HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding

Stem Cells

Volumn 24, Issue 4, 2006, Pages 876-888

  Yu, Xiaobing ^a,b   Alder, Jonathan K ^a   Jong, Ho Chun ^a   Friedman, Alan D ^a   Heimfeld, Shelly ^c   Cheng, Linzhao ^b   Civin, Curt I ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

bHLH; Cell cycle; Hematopoietic progenitor cells; Hematopoietic stem cells; HES1; Notch signaling pathway; Stem cell self renewal

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1; LENTIVIRUS VECTOR; NOTCH RECEPTOR; TRANSCRIPTION FACTOR HES 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA; HES1 PROTEIN, HUMAN; HES1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CELL CULTURE; CELL CYCLE; CELL DIVISION; CELL FUNCTION; CELL MANIPULATION; CELL POPULATION; CELL PROTECTION; CONTROLLED STUDY; DATA ANALYSIS; DNA BINDING; DOWN REGULATION; DOWNSTREAM PROCESSING; EX VIVO STUDY; EXPRESSION VECTOR; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO CULTURE; MOUSE; MUTANT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENE; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; WILD TYPE; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLONOGENIC ASSAY; CYTOLOGY; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN BINDING;

ANIMALS; ANTIGENS, CD34; APOPTOSIS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY-FORMING UNITS ASSAY; DNA; GENE EXPRESSION; GENETIC VECTORS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, INBRED C57BL; PROTEIN BINDING; RNA, MESSENGER; TRANSDUCTION, GENETIC;

EID: 33745487597     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2005-0598     Document Type: Article

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