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Volumn 2, Issue 6, 2011, Pages 538-545

Down syndrome: Is it really characterized by precocious immunosenescence?

Author keywords

Adaptive immune system; Down syndrome; Immunosenescence; Progeria syndromes

Indexed keywords


EID: 84871826330     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (26)

References (44)
  • 2
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: role of telomeres and telomerase
    • Shay JW and Wright WE (2005). Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis, 26: 867-874
    • (2005) Carcinogenesis , vol.26 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 3
    • 79952847690 scopus 로고    scopus 로고
    • Aging and immune function: molecular mechanisms to interventions
    • Ponnappan S and Ponnappan U (2011). Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal, 14: 1551-1585
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1551-1585
    • Ponnappan, S.1    Ponnappan, U.2
  • 5
    • 0020301505 scopus 로고
    • Down's syndrome, aging, and Alzheimer's disease: a clinical review
    • Lott IT (1982). Down's syndrome, aging, and Alzheimer's disease: a clinical review. Ann N Y Acad Sci, 396: 15-27
    • (1982) Ann N Y Acad Sci , vol.396 , pp. 15-27
    • Lott, I.T.1
  • 6
    • 0029871363 scopus 로고    scopus 로고
    • Immune dysfunction in Down's syndrome: primary immune deficiency or early senescence of the immune system?
    • Cuadrado E and Barrena MJ (1996). Immune dysfunction in Down's syndrome: primary immune deficiency or early senescence of the immune system? Clin Immunol Immunopathol, 78: 209-214
    • (1996) Clin Immunol Immunopathol , vol.78 , pp. 209-214
    • Cuadrado, E.1    Barrena, M.J.2
  • 7
    • 77954950116 scopus 로고    scopus 로고
    • Progeria syndromes and ageing: what is the connection?
    • Burtner CR and Kennedy BK (2010). Progeria syndromes and ageing: what is the connection? Nat Rev Mol Cell Biol, 11: 567-578
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 567-578
    • Burtner, C.R.1    Kennedy, B.K.2
  • 8
    • 64649097543 scopus 로고    scopus 로고
    • Intrinsic defect of the immune system in children with Down syndrome: a review
    • Kusters MA, Verstegen RH, Gemen EF and de Vries E (2009). Intrinsic defect of the immune system in children with Down syndrome: a review. Clin Exp Immunol, 156: 189-193
    • (2009) Clin Exp Immunol , vol.156 , pp. 189-193
    • Kusters, M.A.1    Verstegen, R.H.2    Gemen, E.F.3    de Vries, E.4
  • 12
    • 77951437650 scopus 로고    scopus 로고
    • Both normal memory counts and decreased naive cells favor intrinsic defect over early senescence of Down syndrome T lymphocytes
    • E DEV
    • Kusters MA, Gemen EF, Verstegen RH, Wever PC and E DEV (2010). Both normal memory counts and decreased naive cells favor intrinsic defect over early senescence of Down syndrome T lymphocytes. Pediatr Res, 67: 557-562
    • (2010) Pediatr Res , vol.67 , pp. 557-562
    • Kusters, M.A.1    Gemen, E.F.2    Verstegen, R.H.3    Wever, P.C.4
  • 17
    • 78651262051 scopus 로고    scopus 로고
    • T lymphocytes apoptosis and mitochondrial membrane potential in Down's syndrome
    • Abu Faddan N, Sayed D and Ghaleb F (2011). T lymphocytes apoptosis and mitochondrial membrane potential in Down's syndrome. Fetal Pediatr Pathol, 30: 45-52
    • (2011) Fetal Pediatr Pathol , vol.30 , pp. 45-52
    • Abu Faddan, N.1    Sayed, D.2    Ghaleb, F.3
  • 20
    • 78651103619 scopus 로고    scopus 로고
    • Analysis of peripheral blood T-cell subsets, natural killer cells and serum levels of cytokines in children with Down syndrome
    • Cetiner S, Demirhan O, Inal TC, Tastemir D, Sertdemir Y (2010). Analysis of peripheral blood T-cell subsets, natural killer cells and serum levels of cytokines in children with Down syndrome. Int J Immunogenet, 37:233-237.
    • (2010) Int J Immunogenet , vol.37 , pp. 233-237
    • Cetiner, S.1    Demirhan, O.2    Inal, T.C.3    Tastemir, D.4    Sertdemir, Y.5
  • 21
    • 77951452285 scopus 로고    scopus 로고
    • Down syndrome B-lymphocyte subpopulations, intrinsic defect or decreased T-lymphocyte help
    • E DEV
    • Verstegen RH, Kusters MA, Gemen EF and E DEV (2010). Down syndrome B-lymphocyte subpopulations, intrinsic defect or decreased T-lymphocyte help. Pediatr Res, 67: 563-569
    • (2010) Pediatr Res , vol.67 , pp. 563-569
    • Verstegen, R.H.1    Kusters, M.A.2    Gemen, E.F.3
  • 24
    • 77952300034 scopus 로고    scopus 로고
    • The effect of age on the response to the pneumococcal polysaccharide vaccine
    • Lee H, Nahm MH and Kim KH (2010). The effect of age on the response to the pneumococcal polysaccharide vaccine. BMC Infect Dis, 10: 60
    • (2010) BMC Infect Dis , vol.10 , pp. 60
    • Lee, H.1    Nahm, M.H.2    Kim, K.H.3
  • 26
    • 0022572635 scopus 로고
    • Abnormalities of the in vitro cellular and humoral responses to tetanus and influenza antigens with concomitant numerical alterations in lymphocyte subsets in Down syndrome (trisomy 21)
    • Philip R, Berger AC, McManus NH, Warner NH, Peacock MA and Epstein LB (1986). Abnormalities of the in vitro cellular and humoral responses to tetanus and influenza antigens with concomitant numerical alterations in lymphocyte subsets in Down syndrome (trisomy 21). J Immunol, 136: 1661-1667
    • (1986) J Immunol , vol.136 , pp. 1661-1667
    • Philip, R.1    Berger, A.C.2    McManus, N.H.3    Warner, N.H.4    Peacock, M.A.5    Epstein, L.B.6
  • 28
    • 79959696116 scopus 로고    scopus 로고
    • Immune evaluation and vaccine responses in Down syndrome: evidence of immunodeficiency?
    • Joshi AY, Abraham RS, Snyder MR, Boyce TG (2011) Immune evaluation and vaccine responses in Down syndrome: evidence of immunodeficiency? Vaccine, 29:5040-6
    • (2011) Vaccine , vol.29 , pp. 5040-5046
    • Joshi, A.Y.1    Abraham, R.S.2    Snyder, M.R.3    Boyce, T.G.4
  • 29
    • 2342527293 scopus 로고    scopus 로고
    • Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation
    • Goronzy JJ and Weyand CM (2003). Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther, 5: 225-234
    • (2003) Arthritis Res Ther , vol.5 , pp. 225-234
    • Goronzy, J.J.1    Weyand, C.M.2
  • 30
    • 77957749242 scopus 로고    scopus 로고
    • Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system
    • Bloemers BLP, Broers CJM, Bont L, Weijerman ME, Gemke RJBJ, van Furth AM (2010). Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system. Microbes Infect, 12:799-808.
    • (2010) Microbes Infect , vol.12 , pp. 799-808
    • Bloemers, B.L.P.1    Broers, C.J.M.2    Bont, L.3    Weijerman, M.E.4    Gemke, R.J.B.J.5    van Furth, A.M.6
  • 31
    • 0345486634 scopus 로고
    • Susceptibility to infectious disease in Down syndrome
    • Lott I.T. McCoy E.E. editors. . New York: Wiley-Liss
    • Lang D. Susceptibility to infectious disease in Down syndrome. In: Lott IT, McCoy EE, editors. Down syndrome: advances in medical care. New York: Wiley-Liss; 1992. p. 83-92.
    • (1992) Down syndrome: advances in medical care , pp. 83-92
    • Lang, D.1
  • 32
    • 14044254171 scopus 로고    scopus 로고
    • Mortality and causes of death in persons with Down syndrome in California
    • Day SM, Strauss DJ, Shavelle RM and Reynolds RJ (2005). Mortality and causes of death in persons with Down syndrome in California. Dev Med Child Neurol, 47: 171-176
    • (2005) Dev Med Child Neurol , vol.47 , pp. 171-176
    • Day, S.M.1    Strauss, D.J.2    Shavelle, R.M.3    Reynolds, R.J.4
  • 33
    • 0031691872 scopus 로고    scopus 로고
    • Thyroid dysfunction in Down's syndrome: relation to age and thyroid autoimmunity
    • Karlsson B, Gustafsson J, Hedov G, Ivarsson SA and Anneren G (1998). Thyroid dysfunction in Down's syndrome: relation to age and thyroid autoimmunity. Arch Dis Child, 79: 242-245
    • (1998) Arch Dis Child , vol.79 , pp. 242-245
    • Karlsson, B.1    Gustafsson, J.2    Hedov, G.3    Ivarsson, S.A.4    Anneren, G.5
  • 35
    • 0031882343 scopus 로고    scopus 로고
    • Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications
    • Anwar AJ, Walker JD and Frier BM (1998). Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications. Diabet Med, 15: 160-163
    • (1998) Diabet Med , vol.15 , pp. 160-163
    • Anwar, A.J.1    Walker, J.D.2    Frier, B.M.3
  • 36
    • 7944222395 scopus 로고    scopus 로고
    • Cancers and immune related diseases associated with Down's syndrome: a record linkage study
    • Goldacre MJ, Wotton CJ, Seagroatt V and Yeates D (2004). Cancers and immune related diseases associated with Down's syndrome: a record linkage study. Arch Dis Child, 89: 1014-1017
    • (2004) Arch Dis Child , vol.89 , pp. 1014-1017
    • Goldacre, M.J.1    Wotton, C.J.2    Seagroatt, V.3    Yeates, D.4
  • 37
    • 58149235463 scopus 로고    scopus 로고
    • Werner Syndrome, aging and cancer
    • Ozgenc A and Loeb LA (2006). Werner Syndrome, aging and cancer. Genome Dyn, 1: 206-217
    • (2006) Genome Dyn , vol.1 , pp. 206-217
    • Ozgenc, A.1    Loeb, L.A.2
  • 41
    • 58149235463 scopus 로고    scopus 로고
    • Werner Syndrome, aging and cancer
    • Ozgenc A, Loeb LA (2006). Werner Syndrome, aging and cancer. Genome Dyn, 1:206-17.
    • (2006) Genome Dyn , vol.1 , pp. 206-217
    • Ozgenc, A.1    Loeb, L.A.2
  • 42
    • 0025159160 scopus 로고
    • Immune function, mutant frequency, and cancer risk in the DNA repair defective genodermatoses xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy
    • Norris PG, Limb GA, Hamblin AS, Lehmann AR, Arlett CF, Cole J, Waugh AP, Hawk JL (1990). Immune function, mutant frequency, and cancer risk in the DNA repair defective genodermatoses xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy. J Invest Dermatol, 94:94-100.
    • (1990) J Invest Dermatol , vol.94 , pp. 94-100
    • Norris, P.G.1    Limb, G.A.2    Hamblin, A.S.3    Lehmann, A.R.4    Arlett, C.F.5    Cole, J.6    Waugh, A.P.7    Hawk, J.L.8
  • 44
    • 0016307808 scopus 로고
    • Immunological studies in children with xeroderma pigmentosum
    • Berkel AI, Kiran O (1974). Immunological studies in children with xeroderma pigmentosum. Turk J Paed, 16:43-52.
    • (1974) Turk J Paed , vol.16 , pp. 43-52
    • Berkel, A.I.1    Kiran, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.