TLR signaling in B-cell development and activation

Cellular and Molecular Immunology

Volumn 10, Issue 2, 2013, Pages 103-106

  Hua, Zhaolin ^a   Hou, Baidong ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

Author keywords

autoimmunity; B cell development; germinal center; Toll like receptor

Indexed keywords

AUTOANTIBODY; B LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL SURVIVAL; CYTOKINE RELEASE; HOST RESISTANCE; HUMAN; IMMUNIZATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MOLECULAR PATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; HUMANS; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84874605001     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2012.61     Document Type: Review

References (37)

1. Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 2010; 327: 291-295.
2. Akira S. Toll-like receptors and innate immunity. Adv Immunol 2001; 78: 1-56.
3. Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol 2009; 9: 535-542.
4. Bekeredjian-Ding I, Jego G. Toll-like receptors-sentries in the B-cell response. Immunology 2009; 128: 311-323.
5. Halperin SA, Dobson S, McNeil S, Langley JM, Smith B, McCall-Sani R et al. Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults. Vaccine 2006; 24: 20-26.
6. Jennings GT, Bachmann MF. The coming of age of virus-like particle vaccines. Biol Chem 2008; 389: 521-536.
7. Hardy RR, Kincade PW, Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity 2007; 26: 703-714.
8. Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 2006; 24: 801-812.
9. Welner RS, Pelayo R, Nagai Y, Garrett KP, Wuest TR, Carr DJ et al. Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood 2008; 112: 3753-3761.
10. Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q et al. Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol 2011; 186: 5367-5375.
11. Meffre E. The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases. Ann N Y Acad Sci 2011; 1246: 1-10.
12. Rawlings DJ, Schwartz MA, Jackson SW, Meyer-Bahlburg A. Integration of B cell responses through Toll-like receptors and antigen receptors. Nat Rev Immunol 2012; 12: 282-294.
13. Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol 2009; 182: 5382-5392.
14. Seo S, Buckler J, Erikson J. Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-doublestranded DNA Ig transgenic mice. J Immunol 2001; 166: 3710-3716.
15. Ueda Y, Liao D, Yang K, Patel A, Kelsoe G. T-independent activationinduced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. J Immunol 2007; 178: 3593-3601.
16. Hasan M, Lopez-Herrera G, Blomberg KE, Lindvall JM, Berglof A, Smith CI et al. Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice. Immunology 2008; 123: 239-249.
17. Capolunghi F, Cascioli S, Giorda E, Rosado MM, Plebani A, Auriti C et al. CpG drives human transitional B cells to terminal differentiation and production of natural antibodies. J Immunol 2008; 180: 800-808.
18. Aranburu A, Ceccarelli S, Giorda E, Lasorella R, Ballatore G, Carsetti R. TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells. J Immunol 2010; 185: 7293-7301.
19. Weller S, Bonnet M, Delagreverie H, Israel L, Chrabieh M, Marodi L et al. IgM1IgD1CD271 B cells are markedly reduced in IRAK-4-, MyD88-and TIRAP-but not UNC-93B-deficient patients. Blood; epub ahead of print 21 September 2012; doi:10.1182/blood-2012-07-440776.
20. Gavin AL, Hoebe K, Duong B, Ota T, Martin C, Beutler B et al. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 2006; 314: 1936-1938.
21. Alugupalli KR, Akira S, Lien E, Leong JM. MyD88-and Bruton's tyrosine kinase-mediated signals are essential for T cellindependent pathogen-specific IgM responses. J Immunol 2007; 178: 3740-3749.
22. Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L et al. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity 2011; 34: 375-384.
23. Meyer-Bahlburg A, Khim S, Rawlings DJ. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med 2007; 204: 3095-3101.
24. Pasare C, Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 2005; 438: 364-368.
25. Jegerlehner A, Maurer P, Bessa J, Hinton HJ, Kopf M, Bachmann MF. TLR9 signaling in B cells determines class switch recombination to IgG2a. J Immunol 2007; 178: 2415-2420.
26. Lanzavecchia A, Sallusto F. Toll-like receptors and innate immunity in B-cell activation and antibody responses. Curr Opin Immunol 2007; 19: 268-274.
27. Hou B, Reizis B, DeFranco AL. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and-extrinsic mechanisms. Immunity 2008; 29: 272-282.
28. Browne EP. Toll-like receptor 7 controls the anti-retroviral germinal center response. PLoS Pathog 2011; 7: e1002293.
29. Victora GD, Nussenzweig MC. Germinal Centers. Annu Rev Immunol 2012; 30: 429-457.
30. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002; 416: 603-607.
31. Green NM, Marshak-Rothstein A. Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin Immunol 2011; 23: 106-112.
32. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006; 6: 823-835.
33. William J, Euler C, Christensen S, Shlomchik MJ. Evolution of autoantibody responses via somatic hypermutation outside of germinal centers. Science 2002; 297: 2066-2070.
34. Herlands RA, Christensen SR, Sweet RA, Hershberg U, Shlomchik MJ. T cell-independent and toll-like receptor-dependent antigendriven activation of autoreactive B cells. Immunity 2008; 29: 249-260.
35. Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006; 203: 553-561.
36. Groom JR, Fletcher CA, Walters SN, Grey ST, Watt SV, Sweet MJ et al. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med 2007; 204: 1959-1971.
37. Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C et al. WASp-deficient B cells play a critical, cellintrinsic role in triggering autoimmunity. J Exp Med 2011; 208: 2033-2042.