Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue

Journal of Biological Chemistry

Volumn 285, Issue 34, 2010, Pages 26506-26518

  Fiorillo, Edoardo ^a   Orrú, Valeria ^a   Stanford, Stephanie M ^a,b   Liu, Yingge ^a   Salek, Mogjiborahman ^c   Rapini, Novella ^d   Schenone, Aaron D ^b   Saccucci, Patrizia ^d   Delogu, Lucia G ^a   Angelini, Federica ^d   Bitti, Maria Luisa Manca ^d   Schmedt, Christian ^e   Chan, Andrew C ^f   Acuto, Oreste ^c   Bottini, Nunzio ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^f GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEGATIVE REGULATORS; RISK FACTORS; SINGLE NUCLEOTIDE POLYMORPHISMS; T CELL RECEPTOR; T-CELL SIGNALING; TYROSINE PHOSPHATASE; TYROSINE RESIDUES;

AMINO ACIDS; CELL MEMBRANES; NUCLEOTIDES; PHOSPHORYLATION; POLYMORPHISM; SIGNALING;

PHOSPHATASES;

NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR; TYROSINE;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CELL ISOLATION; CONTROLLED STUDY; GENE DISRUPTION; GENE MAPPING; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE;

ANIMALS; AUTOIMMUNITY; CELLS, CULTURED; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TYROSINE;

EID: 77956216562     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.111104     Document Type: Article

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