Telomere length and aging biomarkers in 70-year-olds: The Lothian Birth Cohort 1936

Neurobiology of Aging

Volumn 33, Issue 7, 2012, Pages 1486.e3-1486.e8

  Harris, Sarah E ^a   Martin Ruiz, Carmen ^b   von Zglinicki, Thomas ^b   Starr, John M ^a   Deary, Ian J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Aging; Biomarker; Cognitive; Inflammatory; LBC1936; Physical; Social class; Telomere

Indexed keywords

ALCOHOL; C REACTIVE PROTEIN; FIBRINOGEN; HEMOGLOBIN A1C;

AGED; AGING; ALCOHOL CONSUMPTION; ARTICLE; BRAIN FUNCTION; CIGARETTE SMOKING; COGNITION; COHORT ANALYSIS; EDUCATIONAL STATUS; FEMALE; FIBRINOGEN BLOOD LEVEL; GENERAL PROCESSING SPEED; HEALTH STATUS; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INTELLIGENCE QUOTIENT; LIFESTYLE; MALE; MEMORY; MORAY HOUSE TEST IQ SCORE; NORMAL HUMAN; OCCUPATIONAL SOCIAL CLASS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; SOCIAL CLASS; TELOMERE; TELOMERE LENGTH;

EID: 84861192424     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2010.11.013     Document Type: Article

References (33)

1. Adams J., Martin-Ruiz C., Pearce M.S., White M., Parker L., von Zglinicki T. No association between socio-economic status and white blood cell telomere length. Aging Cell 2007, 6:125-128.
2. Anstey K.J., Dear K., Christensen H., Jorm A.F. Biomarkers, health, lifestyle, and demographic variables as correlates of reaction time performance in early, middle, and late adulthood. Q. J. Exp. Psychol. A 2005, 58:5-21.
3. Aviv A. Telomeres and human somatic fitness. J. Gerontol. A Biol. Sci. Med. Sci 2006, 61:871-873.
4. Batty G.D., Wang Y., Brouilette S.W., Shiels P., Packard C., Moore J., Samani N.J., Ford I. Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study. J. Epidemiol. Community Health 2009, 63:839-841.
5. Bischoff C., Graakjaer J., Petersen H.C., Jeune B., Bohr V.A., Koelvraa S., Christensen K. Telomere length among the elderly and oldest-old. Twin Res. Hum. Genet 2005, 8:425-432.
6. Bischoff C., Petersen H.C., Graakjaer J., Andersen-Ranberg K., Vaupel J.W., Bohr V.A., Kølvraa S., Christensen K. No Association Between Telomere Length and Survival Among the Elderly and Oldest Old. Epidemiology 2006, 17:190-194.
7. Cherkas L.F., Aviv A., Valdes A.M., Hunkin J.L., Gardner J.P., Surdulescu G.L., Kimura M., Spector T.D. The effects of social status on biological aging as measured by white blood cell telomere length. Aging Cell 2006, 5:361-365.
8. Collerton J., Davies K., Jagger C., Kingston A., Bond J., Eccles M.P., Robinson L.A., Martin-Ruiz C., von Zglinicki T., James O.F., Kirkwood T.B. Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ 2009, 339:b4904.
9. Deary I.J., Gow A.J., Taylor M.D., Corley J., Brett C., Wilson V., Campbell H., Whalley L.J., Visscher P.M., Porteous D.J., Starr J.M. The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr 2007, 7:28.
10. Deary I.J., Whalley L.J., Batty G.D., Starr J.M. Physical fitness and lifetime cognitive change. Neurology 2006, 67:1195-1200.
11. Elias P.K., Elias M.F., D'Agostino R.B., Silbershatz H., Wolf P.A. Alcohol consumption and cognitive performance in the Framingham Heart Study. Am. J. Epidemiol 1999, 150:580-589.
12. Grodstein F., van Oijen M., Irizarry M.C., Rosas H.D., Hyman B.T., Growdon J.H., De Vivo I. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS One 2008, 3:e1590.
13. Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
14. Harris S.E., Deary I.J., MacIntyre A., Lamb K.J., Radhakrishnan K., Starr J.M., Whalley L.J., Shiels P.G. The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci. Lett 2006, 406:260-264.
15. Lindsey J., McGill N.I., Lindsey L.A., Green D.K., Cooke H.J. In vivo loss of telomeric repeats with age in humans. Mutat. Res 1991, 256:45-48.
16. Luciano M., Gow A.J., Harris S.E., Hayward C., Allerhand M., Starr J.M., Visscher P.M., Deary I.J. Cognitive ability at age 11 and 70 years, information processing speed, and APOE variation: the Lothian Birth Cohort 1936 study. Psychol. Aging 2009, 24:129-138.
17. Luciano M., Marioni R.E., Gow A.J., Starr J.M., Deary I.J. Reverse causation in the association between C-reactive protein and fibrinogen levels and cognitive abilities in an aging sample. Psychosom. Med 2009, 71:404-409.
18. Martin-Ruiz C., Dickinson H.O., Keys B., Rowan E., Kenny R.A., Von Z.T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann. Neurol 2006, 60:174-180.
19. Martin-Ruiz C., Saretzki G., Petrie J., Ladhoff J., Jeyapalan J., Wei W., Sedivy J., von Zglinicki T. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J. Biol. Chem 2004, 279:17826-17833.
20. Martin-Ruiz C.M., Gussekloo J., van Heemst D., von Zglinicki T., Westendorp R.G. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 2005, 4:287-290.
21. Nordfjall K., Svenson U., Norrback K.F., Adolfsson R., Roos G. Large-scale parent-child comparison confirms a strong paternal influence on telomere length. Eur. J. Hum. Genet 2010, 18:385-389.
22. Panossian L.A., Porter V.R., Valenzuela H.F., Zhu X., Reback E., Masterman D., Cummings J.L., Effros R.B. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol. Aging 2003, 24:77-84.
23. Saretzki G., von Zglinicki T. Replicative aging, telomeres, and oxidative stress. Ann. N. Y. Acad. Sci 2002, 959:24-29.
24. Shiels P.G., Davies R.W. Ageing and death in neurones. The Molecular Biology of the Neurone 2003, 435-464. Oxford University Press, Oxford, UK. second ed. R.W. Davies, B.J. Morris (Eds.).
25. Starr J.M., Deary I.J., Lemmon H., Whalley L.J. Mental ability age 11 years and health status age 77 years. Age Ageing 2000, 29:523-528.
26. Starr J.M., Shiels P.G., Harris S.E., Pattie A., Pearce M.S., Relton C.L., Deary I.J. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Mech. Ageing Dev 2008, 129:745-751.
27. Valdes A.M., Andrew T., Gardner J.P., Kimura M., Oelsner E., Cherkas L.F., Aviv A., Spector T.D. Obesity, cigarette smoking, and telomere length in women. Lancet 2005, 366:662-664.
28. Valdes A.M., Deary I.J., Gardner J., Kimura M., Lu X., Spector T.D., Aviv A., Cherkas L.F. Leukocyte telomere length is associated with cognitive performance in healthy women. Neurobiol. Aging 2010, 31:986-992.
29. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem. Sci 2002, 27:339-344.
30. von Zglinicki T., Serra V., Lorenz M., Saretzki G., Lenzen-Grossimlighaus R., Gessner R., Risch A., Steinhagen-Thiessen E. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?. Lab. Invest 2000, 80:1739-1747.
31. Woo J., Suen E.W., Leung J.C., Tang N.L., Ebrahim S. Older men with higher self-rated socioeconomic status have shorter telomeres. Age Ageing 2009, 38:553-558.
32. Yaffe K., Lindquist K., Kluse M., Cawthon R., Harris T., Hsueh W.C., Simonsick E.M., Kuller L., Li R., Ayonayon H.N., Rubin S.M., Cummings S.R. Telomere length and cognitive function in community-dwelling elders: Findings from the Health ABC Study. Neurobiol Aging 2009, in press. 10.1016/j.neurobiolaging.2009.12.006.
33. Zekry D., Herrmann F.R., Irminger-Finger I., Ortolan L., Genet C., Vitale A.M., Michel J.P., Gold G., Krause K.H. Telomere length is not predictive of dementia or MCI conversion in the oldest old. Neurobiol. Aging 2010, 31:719-720.