Use of cyclodextrins as solubilizing agents for simvastatin: Effect of hydroxypropyl-β-cyclodextrin on lactone/hydroxyacid aqueous equilibrium

International Journal of Pharmaceutics

Volumn 404, Issue 1-2, 2011, Pages 49-56

  Ungaro, Francesca ^a   Giovino, Concetta ^a   Catanzano, Ovidio ^a   Miro, Agnese ^a   Mele, Andrea ^b   Quaglia, Fabiana ^a   La Rotonda, Maria Immacolata ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b POLITECNICO DI MILANO   (Italy)

Author keywords

Cyclodextrin; HPLC; Hydrolysis; Simvastatin; Stability

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; HYDROXYACID; LACTONE; SIMVASTATIN;

AQUEOUS SOLUTION; ARTICLE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

BETA-CYCLODEXTRINS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DRUG COMPOUNDING; DRUG STABILITY; HYDROLYSIS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROXY ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; SIMVASTATIN; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; TECHNOLOGY, PHARMACEUTICAL;

EID: 78650676847     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.10.050     Document Type: Article

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