-
1
-
-
84874721928
-
Métodos Para O Incremento Da Solubilidade De Substâncias Activas Pouco Solúveis (BCS - Classe II)
-
[Dissertação]. Lisboa: Faculdade de Farmácia, Universidade de Lisboa
-
Almeida H. Métodos para o incremento da solubilidade de substâncias activas pouco solúveis (BCS - Classe II). [Dissertação]. Lisboa: Faculdade de Farmácia, Universidade de Lisboa; 2009.
-
(2009)
-
-
Almeida, H.1
-
2
-
-
34548040152
-
High throughput solubility measurement in drug discovery and development
-
Alsenz J, Kansy M. High throughput solubility measurement in drug discovery and development. Adv Drug Deliv Rev. 2007;30; 59(7):546-67.
-
(2007)
Adv Drug Deliv Rev
, vol.30
, Issue.7
, pp. 546-567
-
-
Alsenz, J.1
Kansy, M.2
-
3
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 1995;12(3):413-20.
-
(1995)
Pharm Res
, vol.12
, Issue.3
, pp. 413-420
-
-
Amidon, G.L.1
Lennernas, H.2
Shah, V.P.3
Crison, J.R.4
-
4
-
-
21244445440
-
Spray-Dried amorphous solid dispersions of simvastatin, a low Tg drug: In vitro and in vivo evaluations
-
Ambike AA, Mahadik, KR, Paradkar A. Spray-Dried amorphous solid dispersions of simvastatin, a low Tg drug: in vitro and in vivo evaluations. Pharm Res. 2005;22(6):990-98.
-
(2005)
Pharm Res
, vol.22
, Issue.6
, pp. 990-998
-
-
Ambike, A.A.1
Mahadik, K.R.2
Paradkar, A.3
-
6
-
-
0034212876
-
Swellable matrices for controlled drug delivery:Gel-layer behaviour, mechanisms and optimal performance
-
Colombo P, Bettini R, Santi P. Swellable matrices for controlled drug delivery:gel-layer behaviour, mechanisms and optimal performance. Pharm Sci Tech Today. 2000;3(6):198-04.
-
(2000)
Pharm Sci Tech Today
, vol.3
, Issue.6
, pp. 198-204
-
-
Colombo, P.1
Bettini, R.2
Santi, P.3
-
7
-
-
39549098143
-
Utilização de ciclodextrinas na formação de complexos de inclusão de interesse farmacêutico
-
Cunha-Filho MSS, Sá-Barreto LCL. Utilização de ciclodextrinas na formação de complexos de inclusão de interesse farmacêutico. Rev Ciênc Farm Básica Apl. 2007;28(1):1-9.
-
(2007)
Rev Ciênc Farm Básica Apl
, vol.28
, Issue.1
, pp. 1-9
-
-
Cunha-Filho, M.S.S.1
Sá-Barreto, L.C.L.2
-
8
-
-
73049095512
-
Induced surface activity of supramolecular cyclodextrin-statin complexes: Relevance in drug delivery
-
Csempesz F, Süle A, Puskas I. Induced surface activity of supramolecular cyclodextrin-statin complexes: relevance in drug delivery. Colloids Surf A. 2010;354(1-3):308-13.
-
(2010)
Colloids Surf A
, vol.354
, Issue.1-3
, pp. 308-313
-
-
Csempesz, F.1
Süle, A.2
Puskas, I.3
-
9
-
-
79959509620
-
Microemulsão: Um promissor carreador para moléculas insolúveis
-
Damasceno BPGL, Silva JA, Oliveira EE, Silveira WLL, Araújo IB, Oliveira AG, Egito EST. Microemulsão: um promissor carreador para moléculas insolúveis. Rev Ciênc Farm Básica Apl. 2011;32(1):9-18.
-
(2011)
Rev Ciênc Farm Básica Apl
, vol.32
, Issue.1
, pp. 9-18
-
-
Damasceno, B.P.G.L.1
Silva, J.A.2
Oliveira, E.E.3
Silveira, W.L.L.4
Araújo, I.B.5
Oliveira, A.G.6
Egito, E.S.T.7
-
10
-
-
34248592924
-
Surface properties and solubility of simvastatin in the micelles of polyglycerol diisostearate ethoxylates
-
Ding Z, Hao A, Zhang P, Wang Z. Surface properties and solubility of simvastatin in the micelles of polyglycerol diisostearate ethoxylates. J Dispersion Sci Technol., 2007;28(4):495-00.
-
(2007)
J Dispersion Sci Technol
, vol.28
, Issue.4
, pp. 495-500
-
-
Ding, Z.1
Hao, A.2
Zhang, P.3
Wang, Z.4
-
11
-
-
78049520102
-
Optimized microemulsions and solid microemulsion systems of simvastatin: Characterization and in vivo evaluation
-
Dixit RP, Nagarsenker MS. Optimized microemulsions and solid microemulsion systems of simvastatin: characterization and in vivo evaluation. J Pharm Sci. 2010;99(12):4892-02.
-
(2010)
J Pharm Sci
, vol.99
, Issue.12
, pp. 4892-4902
-
-
Dixit, R.P.1
Nagarsenker, M.S.2
-
12
-
-
0022650603
-
The current status of solid dispersions
-
Ford JL. The current status of solid dispersions. Pharm Acta Helv. 1986;61(3):69-88.
-
(1986)
Pharm Acta Helv
, vol.61
, Issue.3
, pp. 69-88
-
-
Ford, J.L.1
-
13
-
-
84984082270
-
Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II - Experimental evaluation of a eutectic mixture: Urea-acetaminophen system
-
Goldberg AH, Gibaldi M, Kanig JL. Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II - Experimental evaluation of a eutectic mixture: Urea-acetaminophen system. J Pharm Sci. 1966;55(5):482-87.
-
(1966)
J Pharm Sci
, vol.55
, Issue.5
, pp. 482-487
-
-
Goldberg, A.H.1
Gibaldi, M.2
Kanig, J.L.3
-
15
-
-
34248561935
-
Preparation and characterization of simvastatin/hydroxypropyl-b-cyclodextrin inclusion complex using supercritical antisolvent (SAS) process
-
Jun SW, Kim M, Kim J, Park H, Lee S, Woo J, Hwang S. Preparation and characterization of simvastatin/hydroxypropyl-b-cyclodextrin inclusion complex using supercritical antisolvent (SAS) process. Eur J Pharm Biopharm. 2007;66(3):413-21.
-
(2007)
Eur J Pharm Biopharm
, vol.66
, Issue.3
, pp. 413-421
-
-
Jun, S.W.1
Kim, M.2
Kim, J.3
Park, H.4
Lee, S.5
Woo, J.6
Hwang, S.7
-
16
-
-
1842609789
-
Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs
-
Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm. 2004;274(1-2):65-7.
-
(2004)
Int J Pharm
, vol.274
, Issue.1-2
, pp. 65-67
-
-
Kang, B.K.1
Lee, J.S.2
Chon, S.K.3
Jeong, S.Y.4
Yuk, S.H.5
Khang, G.6
Lee, H.B.7
Cho, S.H.8
-
17
-
-
3242728351
-
Molecular properties of WHO essential drugs and provisional Biopharmaceutical Classification
-
Kasin NA, et al. Molecular properties of WHO essential drugs and provisional Biopharmaceutical Classification. Mol Pharm. 2004;1(1):85-96.
-
(2004)
Mol Pharm
, vol.1
, Issue.1
, pp. 85-96
-
-
Kasin, N.A.1
-
18
-
-
79151485330
-
Performance evaluation of PAMAM dendrimer based simvastatin formulations
-
Kulhari H, Poojaa D, Prajapatia SK, Chauhanb AS. Performance evaluation of PAMAM dendrimer based simvastatin formulations. Int J Pharm. 2011;405(1-2):203-09.
-
(2011)
Int J Pharm
, vol.405
, Issue.1-2
, pp. 203-209
-
-
Kulhari, H.1
Poojaa, D.2
Prajapatia, S.K.3
Chauhanb, A.S.4
-
19
-
-
70449536503
-
Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems I. Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin
-
Lai J, Chen J, Lu Y, Sun J, Hu F, Yin Z, Wu W. Glyceryl Monooleate/Poloxamer 407 Cubic Nanoparticles as Oral Drug Delivery Systems I. In Vitro Evaluation and Enhanced Oral Bioavailability of the Poorly Water-Soluble Drug Simvastatin. AAPS PharmSciTech. 2009;10(3):960-6.
-
(2009)
AAPS PharmSciTech
, vol.10
, Issue.3
, pp. 960-966
-
-
Lai, J.1
Chen, J.2
Lu, Y.3
Sun, J.4
Hu, F.5
Yin, Z.6
Wu, W.7
-
20
-
-
0034601240
-
Improving drug solubility for oral delivery using solid dispersions (Review Article)
-
Jul
-
Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions (Review Article). Eur J Pharm Biopharm. 2000 Jul;50(1):47-60.
-
(2000)
Eur J Pharm Biopharm
, vol.50
, Issue.1
, pp. 47-60
-
-
Leuner, C.1
Dressman, J.2
-
21
-
-
26244453504
-
Formas farmacêuticas de liberação modificada: Polímeros hidrofílicos
-
Lopes CM, Lobo JM, Costa SP. Formas farmacêuticas de liberação modificada: polímeros hidrofílicos. Rev Bras Cienc Farm. 2005;41(2):143-54.
-
(2005)
Rev Bras Cienc Farm
, vol.41
, Issue.2
, pp. 143-154
-
-
Lopes, C.M.1
Lobo, J.M.2
Costa, S.P.3
-
22
-
-
78049429892
-
Formation of drug nanoparticles from microemulsions
-
Magdassi S, Margulis-Goshen K. Formation of drug nanoparticles from microemulsions. Nanotech. 2010;3:308-11.
-
(2010)
Nanotech
, vol.3
, pp. 308-311
-
-
Magdassi, S.1
Margulis-Goshen, K.2
-
23
-
-
0032756138
-
Physical properties of solid molecular dispersions of indomethacin with poly-(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyllactate) in relation to indomethacin crystallization
-
Matsumoto T, Zografi G. Physical properties of solid molecular dispersions of indomethacin with poly-(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyllactate) in relation to indomethacin crystallization. Pharm Res. 1999;16:1722-28.
-
(1999)
Pharm Res
, vol.16
, pp. 1722-1728
-
-
Matsumoto, T.1
Zografi, G.2
-
24
-
-
69249236865
-
Formation of simvastatin nanoparticles from microemulsion
-
Margulis-Goshen K, Magdassi S. Formation of simvastatin nanoparticles from microemulsion. Nanomedicine. 2009;5(3):274-81.
-
(2009)
Nanomedicine
, vol.5
, Issue.3
, pp. 274-281
-
-
Margulis-Goshen, K.1
Magdassi, S.2
-
25
-
-
84874741707
-
Efeito da hidroxipropilmetilcelulose nas propriedades de complexação de beta-ciclodextrina com praziquantel
-
o Worshop Brasileiro de Tecnologia Farmacêutica e Inovação, Universidade Federal de Sergipe
-
Mourão LCS, Moura TFAL, Morais WA. Efeito da hidroxipropilmetilcelulose nas propriedades de complexação de beta-ciclodextrina com praziquantel. In: 1. Workshop Brasileiro de Tecnologia Farmacêutica e Inovação; 2011; Aracajú: Anais do 1o Worshop Brasileiro de Tecnologia Farmacêutica e Inovação, Universidade Federal de Sergipe; 2011.
-
(2011)
Workshop Brasileiro De Tecnologia Farmacêutica E Inovação
-
-
Mourão, L.C.S.1
Moura, T.F.A.L.2
Morais, W.A.3
-
26
-
-
84874689155
-
Obtenção E Caracterização De Complexos De Inclusão Binários E Ternários Com Praziquantel
-
[Dissertação]. Natal: Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte
-
Mourão LCS. Obtenção e caracterização de complexos de inclusão binários e ternários com praziquantel. [Dissertação]. Natal: Faculdade de Farmácia, Universidade Federal do Rio Grande do Norte; 2012.
-
(2012)
-
-
Mourão, L.C.S.1
-
27
-
-
63649134819
-
Co-solvent evaporation method for enhancement of solubility and dissolution rate of poorly aqueous soluble drug simvastatin: In Vitro-In Vivo evaluation
-
Pandya P, Gattani S, Jain P, Khirwal L, Surana S. Co-solvent evaporation method for enhancement of solubility and dissolution rate of poorly aqueous soluble drug simvastatin: In Vitro-In Vivo evaluation. AAPS PharmSciTech. 2008;9(4):1247-52.
-
(2008)
AAPS PharmSciTech
, vol.9
, Issue.4
, pp. 1247-1252
-
-
Pandya, P.1
Gattani, S.2
Jain, P.3
Khirwal, L.4
Surana, S.5
-
28
-
-
79952504170
-
Effect of different stabilizer on the formulation of simvastatin nanosuspension prepared by nanoprecipitation technique
-
Pandya VM, Patel JK, Patel DJ. Effect of different stabilizer on the formulation of simvastatin nanosuspension prepared by nanoprecipitation technique. Res J Pharm, Biol Chem Sci. 2010;910-17.
-
(2010)
Res J Pharm, Biol Chem Sci
, pp. 910-917
-
-
Pandya, V.M.1
Patel, J.K.2
Patel, D.J.3
-
29
-
-
39049128727
-
Preparation, characterization, and dissolution behavior of a solid dispersion of simvastatin with polyethylene glycol 4000 and polyvinylpyrrolidone K30
-
Patel R, Patel M. Preparation, characterization, and dissolution behavior of a solid dispersion of simvastatin with polyethylene glycol 4000 and polyvinylpyrrolidone K30. J Disper Sci Technol. 2008;29:193-204.
-
(2008)
J Disper Sci Technol
, vol.29
, pp. 193-204
-
-
Patel, R.1
Patel, M.2
-
30
-
-
84866875579
-
Tekad AR Preparation and optimization of simvastatin nanoparticle for solubility enhancement and In Vivo study
-
Patil MS, Bavaskar KR, Girnar GA, Jain AS, Tekad AR Preparation and optimization of simvastatin nanoparticle for solubility enhancement and In Vivo study. Intern J Pharm Res Develop. 2011;2(12):219-26.
-
(2011)
Intern J Pharm Res Develop
, vol.2
, Issue.12
, pp. 219-226
-
-
Patil, M.S.1
Bavaskar, K.R.2
Girnar, G.A.3
Jain, A.S.4
-
32
-
-
77954684495
-
Dissolution improvement of simvastatin by surface solid dispersion technology
-
Rao M, Mandage Y, Thanki K, Bhise S. Dissolution improvement of simvastatin by surface solid dispersion technology. Dis Tech. 2010:27-34.
-
(2010)
Dis Tech
, pp. 27-34
-
-
Rao, M.1
Mandage, Y.2
Thanki, K.3
Bhise, S.4
-
33
-
-
85008071016
-
Studies on absorption of eutectic mixtures. I. A comparison of the behavior of eutectic mixtures of sulphathiazole and that of ordinary sulphathiazole in man
-
Sekiguchi K, Obi N. Studies on absorption of eutectic mixtures. I. A comparison of the behavior of eutectic mixtures of sulphathiazole and that of ordinary sulphathiazole in man. Chem Pharm Bull. 1961;9(11):866-72.
-
(1961)
Chem Pharm Bull
, vol.9
, Issue.11
, pp. 866-872
-
-
Sekiguchi, K.1
Obi, N.2
-
34
-
-
84874755986
-
Desenvolvimento De Métodos Analíticos E De Formulações Para Estatinas
-
[Dissertação]. Belo Horizonte: Faculdade de Farmácia, Universidade Federal de Minas Gerais
-
Silva TD. Desenvolvimento de métodos analíticos e de formulações para estatinas. [Dissertação]. Belo Horizonte: Faculdade de Farmácia, Universidade Federal de Minas Gerais; 2009.
-
(2009)
-
-
Silva, T.D.1
-
35
-
-
84860812012
-
Preparação de Nanopartículas Poliméricas a partir de Polímeros Pré-formados - Parte II (Artigo de Revisão)
-
Souto EB, Severino P, Santana MHA. Preparação de Nanopartículas Poliméricas a partir de Polímeros Pré-formados - Parte II (Artigo de Revisão). Polimeros. 2012;22(1):101-06.
-
(2012)
Polimeros
, vol.22
, Issue.1
, pp. 101-106
-
-
Souto, E.B.1
Severino, P.2
Santana, M.H.A.3
-
36
-
-
42149166134
-
Modelos in vitro para determinação da absorção de fármacos e previsão da relação dissolução/absorção
-
Souza J, Freitas ZMF, Storpirtis S. Modelos in vitro para determinação da absorção de fármacos e previsão da relação dissolução/absorção. Rev Bras Ciênc Farm. 2007;43(4):515-27.
-
(2007)
Rev Bras Ciênc Farm
, vol.43
, Issue.4
, pp. 515-527
-
-
Souza, J.1
Freitas, Z.M.F.2
Storpirtis, S.3
-
38
-
-
28744443398
-
Dendrimers in biomedical applications-reflection on the field
-
Svenson S, Tomalia DA. Dendrimers in biomedical applications-reflection on the field. Adv Drug Deliv Rev. 2005;57(15):2106-29.
-
(2005)
Adv Drug Deliv Rev
, vol.57
, Issue.15
, pp. 2106-2129
-
-
Svenson, S.1
Tomalia, D.A.2
-
39
-
-
62449282129
-
Complexation of statins with ß-cyclodextrin in solutions of small molecular additives and macromolecular colloids
-
Süle A, Csempesz F. Complexation of statins with ß-cyclodextrin in solutions of small molecular additives and macromolecular colloids. Prog Coll Pol Scis. 2008;135:93-100.
-
(2008)
Prog Coll Pol Scis
, vol.135
, pp. 93-100
-
-
Süle, A.1
Csempesz, F.2
-
40
-
-
84874751807
-
Obtenção E Caracterização De Complexos Binários E Ternários De Sinvastatina E Ciclodextrinas
-
[Dissertação]. São Paulo. Faculdade de Ciências Farmacêuticas, Universidade de São Paulo
-
Takahashi AI. Obtenção e caracterização de complexos binários e ternários de sinvastatina e ciclodextrinas. [Dissertação]. São Paulo. Faculdade de Ciências Farmacêuticas, Universidade de São Paulo; 2009.
-
(2009)
-
-
Takahashi, A.I.1
-
41
-
-
79960190356
-
Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin - Comparative analysis of characteristics, pharmacokinetics and tissue uptake
-
Tiwari R, Pathak K. Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin - Comparative analysis of characteristics, pharmacokinetics and tissue uptake. Int J Pharm. 2011;415(1-2):232-43.
-
(2011)
Int J Pharm
, vol.415
, Issue.1-2
, pp. 232-243
-
-
Tiwari, R.1
Pathak, K.2
-
42
-
-
78650676847
-
Use of cyclodextrins as solubilizing agents for simvastatin: Effect of hydroxypropyl-ß-cyclodextrin on lactone/hydroxyacid aqueous equilibrium
-
Ungaro F, Giovino C, Catanzano O, Miro A, Mele A, Quaglia F, La Rotonda MI. Use of cyclodextrins as solubilizing agents for simvastatin: Effect of hydroxypropyl-ß-cyclodextrin on lactone/hydroxyacid aqueous equilibrium. Int J Pharm. 2011;404(1-2):49-56.
-
(2011)
Int J Pharm
, vol.404
, Issue.1-2
, pp. 49-56
-
-
Ungaro, F.1
Giovino, C.2
Catanzano, O.3
Miro, A.4
Mele, A.5
Quaglia, F.6
la Rotonda, M.I.7
-
43
-
-
84874719924
-
Evaluation of phisicochemical properties of poorly water soluble drug (simvastatin) obtained by recristalization
-
Natal: Annals of International Symposium of Pharmaceutical Sciences, Universidade Federal do Rio Grande do Norte; 2011
-
Vargas MRW, Lima Neto SA, Torres SM, Moura TFAL. Evaluation of phisicochemical properties of poorly water soluble drug (simvastatin) obtained by recristalization. In: 2. International Symposium of Pharmaceutical Sciences; 2011; Natal: Annals of International Symposium of Pharmaceutical Sciences, Universidade Federal do Rio Grande do Norte; 2011.
-
(2011)
International Symposium of Pharmaceutical Sciences
-
-
Vargas, M.R.W.1
Lima, N.S.A.2
Torres, S.M.3
Moura, T.F.A.L.4
-
44
-
-
36549042006
-
Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
-
Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007; 12(23-24):1068-75.
-
(2007)
Drug Discov Today
, vol.12
, Issue.23-24
, pp. 1068-1075
-
-
Vasconcelos, T.1
Sarmento, B.2
Costa, P.3
-
45
-
-
77952288694
-
Encapsulation of cyclodextrin complexed simvastatin in chitosan nanocarriers: A novel technique for oral delivery
-
Vyas A, Saraf S, Saraf S. Encapsulation of cyclodextrin complexed simvastatin in chitosan nanocarriers: A novel technique for oral delivery. J Incl Phenom Macrocycl Chem. 2010;66:251-59.
-
(2010)
J Incl Phenom Macrocycl Chem
, vol.66
, pp. 251-259
-
-
Vyas, A.1
Saraf, S.2
Saraf, S.3
-
46
-
-
16244419102
-
Mass spectrometry and molecular modeling studies on the inclusion complexes between α, ß-cyclodextrins and simvastatin
-
Wen X, Liu Z, Zhu T. Mass spectrometry and molecular modeling studies on the inclusion complexes between α, ß-cyclodextrins and simvastatin. Chem Phys Lett. 2005;405(1-3):114-17.
-
(2005)
Chem Phys Lett
, vol.405
, Issue.1-3
, pp. 114-117
-
-
Wen, X.1
Liu, Z.2
Zhu, T.3
-
47
-
-
79955640333
-
Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties
-
Zhang Y, Zhang J, Jiang T, Wang S. Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties. Int J Pharm. 2011;410(1-2):118-24.
-
(2011)
Int J Pharm
, vol.410
, Issue.1-2
, pp. 118-124
-
-
Zhang, Y.1
Zhang, J.2
Jiang, T.3
Wang, S.4
|