A quality by design study applied to an industrial pharmaceutical fluid bed granulation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 2, 2012, Pages 438-447

  Lourenço, Vera ^a,b   Lochmann, Dirk ^b   Reich, Gabriele ^c   Menezes, José C ^a   Herdling, Thorsten ^b   Schewitz, Jens ^b  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b MERCK KGAA   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Design Space; Fluid bed granulation; Multivariate data analysis; Process Analytical Technology; Quality by Design

Indexed keywords

AIR TEMPERATURE; ARTICLE; BULK DENSITY; DRUG GRANULATION; DRUG GRANULE; DRUG INDUSTRY; FLUID BED GRANULATION; PROCESS DESIGN; PROCESS TECHNOLOGY; QUALITY CONTROL; RISK ASSESSMENT; SCALE UP; TABLET; TABLET DISINTEGRATION; TABLET HARDNESS;

DRUG COMPOUNDING; DRUG INDUSTRY; MULTIVARIATE ANALYSIS; PHARMACEUTICAL PREPARATIONS; QUALITY CONTROL; RESEARCH DESIGN; RISK ASSESSMENT; TECHNOLOGY, PHARMACEUTICAL;

EID: 84861621493     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.03.003     Document Type: Article

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