Inhibition of human mesangial cell proliferation by targeting T-type calcium channels

Nephron - Experimental Nephrology

Volumn 113, Issue 2, 2009, Pages

  Mulgrew, Christopher J ^a   Cove Smith, Andrea ^a   McLatchie, Linda M ^b   Brooks, Gavin ^c   Shattock, Michael J ^b   Hendry, Bruce M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c UNIVERSITY OF READING   (United Kingdom)

Author keywords

Calcium channel; Glomerulonephritis; Human mesangial cell proliferation; Mesangial cell proliferation; Mesangial cells; Non excitable cells; T type calcium channels

Indexed keywords

BROXURIDINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; ISOPROTEIN; MESSENGER RNA; MIBEFRADIL; NICKEL CHLORIDE; SMALL INTERFERING RNA; TETRAZOLIUM; TH 1177; UNCLASSIFIED DRUG; VERAPAMIL;

ADULT; APOPTOSIS; ARTICLE; CELL ASSAY; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOTHESIS; KIDNEY DISEASE; MESANGIUM CELL; MITOSIS INHIBITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VOLTAGE CLAMP;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; MESANGIAL CELLS;

EID: 68349123572     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000232590     Document Type: Article

References (34)

1. Schöcklmann HO, Lang S, Sterzel RB: Regulation of mesangial cell proliferation. Kidney Int 1999; 56: 1199-1207
2. Wenzel UO, Troschau G, Schoeppe W, et al: Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension. Hypertension 1992; 20: 233-241.
3. Harris DC, Hammond WS, Burke TJ, et al: Verapamil protects against progression of experimental chronic renal failure. Kidney Int 1987; 31: 41-46.
4. Aguas AP, Nickerson PA: Effect of verapamil on blood pressure and lesions in heart and kidney of rats made hypertensive by deoxycorticosterone. Am J Pathol 1983; 110: 48-54.
5. Moriyama T, Oka K, Ueda H, et al: Nilvadipine attenuates mesangial expansion and glomerular hypertrophy in diabetic db/db mice, a model for type 2 diabetes. Clin Exp Nephrol 2004; 8: 230-236
6. Perico N, Amuchastegui CS, Malanchini B, et al: Angiotensin-converting enzyme inhibition and calcium channel blockade both normalize early hyperfiltration in experimental diabetes, but only the former prevents late renal structural damage. Exp Nephrol 1994; 2: 220-228.
7. Bakris GL, Copley JB, Vicknair N, et al: Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy. Kidney Int 1996; 50: 1641-1650.
8. Lewis EJ, Hunsicker LG, Clarke WR, et al: Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001; 345: 851-860.
9. Ono T, Liu N, Kusano H, et al: Broad antiproliferative effects of benidipine on cultured human mesangial cells in cell cycle phases. Am J Nephrol 2002; 22: 581-586.
10. Sugiura T, Imai E, Moriyama T, et al: Calcium channel blockers inhibit proliferation and matrix production in rat mesangial cells: possible mechanism of suppression of AP-1 and CREB activities. Nephron 2000; 85: 71-80.
11. Orth SR, Nobiling R, Bonisch S, et al: Inhibitory effect of calcium channel blockers on human mesangial cell growth: evidence for actions independent of L-type Ca 2+ channels. Kidney Int 1996; 49: 868-879.
12. Guo W, Kamiya K, Kodama I, et al: Cell cycle- related changes in the voltage-gated Ca 2+ currents in cultured newborn rat ventricular myocytes. J Mol Cell Cardiol 1998; 30: 1095-1103.
13. Xu X, Best PM: Postnatal changes in T-type calcium current density in rat atrial myocytes. J Physiol 1992; 454: 657-672.
14. Xu XP, Best PM: Increase in T-type calcium current in atrial myocytes from adult rats with growth hormone-secreting tumors. Proc Natl Acad Sci USA 1990; 87: 4655-4659.
15. Akaike N, Kanaide H, Kuga T, et al: Lowvoltage activated calcium current in rat aorta smooth muscle cells in primary culture. J Physiol 1989; 416: 141-160.
16. Richard S, Neveu D, Carnac G, et al: Differential expression of voltage-gated Ca 2+ currents in cultivated aortic myocytes. Biochem Biophys Acta 1992; 1160: 95-104.
17. Kuga T, Kobayashi S, Hirakawa Y, et al: Cell cycle-dependant expression of L- and T-type Ca 2+ currents in rat aortic smooth muscle cells in primary culture. Circ Res 1996; 79: 14-19.
18. Brooks G, Harper JV, Bates SE, et al: Overexpression of the voltage-gated T-type calcium channel induces vascular smooth muscle cell proliferation (abstract). Circulation 1999; 100:I-209.
19. Wang YQ, Brooks G, Yuan WZ, et al: Functional analysis of the human T-type calcium channelα1 H subunit gene in cellular proliferation. Yi Chuan Xue Bao 2002; 29: 659-665.
20. Rodman DM, Reese K, Harral J, et al: Lowvoltage- activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res 2005; 96: 864-872. (Pubitemid 40604970)
21. Schmitt R, Clozel JP, Iberg N, et al: Mibefradil prevents neointima formation after vascular injury in rats: possible role of the blockade of the T-type voltage-operated calcium channel. Arter Thromb Vasc Biol 1995; 15: 1161-1165.
22. Haverstick DM, Heady TN, Macdonald TL, et al: Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca 2+ entry. Cancer Res 2000; 60: 1002-1008.
23. Gray LS, Perez-Reyes E, Gamorra JC, et al: The role of voltage-gated T-type Ca 2+ isoforms in mediating 'capacitative' Ca 2+ entry in cancer cells. Cell Calcium 2004; 36: 489-497.
24. Chemin J, Monteil A, Briquaire C, et al: Overexpression of T-type calcium channels in HEK-293 cells increases intracellular calcium without affecting cellular proliferation. FEBS Lett 2000; 478: 166-172.
25. Sachs HG, Stambrook PJ, Ebert JD: Changes in membrane potential during the cell cycle. Exp Cell Res 1974; 83: 362-366.
26. Lee JH GJ, Cribbs LL, Perez-Reyes E: Nickel block of three cloned T-type calcium channels: low concentrations selectively blockα1 H. Biophys J 1999; 3034-3042.
27. Hall DA, Carmines PK, Sansom SC: Dihydropyridine- sensitive Ca 2+ channels in human glomerular mesangial cells. Am J Physiol Renal Physiol 2000; 278:F97-F103.
28. Kahl CR, Means AR: Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr Rev 2003; 24: 719-736
29. Zeng H, Liu Y, Templeton DM: Ca 2+ /calmodulin- dependent and cAMP-dependent kinases in induction of c-fos in human mesangial cells. Am J Physiol Renal Physiol 2002; 283:F888-F894.
30. Welsby PJ, Wang H, Wolfe JT, et al: A mechanism for the direct regulation of T-type calcium channels by Ca 2+ /calmodulin-dependent kinase II. J Neurosci 2003; 23: 10116-10121.
31. Honda M, Hayashi K, Matsuda H, et al: Divergent renal vasodilator action of L- and Ttype calcium antagonists in vivo. J Hypertens 2001; 19: 2031-2037.
32. Ohishi M, Takagi T, Ito N, et al: Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study. Hypertens Res 2007; 30: 797-806.
33. Ishimitsu T, Kameda T, Akashiba A, et al: Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis. Hypertens Res 2007; 30: 621-626.
34. Sugano N, Wakino S, Kanda T, et al: T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy. Kidney Int 2008; 73: 826-834.