-
1
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl, F. U., Bracher, A., and Hayer-Hartl, M. (2011) Molecular chaperones in protein folding and proteostasis. Nature 475, 324-332
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
2
-
-
41049092281
-
Diseases of protein aggregation and the hunt for potential pharmacological agents
-
Wang, S. S., Wu, J. W., Yamamoto, S., and Liu, H. S. (2008) Diseases of protein aggregation and the hunt for potential pharmacological agents. Biotechnol. J. 3, 165-192
-
(2008)
Biotechnol. J.
, vol.3
, pp. 165-192
-
-
Wang, S.S.1
Wu, J.W.2
Yamamoto, S.3
Liu, H.S.4
-
3
-
-
84863723691
-
Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation
-
Fredrickson, E. K., and Gardner, R. G. (2012) Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation. Semin. Cell Dev. Biol. 23, 530-537
-
(2012)
Semin. Cell Dev. Biol.
, vol.23
, pp. 530-537
-
-
Fredrickson, E.K.1
Gardner, R.G.2
-
4
-
-
0031885043
-
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded luminal and integral membrane proteins
-
Bordallo, J., Plemper, R. K., Finger, A., and Wolf, D. H. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded luminal and integral membrane proteins. Mol. Biol. Cell 9, 209-222
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 209-222
-
-
Bordallo, J.1
Plemper, R.K.2
Finger, A.3
Wolf, D.H.4
-
5
-
-
0035807839
-
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
-
Fang, S., Ferrone, M., Yang, C., Jensen, J. P., Tiwari, S., and Weissman, A. M. (2001) The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 98, 14422-14427
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 14422-14427
-
-
Fang, S.1
Ferrone, M.2
Yang, C.3
Jensen, J.P.4
Tiwari, S.5
Weissman, A.M.6
-
6
-
-
0029811218
-
Role of 26 S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
-
Hampton, R. Y., Gardner, R. G., and Rine, J. (1996) Role of 26 S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol. Biol. Cell 7, 2029-2044
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 2029-2044
-
-
Hampton, R.Y.1
Gardner, R.G.2
Rine, J.3
-
7
-
-
0037021416
-
Human HRD1 protects against ER stress-induced apoptosis through ERassociated degradation
-
Kaneko, M., Ishiguro, M., Niinuma, Y., Uesugi, M., and Nomura, Y. (2002) Human HRD1 protects against ER stress-induced apoptosis through ERassociated degradation. FEBS Lett. 532, 147-152
-
(2002)
FEBS Lett.
, vol.532
, pp. 147-152
-
-
Kaneko, M.1
Ishiguro, M.2
Niinuma, Y.3
Uesugi, M.4
Nomura, Y.5
-
8
-
-
0037470838
-
A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1
-
Nadav, E., Shmueli, A., Barr, H., Gonen, H., Ciechanover, A., and Reiss, Y. (2003) A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem. Biophys. Res. Commun. 303, 91-97
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.303
, pp. 91-97
-
-
Nadav, E.1
Shmueli, A.2
Barr, H.3
Gonen, H.4
Ciechanover, A.5
Reiss, Y.6
-
9
-
-
0035887277
-
A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation
-
Swanson, R., Locher, M., and Hochstrasser, M. (2001) A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation. Genes Dev. 15, 2660-2674
-
(2001)
Genes Dev.
, vol.15
, pp. 2660-2674
-
-
Swanson, R.1
Locher, M.2
Hochstrasser, M.3
-
10
-
-
75749101057
-
Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1
-
Heck, J. W., Cheung, S. K., and Hampton, R. Y. (2010) Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proc. Natl. Acad. Sci. U.S.A. 107, 1106-1111
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 1106-1111
-
-
Heck, J.W.1
Cheung, S.K.2
Hampton, R.Y.3
-
11
-
-
0035900793
-
CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
-
Jiang, J., Ballinger, C. A., Wu, Y., Dai, Q., Cyr, D. M., Höhfeld, J., and Patterson, C. (2001) CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J. Biol. Chem. 276, 42938-42944
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42938-42944
-
-
Jiang, J.1
Ballinger, C.A.2
Wu, Y.3
Dai, Q.4
Cyr, D.M.5
Höhfeld, J.6
Patterson, C.7
-
12
-
-
0035684430
-
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein
-
Murata, S., Minami, Y., Minami, M., Chiba, T., and Tanaka, K. (2001) CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep. 2, 1133-1138
-
(2001)
EMBO Rep.
, vol.2
, pp. 1133-1138
-
-
Murata, S.1
Minami, Y.2
Minami, M.3
Chiba, T.4
Tanaka, K.5
-
13
-
-
77954196466
-
Ubr1 and Ubr2 Function in a quality control pathway for degradation of unfolded cytosolic proteins
-
Nillegoda, N. B., Theodoraki, M. A., Mandal, A. K., Mayo, K. J., Ren, H. Y., Sultana, R., Wu, K., Johnson, J., Cyr, D. M., and Caplan, A. J. (2010) Ubr1 and Ubr2 Function in a quality control pathway for degradation of unfolded cytosolic proteins. Mol. Biol. Cell 21, 2102-2116
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2102-2116
-
-
Nillegoda, N.B.1
Theodoraki, M.A.2
Mandal, A.K.3
Mayo, K.J.4
Ren, H.Y.5
Sultana, R.6
Wu, K.7
Johnson, J.8
Cyr, D.M.9
Caplan, A.J.10
-
14
-
-
26244451787
-
Nuclear aggresomes form by fusion of PML-associated aggregates
-
Fu, L., Gao, Y. S., Tousson, A., Shah, A., Chen, T. L., Vertel, B. M., and Sztul, E. (2005) Nuclear aggresomes form by fusion of PML-associated aggregates. Mol. Biol. Cell 16, 4905-4917
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4905-4917
-
-
Fu, L.1
Gao, Y.S.2
Tousson, A.3
Shah, A.4
Chen, T.L.5
Vertel, B.M.6
Sztul, E.7
-
15
-
-
17644396667
-
Degradationmediated protein quality control in the nucleus
-
Gardner, R. G., Nelson, Z. W., and Gottschling, D. E. (2005) Degradationmediated protein quality control in the nucleus. Cell 120, 803-815
-
(2005)
Cell
, vol.120
, pp. 803-815
-
-
Gardner, R.G.1
Nelson, Z.W.2
Gottschling, D.E.3
-
16
-
-
65649121163
-
Intranuclear degradation of polyglutamine aggregates by the ubiquitin proteasome system
-
Iwata, A., Nagashima, Y., Matsumoto, L., Suzuki, T., Yamanaka, T., Date, H., Deoka, K., Nukina, N., and Tsuji, S. (2009) Intranuclear degradation of polyglutamine aggregates by the ubiquitin proteasome system. J. Biol. Chem. 284, 9796-9803
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9796-9803
-
-
Iwata, A.1
Nagashima, Y.2
Matsumoto, L.3
Suzuki, T.4
Yamanaka, T.5
Date, H.6
Deoka, K.7
Nukina, N.8
Tsuji, S.9
-
17
-
-
33745612063
-
PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins
-
Janer, A., Martin, E., Muriel, M. P., Latouche, M., Fujigasaki, H., Ruberg, M., Brice, A., Trottier, Y., and Sittler, A. (2006) PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins. J. Cell Biol. 174, 65-76
-
(2006)
J. Cell Biol.
, vol.174
, pp. 65-76
-
-
Janer, A.1
Martin, E.2
Muriel, M.P.3
Latouche, M.4
Fujigasaki, H.5
Ruberg, M.6
Brice, A.7
Trottier, Y.8
Sittler, A.9
-
18
-
-
63049110916
-
Quality control of a transcriptional regulator by SUMO-targeted degradation
-
Wang, Z., and Prelich, G. (2009) Quality control of a transcriptional regulator by SUMO-targeted degradation. Mol. Cell. Biol. 29, 1694-1706
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 1694-1706
-
-
Wang, Z.1
Prelich, G.2
-
19
-
-
0035144199
-
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
-
Bays, N. W., Gardner, R. G., Seelig, L. P., Joazeiro, C. A., and Hampton, R. Y. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat. Cell Biol. 3, 24-29
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 24-29
-
-
Bays, N.W.1
Gardner, R.G.2
Seelig, L.P.3
Joazeiro, C.A.4
Hampton, R.Y.5
-
20
-
-
4444355303
-
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein
-
Huyer, G., Piluek, W. F., Fansler, Z., Kreft, S. G., Hochstrasser, M., Brodsky, J. L., and Michaelis, S. (2004) Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J. Biol. Chem. 279, 38369-38378
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38369-38378
-
-
Huyer, G.1
Piluek, W.F.2
Fansler, Z.3
Kreft, S.G.4
Hochstrasser, M.5
Brodsky, J.L.6
Michaelis, S.7
-
21
-
-
33750349837
-
Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase
-
Deng, M., and Hochstrasser, M. (2006) Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature 443, 827-831
-
(2006)
Nature
, vol.443
, pp. 827-831
-
-
Deng, M.1
Hochstrasser, M.2
-
22
-
-
0034651604
-
Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system
-
Hill, K., and Cooper, A. A. (2000) Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system. EMBO J. 19, 550-561
-
(2000)
EMBO J.
, vol.19
, pp. 550-561
-
-
Hill, K.1
Cooper, A.A.2
-
23
-
-
0034108089
-
HRD gene dependence of endoplasmic reticulum-associated degradation
-
Wilhovsky, S., Gardner, R., and Hampton, R. (2000) HRD gene dependence of endoplasmic reticulum-associated degradation. Mol. Biol. Cell 11, 1697-1708
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 1697-1708
-
-
Wilhovsky, S.1
Gardner, R.2
Hampton, R.3
-
24
-
-
0141592584
-
Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD
-
Taxis, C., Hitt, R., Park, S. H., Deak, P. M., Kostova, Z., and Wolf, D. H. (2003) Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J. Biol. Chem. 278, 35903-35913
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35903-35913
-
-
Taxis, C.1
Hitt, R.2
Park, S.H.3
Deak, P.M.4
Kostova, Z.5
Wolf, D.H.6
-
25
-
-
33746228127
-
Distinct ubiquitinligase complexes define convergent pathways for the degradation of ER proteins
-
Carvalho, P., Goder, V., and Rapoport, T. A. (2006) Distinct ubiquitinligase complexes define convergent pathways for the degradation of ER proteins. Cell 126, 361-373
-
(2006)
Cell
, vol.126
, pp. 361-373
-
-
Carvalho, P.1
Goder, V.2
Rapoport, T.A.3
-
26
-
-
77949351438
-
Modularity of the Hrd1 ERAD complex underlies its diverse client range
-
Kanehara, K., Xie, W., and Ng, D. T. (2010) Modularity of the Hrd1 ERAD complex underlies its diverse client range. J. Cell Biol. 188, 707-716
-
(2010)
J. Cell Biol.
, vol.188
, pp. 707-716
-
-
Kanehara, K.1
Xie, W.2
Ng, D.T.3
-
27
-
-
79959888485
-
Exposed hydrophobicity is a key determinant of nuclear quality control degradation
-
Fredrickson, E. K., Rosenbaum, J. C., Locke, M. N., Milac, T. I., and Gard- ner, R. G. (2011) Exposed hydrophobicity is a key determinant of nuclear quality control degradation. Mol. Biol. Cell 22, 2384-2395
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 2384-2395
-
-
Fredrickson, E.K.1
Rosenbaum, J.C.2
Locke, M.N.3
Milac, T.I.4
Gard-Ner, R.G.5
-
28
-
-
0032579440
-
Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
-
Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E., Li, J., Hieter, P., and Boeke, J. D. (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14, 115-132
-
(1998)
Yeast
, vol.14
, pp. 115-132
-
-
Brachmann, C.B.1
Davies, A.2
Cost, G.J.3
Caputo, E.4
Li, J.5
Hieter, P.6
Boeke, J.D.7
-
29
-
-
0025994140
-
Guide to yeast genetics and molecular biology
-
Guthrie, C., and Fink, G. R. (1991) Guide to yeast genetics and molecular biology. Methods Enzymol. 194, 1-863
-
(1991)
Methods Enzymol.
, vol.194
, pp. 1-863
-
-
Guthrie, C.1
Fink, G.R.2
-
30
-
-
84863615329
-
A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast
-
Theodoraki, M. A., Nillegoda, N. B., Saini, J., and Caplan, A. J. (2012) A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast. J. Biol. Chem. 287, 23911-23922
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 23911-23922
-
-
Theodoraki, M.A.1
Nillegoda, N.B.2
Saini, J.3
Caplan, A.J.4
-
31
-
-
78650731442
-
Disorder targets misorder in nuclear quality control degradation: A disordered ubiquitin ligase directly recognizes its misfolded substrates
-
Rosenbaum, J. C., Fredrickson, E. K., Oeser, M. L., Garrett-Engele, C. M., Locke, M. N., Richardson, L. A., Nelson, Z. W., Hetrick, E. D., Milac, T. I., Gottschling, D. E., and Gardner, R. G. (2011) Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol. Cell 41, 93-106
-
(2011)
Mol. Cell
, vol.41
, pp. 93-106
-
-
Rosenbaum, J.C.1
Fredrickson, E.K.2
Oeser, M.L.3
Garrett-Engele, C.M.4
Locke, M.N.5
Richardson, L.A.6
Nelson, Z.W.7
Hetrick, E.D.8
Milac, T.I.9
Gottschling, D.E.10
Gardner, R.G.11
-
32
-
-
2442637627
-
Pressure dissociation studies provide insight into oligomerization competence of temperature-sensitive folding mutants of P22 tailspike
-
Lefebvre, B. G., Comolli, N. K., Gage, M. J., and Robinson, A. S. (2004) Pressure dissociation studies provide insight into oligomerization competence of temperature-sensitive folding mutants of P22 tailspike. Protein Sci. 13, 1538-1546
-
(2004)
Protein Sci.
, vol.13
, pp. 1538-1546
-
-
Lefebvre, B.G.1
Comolli, N.K.2
Gage, M.J.3
Robinson, A.S.4
-
33
-
-
1342331854
-
Retarded protein folding of deficient human alpha 1-antitrypsin D256V and L41P variants
-
Jung, C. H., Na, Y. R., and Im, H. (2004) Retarded protein folding of deficient human alpha 1-antitrypsin D256V and L41P variants. Protein Sci. 13, 694-702
-
(2004)
Protein Sci.
, vol.13
, pp. 694-702
-
-
Jung, C.H.1
Na, Y.R.2
Im, H.3
-
34
-
-
1542782213
-
Yeast [PSI+] prion aggregates are formed by small Sup35 polymers fragmented by Hsp104
-
Kryndushkin, D. S., Alexandrov, I. M., Ter-Avanesyan, M. D., and Kushnirov, V. V. (2003) Yeast [PSI+] prion aggregates are formed by small Sup35 polymers fragmented by Hsp104. J. Biol. Chem. 278, 49636-49643
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49636-49643
-
-
Kryndushkin, D.S.1
Alexandrov, I.M.2
Ter-Avanesyan, M.D.3
Kushnirov, V.V.4
-
35
-
-
0037221524
-
Binding dynamics of structural nucleoporins govern nuclear pore complex permeability and may mediate channel gating
-
Shulga, N., and Goldfarb, D. S. (2003) Binding dynamics of structural nucleoporins govern nuclear pore complex permeability and may mediate channel gating. Mol. Cell. Biol. 23, 534-542
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 534-542
-
-
Shulga, N.1
Goldfarb, D.S.2
-
36
-
-
0034729194
-
Yeast nucleoporins involved in passive nuclear envelope permeability
-
Shulga, N., Mosammaparast, N., Wozniak, R., and Goldfarb, D. S. (2000) Yeast nucleoporins involved in passive nuclear envelope permeability. J. Cell Biol. 149, 1027-1038
-
(2000)
J. Cell Biol.
, vol.149
, pp. 1027-1038
-
-
Shulga, N.1
Mosammaparast, N.2
Wozniak, R.3
Goldfarb, D.S.4
-
37
-
-
0020475449
-
A simple method for displaying the hydropathic character of a protein
-
Kyte, J., and Doolittle, R. F. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132
-
(1982)
J. Mol. Biol.
, vol.157
, pp. 105-132
-
-
Kyte, J.1
Doolittle, R.F.2
-
38
-
-
33947517558
-
AGGRESCAN: A server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
-
Conchillo-Solé, O., de Groot, N. S., Avilés, F. X., Vendrell, J., Daura, X., and Ventura, S. (2007) AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides. BMC Bioinformatics 8, 65
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 65
-
-
Conchillo-Solé, O.1
De Groot, N.S.2
Avilés, F.X.3
Vendrell, J.4
Daura, X.5
Ventura, S.6
-
39
-
-
77954178073
-
A nucleus-based quality control mechanism for cytosolic proteins
-
Prasad, R., Kawaguchi, S., and Ng, D. T. (2010) A nucleus-based quality control mechanism for cytosolic proteins. Mol. Biol. Cell 21, 2117-2127
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2117-2127
-
-
Prasad, R.1
Kawaguchi, S.2
Ng, D.T.3
-
40
-
-
84055200360
-
Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope
-
Furth, N., Gertman, O., Shiber, A., Alfassy, O. S., Cohen, I., Rosenberg, M. M., Doron, N. K., Friedler, A., and Ravid, T. (2011) Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope. Mol. Biol. Cell 22, 4726-4739
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 4726-4739
-
-
Furth, N.1
Gertman, O.2
Shiber, A.3
Alfassy, O.S.4
Cohen, I.5
Rosenberg, M.M.6
Doron, N.K.7
Friedler, A.8
Ravid, T.9
-
41
-
-
77949412662
-
F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics
-
Angeli, S., Shao, J., and Diamond, M. I. (2010) F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics. PLoS One 5, e9053
-
(2010)
PLoS One
, vol.5
-
-
Angeli, S.1
Shao, J.2
Diamond, M.I.3
-
42
-
-
84862981596
-
Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness
-
Beerten, J., Jonckheere, W., Rudyak, S., Xu, J., Wilkinson, H., De Smet, F., Schymkowitz, J., and Rousseau, F. (2012) Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness. Protein Eng. Des. Sel. 25, 357-366
-
(2012)
Protein Eng. Des. Sel.
, vol.25
, pp. 357-366
-
-
Beerten, J.1
Jonckheere, W.2
Rudyak, S.3
Xu, J.4
Wilkinson, H.5
De Smet, F.6
Schymkowitz, J.7
Rousseau, F.8
-
43
-
-
33746635502
-
Flanking sequences profoundly alter polyglutamine toxicity in yeast
-
Duennwald, M. L., Jagadish, S., Muchowski, P. J., and Lindquist, S. (2006) Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc. Natl. Acad. Sci. U.S.A. 103, 11045-11050
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 11045-11050
-
-
Duennwald, M.L.1
Jagadish, S.2
Muchowski, P.J.3
Lindquist, S.4
-
44
-
-
37549011420
-
In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence
-
Ignatova, Z., Thakur, A. K., Wetzel, R., and Gierasch, L. M. (2007) In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence. J. Biol. Chem. 282, 36736-36743
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 36736-36743
-
-
Ignatova, Z.1
Thakur, A.K.2
Wetzel, R.3
Gierasch, L.M.4
-
45
-
-
77954616668
-
Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences
-
Lakhani, V. V., Ding, F., and Dokholyan, N. V. (2010) Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences. PLoS Comput. Biol. 6, e1000772
-
(2010)
PLoS Comput. Biol.
, vol.6
-
-
Lakhani, V.V.1
Ding, F.2
Dokholyan, N.V.3
-
46
-
-
58749112388
-
The structural impact of a polyglutamine tract is location-dependent
-
Robertson, A. L., Horne, J., Ellisdon, A. M., Thomas, B., Scanlon, M. J., and Bottomley, S. P. (2008) The structural impact of a polyglutamine tract is location-dependent. Biophys. J. 95, 5922-5930
-
(2008)
Biophys. J.
, vol.95
, pp. 5922-5930
-
-
Robertson, A.L.1
Horne, J.2
Ellisdon, A.M.3
Thomas, B.4
Scanlon, M.J.5
Bottomley, S.P.6
-
47
-
-
79959946977
-
Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model
-
Siwach, P., Sengupta, S., Parihar, R., and Ganesh, S. (2011) Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model. Neurosci. Res. 70, 435-441
-
(2011)
Neurosci. Res.
, vol.70
, pp. 435-441
-
-
Siwach, P.1
Sengupta, S.2
Parihar, R.3
Ganesh, S.4
-
48
-
-
33846262456
-
Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: A work in progress
-
Woulfe, J. M. (2007) Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progress. Neuropathol. Appl. Neurobiol. 33, 2-42
-
(2007)
Neuropathol. Appl. Neurobiol.
, vol.33
, pp. 2-42
-
-
Woulfe, J.M.1
-
49
-
-
84865549121
-
Biosynthetic mode can determine the mechanism of protein quality control
-
Prasad, R., Kawaguchi, S., and Ng, D. T. (2012) Biosynthetic mode can determine the mechanism of protein quality control. Biochem. Biophys. Res. Commun. 425, 689-695
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.425
, pp. 689-695
-
-
Prasad, R.1
Kawaguchi, S.2
Ng, D.T.3
-
50
-
-
9144223729
-
Inefficient degradation of truncated polyglutamine proteins by the proteasome
-
Holmberg, C. I., Staniszewski, K. E., Mensah, K. N., Matouschek, A., and Morimoto, R. I. (2004) Inefficient degradation of truncated polyglutamine proteins by the proteasome. EMBO J. 23, 4307-4318
-
(2004)
EMBO J.
, vol.23
, pp. 4307-4318
-
-
Holmberg, C.I.1
Staniszewski, K.E.2
Mensah, K.N.3
Matouschek, A.4
Morimoto, R.I.5
-
51
-
-
0038413759
-
Aggregated and monomeric α-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function
-
Snyder, H., Mensah, K., Theisler, C., Lee, J., Matouschek, A., and Wolozin, B. (2003) Aggregated and monomeric α-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function. J. Biol. Chem. 278, 11753-11759
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11753-11759
-
-
Snyder, H.1
Mensah, K.2
Theisler, C.3
Lee, J.4
Matouschek, A.5
Wolozin, B.6
-
52
-
-
0037108725
-
Aggregate formation inhibits proteasomal degradation of polyglutamine proteins
-
Verhoef, L. G., Lindsten, K., Masucci, M. G., and Dantuma, N. P. (2002) Aggregate formation inhibits proteasomal degradation of polyglutamine proteins. Hum. Mol. Genet. 11, 2689-2700
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2689-2700
-
-
Verhoef, L.G.1
Lindsten, K.2
Masucci, M.G.3
Dantuma, N.P.4
-
53
-
-
23144443884
-
Protein quality control: Chaperones culling corrupt conformations
-
McClellan, A. J., Tam, S., Kaganovich, D., and Frydman, J. (2005) Protein quality control: chaperones culling corrupt conformations. Nat. Cell Biol. 7, 736-741
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 736-741
-
-
McClellan, A.J.1
Tam, S.2
Kaganovich, D.3
Frydman, J.4
-
54
-
-
0033520987
-
Posttranslational quality control: Folding, refolding, and degrading proteins
-
Wickner, S., Maurizi, M. R., and Gottesman, S. (1999) Posttranslational quality control: folding, refolding, and degrading proteins. Science 286, 1888-1893
-
(1999)
Science
, vol.286
, pp. 1888-1893
-
-
Wickner, S.1
Maurizi, M.R.2
Gottesman, S.3
|