Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1

Journal of Biological Chemistry

Volumn 288, Issue 9, 2013, Pages 6212-6226

  Rafikov, Ruslan ^a   Rafikova, Olga ^a   Aggarwal, Saurabh ^a   Gross, Christine ^a   Sun, Xutong ^a   Desai, Julin ^a   Fulton, David ^a   Black, Stephen M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTERIAL ENDOTHELIAL CELLS; ASYMMETRIC DIMETHYLARGININE; ATP LEVEL; ENDOTHELIAL NITRIC-OXIDE SYNTHASE (ENOS); MITOCHONDRIAL OXYGEN CONSUMPTION; MITOCHONDRIAL TRANSLOCATION; NEW MECHANISMS; NITRIC-OXIDE SYNTHASE; OVER-EXPRESSION; PHOSPHORYLATION SITES; PHYSIOLOGIC CONDITIONS; PROTEIN NITRATION; SERINE RESIDUES; SUPEROXIDE PRODUCTION; TYROSINE RESIDUES;

AMINO ACIDS; ENDOTHELIAL CELLS; MASS SPECTROMETRY; NITRATION; OXYGEN; PHOSPHORYLATION; PROTEINS;

MITOCHONDRIA;

ADENOSINE TRIPHOSPHATE; ALANINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G),N(G) DIMETHYLARGININE; PHENYLALANINE; PROTEIN AKT1; PROTEIN KINASE B; SERINE; SUPEROXIDE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRION; NITRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TRANSPORT;

ANIMALS; ARGININE; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NITRIC OXIDE SYNTHASE TYPE III; OXYGEN CONSUMPTION; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SHEEP;

EID: 84874771073     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.423269     Document Type: Article

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