ (2010). Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936. Neurobiol Aging, doi:10.1016/j.neurobiolaging.2010.11.013:
36. Prescott J, Kraft P, Chasman DI, Savage SA, Mirabello L, Berndt SI, Weissfeld JL, Han J, Hayes RB, Chanock SJ, Hunter DJ, De Vivo I (2011). Genome-wide association study of relative telomere length. PLoS One, 6: e19635.
37. Kim S, Bi X, Czarny-Ratajczak M, Dai J, Welsh DA, Myers L, Welsch MA, Cherry KE, Arnold J, Poon LW, Jazwinski SM (2011). Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity. Biogerontology, DOI 10.1007/s10522-011-9360-5:
38. Shimada A, Hasegawa-Ishii S (2011). Senescence-accelerated mice (SAMs) as a model for brain aging and immunosenescence. Aging DIs, 2: 414-35.
39. Goss JR, Stolz DB, Robinson AR, Zhang M, Arbujas N, Robbins PD, Glorioso JC, Niedernhofer LJ (2011). Premature aging-related peripheral neuropathy in a mouse model of progeria. Mech Ageing Dev, 132: 437-42.
40. Kusters MAA, Verstegen RHJ, de Vries VC (2011). Down's syndrome: It is really characterized by precocious immunosenescence? Aging Dis, 2:538-545.
41. Li G, Weyand CM, Goronzy JJ (2008). Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells. J Leukoc Biol, 84: 824-34.
42. Chen Y, Gorelik GJ, Strickland FM, Richardson BC (2009). Decreased ERK and JNK signaling contribute to gene overexpression in "senescent" CD4+CD28-T cells through epigenetic mechanisms. J Leukoc Biol, 87: 137-45.
43. Vallejo AN, Hamel Jr. DL, Mueller RG, Ives DG, Michel JJ, Boudreau RM, Newman AB (2011). NK-like T cells and plasma cytokines, but not anti-viral serology, define immune fingerprints of resilience and mild disability in exceptional aging. PLoS One, 6: e26558.
44. Weinberg A, Zhang JH, Oxman MN, Johnson GR, Hayward AR, Caulfield MJ, Irwin MR, Clair J, Smith JG, Stanley H, Marchese RD, Harbecke R, Williams HM, Chan IS, Arbeit RD, Gershon AA, Schodel F, Morrison VA, Kauffman CA, Straus SE, Schmader KE, Davis LE, Levin MJ (2009). Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine. J Infect Dis, 200: 1068-77.
45. McElhaney JE, Xie D, Hager WD, Barry MB, Wang Y, Kleppinger A, Ewen C, Kane KP, Bleackley RC (2006). T cell responses are better correlates of vaccine protection in the elderly. J Immunol, 176: 6333-9.
46. Schwaiger S, Wolf AM, Robatscher P, Jenewein B, Grubeck-Loebenstein B (2003). IL-4-producing CD8+ T cells with a CD62L++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age. J Immunol, 170: 613-9.
47. Taylor PC, Feldmann M (2009). Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol, 5: 578-82.
48. Ronnblom L, Elkon KB (2010). Cytokines as therapeutic targets in SLE. Nat Rev Rheumatol, 6: 339-47.