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Volumn 8, Issue 3, 2013, Pages

CD44 Plays a Critical Role in Regulating Diet-Induced Adipose Inflammation, Hepatic Steatosis, and Insulin Resistance

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; COLLAGEN; GLUCOSE; INSULIN; MATRIX METALLOPROTEINASE; OSTEOPONTIN;

EID: 84874725462     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058417     Document Type: Article
Times cited : (64)

References (61)
  • 1
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, et al. (2004) Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40: 1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5
  • 2
    • 84856433589 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
    • Ogden CL, Carroll MD, Kit BK, Flegal KM, (2012) Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA 307: 483-490.
    • (2012) JAMA , vol.307 , pp. 483-490
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 3
    • 78651089694 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease
    • Hebbard L, George J, (2011) Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 8: 35-44.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 35-44
    • Hebbard, L.1    George, J.2
  • 4
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: common threads and missing links
    • Samuel VT, Shulman GI, (2012) Mechanisms for insulin resistance: common threads and missing links. Cell 148: 852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 5
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
    • Fabbrini E, Sullivan S, Klein S, (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51: 679-689.
    • (2010) Hepatology , vol.51 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 7
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath MY, Shoelson SE, (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11: 98-107.
    • (2011) Nat Rev Immunol , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 8
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng CN, Saltiel AR, (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121: 2111-2117.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 9
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, et al. (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15: 914-920.
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5
  • 10
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, et al. (2008) Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab 7: 496-507.
    • (2008) Cell Metab , vol.7 , pp. 496-507
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Red Eagle, A.3    Vats, D.4    Morel, C.R.5
  • 11
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5
  • 12
    • 70349325630 scopus 로고    scopus 로고
    • CD44 and its role in inflammation and inflammatory diseases
    • Johnson P, Ruffell B, (2009) CD44 and its role in inflammation and inflammatory diseases. Inflamm Allergy Drug Targets 8: 208-220.
    • (2009) Inflamm Allergy Drug Targets , vol.8 , pp. 208-220
    • Johnson, P.1    Ruffell, B.2
  • 13
    • 73349134974 scopus 로고    scopus 로고
    • Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities
    • Toole BP, (2009) Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities. Clin Cancer Res 15: 7462-7468.
    • (2009) Clin Cancer Res , vol.15 , pp. 7462-7468
    • Toole, B.P.1
  • 14
    • 79953042645 scopus 로고    scopus 로고
    • CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?
    • Zoller M, (2011) CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer 11: 254-267.
    • (2011) Nat Rev Cancer , vol.11 , pp. 254-267
    • Zoller, M.1
  • 15
    • 78751670809 scopus 로고    scopus 로고
    • Hyaluronan as an immune regulator in human diseases
    • Jiang D, Liang J, Noble PW, (2011) Hyaluronan as an immune regulator in human diseases. Physiol Rev 91: 221-264.
    • (2011) Physiol Rev , vol.91 , pp. 221-264
    • Jiang, D.1    Liang, J.2    Noble, P.W.3
  • 16
    • 0029808003 scopus 로고    scopus 로고
    • Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44
    • McKee CM, Penno MB, Cowman M, Burdick MD, Strieter RM, et al. (1996) Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest 98: 2403-2413.
    • (1996) J Clin Invest , vol.98 , pp. 2403-2413
    • McKee, C.M.1    Penno, M.B.2    Cowman, M.3    Burdick, M.D.4    Strieter, R.M.5
  • 18
    • 84863388257 scopus 로고    scopus 로고
    • Hyaluronan regulates cell behavior: a potential niche matrix for stem cells
    • Solis MA, Chen YH, Wong TY, Bittencourt VZ, Lin YC, et al. (2012) Hyaluronan regulates cell behavior: a potential niche matrix for stem cells. Biochem Res Int 2012: 346972.
    • (2012) Biochem Res Int , vol.2012 , pp. 346972
    • Solis, M.A.1    Chen, Y.H.2    Wong, T.Y.3    Bittencourt, V.Z.4    Lin, Y.C.5
  • 19
    • 84861732970 scopus 로고    scopus 로고
    • Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD): MODULATION OF MATRIX METALLOPROTEINASE 9 (MMP-9) TRANSCRIPTION VIA NOVEL PROMOTER RESPONSE ELEMENT
    • Miletti-Gonzalez KE, Murphy K, Kumaran MN, Ravindranath AK, Wernyj RP, et al. (2012) Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD): MODULATION OF MATRIX METALLOPROTEINASE 9 (MMP-9) TRANSCRIPTION VIA NOVEL PROMOTER RESPONSE ELEMENT. J Biol Chem 287: 18995-19007.
    • (2012) J Biol Chem , vol.287 , pp. 18995-19007
    • Miletti-Gonzalez, K.E.1    Murphy, K.2    Kumaran, M.N.3    Ravindranath, A.K.4    Wernyj, R.P.5
  • 20
    • 63249096236 scopus 로고    scopus 로고
    • Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity
    • Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, et al. (2009) Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity. Diabetes 58: 125-133.
    • (2009) Diabetes , vol.58 , pp. 125-133
    • Bertola, A.1    Deveaux, V.2    Bonnafous, S.3    Rousseau, D.4    Anty, R.5
  • 21
    • 84860791012 scopus 로고    scopus 로고
    • Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes
    • Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, et al. (2012) Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A.
    • (2012) Proc Natl Acad Sci U S A.
    • Kodama, K.1    Horikoshi, M.2    Toda, K.3    Yamada, S.4    Hara, K.5
  • 22
    • 0030796519 scopus 로고    scopus 로고
    • CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity
    • Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, et al. (1997) CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90: 2217-2233.
    • (1997) Blood , vol.90 , pp. 2217-2233
    • Schmits, R.1    Filmus, J.2    Gerwin, N.3    Senaldi, G.4    Kiefer, F.5
  • 23
    • 78751508897 scopus 로고    scopus 로고
    • Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance
    • Kang HS, Okamoto K, Kim YS, Takeda Y, Bortner CD, et al. (2011) Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes 60: 177-188.
    • (2011) Diabetes , vol.60 , pp. 177-188
    • Kang, H.S.1    Okamoto, K.2    Kim, Y.S.3    Takeda, Y.4    Bortner, C.D.5
  • 24
    • 0041353552 scopus 로고    scopus 로고
    • Cidea-deficient mice have lean phenotype and are resistant to obesity
    • Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet 35: 49-56.
    • (2003) Nat Genet , vol.35 , pp. 49-56
    • Zhou, Z.1    Yon Toh, S.2    Chen, Z.3    Guo, K.4    Ng, C.P.5
  • 25
    • 79960416891 scopus 로고    scopus 로고
    • Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis
    • Kang HS, Okamoto K, Takeda Y, Beak JY, Gerrish K, et al. (2011) Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiol Genomics 43: 818-828.
    • (2011) Physiol Genomics , vol.43 , pp. 818-828
    • Kang, H.S.1    Okamoto, K.2    Takeda, Y.3    Beak, J.Y.4    Gerrish, K.5
  • 26
    • 35548949049 scopus 로고    scopus 로고
    • Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism
    • Kang HS, Angers M, Beak JY, Wu X, Gimble JM, et al. (2007) Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics 31: 281-294.
    • (2007) Physiol Genomics , vol.31 , pp. 281-294
    • Kang, H.S.1    Angers, M.2    Beak, J.Y.3    Wu, X.4    Gimble, J.M.5
  • 27
    • 66349088529 scopus 로고    scopus 로고
    • Hepatic triacylglycerol accumulation and insulin resistance
    • Nagle CA, Klett EL, Coleman RA, (2009) Hepatic triacylglycerol accumulation and insulin resistance. J Lipid Res 50Suppl: S74-79.
    • (2009) J Lipid Res , vol.50
    • Nagle, C.A.1    Klett, E.L.2    Coleman, R.A.3
  • 28
    • 64549137257 scopus 로고    scopus 로고
    • CIDE proteins and metabolic disorders
    • Gong J, Sun Z, Li P, (2009) CIDE proteins and metabolic disorders. Curr Opin Lipidol 20: 121-126.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 121-126
    • Gong, J.1    Sun, Z.2    Li, P.3
  • 29
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • Wouters K, van Gorp PJ, Bieghs V, Gijbels MJ, Duimel H, et al. (2008) Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48: 474-486.
    • (2008) Hepatology , vol.48 , pp. 474-486
    • Wouters, K.1    van Gorp, P.J.2    Bieghs, V.3    Gijbels, M.J.4    Duimel, H.5
  • 30
    • 66349126363 scopus 로고    scopus 로고
    • Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver
    • Guillen N, Navarro MA, Arnal C, Noone E, Arbones-Mainar JM, et al. (2009) Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Physiol Genomics 37: 187-198.
    • (2009) Physiol Genomics , vol.37 , pp. 187-198
    • Guillen, N.1    Navarro, M.A.2    Arnal, C.3    Noone, E.4    Arbones-Mainar, J.M.5
  • 31
    • 78649759561 scopus 로고    scopus 로고
    • Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice
    • Chapman J, Miles PD, Ofrecio JM, Neels JG, Yu JG, et al. (2010) Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice. PLoS One 5: e13959.
    • (2010) PLoS One , vol.5
    • Chapman, J.1    Miles, P.D.2    Ofrecio, J.M.3    Neels, J.G.4    Yu, J.G.5
  • 32
    • 79956324407 scopus 로고    scopus 로고
    • Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function
    • Zeyda M, Gollinger K, Todoric J, Kiefer FW, Keck M, et al. (2011) Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function. Endocrinology 152: 2219-2227.
    • (2011) Endocrinology , vol.152 , pp. 2219-2227
    • Zeyda, M.1    Gollinger, K.2    Todoric, J.3    Kiefer, F.W.4    Keck, M.5
  • 33
    • 84863098121 scopus 로고    scopus 로고
    • Inflammation and fibrogenesis in steatohepatitis
    • Fujii H, Kawada N, (2012) Inflammation and fibrogenesis in steatohepatitis. Journal of gastroenterology 47: 215-225.
    • (2012) Journal of Gastroenterology , vol.47 , pp. 215-225
    • Fujii, H.1    Kawada, N.2
  • 36
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, et al. (2002) A central role for JNK in obesity and insulin resistance. Nature 420: 333-336.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3    Gorgun, C.Z.4    Uysal, K.T.5
  • 37
    • 79960901954 scopus 로고    scopus 로고
    • Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice
    • Kiefer FW, Neschen S, Pfau B, Legerer B, Neuhofer A, et al. (2011) Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diabetologia 54: 2132-2142.
    • (2011) Diabetologia , vol.54 , pp. 2132-2142
    • Kiefer, F.W.1    Neschen, S.2    Pfau, B.3    Legerer, B.4    Neuhofer, A.5
  • 38
    • 84856273971 scopus 로고    scopus 로고
    • Epinephrine induces PDK4 mRNA expression in adipose tissue from obese, insulin resistant rats
    • Wan Z, Frier BC, Williams DB, Wright DC, (2012) Epinephrine induces PDK4 mRNA expression in adipose tissue from obese, insulin resistant rats. Obesity (Silver Spring) 20: 453-456.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 453-456
    • Wan, Z.1    Frier, B.C.2    Williams, D.B.3    Wright, D.C.4
  • 39
    • 80054943500 scopus 로고    scopus 로고
    • Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells
    • Zheng YH, Tian C, Meng Y, Qin YW, Du YH, et al. (2012) Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. Journal of cellular physiology 227: 127-135.
    • (2012) Journal of Cellular Physiology , vol.227 , pp. 127-135
    • Zheng, Y.H.1    Tian, C.2    Meng, Y.3    Qin, Y.W.4    Du, Y.H.5
  • 40
    • 78650637999 scopus 로고    scopus 로고
    • Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism
    • Pivetta E, Scapolan M, Wassermann B, Steffan A, Colombatti A, et al. (2011) Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism. Journal of cellular physiology 226: 769-779.
    • (2011) Journal of Cellular Physiology , vol.226 , pp. 769-779
    • Pivetta, E.1    Scapolan, M.2    Wassermann, B.3    Steffan, A.4    Colombatti, A.5
  • 41
    • 48749103552 scopus 로고    scopus 로고
    • FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets
    • Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, et al. (2008) FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 118: 2808-2821.
    • (2008) J Clin Invest , vol.118 , pp. 2808-2821
    • Nishino, N.1    Tamori, Y.2    Tateya, S.3    Kawaguchi, T.4    Shibakusa, T.5
  • 42
    • 44949130214 scopus 로고    scopus 로고
    • Fat-specific protein 27 regulates storage of triacylglycerol
    • Keller P, Petrie JT, De Rose P, Gerin I, Wright WS, et al. (2008) Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem 283: 14355-14365.
    • (2008) J Biol Chem , vol.283 , pp. 14355-14365
    • Keller, P.1    Petrie, J.T.2    De Rose, P.3    Gerin, I.4    Wright, W.S.5
  • 43
    • 84863517798 scopus 로고    scopus 로고
    • Cidea promotes hepatic steatosis by sensing dietary fatty acids
    • Zhou L, Xu L, Ye J, Li D, Wang W, et al. (2012) Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology 56: 95-107.
    • (2012) Hepatology , vol.56 , pp. 95-107
    • Zhou, L.1    Xu, L.2    Ye, J.3    Li, D.4    Wang, W.5
  • 44
    • 0036109168 scopus 로고    scopus 로고
    • Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
    • Hajri T, Han XX, Bonen A, Abumrad NA, (2002) Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest 109: 1381-1389.
    • (2002) J Clin Invest , vol.109 , pp. 1381-1389
    • Hajri, T.1    Han, X.X.2    Bonen, A.3    Abumrad, N.A.4
  • 45
    • 79953176650 scopus 로고    scopus 로고
    • Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue
    • Nicholls HT, Kowalski G, Kennedy DJ, Risis S, Zaffino LA, et al. (2011) Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes 60: 1100-1110.
    • (2011) Diabetes , vol.60 , pp. 1100-1110
    • Nicholls, H.T.1    Kowalski, G.2    Kennedy, D.J.3    Risis, S.4    Zaffino, L.A.5
  • 46
    • 70349308483 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (Review)
    • Consolo M, Amoroso A, Spandidos DA, Mazzarino MC, (2009) Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (Review). Int J Mol Med 24: 143-152.
    • (2009) Int J Mol Med , vol.24 , pp. 143-152
    • Consolo, M.1    Amoroso, A.2    Spandidos, D.A.3    Mazzarino, M.C.4
  • 47
    • 34047121535 scopus 로고    scopus 로고
    • Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies
    • Hemmann S, Graf J, Roderfeld M, Roeb E, (2007) Expression of MMPs and TIMPs in liver fibrosis- a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 46: 955-975.
    • (2007) J Hepatol , vol.46 , pp. 955-975
    • Hemmann, S.1    Graf, J.2    Roderfeld, M.3    Roeb, E.4
  • 48
    • 34147164049 scopus 로고    scopus 로고
    • Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
    • Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, et al. (2007) Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 117: 902-909.
    • (2007) J Clin Invest , vol.117 , pp. 902-909
    • Tsou, C.L.1    Peters, W.2    Si, Y.3    Slaymaker, S.4    Aslanian, A.M.5
  • 49
    • 82455167937 scopus 로고    scopus 로고
    • An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice
    • Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D, (2011) An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology 54: 2185-2197.
    • (2011) Hepatology , vol.54 , pp. 2185-2197
    • Mandrekar, P.1    Ambade, A.2    Lim, A.3    Szabo, G.4    Catalano, D.5
  • 50
    • 84868202269 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice
    • Nio Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Funata M, et al. (2012) Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice. Diabetologia.
    • (2012) Diabetologia
    • Nio, Y.1    Yamauchi, T.2    Iwabu, M.3    Okada-Iwabu, M.4    Funata, M.5
  • 51
    • 79960354059 scopus 로고    scopus 로고
    • Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44
    • Li Y, Jiang D, Liang J, Meltzer EB, Gray A, et al. (2011) Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44. The Journal of experimental medicine 208: 1459-1471.
    • (2011) The Journal of Experimental Medicine , vol.208 , pp. 1459-1471
    • Li, Y.1    Jiang, D.2    Liang, J.3    Meltzer, E.B.4    Gray, A.5
  • 52
    • 84863223829 scopus 로고    scopus 로고
    • CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status
    • Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, et al. (2012) CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status. Diabetes.
    • (2012) Diabetes
    • Kitade, H.1    Sawamoto, K.2    Nagashimada, M.3    Inoue, H.4    Yamamoto, Y.5
  • 53
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS, (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 54
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: modulation by nutrients and inflammation
    • Schenk S, Saberi M, Olefsky JM, (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118: 2992-3002.
    • (2008) J Clin Invest , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 55
    • 84864184031 scopus 로고    scopus 로고
    • Growth signals, inflammation, and vascular perturbations: mechanistic links between obesity, metabolic syndrome, and cancer
    • Hursting SD, Hursting MJ, (2012) Growth signals, inflammation, and vascular perturbations: mechanistic links between obesity, metabolic syndrome, and cancer. Arterioscler Thromb Vasc Biol 32: 1766-1770.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1766-1770
    • Hursting, S.D.1    Hursting, M.J.2
  • 56
    • 84866616241 scopus 로고    scopus 로고
    • Adiponectin and interleukin-6 in inflammation-associated disease
    • Li L, Wu LL, (2012) Adiponectin and interleukin-6 in inflammation-associated disease. Vitam Horm 90: 375-395.
    • (2012) Vitam Horm , vol.90 , pp. 375-395
    • Li, L.1    Wu, L.L.2
  • 57
    • 77949447135 scopus 로고    scopus 로고
    • Osteopontin: an effector and an effect of tumor metastasis
    • Shevde LA, Das S, Clark DW, Samant RS, (2010) Osteopontin: an effector and an effect of tumor metastasis. Curr Mol Med 10: 71-81.
    • (2010) Curr Mol Med , vol.10 , pp. 71-81
    • Shevde, L.A.1    Das, S.2    Clark, D.W.3    Samant, R.S.4
  • 58
    • 77950833119 scopus 로고    scopus 로고
    • Osteopontin; as a target molecule for the treatment of inflammatory diseases
    • Morimoto J, Kon S, Matsui Y, Uede T, (2010) Osteopontin; as a target molecule for the treatment of inflammatory diseases. Curr Drug Targets 11: 494-505.
    • (2010) Curr Drug Targets , vol.11 , pp. 494-505
    • Morimoto, J.1    Kon, S.2    Matsui, Y.3    Uede, T.4
  • 59
    • 34249656915 scopus 로고    scopus 로고
    • PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes
    • Nakamachi T, Nomiyama T, Gizard F, Heywood EB, Jones KL, et al. (2007) PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes. Diabetes 56: 1662-1670.
    • (2007) Diabetes , vol.56 , pp. 1662-1670
    • Nakamachi, T.1    Nomiyama, T.2    Gizard, F.3    Heywood, E.B.4    Jones, K.L.5
  • 60
    • 33947249865 scopus 로고    scopus 로고
    • A constitutive endogenous osteopontin production is important for macrophage function and differentiation
    • Nystrom T, Duner P, Hultgardh-Nilsson A, (2007) A constitutive endogenous osteopontin production is important for macrophage function and differentiation. Exp Cell Res 313: 1149-1160.
    • (2007) Exp Cell Res , vol.313 , pp. 1149-1160
    • Nystrom, T.1    Duner, P.2    Hultgardh-Nilsson, A.3
  • 61
    • 1642316557 scopus 로고    scopus 로고
    • Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin
    • Zhu B, Suzuki K, Goldberg HA, Rittling SR, Denhardt DT, et al. (2004) Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin. J Cell Physiol 198: 155-167.
    • (2004) J Cell Physiol , vol.198 , pp. 155-167
    • Zhu, B.1    Suzuki, K.2    Goldberg, H.A.3    Rittling, S.R.4    Denhardt, D.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.