In Vivo Knockdown of TAK1 Accelerates Bone Marrow Proliferation/Differentiation and Induces Systemic Inflammation

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Vink, Paul M ^a   Smout, Wendy M ^a   Driessen Engels, Lilian J ^a   de Bruin, Alex M ^b   Delsing, Dianne ^a   Krajnc Franken, Magda A ^a   Jansen, Aswin J ^a   Rovers, Eric F ^a   van Puijenbroek, André A ^a   Kaptein, Allard ^a   Nolte, Martijn A ^b,c   Garritsen, Anja ^a   van Eenennaam, Hans ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c SANQUIN RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; DOXYCYCLINE; MESSENGER RNA; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CD3+ T LYMPHOCYTE; CD4 LYMPHOCYTE COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RELEASE; DEGENERATION; GENE IDENTIFICATION; GENE SILENCING; HEART DISEASE; HISTOPATHOLOGY; IN VIVO STUDY; INFLAMMATORY DISEASE; INTRACELLULAR SIGNALING; KIDNEY DISEASE; LYMPHOCYTE SUBPOPULATION; MONOCYTE; MOUSE; MYELOID PROGENITOR CELL; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN DISEASE; SPLENOMEGALY; TGF BETA ACTIVATED KINASE 1 GENE; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOKINES; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; HOMEOSTASIS; INFLAMMATION; KIDNEY; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MAP KINASE KINASE KINASES; MICE; MICE, TRANSGENIC; MYOCARDIUM; RNA INTERFERENCE; SPLEEN;

EID: 84874680253     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057348     Document Type: Article

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