Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion

European Journal of Pharmacology

Volumn 492, Issue 2-3, 2004, Pages 203-210

  Di Paola, Rosanna ^a   Genovese, Tiziana ^a   Caputi, Achille P ^a   Threadgill, Mike ^b   Thiemermann, Christoph ^c   Cuzzocrea, Salvatore ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b University of Bath   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

5 Aminoisoquinolinone; Artery occlusion; Reperfusion

Indexed keywords

3 NITROTYROSINE; 5 AMINOISOQUINOLINONE; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTECTIVE AGENT; PROTEINASE ACTIVATED RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY; ARTERY CLAMP; ARTICLE; BLOOD VESSEL OCCLUSION; CELIAC ARTERY; CELIAC ARTERY STENOSIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SOLUBILITY; HISTOPATHOLOGY; ILEUM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE INJURY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTECTION; RAT; REPERFUSION INJURY; SPLANCHNIC ARTERY; SPLANCHNIC BLOOD FLOW; STATISTICAL SIGNIFICANCE; SUPERIOR MESENTERIC ARTERY; SUPERIOR MESENTERIC ARTERY OBSTRUCTION;

ANIMALS; CELIAC ARTERY; DISEASE MODELS, ANIMAL; INTERCELLULAR ADHESION MOLECULE-1; INTESTINE, SMALL; ISCHEMIA; ISOQUINOLINES; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MESENTERIC ARTERY, SUPERIOR; MESENTERIC VASCULAR OCCLUSION; PEROXIDASE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION; REPERFUSION INJURY; SOLUBILITY; TYROSINE; WATER;

EID: 2642537476     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.03.033     Document Type: Article

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