Modified release of drug delivery systems: Hydrophilic polymers;Formas farmacêuticas de liberação modificada: Polímeros hidrifílicos

Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Volumn 41, Issue 2, 2005, Pages 143-154

  Lopes, Carla Martins ^a   Lobo, José Manuel Sousa ^a   Costa, Paulo ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Controlled release; Hydrophilic matrices; Matrix polymers

Indexed keywords

POLYMER;

COMPRESSION; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RESEARCH; DRUG SOLUBILITY; HYDROPHILICITY; IN VITRO STUDY; KINETICS; POWDER; REVIEW; TECHNOLOGY;

EID: 26244453504     PISSN: 15169332     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1516-93322005000200003     Document Type: Review

References (50)

1. BETTINI, R., COLOMBO, P., MASSIMO, G., SANTI, P., CATELLANI, P.L., PEPPAS, N.A. Moving fronts and drug release from hydrophilic matrices. INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS. 21., Nice, France, 1994. Proceedings. Deerfield: Controlled Release Society, 1994. v. 21, p. 19-20.
2. BETTINI, R., COLOMBO, P., PEPPAS, N.A. Drug concentration profiles during release from hydrophilic matrices. INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS. 24., Stockholm, Sweden, 1997. Proceedings. Deerfield: Controlled Release Society, 1997. v. 24, p. 635-636.
3. BETTINI, R., PEPPAS, N.A., COLOMBO, P. Polymer relaxation in swellable matrices contributes to drug release". INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS. 25., Las Vegas, Nevada, USA, 1998. Proceedings. Deerfield: Controlled Release Society, 1998. v. 25, p. 36-37.
4. BURI, P. Définition et classification des systèmes matriciels. S. T. P. Pharma., v. 3, p. 193-199, 1987.
5. BURI, P.; DOELKER, E. Formulation des comprimés à libération prolongée II. Matrices hydrophiles. Pharm. Acta Helv., Amsterdam, v. 55, n. 7-8, p. 189-197, 1980.
6. COLOMBO, P.; BETTINI, R.; MASSIMO, G.; CATELLANI, P.L.; SANTI, P.; PEPPAS, N.A. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J. Pharm. Sci., New York, v. 84, n. 8, p. 991-997, 1995.
7. COLOMBO, P.; BETTINI, R.; PEPPAS, N.A. Observation of swelling process and diffusion front position during swelling in hydroxylpropyl methylcellulose matrices containing a soluble drug. J. Control. Release, Amsterdam, v. 61, n. 1-2, p. 83-91, 1999.
8. COLOMBO, P.; BETTINI, R.; SANTI, P. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. PSTT, New York, v. 3, n. 6, p. 198-204, 2000.
9. COLOMBO, P.; BETTINI, R.; SANTI, P.; DEASCENTIS, A.; PEPPAS, N.A. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. J. Control. Release, Amsterdam, v. 39, n. 2-3, p. 231-237, 1996.
10. COSTA, P.; SOUSA LOBO, J.M. Formas farmacêuticas de libertação modificada. Rev. Port. Farm., Lisboa, v. 59, n. 4, p. 181-190, 1999.
11. COSTA, P.; SOUSA LOBO, J.M. Modelling and comparison of dissolution profiles. Eur. J. Pharm. Sci., Amsterdam, v. 13, n. 2, p. 123-133, 2001.
12. DAS, N. G.; DAS, S.K. Controlled-release of oral dosage forms. Formulation, Fill & Finish - a Technology Primer 2003 - a supplement to Pharm. Tec., v. 27, p. 10-16, 2003. Disponível em: Acesso em: 17 ago. 2004.
13. DOELKER, E. Cellulose derivatives. Adv. Polym. Sci., Berlin, v. 107, p. 199-265, 1993.
14. ENSCORE, D.; HOPFENBERG, H.; STANNETT, V. Effect of particle size on the mechanism controlling n-hexane in glassy polystyrene microspheres. Polymer, Amsterdam, v. 18, n. 8, p. 793-800, 1977.
15. EYJOLFSSON, R. Hydroxypropyl methylcellulose mixtures: effects and kinetics of release of an insoluble drug. Drug Dev. Ind. Pharm., New York, v. 25, n. 5, p. 667-669, 1999.
16. FEELY, L. S.; DAVIS, S. S. The influence of surfactants on drug release from hydroxypropylmethylcellulose matrices. Int. J. Pharm., Amsterdam, v. 41, n. 1-2, p. 83-90, 1988a.
17. FEELY, L. S.; DAVIS, S. S. The influence of polymeric excipients on drug release from hydroxypropylmethylcellulose matrices. Int. J. Pharm., Amsterdam, v. 44, n. 1-3, p. 131-139, 1988b.
18. FERRERO, C.; MUÑOZ-RUIZ, A.; JIMÉNEZ-CASTELLANOS, M.R. Fronts movement as a useful tool for hydrophilic matrix release mechanism elucidation. Int. J. Pharm., Amsterdam, v. 202, n. 1-2, p. 21-28, 2000.
19. FORD, J.L.; RUBINSTEIN, M.H.; HOGAN, J.E. Formulation of sustained release promethazine hydrochloride tablets using hydroxypropylmethylcellulose matrices. Int. J. Pharm., Amsterdam, v. 24, n. 2-3, p. 337-338, 1985.
20. FORD, J.L.; RUBINSTEIN, M.H.; McCAUL, F.; HOGAN, J.E.; EDGAR, P.J. Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets. Int. J. Pharm., Amsterdam, v. 40, n. 3, p. 223-234, 1987.
21. FYFE, C. A.; BLAZED, A. I. Investigation of hydrogel formation from hydroxypropylmethylcellulose (HPMC) by NMR spectroscopy and NMR imaging techniques. Macromolecules, Easton, v. 30, n. 20, p. 6230-6237, 1997.
22. GAO, P.; FAGERNESS, P.E. Diffusion in HPMC gels. I. Determination of drug and water difiiisity by pulsed-field-gradient spin-echo NMR. Pharm. Res., New York, v. 12, n. 7, p. 955-964, 1995.
23. GAO, P.; SKOUG, J.W.; NIXON, P.R.; JU, T.R.; STEMM, N.L.; SUNG, K.C. Swelling of hydroxypropyl methylcellulose matrix tablets. 2. Mechanistic study of the influence of formulation variables on matrix performance and drug release. J. Pharm. Sci., New York, v. 85, n. 7, p. 732-740, 1996.
24. HARIHARAM, D.; PEPPAS, N.A.; BETTINI, R.; COLOMBO, P. Mathematical analysis of drug delivery from swellable systems with parcial physical restrictions or impermeable coatings. Int. J. Pharm., Amsterdam, v. 112, n. 1, p. 47-54, 1994.
25. HIGUCHI, T. Rate of release of medicaments from ointment bases containing drugs in suspension. J. Pharm. Sci., New York, v. 50, p. 874-875, 1961.
26. JUANG, R.H.; STOREY, D. Correlation of characteristics of gel extrusion module (GEM) tablet formulation and drug dissolution rate. J. Control. Release, Amsterdam, v. 89, n. 3, p. 375-385, 2003.
27. KIIL, S.; DAM-JOHANSEN, K. Controlled drug delivery from swellable hydroxypropylmethylcellulose matrices: Model-based analysis of observed radial front movements. J. Control Release, Amsterdam, v. 90, n. 1, p. 1-21, 2003.
28. KORSMEYER, R. W.; GURNY, R.; DOELKER, E.; BURI, P.; PEPPAS, N. A. Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm., Amsterdam, v. 15, n. 1, p. 25-35, 1983.
29. KORSMEYER, R. W.; PEPPAS, N.A. Macromolecular and modeling aspects of swelling-controlled systems. In: ROSEMAN, T.J.; MANSDORF, S.Z., (Eds.). Controlled release delivery systems. New York: Marcel Dekker Inc., 1981. p. 77-90.
30. LEE, P.I.; KIM, C. Probing the mechanisms of drug release from hydrogels. J. Control. Release, Amsterdam, v. 16, n. 1-2, p. 229-236, 1991.
31. LORDI, N.G. Formas farmacêuticas de liberaçäo prolongada In: LACHMAN, L.; LIEBERMAN, H. A.; KANIE, J. L. (Eds.). Teoria eprática na indústria farmacêutica. Lisboa: Ed. Fundação Calouste Gulbenkia, 2001. v. II, p. 737-781.
32. NARASIMHAN, B.; PEPPAS, N.A. Molecular analysis of drug delivery systems controlled by dissolution of the polymer carrier. J. Pharm. Sci., New York, v. 86, n. 3, p. 297-304, 1997.
33. PHAM, A.T.; LEE, P.I. Probing the mechanism of drug release from hydroxypropyl methylcellulose matrices. Pharm. Res. New York, v. 11, n. 10, p. 1379-1384, 1994.
34. PEPPAS, N.A.; BURES, P.; LEOBANDUNG, W.; ICHIKAWA, H. Hydrogeles in pharmaceutical formulations. Eur. J. Pharm. Biopharm., Amsterdam, v. 50, n. 1, p. 27-46, 2000.
35. PEPPAS, N.A.; SAHLIN, J.J. A simple equation for the description of solute release, III. Coupling of diffusion and relaxation. Int J. Pharm., Amsterdam, v. 57, n. 2, p.169-172, 1989.
36. RANGARAO, K.V.; DEVI, K.P. Swelling controlled release systems: recent development and application. Int. J. Pharm., Amsterdam, v. 48, n. 1-3, p.1-13, 1988.
37. RITGER, P.; PEPPAS, N.A. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J. Control. Release, Amsterdam, v. 5, n. 1, p. 37-42, 1987.
38. RODRIGUEZ, C.F., BRUNEAU, N., BARRA, J., ALFONSO, D., DOELKER, E. Hydrophilic cellulose derivatives as drug delivery carriers: influence of substitution type on the properties of compressed matrix tablets. In: WISE, D.L., (Ed.). Handbook of Pharmaceutical Controlled Release Technology. New York: Marcel Dekker, Inc, 2000.
39. SALOMON, J.L.; DOELKER, E. Formulation of sustained release tablets. I. Inert matrices. Pharm. Acta Helv., Amsterdam, v. 55, p.174-182, 1980.
40. SHESKEY, P.J.; CABELKA, T.D. Reworkability of sustained-release tablet formulations containing HPMC polymers. Pharm. Technol, New York, v. 7, p. 60-74, 1992.
41. SHESKEY, P.J.; CABELKA, T.D.; ROBB, R.T., BOYCE, B.M. Use of roller compaction in the preparation of controlled-release hydrophilic matrix tablets containing methylcellulose and hydroxypropyl methylcellulose polymers. Pharm. Technol, New York, v. 9, p. 133-150, 1994.
42. SIEPMANN, J.; PEPPAS, N.A. Modelling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv. Drug Deliv. Rev., New York, v. 48, n. 2-3, p. 139-157, 2001.
43. SIEPMANN, J.; PEPPAS, N.A. Hydrophilic matrices for controlled drug delivery: an improved mathematical model to predict the resulting drug delivery kinetics (the "sequential layer" model). Pharm. Res., New York, v. 17, n. 10, p. 1290-1298, 2000.
44. SKOUG, J.W.; MIKELSONS, M.V.; VIGNERON, C.N.; STEMM, N.L. Qualitative evaluation of the mechanism of release of matrix sustained release dosage forms by measurement of polymer release. J. Controlled Release, Amsterdam, v. 27, n. 3, p. 227-245, 1993.
45. TAHARA, K.; YAMAMOTO, K.; NISHIHATA, T. Application of model-independent and model analysis for the investigation of effect of drug solubility on its release rate from hydroxypropyl methylcellulose sustained release tablets. Int. J. Pharm., Amsterdam, v. 133, n. 1, p. 17-27, 1996.
46. TAHARA, K.; YAMAMOTO, K.; NISHIHATA, T. Overall mechanism behind matrix sustained release (SR) tablets prepared with hydroxypropyl methylcellulose. J. Controlled Release, Amsterdam, v. 35, n. 1, p. 59-66, 1995.
47. VARELAS, C.G.; DIXON, D.G.; CAROL, S. Zero-order release from biphasic polymer hydrogels. J. Controlled Release, Amsterdam, v. 34, n. 3, p. 185-192, 1995.
48. WAN, L.S.C.; HENG, P.W.S.; WONG, L.F. The effect of hydroxypropyl methylcellulose on water penetration into a matrix system. Int. J. Pharm., Amsterdam, v. 73, n. 2, p. 111-116, 1991.
49. WAN, L.S.C.; HENG, P.W.S.; WONG, L.F. Matrix swelling: a simple model describing extent of swelling of HPMC matrices. Int. J. Pharm., Amsterdam, v. 116, n. 2, p. 159-168, 1995.
50. WESSENLINGH, J.A. Controlling diffusion. J. Controlled Release, Amsterdam, v. 24, n. 1-3, p. 47-60, 1993.