Anoxia-induced NF-kB-dependent upregulation of NCX1 contributes to Ca 2+ refilling into endoplasmic reticulum in cortical neurons

Stroke

Volumn 40, Issue 3, 2009, Pages 922-929

  Sirabella, Rossana ^b   Secondo, Agnese ^a   Pannaccione, Anna ^c   Scorziello, Antonella ^a   Valsecchi, Valeria ^a   Adornetto, Annagrazia ^c   Bilo, Leonilda ^a   Di Renzo, Gianfranco ^a   Annunziato, Lucio ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRCCS SDN   (Italy)

^c Federico II University of Naples ^*

Author keywords

Ca2+ i homeostasis; ER stress; Na+ Ca 2+ exchanger; Neuroprotection; OGD

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALCIUM ION; CASPASE 12; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NIMODIPINE; OMEGA AGATOXIN; OMEGA CONOTOXIN; OXYGEN; PROTEASOME INHIBITOR; SMALL INTERFERING RNA; SN 50; SODIUM CALCIUM EXCHANGE PROTEIN; SYNAPTOTAGMIN I; DIAGNOSTIC AGENT; FLUORESCENT DYE; FURA 2; SODIUM CALCIUM EXCHANGER 1; SODIUM-CALCIUM EXCHANGER 1; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN HYPOXIA; BRAIN ISCHEMIA; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; GENE SILENCING; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REOXYGENATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BRAIN CORTEX; CALCIUM SIGNALING; CELL DEATH; CELL HYPOXIA; CYTOLOGY; ENDOPLASMIC RETICULUM; FEMALE; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; PREGNANCY; RNA INTERFERENCE; UPREGULATION; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; CALCIUM SIGNALING; CASPASE 12; CELL DEATH; CELL HYPOXIA; CEREBRAL CORTEX; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FEMALE; FLUORESCENT DYES; FURA-2; GLUCOSE; NEURONS; NF-KAPPA B; PREGNANCY; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SODIUM-CALCIUM EXCHANGER; TRANSCRIPTION FACTOR RELA; UP-REGULATION;

EID: 62449201739     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.531962     Document Type: Article

References (24)

1. Philipson KD, Nicoll DA. Sodium-calcium exchange: a molecular perspective. Annu Rev Physiol. 2000;62:111-133.
2. Annunziato L, Pignataro G, Di Renzo GF. Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol Rev. 2004;56:633-654.
3. Nicoll DA, Longoni S, Philipson KD. Molecular cloning and functional expression of the cardiac sarcolemmal Na+-Ca2+ exchanger. Science. 1990;250:562-565.
4. Li Z, Matsuoka S, Hryshko LV, Nicoll DA, Bersohn MM, Burke EP, Lifton RP, Philipson KD. Cloning of the NCX2 isoform of the plasma membrane Na+-Ca2+ exchanger. J Biol Chem. 1994;269:17434-17439.
5. Nicoll DA, Quednau BD, Qui Z, Xia YR, Lusis AJ, Philipson KD. Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. J Biol Chem. 1996;271:24914-24921.
6. Papa M, Canitano A, Boscia F, Castaldo P, Sellitti S, Porzig H, Taglialatela M, Annunziato L. Differential expression of the Na+-Ca2+ exchanger transcripts and proteins in rat brain regions. J Comp Neurol. 2003;461:31-48.
7. Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev. 1999;79:763-854.
8. Molinaro P, Cuomo O, Pignataro O, Boscia F, Sirabella R, Pannaccione A, Secondo A, Scorziello A, Adornetto A, Gala R, Viggiano D, Sokolow S, Herchuelz A, Schurmans S, Di Renzo GF, Annunziato L. Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. J Neurosci. 2008;28:1179-1184.
9. Secondo A, Staiano RI, Scorziello A, Sirabella R, Boscia F, Adornetto A, Valsecchi V, Molinaro P, Canzoniero LMT, Di Renzo GF, Annunziato L. BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: possible relationship with mitochondrial membrane potential. Cell Calcium. 2007; 42:521-535.
10. Pignataro G, Gala R, Cuomo O, Tortiglione A, Giaccio L, Castaldo P, Sirabella R, Matrone C, Canitano A, Amoroso S, Di Renzo GF, Annunziato L. Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke. 2004;35:2566-2570.
11. Boscia F, Gala R, Pignataro G, de Bartolomeis A, Cicale M, Ambesi-Impiombato A, Di Renzo GF, Annunziato L. Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. J Cereb Blood Flow Metab. 2006;26: 502-517.
12. Paschen W, Mengesdorf T, Althausen S, Hotop S. Peroxidative stress selectively down-regulates the neuronal stress response activated under conditions of endoplasmic reticulum dysfunction. J Neurochem. 2001;76: 1916-1924.
13. Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD. Calcium signalling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2000;23:222-229.
14. Fameli N, van Breemen C, Kuo KH. A quantitative model for linking Na+/Ca2+ exchanger to SERCA during refilling of the sarcoplasmic reticulum to sustain [Ca2+] oscillations in vascular smooth muscle. Cell Calcium. 2007;42:565-575.
15. Scorziello A, Pellegrini C, Forte L, Tortiglione A, Gioielli A, Iossa S, Amoroso S, Tufano R, Di Renzo GF, Annunziato L. Differential vulnerability of cortical and cerebellar neurons in primary culture to oxygen glucose deprivation followed by reoxygenation. J Neurosci Res. 2001; 63:20-26.
16. Goldberg MP, Choi DW. Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci. 1993;13:3510-3524.
17. Formisano L, Saggese M, Secondo A, Sirabella R, Vito P, Valsecchi V, Molinaro P, Di Renzo GF, Annunziato L. The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway. Mol Pharmacol. 2008;73:727-737.
18. He LP, Cleemann L, Soldatov NM, Morad M. Molecular determinants of cAMP-mediated regulation of the Na+-Ca2+ exchanger expressed in human cell lines. J Physiol. 2003;548:677-689.
19. Verkhratsky A, Toescu EC. Endoplasmic reticulum Ca(2+) homeostasis and neuronal death. J Cell Mol Med. 2003;7:351-361.
20. Michiels C, Minet E, Mottet D, Raes M. Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes. Free Radic Biol Med. 2002;33:1231-1242.
21. Nakagawa T, Yuan J. Cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis. J Cell Biol. 2000;150: 887-894.
22. Canu N, Barbato C, Ciotti MT, Serafino A, Dus L, Calissano P. Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. J Neurosci. 2000;20: 589-599.
23. Bano D, Young KW, Guerin CJ, LeFeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera PL. Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell. 2005;120:275-285.
24. Lenart B, Kintner DB, Shull GE, Sun D. Na-K-Cl cotransporter-mediated intracellular Na+ accumulation affects Ca2+ signaling in astrocytes in an in vitro ischemic model. J Neurosci. 2004;24:9585-9597.