Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer's disease in mice

Neurobiology of Learning and Memory

Volumn 102, Issue , 2013, Pages 7-11

  Devi, Latha ^a   Ohno, Masuo ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aging; Alzheimer's disease; Antiepileptic drug; Fear conditioning; Learning and memory; Levetiracetam

Indexed keywords

ETIRACETAM;

AGE DISTRIBUTION; AGED; AGING; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG EFFICACY; FEAR; FEMALE; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NONHUMAN; SINGLE DRUG DOSE; TASK PERFORMANCE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; FEAR; FEMALE; MALE; MEMORY; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NOOTROPIC AGENTS; PIRACETAM;

EID: 84874770890     PISSN: 10747427     EISSN: 10959564     Source Type: Journal    
DOI: 10.1016/j.nlm.2013.02.001     Document Type: Article

References (32)

1. Amatniek J.C., Hauser W.A., DelCastillo-Castaneda C., Jacobs D.M., Marder K., Bell K., et al. Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia 2006, 47:867-872.
2. Bakker A., Krauss G.L., Albert M.S., Speck C.L., Jones L.R., Stark C.E., et al. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron 2012, 74:467-474.
3. Busche M.A., Eichhoff G., Adelsberger H., Abramowski D., Wiederhold K.H., Haass C., et al. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science 2008, 321:1686-1689.
4. Devi L., Alldred M.J., Ginsberg S.D., Ohno M. Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease. Molecular Brain 2010, 3:34.
5. Devi L., Ohno M. Genetic reductions of β-site amyloid precursor protein-cleaving enzyme 1 and amyloid-β ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice. European Journal of Neuroscience 2010, 31:110-118.
6. Ewers M., Sperling R.A., Klunk W.E., Weiner M.W., Hampel H. Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia. Trends in Neurosciences 2011, 34:430-442.
7. Fanselow M.S. Contextual fear, gestalt memories, and the hippocampus. Behavioural Brain Research 2000, 110:73-81.
8. Franklin K.B.J., Paxinos G. The mouse brain in stereotaxic coordinates 2008, Academic Press, New York. 3rd ed.
9. Gallagher M., Koh M.T. Episodic memory on the path to Alzheimer's disease. Current Opinion in Neurobiology 2011, 21:929-934.
10. Kimura R., Devi L., Ohno M. Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice. Journal of Neurochemistry 2010, 113:248-261.
11. Kimura R., Ohno M. Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model. Neurobiology of Disease 2009, 33:229-235.
12. Koh M.T., Haberman R.P., Foti S., McCown T.J., Gallagher M. Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology 2010, 35:1016-1025.
13. A α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. Neuropharmacology 2013, 64:145-152.
14. Maren S. Neurobiology of Pavlovian fear conditioning. Annual Review of Neuroscience 2001, 24:897-931.
15. Miller S.L., Fenstermacher E., Bates J., Blacker D., Sperling R.A., Dickerson B.C. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. Journal of Neurology, Neurosurgery and Psychiatry 2008, 79:630-635.
16. Minkeviciene R., Rheims S., Dobszay M.B., Zilberter M., Hartikainen J., Fulop L., et al. Amyloid β-induced neuronal hyperexcitability triggers progressive epilepsy. Journal of Neuroscience 2009, 29:3453-3462.
17. Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., et al. Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation. Journal of Neuroscience 2006, 26:10129-10140.
18. Ohno M. Failures to reconsolidate memory in a mouse model of Alzheimer's disease. Neurobiology of Learning and Memory 2009, 92:455-459.
19. Ohno M., Chang L., Tseng W., Oakley H., Citron M., Klein W.L., et al. Temporal memory deficits in Alzheimer's mouse models: Rescue by genetic deletion of BACE1. European Journal of Neuroscience 2006, 23:251-260.
20. Ohno M., Cole S.L., Yasvoina M., Zhao J., Citron M., Berry R., et al. BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiology of Disease 2007, 26:134-145.
21. Ohno M., Frankland P.W., Chen A.P., Costa R.M., Silva A.J. Inducible, pharmacogenetic approaches to the study of learning and memory. Nature Neuroscience 2001, 4:1238-1243.
22. Palop J.J., Chin J., Roberson E.D., Wang J., Thwin M.T., Bien-Ly N., et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007, 55:697-711.
23. Palop J.J., Mucke L. Amyloid-β-induced neuronal dysfunction in Alzheimer's disease: From synapses toward neural networks. Nature Neuroscience 2010, 13:812-818.
24. Putcha D., Brickhouse M., O'Keefe K., Sullivan C., Rentz D., Marshall G., et al. Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults. Journal of Neuroscience 2011, 31:17680-17688.
25. Qing H., He G., Ly P.T., Fox C.J., Staufenbiel M., Cai F., et al. Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. Journal of Experimental Medicine 2008, 205:2781-2789.
26. Rabinowicz A.L., Starkstein S.E., Leiguarda R.C., Coleman A.E. Transient epileptic amnesia in dementia: A treatable unrecognized cause of episodic amnestic wandering. Alzheimer Disease and Associated Disorders 2000, 14:231-233.
27. Rao S.C., Dove G., Cascino G.D., Petersen R.C. Recurrent seizures in patients with dementia: Frequency, seizure types, and treatment outcome. Epilepsy & Behavior 2009, 14:118-120.
28. Sanchez P.E., Zhu L., Verret L., Vossel K.A., Orr A.G., Cirrito J.R., et al. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proceedings National Academy Science USA 2012, 109:E2895-E2903.
29. Wilson I.A., Gallagher M., Eichenbaum H., Tanila H. Neurocognitive aging: Prior memories hinder new hippocampal encoding. Trends in Neurosciences 2006, 29:662-670.
30. Wilson I.A., Ikonen S., Gallagher M., Eichenbaum H., Tanila H. Age-associated alterations of hippocampal place cells are subregion specific. Journal of Neuroscience 2005, 25:6877-6886.
31. Yassa M.A., Stark S.M., Bakker A., Albert M.S., Gallagher M., Stark C.E. High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment. Neuroimage 2010, 51:1242-1252.
32. Ziyatdinova S., Gurevicius K., Kutchiashvili N., Bolkvadze T., Nissinen J., Tanila H., et al. Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels. Epilepsy Research 2011, 94:75-85.