5-Aminoisoquinolinone, a potent inhibitor of poly (adenosine 5′-diphosphate ribose) polymerase, reduces myocardial infarct size

European Journal of Pharmacology

Volumn 430, Issue 1, 2001, Pages 93-100

  Wayman, Nicole ^a   McDonald, Michelle C ^a   Thompson, Andrew S ^b   Threadgill, Michael D ^b   Thiemermann, Christoph ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

Cardiomyoblast; Heart; Infarct size, (rat); Poly (adenosine 5 diphosphate ribose) polymerase; Reactive oxygen species

Indexed keywords

1,5 DIHYDROXYISOQUINOLINONE[5 HYDROXYISOQUINOLIN 1(2H) ONE]; 3 AMINOBENZAMIDE; 3,4 DIHYDRO 5 [4 (PIPERIDIN 1 YL)BUTOXY]ISOQUINOLIN 1(2H) ONE; 5 AMINOISOQUINOLINONE; ENZYME INHIBITOR; HYDROGEN PEROXIDE; ISOQUINOLINE DERIVATIVE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; IC 50; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MITOCHONDRIAL RESPIRATION; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; ENZYME INHIBITORS; HEART; HYDROGEN PEROXIDE; ISOQUINOLINES; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; NITROBLUE TETRAZOLIUM; POLY(ADP-RIBOSE) POLYMERASES; RATS; STAINING AND LABELING;

EID: 0035955411     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01359-0     Document Type: Article

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