Telomere length and anaemia in old age: Results from the Newcastle 85-plus study* and the Leiden 85-plus study

Age and Ageing

Volumn 40, Issue 4, 2011, Pages 494-500

  Den elzen, Wendy P J ^a,b   Martin ruiz, Carmen ^b   Von zglinicki, Thomas ^b   Westendorp, Rudi G J ^a,c   Kirkwood, Thomas B L ^b   Gussekloo, Jacobijn ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c Netherlands Consortium for Healthy Ageing   (Netherlands)

Author keywords

Aging; Anaemia; Elderly; Telomeres

Indexed keywords

DNA;

AGED; ANEMIA; ARTICLE; CHROMOSOME SIZE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DNA ISOLATION; FEMALE; GENETIC RISK; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; MALE; MOLECULAR WEIGHT; PERIPHERAL BLOOD MONONUCLEAR CELL; PREVALENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SEX DIFFERENCE; TELOMERE;

AGE FACTORS; AGED, 80 AND OVER; AGING; ANEMIA; CHI-SQUARE DISTRIBUTION; CROSS-SECTIONAL STUDIES; ENGLAND; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINEAR MODELS; MALE; NETHERLANDS; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTORS; TELOMERE;

EID: 79959547081     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afr048     Document Type: Article

References (30)

1. Martin-Ruiz C, Dickinson HO, Keys B et al. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann Neurol 2006; 60: 174-80.
2. Brouilette S, Singh RK, Thompson JR et al. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 2003; 23: 842-6.
3. Collerton J, Martin-Ruiz C, Kenny A et al. Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study. Eur Heart J 2007; 28: 172-6.
4. Benetos A, Gardner JP, Zureik M et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 2004; 43: 182-5.
5. Wu X, Amos CI, Zhu Y et al. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 2003; 95: 1211-8.
6. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002; 27: 339-44.
7. Guralnik JM, Eisenstaedt RS, Ferrucci L et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004; 104: 2263-8.
8. Collerton J, Barrass K, Bond J et al. The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol. BMC Geriatr 2007; 7: 14.
9. Collerton J, Davies K, Jagger C et al. Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ 2009; 339: b4904.
10. Heeren TJ, Lagaay AM, von Beek WC et al. Reference values for the Mini-Mental State Examination (MMSE) in octo- and nonagenarians. J Am Geriatr Soc 1990; 38: 1093-6.
11. Weverling-Rijnsburger AW, Blauw GJ, Lagaay AM et al. Total cholesterol and risk of mortality in the oldest old. Lancet 1997; 350: 1119-23.
12. Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser 1968; 405: 5-37.
13. Cawthon RM, Smith KR, O'Brien E et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003; 361: 393-5.
14. Martin-Ruiz C, Saretzki G, Petrie J et al. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem 2004; 279: 17826-33.
15. Rothstein G. Disordered hematopoiesis and myelodysplasia in the elderly. J Am Geriatr Soc 2003; 51: S22-6.
16. Pfeilstocker M, Karlic H, Nosslinger T et al. Myelodysplastic syndromes, aging, and age: correlations, common mechanisms, and clinical implications. Leuk Lymphoma 2007; 48: 1900-9.
17. Vaziri H, Dragowska W, Allsopp RC et al. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994; 91: 9857-60.
18. Globerson A. Hematopoietic stem cells and aging. Exp Gerontol 1999; 34: 137-46.
19. Lansdorp PM. Telomere length and proliferation potential of hematopoietic stem cells. J Cell Sci 1995; 108 (Part 1): 1-6.
20. Boultwood J, Fidler C, Kusec R et al. Telomere length in myelodysplastic syndromes. Am J Hematol 1997; 56: 266-71.
21. Lange K, Holm L, Vang NK et al. Telomere shortening and chromosomal instability in myelodysplastic syndromes. Genes Chromosomes Cancer 2010; 49: 260-9.
22. Sashida G, Ohyashiki JH, Nakajima A et al. Telomere dynamics in myelodysplastic syndrome determined by telomere measurement of marrow metaphases. Clin Cancer Res 2003; 9: 1489-96.
23. Wong LS, Huzen J, van der Harst P et al. Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure. Eur J Heart Fail 2010; 12: 348-53.
24. De Meyer T, De Buyzere ML, Langlois M et al. Lower red blood cell counts in middle-aged subjects with shorter peripheral blood leukocyte telomere length. Aging Cell 2008; 7: 700-5.
25. Martin-Ruiz CM, Gussekloo J, van Heemst D et al. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 2005; 4: 287-90.
26. Mollica L, Fleury I, Belisle C et al. No association between telomere length and blood cell counts in elderly individuals. J Gerontol A Biol Sci Med Sci 2009; 64: 965-7.
27. Cherkas LF, Aviv A, Valdes AM et al. The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell 2006; 5: 361-5.
28. Adams J, Martin-Ruiz C, Pearce MS et al. No association between socio-economic status and white blood cell telomere length. Aging Cell 2007; 6: 125-8.
29. Halaschek-Wiener J, Vulto I, Fornika D et al. Reduced telomere length variation in healthy oldest old. Mech Ageing Dev 2008; 129: 638-41.
30. Hoffmann J, Erben Y, Zeiher AM et al. Telomere lengthheterogeneity among myeloid cells is a predictor for chronological ageing. Exp Gerontol 2009; 44: 363-6.