Co-solvent evaporation method for enhancement of solubility and dissolution rate of poorly aqueous soluble drug simvastatin: In vitro-In vivo evaluation

AAPS PharmSciTech

Volumn 9, Issue 4, 2008, Pages 1247-1252

  Pandya, Priyanka ^a   Gattani, Surendra ^a   Jain, Pankaj ^a   Khirwal, Lokesh ^a   Surana, Sanjay ^a  

^a R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Co solvent evaporation; Hydroxypropyl methylcellulose; Rotaevaporation; Simvastatin; Spray drying

Indexed keywords

CHOLESTEROL; HYDROXYPROPYLMETHYLCELLULOSE; SIMVASTATIN; TRIACYLGLYCEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SOLVENT;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CO SOLVENT EVAPORATION; CONTROLLED STUDY; CRYSTAL; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG FORMULATION; DRUG SOLUBILITY; ENCAPSULATION; EVAPORATION; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; METHODOLOGY; MICELLE; NONHUMAN; RAT; ROTAEVAPORATION; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SPRAY DRYING; TRIACYLGLYCEROL BLOOD LEVEL; VISCOSITY; WISTAR RAT; X RAY DIFFRACTION; ANIMAL; BLOOD; CHEMISTRY; DRUG SCREENING; SOLUBILITY;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHOLESTEROL; DRUG EVALUATION, PRECLINICAL; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICROSCOPY, ELECTRON, SCANNING; RATS; RATS, WISTAR; SIMVASTATIN; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 63649134819     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9176-z     Document Type: Article

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