The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat

Medical Science Monitor

Volumn 8, Issue 11, 2002, Pages

  Mota Filipe, Helder ^a   Sepodes, Bruno ^a   McDonald, Michelle ^b   Cuzzocrea, Salvatore ^c   Pinto, Rui ^a   Thiemermann, Christoph ^b  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

5 aminoisoquinolinone; Liver ischemia; PARP; PARS; Rat; Reperfusion injury

Indexed keywords

5 AMINOISOQUINOLINONE; AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; INTERCELLULAR ADHESION MOLECULE 1; LACTATE DEHYDROGENASE; MALONALDEHYDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; 5-AMINOISOQUINOLINONE; ISOQUINOLINE DERIVATIVE;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER INJURY; LIVER ISCHEMIA; LIVER SURGERY; LIVER TRANSPLANTATION; MALE; NONHUMAN; RAT; REPERFUSION INJURY; SHOCK; TREATMENT OUTCOME; ANIMAL; BLOOD; CELL CULTURE; CELL SURVIVAL; DRUG ANTAGONISM; INJURY; LIVER; METABOLISM; TIME; WISTAR RAT;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; ISOQUINOLINES; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; LIVER; MALE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; REPERFUSION INJURY; TIME FACTORS; TRANSAMINASES;

EID: 0036858375     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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