Separation characteristics of ethanol precipitation for the purification of the water extract of medicinal plants

Separation and Purification Technology

Volumn 107, Issue , 2013, Pages 273-280

  Gong, Xingchu ^a   Wang, Shanshan ^a   Li, Yao ^a   Qu, Haibin ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Botanical medicine; Ethanol precipitation; Mechanism; Quality by design

Indexed keywords

CAFFEIC ACIDS; CHEMICAL TRANSFORMATIONS; CHUANXIONG; DANSHEN; DANSHENSU; DRY MATTERS; ETHANOL ADDITION; ETHANOL PRECIPITATION; FERULIC ACIDS; IONIC FORMS; LIGUSTICUM CHUANXIONG HORT; MEDICINAL PLANTS; PH VALUE; PHENOLIC COMPOUNDS; PRODUCTION OF; QUALITY BY DESIGNS; REFRIGERATION TEMPERATURES; SALVIA MILTIORRHIZA; SALVIANOLIC ACID; SEPARATION CHARACTERISTICS; SEPARATION TECHNOLOGIES; WATER EXTRACTS;

CHEMICAL REACTIONS; ETHANOL; EXTRACTION; LASERS; LIVING SYSTEMS STUDIES; MECHANISMS; PH; PHENOLS; PLANT EXTRACTS; REFRIGERATION;

PRECIPITATION (CHEMICAL);

EID: 84874626959     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2013.01.029     Document Type: Article

References (38)

1. X.M. Xu, A.P. Costa, M.A. Khan, and D.J. Burgess Application of quality by design to formulation and processing of protein liposomes Int. J. Pharm. 434 2012 349 359
2. Z.H. Xu, J.S. Li, and J.X. Zhou Process development for robust removal of aggregates using cation exchange chromatography in monoclonal antibody purification with implementation of quality by design Prep. Biochem. Biotech. 42 2012 183 202
3. V. Lourenco, D. Lochmann, G. Reich, J.C. Menezes, T. Herdling, and J. Schewitz A quality by design study applied to an industrial pharmaceutical fluid bed granulation Eur. J. Pharm. Biopharm. 81 2012 438 447
4. L.X. Yu Pharmaceutical quality by design: Product and process development, understanding, and control Pharm. Res-Dordr. 25 2008 2008 2463 (vol. 25, pg 10
5. M. Boulet, M. Britten, and F. Lamarche Dispersion of food proteins in water-alcohol mixed dispersants Food Chem. 74 2001 69 74 (Pubitemid 32509996)
6. M.E. Lucena, S. Alvarez, C. Menendez, F.A. Riera, and R. Alvarez Alpha-lactalbumin precipitation from commercial whey protein concentrates Sep. Purif. Technol. 52 2007 446 453 (Pubitemid 44810117)
7. P.A.G. Soares, A.F.M. Vaz, M.T.S. Correia, A.P. Jr, and M.G. Carneiro-da-Cunha Purification of bromelain from pineapple wastes by ethanol precipitation Sep. Purif. Technol. 98 2012 389 395
8. R.C. Sun, and J. Tomkinson Fractional separation and physico-chemical analysis of lignins from the black liquor of oil palm trunk fibre pulping Sep. Purif. Technol. 24 2001 529 539 (Pubitemid 32949248)
9. Y. Ku, O. Jansen, C.J. Oles, E.Z. Lazar, and J.I. Rader Precipitation of inulins and oligoglucoses by ethanol and other solvents Food Chem. 81 2003 125 132 (Pubitemid 36801985)
10. V.V. Patil, R.V. Galge, and B.N. Thorat Extraction and purification of phosphatidylcholine from soyabean lecithin Sep. Purif. Technol. 75 2010 138 144
11. J.H. Chen, B.C. Liau, T.T. Jong, and C.M.J. Chang Extraction and purification of flavanone glycosides and kaemferol glycosides from defatted Camellia oleifera seeds by salting-out using hydrophilic isopropanol Sep. Purif. Technol. 67 2009 31 37
12. S. Golunski, V. Astolfi, N. Carniel, D. de Oliveira, M. Di Luccio, M.A. Mazutti, and H. Treichel Ethanol precipitation and ultrafiltration of inulinases from Kluyveromyces marxianus Sep. Purif. Technol. 78 2011 261 265
13. E. Melwita, and Y.H. Ju Separation of azadirachtin and other limonoids from crude neem oil via solvent precipitation Sep. Purif. Technol. 74 2010 219 224
14. G.Y. Koh, G. Chou, and Z. Liu Purification of a water extract of Chinese sweet tea plant (Rubus suavissimus S. Lee) by alcohol precipitation J. Agric. Food Chem. 57 2009 5000 5006
15. M. Xu, J. Han, H.F. Li, L. Fan, A.H. Liu, and D.A. Guo Analysis on the stability of total phenolic acids and salvianolic acid B from Salvia miltiorrhiza by HPLC and HPLC-MSn Nat. Prod. Commun. 3 2008 669 676
16. T.P.A. Devasagayam, and D.K. Maurya Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids Food Chem. Toxicol. 48 2010 3369 3373
17. X.R. Guo, X.H. Chen, L. Li, Z.D. Shen, X.L. Wang, P. Zheng, F.X. Duan, Y.F. Ma, and K.S. Bi LC-MS determination and pharmacokinetic study of six phenolic components in rat plasma after taking traditional Chinese medicinal-preparation: Guanxinning lyophilized powder for injection J Chromatogr. B 873 2008 51 58
18. A. Yan, Studies on the quality control technology of ethanol precipitation for Guanxinning Injection, Master's thesis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China, 2012, pp. 61-68.
19. K.K.T. Goh, D.R. Haisman, R.H. Archer, and H. Singh Evaluation and modification of existing methods for the quantification of exopolysaccharides in milk-based media Food Res. Int. 38 2005 605 613 (Pubitemid 40560922)
20. F.S. Asghari, and H. Yoshida Acid-catalyzed production of 5-hydroxymethyl furfural from D-fructose in subcritical water Ind. Eng. Chem. Res. 45 2006 2163 2173
21. E.A. Macedo, and A.M. Peres Thermodynamics of ternary mixtures containing sugars. SLE of D-fructose in pure and mixed solvents. Comparison between modified UNIQUAC and modified UNIFAC Ind. Eng. Chem. Res. 40 2001 4633 4640 (Pubitemid 32995269)
22. A.E. Flood, J. Addai-Mensah, M.R. Johns, and E.T. White Refractive index, viscosity, density, and solubility in the system fructose plus ethanol plus water at 30, 40, and 50 degrees C J. Chem. Eng. Data 41 1996 418 421 (Pubitemid 126606756)
23. A.M. Peres, and E.A. Macedo Phase equilibria of D-glucose and sucrose in mixed solvent mixtures: Comparison of UNIQUAC-based models Carbohyd. Res. 303 1997 135 151 (Pubitemid 27425183)
24. X.C. Gong, S.S. Wang, and H.B. Qu Solid-liquid equilibria of D-Glucose, D-fructose and sucrose in the mixture of ethanol and water from 273.2 K to 293.2 K Chin. J. Chem. Eng. 19 2011 217 222
25. A. Bouchard, G.W. Hofland, and G.J. Witkamp Properties of sugar, polyol, and polysaccharide water-ethanol solutions J. Chem. Eng. Data 52 2007 1838 1842 (Pubitemid 47522289)
26. L. Zhang, X.C. Gong, Y.F. Wang, and H.B. Qu Solubilities of protocatechuic aldehyde, caffeic acid, D-Galactose, and D-Raffinose pentahydrate in ethanol-water solutions J. Chem. Eng. Data 57 2012 2018 2022
27. A.E. Flood, and S. Puagsa Refractive index, viscosity, and solubility at 30 degrees C, and density at 25 degrees C for the system fructose plus glucose plus ethanol plus water J. Chem. Eng. Data 45 2000 902 907
28. Y.X. Guo, Z.L. Xiu, D.J. Zhang, H. Wang, L.X. Wang, and H.B. Xiao Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution J. Pharm. Biomed. 43 2007 1249 1255 (Pubitemid 46282367)
29. X.N. Yang, X. Tang, and Y.S. Liu Separation and purification of salvianolic acids from Salvia miltiorrhiza Chin. Trad. Herbal Drug. 38 2007 843 846 (Pubitemid 47162506)
30. Y.X. Guo, D.J. Zhang, H. Wang, Z.L. Xiu, L.X. Wang, and H.B. Xiao Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza J. Pharm. Biomed. 43 2007 435 439 (Pubitemid 44960571)
31. S.S. Liu, F. Han, H. Xu, and K. Liu Isolation and identification of chemical constituents from thermal decomposition extract of salvianolic acid B Chin. Trad. Herbal Drug. 42 2011 247 250
32. Y. Wang, J. Zhu, S. Fu, L. Zhu, and Y. Zhang Study on chemical changes of salvianolic acid B and lithospermic acid aqueous under conditions of high temperature and high pressure Zhongguo Zhong Yao Za Zhi 36 2011 434 438
33. Y.Y. Xu Yuan-Chao, Du Li-Bo, Shen Jian-Gang, Wang Guang-Qing, He Zeng, Tian Qiu, and Liu Yang Autoxidation and prooxidation mechanisms of Danshensu Acta Phys. -Chim. Sin. 26 2010 1737 1741
34. X.C. Gong, S.S. Wang, and H.B. Qu Comparison of two separation technologies applied in the manufacture of botanical injections: second ethanol precipitation and solvent extraction Ind. Eng. Chem. Res. 50 2011 7542 7548
35. D. Lu, Study on separation and analysis of effective constituents from some medicinal plants with RP-HPLC, Doctorial thesis, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China, 2010, pp. 91.
36. Y. Guo, Study on degradation mechanism and purification technique of lithospermic acid B, Doctoral thesis, School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China, 2007, pp. 50.
37. I. Canals, J.A. Portal, E. Bosch, and M. Roses Retention of ionizable compounds on HPLC. 4. Mobile-phase pH measurement in methanol/water Anal. Chem. 72 2000 1802 1809 (Pubitemid 30220173)
38. I. Canals, F.Z. Oumada, M. Roses, and E. Bosch Retention of ionizable compounds on HPLC. 6. pH measurements with the glass electrode in methanol-water mixtures J. Chromatogr. A 911 2001 191 202 (Pubitemid 32166996)