5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt/GSK-3β signaling pathway in H9c2 cardiomyocytes

Toxicology and Applied Pharmacology

Volumn 268, Issue 1, 2013, Pages 90-98

  Park, Eun Seok ^a   Kang, Jun Chul ^a   Kang, Do Hyun ^a   Jang, Yong Chang ^a   Yi, Kyu Yang ^b   Chung, Hun Jong ^a   Park, Jong Seok ^c   Kim, Bokyung ^a   Feng, Zhong Ping ^d   Shin, Hwa Sup ^a  

^a Konkuk University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Taegu Health College   (South Korea)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 AIQ; Akt glycogen synthase kinase 3 ; Myocardial apoptosis; PARP inhibitor; Reactive oxygen species

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 5 AMINOISOQUINOLINONE; ANTIOXIDANT; CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; EMBRYO; HEART MUSCLE CELL; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE 3; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; ISOQUINOLINES; MYOCYTES, CARDIAC; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84874510853     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.01.004     Document Type: Article

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